Ligand: 5L4

Total number of chains: 3
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 5E8ZA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL TGFBR1 TGFR1_HUMAN 5E90A P36897 200 499 503.0 5L4:60601 Type1 Active DFGin 7.0329 13.9683 BLAminus -132.44, -170.95 59.07, 73.91 -100.08, 11.67 293.12, 109.78 -58.9, -27.5 in-in in 7.7319 Saltbr-in 2.8651 HRD-in -62.69, -55.46 77.29, -2.06 in-in-in SNCiii in-in ActLoopNT-in 2.8722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.74, -31.43 APE9-dihe-na -82.55, -164.68 APE8-dihe-in -74.68, 122.19 APE8-rot-in 303.81 APE67-dihe-in -54.67, -36.7 -55.17, -42.7 APE12-dist-in 12.5936 APE11-dist-in 11.8996 APE10-dist-in 5.8869 APE9-dist-in 3.841 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None None XRAY 2.05 0.178 0.218 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5e90 TKL_TGFBR1_HUMAN TKL 2.3e-85 292.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 5E8ZA P36897 200 499 503.0 5L4:60601 Type1 Active DFGin 5.9379 12.7418 BLAminus -131.72, -172.47 57.21, 65.07 -93.0, 9.47 305.33, 7.41 -62.65, -21.83 in-in in 7.8695 Saltbr-in 2.9396 HRD-in -73.84, -51.69 76.4, -3.34 in-in-in SNCiii in-in ActLoopNT-in 2.9146 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -86.19, -27.35 APE9-dihe-na -88.81, -157.37 APE8-dihe-in -81.17, 121.36 APE8-rot-in 303.09 APE67-dihe-in -55.51, -33.19 -54.0, -44.23 APE12-dist-in 13.1171 APE11-dist-in 12.1808 APE10-dist-in 6.1394 APE9-dist-in 3.7752 T204D None None XRAY 1.51 0.183 0.207 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5e8z TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 5E91A P37173 240 543 567.0 5L4:601 Type1 Active DFGin 7.3985 13.6133 BLAminus -147.14, -171.85 61.39, 64.81 -93.01, 17.49 298.43, 101.83 -55.7, -31.33 in-in in 7.6524 Saltbr-in 2.7401 HRD-in -67.96, -50.27 72.9, 0.64 in-in-in SNCiii in-in ActLoopNT-in 2.9217 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.96, 139.39 APE9-dihe-na 125.36, -159.39 APE8-dihe-in -101.78, 120.18 APE8-rot-in 301.71 APE67-dihe-in -56.78, -33.79 -49.19, -43.11 APE12-dist-in 11.4745 APE11-dist-in 11.874 APE10-dist-in 5.9086 APE9-dist-in 3.6604 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 2.42 0.209 0.242 A 316.0 297.0 7 32 32 0 [[244, 540]] 1.0 5e91 TKL_TGFBR2_HUMAN TKL 1.9e-77 266.3 2.0 266.0 265.0 396 397 398 400 402 277 290 294 376 378 377 379.0 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2

Ligand: 5L4

Total number of chains: 3
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 5E8ZA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL TGFBR1 TGFR1_HUMAN 5E90A P36897 200 499 503.0 5L4:60601 Type1 Active DFGin 7.0329 13.9683 BLAminus -132.44, -170.95 59.07, 73.91 -100.08, 11.67 293.12, 109.78 -58.9, -27.5 in-in in 7.7319 Saltbr-in 2.8651 HRD-in -62.69, -55.46 77.29, -2.06 in-in-in SNCiii in-in ActLoopNT-in 2.8722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.74, -31.43 APE9-dihe-na -82.55, -164.68 APE8-dihe-in -74.68, 122.19 APE8-rot-in 303.81 APE67-dihe-in -54.67, -36.7 -55.17, -42.7 APE12-dist-in 12.5936 APE11-dist-in 11.8996 APE10-dist-in 5.8869 APE9-dist-in 3.841 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None None XRAY 2.05 0.178 0.218 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5e90 Homo sapiens TKL_TGFBR1_HUMAN TKL 2.3e-85 292.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 5E8ZA P36897 200 499 503.0 5L4:60601 Type1 Active DFGin 5.9379 12.7418 BLAminus -131.72, -172.47 57.21, 65.07 -93.0, 9.47 305.33, 7.41 -62.65, -21.83 in-in in 7.8695 Saltbr-in 2.9396 HRD-in -73.84, -51.69 76.4, -3.34 in-in-in SNCiii in-in ActLoopNT-in 2.9146 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -86.19, -27.35 APE9-dihe-na -88.81, -157.37 APE8-dihe-in -81.17, 121.36 APE8-rot-in 303.09 APE67-dihe-in -55.51, -33.19 -54.0, -44.23 APE12-dist-in 13.1171 APE11-dist-in 12.1808 APE10-dist-in 6.1394 APE9-dist-in 3.7752 T204D None None XRAY 1.51 0.183 0.207 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5e8z Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 5E91A P37173 240 543 567.0 5L4:601 Type1 Active DFGin 7.3985 13.6133 BLAminus -147.14, -171.85 61.39, 64.81 -93.01, 17.49 298.43, 101.83 -55.7, -31.33 in-in in 7.6524 Saltbr-in 2.7401 HRD-in -67.96, -50.27 72.9, 0.64 in-in-in SNCiii in-in ActLoopNT-in 2.9217 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.96, 139.39 APE9-dihe-na 125.36, -159.39 APE8-dihe-in -101.78, 120.18 APE8-rot-in 301.71 APE67-dihe-in -56.78, -33.79 -49.19, -43.11 APE12-dist-in 11.4745 APE11-dist-in 11.874 APE10-dist-in 5.9086 APE9-dist-in 3.6604 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 2.42 0.209 0.242 A 316.0 297.0 7 32 32 0 [[244, 540]] 1.0 5e91 Homo sapiens TKL_TGFBR2_HUMAN TKL 1.9e-77 266.3 2.0 266.0 265.0 396 397 398 400 402 277 290 294 376 378 377 379.0 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2

Ligand: 5L4

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name