Ligand: 3EW (Selumetinib)

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 2 100.0% 4U7ZA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
STE MAP2K1 MP2K1_HUMAN 4U7ZA 2.805 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_onoo 3EW, ANP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0TB 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo 3EW, ANP Type3, ATPlike 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1

Ligand: 3EW (Selumetinib)

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 4 100.0% 4U7ZA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
STE MAP2K1 MP2K1_HUMAN 4U7ZA 2.805 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_onoo 3EW, ANP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0TB 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo 3EW, ANP Type3, ATPlike 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_RABIT 7JUTC 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 41 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUZC 3.21 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus

Ligand: 3EW (Selumetinib)

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 2 100.0% 7JUZC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
STE MAP2K1 MP2K1_RABIT 7JUTC 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 41 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUZC 3.21 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus