Ligand: 1FM

Total number of chains: 4
Active chains: 0
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 25.0% 3W55A
DFGin BLBminus 1 25.0% 4GS6A
DFGin BLBplus 1 25.0% 8YP5A
DFGout None 1 25.0% 3WZUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK1 MK01_HUMAN 3W55A P28482 11 357 360.0 1FM:401 Type1 Inactive DFGin 6.8453 15.3111 BLAminus -114.5, 159.86 66.42, 121.73 -134.68, 25.56 281.37, 73.75 -67.05, -27.15 in-in in 9.7658 Saltbr-in 3.3276 HRD-in -73.73, -41.19 69.72, -22.0 in-in-out SNCiio in-out ActLoopNT-in 3.2448 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, 108.71 APE9-dihe-na 148.35, -177.22 APE8-dihe-out -15.28, -98.64 APE8-rot-out 164.29 APE67-dihe-out -92.01, -3.61 134.93, -62.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.0062 APE9-dist-out 7.3671 None None None XRAY 3.0 0.277 0.281 A 368.0 335.0 12 31 19 12 [[25, 313]] 1.0 3w55 CMGC_MAPK1_HUMAN CMGC 9.9e-86 293.6 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
STE MAP2K4 MP2K4_HUMAN 8YP5A P45985 80 392 399.0 1FM:501 Type1 Inactive DFGin 7.5191 13.7596 BLBplus -152.08, 177.39 57.94, 27.43 -91.01, 160.87 50.54, 97.87 71.82, -120.11 out-na out 15.6965 Saltbr-na 16.6342 HRD-in -46.05, -59.08 77.01, 5.2 na-out-out SNCaoo out-out ActLoopNT-out 8.4883 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -63.73, -5.16 APE9-dihe-na -108.36, -10.27 APE8-dihe-out -119.29, -38.77 APE8-rot-na 65.49 APE67-dihe-in -52.63, -18.08 -55.59, -49.23 APE12-dist-out 18.45 APE11-dist-out 19.2496 APE10-dist-out 20.2703 APE9-dist-out 23.3395 None None None XRAY 2.5 0.237 0.326 A 327.0 307.0 6 27 27 0 [[102, 367]] 1.0 8yp5 STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4.0 257.0 254.0 246 247 248 250 252 131 148 152 226 228 227 229.0 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K7 MP2K7_HUMAN 3WZUA O14733 104 402 419.0 1FM:60600 Type1 Inactive DFGout 11.7992 6.6541 None -93.22, 113.48 -84.76, 103.03 -136.57, -104.81 215.37, 93.4 104.1, 999.0 none-na none 999.0 Saltbr-na 999.0 HRD-out -25.62, 111.55 -64.83, -46.46 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, -69.55 APE9-dihe-na -125.65, -59.15 APE8-dihe-out -72.37, 11.48 APE8-rot-na 285.95 APE67-dihe-in -63.78, -33.54 -102.86, -19.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.3239 None None None XRAY 3.01 0.24 0.322 A 324.0 270.0 29 27 13 14 [[120, 380]] 1.0 3wzu STE_MAP2K7_HUMAN STE 2.9e-80 275.3 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 4GS6A O43318 31 496 606.0 1FM:60611 Type1 Inactive DFGin 5.4999 14.1728 BLBminus -129.67, -179.57 41.4, 77.08 -68.75, 133.58 312.58, 158.89 -63.49, 999.0 in-in in 8.3663 Saltbr-in 2.861 HRD-in -70.16, -52.0 72.73, -10.07 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -28.33 APE8-dihe-out -87.29, -1.72 APE8-rot-in 306.53 APE67-dihe-in -64.56, -22.41 -54.21, -34.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8473 None None None XRAY 2.2 0.223 0.245 A 315.0 260.0 13 25 12 13 [[36, 286]] 1.0 4gs6 TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7

Ligand: 1FM

Total number of chains: 4
Active chains: 0
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 25.0% 3W55A
DFGin BLBminus 1 25.0% 4GS6A
DFGin BLBplus 1 25.0% 8YP5A
DFGout None 1 25.0% 3WZUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK1 MK01_HUMAN 3W55A P28482 11 357 360.0 1FM:401 Type1 Inactive DFGin 6.8453 15.3111 BLAminus -114.5, 159.86 66.42, 121.73 -134.68, 25.56 281.37, 73.75 -67.05, -27.15 in-in in 9.7658 Saltbr-in 3.3276 HRD-in -73.73, -41.19 69.72, -22.0 in-in-out SNCiio in-out ActLoopNT-in 3.2448 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, 108.71 APE9-dihe-na 148.35, -177.22 APE8-dihe-out -15.28, -98.64 APE8-rot-out 164.29 APE67-dihe-out -92.01, -3.61 134.93, -62.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.0062 APE9-dist-out 7.3671 None None None XRAY 3.0 0.277 0.281 A 368.0 335.0 12 31 19 12 [[25, 313]] 1.0 3w55 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.9e-86 293.6 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
STE MAP2K4 MP2K4_HUMAN 8YP5A P45985 80 392 399.0 1FM:501 Type1 Inactive DFGin 7.5191 13.7596 BLBplus -152.08, 177.39 57.94, 27.43 -91.01, 160.87 50.54, 97.87 71.82, -120.11 out-na out 15.6965 Saltbr-na 16.6342 HRD-in -46.05, -59.08 77.01, 5.2 na-out-out SNCaoo out-out ActLoopNT-out 8.4883 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -63.73, -5.16 APE9-dihe-na -108.36, -10.27 APE8-dihe-out -119.29, -38.77 APE8-rot-na 65.49 APE67-dihe-in -52.63, -18.08 -55.59, -49.23 APE12-dist-out 18.45 APE11-dist-out 19.2496 APE10-dist-out 20.2703 APE9-dist-out 23.3395 None None None XRAY 2.5 0.237 0.326 A 327.0 307.0 6 27 27 0 [[102, 367]] 1.0 8yp5 Homo sapiens STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4.0 257.0 254.0 246 247 248 250 252 131 148 152 226 228 227 229.0 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K7 MP2K7_HUMAN 3WZUA O14733 104 402 419.0 1FM:60600 Type1 Inactive DFGout 11.7992 6.6541 None -93.22, 113.48 -84.76, 103.03 -136.57, -104.81 215.37, 93.4 104.1, 999.0 none-na none 999.0 Saltbr-na 999.0 HRD-out -25.62, 111.55 -64.83, -46.46 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, -69.55 APE9-dihe-na -125.65, -59.15 APE8-dihe-out -72.37, 11.48 APE8-rot-na 285.95 APE67-dihe-in -63.78, -33.54 -102.86, -19.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.3239 None None None XRAY 3.01 0.24 0.322 A 324.0 270.0 29 27 13 14 [[120, 380]] 1.0 3wzu Homo sapiens STE_MAP2K7_HUMAN STE 2.9e-80 275.3 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 4GS6A O43318 31 496 606.0 1FM:60611 Type1 Inactive DFGin 5.4999 14.1728 BLBminus -129.67, -179.57 41.4, 77.08 -68.75, 133.58 312.58, 158.89 -63.49, 999.0 in-in in 8.3663 Saltbr-in 2.861 HRD-in -70.16, -52.0 72.73, -10.07 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -28.33 APE8-dihe-out -87.29, -1.72 APE8-rot-in 306.53 APE67-dihe-in -64.56, -22.41 -54.21, -34.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8473 None None None XRAY 2.2 0.223 0.245 A 315.0 260.0 13 25 12 13 [[36, 286]] 1.0 4gs6 Homo sapiens TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7

Ligand: 1FM

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name