Ligand: 5U5

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 2 66.7% 5EYMA
DFGin None 1 33.3% 5MAIA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK MELK MELK_HUMAN 5MAIA Q14680 2 333 651.0 5U5:60402 Type1 Inactive DFGin 8.109 15.012 None -132.28, 170.97 62.08, 71.15 -94.74, 999.0 292.75, 79.84 999.0, 999.0 out-out out 11.882 Saltbr-out 8.222 HRD-in -86.33, -52.07 84.11, -4.76 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -42.92 APE8-rot-out 218.22 APE67-dihe-in -56.7, -25.99 -57.2, -38.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.192 0.237 A 347 311 19 0 0 19 [[11, 263]] 1.0 5mai CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
STE MAP2K1 MP2K1_HUMAN 5EYMA Q02750 41 381 393.0 5U5:401 Type1 Inactive DFGin 6.059 15.659 BLBplus -120.98, 147.02 60.26, 74.87 -99.88, 172.08 67.77, 94.18 -95.96, 104.23 out-out out 14.943 Saltbr-out 14.637 HRD-out -97.04, 164.44 -129.86, 87.96 out-out-out SNCooo out-out ActLoopNT-out 9.839 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 170.38 APE8-rot-out 191.89 APE67-dihe-in -94.98, 9.32 -122.76, 22.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S298N,S299K,Y300F None None XRAY 2.7 0.247 0.308 A 359 292 49 0 0 6 [[68, 361]] 1.0 5eym STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5EYMB Q02750 41 381 393.0 5U5:401 Type1 Inactive DFGin 5.847 15.517 BLBplus -137.53, 139.28 62.1, 82.03 -101.81, 135.65 61.97, 95.79 -72.99, 85.77 out-out out 14.846 Saltbr-out 13.905 HRD-out -85.96, 166.94 -128.86, 78.44 out-out-out SNCooo out-out ActLoopNT-out 9.749 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 169.8 APE8-rot-out 190.32 APE67-dihe-in -105.42, 16.51 -133.2, 32.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S298N,S299K,Y300F None None XRAY 2.7 0.247 0.308 B 359 292 49 0 0 6 [[68, 361]] 1.0 5eym STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1

Ligand: 5U5

Total number of chains: 5
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 40.0% 5EYKB
DFGin BLBplus 2 40.0% 5EYMA
DFGin None 1 20.0% 5MAIA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK MELK MELK_HUMAN 5MAIA Q14680 2 333 651.0 5U5:60402 Type1 Inactive DFGin 8.109 15.012 None -132.28, 170.97 62.08, 71.15 -94.74, 999.0 292.75, 79.84 999.0, 999.0 out-out out 11.882 Saltbr-out 8.222 HRD-in -86.33, -52.07 84.11, -4.76 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -42.92 APE8-rot-out 218.22 APE67-dihe-in -56.7, -25.99 -57.2, -38.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.192 0.237 A 347 311 19 0 0 19 [[11, 263]] 1.0 5mai Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
STE MAP2K1 MP2K1_HUMAN 5EYMA Q02750 41 381 393.0 5U5:401 Type1 Inactive DFGin 6.059 15.659 BLBplus -120.98, 147.02 60.26, 74.87 -99.88, 172.08 67.77, 94.18 -95.96, 104.23 out-out out 14.943 Saltbr-out 14.637 HRD-out -97.04, 164.44 -129.86, 87.96 out-out-out SNCooo out-out ActLoopNT-out 9.839 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 170.38 APE8-rot-out 191.89 APE67-dihe-in -94.98, 9.32 -122.76, 22.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S298N,S299K,Y300F None None XRAY 2.7 0.247 0.308 A 359 292 49 0 0 6 [[68, 361]] 1.0 5eym Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5EYMB Q02750 41 381 393.0 5U5:401 Type1 Inactive DFGin 5.847 15.517 BLBplus -137.53, 139.28 62.1, 82.03 -101.81, 135.65 61.97, 95.79 -72.99, 85.77 out-out out 14.846 Saltbr-out 13.905 HRD-out -85.96, 166.94 -128.86, 78.44 out-out-out SNCooo out-out ActLoopNT-out 9.749 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 169.8 APE8-rot-out 190.32 APE67-dihe-in -105.42, 16.51 -133.2, 32.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S298N,S299K,Y300F None None XRAY 2.7 0.247 0.308 B 359 292 49 0 0 6 [[68, 361]] 1.0 5eym Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
CAMK AURKBA AUKBA_XENLA 5EYKB Q6DE08 81 356 361.0 5U5:401 Type1 Inactive DFGin 6.068 16.575 ABAminus -112.09, -11.83 -128.8, 128.82 -123.57, 29.05 279.71, 82.37 -53.88, -31.06 out-out out 11.193 Saltbr-out 6.626 HRD-in -71.23, -53.97 71.23, 1.84 out-in-in SNCoii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.26, 167.32 APE9-dihe-na 120.55, -149.48 APE8-dihe-in -136.43, 131.31 APE8-rot-in 300.33 APE67-dihe-in -64.5, -20.98 -31.7, -60.74 APE12-dist-in 7.777 APE11-dist-in 10.806 APE10-dist-in 5.18 APE9-dist-in 3.586 G96V TPO248 TPO248 XRAY 1.93 0.2 0.222 B 276 276 0 0 0 0 [[93, 343]] 1.0 5eyk Xenopus laevis CAMK_AURKBA_XENLA CAMK 5.3e-77 264.5 1 256 256 233 234 235 237 239 122 141 145 213 215 214 216 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A
CAMK AURKBA AUKBA_XENLA 5EYKA Q6DE08 88 355 361.0 5U5:401 Type1.5_Back Inactive DFGin 5.818 16.494 ABAminus -113.53, -11.3 -127.89, 127.9 -123.36, 28.44 280.86, 83.1 -54.75, -34.31 out-out out 11.167 Saltbr-out 6.298 HRD-in -71.81, -53.56 69.94, 2.34 out-in-in SNCoii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.24, 164.73 APE9-dihe-na 118.09, -143.76 APE8-dihe-in -130.69, 133.69 APE8-rot-in 302.79 APE67-dihe-in -64.89, -21.02 -31.66, -60.88 APE12-dist-in 8.059 APE11-dist-in 11.155 APE10-dist-in 5.517 APE9-dist-in 3.686 G96V TPO248 TPO248 XRAY 1.93 0.2 0.222 A 276 264 4 0 0 4 [[93, 343]] 1.0 5eyk Xenopus laevis CAMK_AURKBA_XENLA CAMK 5.3e-77 264.5 1 256 256 233 234 235 237 239 122 141 145 213 215 214 216 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A

Ligand: 5U5

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 5EYKB
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK AURKBA AUKBA_XENLA 5EYKB Q6DE08 81 356 361.0 5U5:401 Type1 Inactive DFGin 6.068 16.575 ABAminus -112.09, -11.83 -128.8, 128.82 -123.57, 29.05 279.71, 82.37 -53.88, -31.06 out-out out 11.193 Saltbr-out 6.626 HRD-in -71.23, -53.97 71.23, 1.84 out-in-in SNCoii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.26, 167.32 APE9-dihe-na 120.55, -149.48 APE8-dihe-in -136.43, 131.31 APE8-rot-in 300.33 APE67-dihe-in -64.5, -20.98 -31.7, -60.74 APE12-dist-in 7.777 APE11-dist-in 10.806 APE10-dist-in 5.18 APE9-dist-in 3.586 G96V TPO248 TPO248 XRAY 1.93 0.2 0.222 B 276 276 0 0 0 0 [[93, 343]] 1.0 5eyk Xenopus laevis CAMK_AURKBA_XENLA CAMK 5.3e-77 264.5 1 256 256 233 234 235 237 239 122 141 145 213 215 214 216 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A
CAMK AURKBA AUKBA_XENLA 5EYKA Q6DE08 88 355 361.0 5U5:401 Type1.5_Back Inactive DFGin 5.818 16.494 ABAminus -113.53, -11.3 -127.89, 127.9 -123.36, 28.44 280.86, 83.1 -54.75, -34.31 out-out out 11.167 Saltbr-out 6.298 HRD-in -71.81, -53.56 69.94, 2.34 out-in-in SNCoii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.24, 164.73 APE9-dihe-na 118.09, -143.76 APE8-dihe-in -130.69, 133.69 APE8-rot-in 302.79 APE67-dihe-in -64.89, -21.02 -31.66, -60.88 APE12-dist-in 8.059 APE11-dist-in 11.155 APE10-dist-in 5.517 APE9-dist-in 3.686 G96V TPO248 TPO248 XRAY 1.93 0.2 0.222 A 276 264 4 0 0 4 [[93, 343]] 1.0 5eyk Xenopus laevis CAMK_AURKBA_XENLA CAMK 5.3e-77 264.5 1 256 256 233 234 235 237 239 122 141 145 213 215 214 216 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A