Ligand: 1FM

Total number of chains: 8
Active chains: 0
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 5 62.5% 9M1ZC
DFGin BLAminus 1 12.5% 3W55A
DFGin BLBminus 1 12.5% 4GS6A
DFGin BLBplus 1 12.5% 8YP5A
All chains
Pymol session (all) Pymol script (all)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK1 MK01_HUMAN 3W55A P28482 11 357 360.0 1FM:401 Type1 Inactive DFGin 6.845 15.311 BLAminus DFGAsp-rot-in -114.5, 159.86 66.42, 121.73 211.71, -54.89 -134.68, 25.56 281.37, 73.75 -67.05, -27.15 in-in in 9.766 Saltbr-in 3.328 HRD-in -73.73, -41.19 69.72, -22.0 in-in-out SNCiio in-out ActLoopNT-in 3.245 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, 108.71 APE9-dihe-na 148.35, -177.22 APE8-dihe-out -15.28, -98.64 APE8-rot-out 164.29 APE67-dihe-out -92.01, -3.61 134.93, -62.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.006 APE9-dist-out 7.367 None None None XRAY 3.0 0.277 0.281 A 368 335 12 0 0 12 [[25, 313]] 1.0 3w55 CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
STE MAP2K4 MP2K4_HUMAN 8YP5A P45985 80 392 399.0 1FM:501 Type1 Inactive DFGin 7.519 13.76 BLBplus DFGAsp-rot-out -152.08, 177.39 57.94, 27.43 281.52, -47.29 -91.01, 160.87 50.54, 97.87 71.82, -120.11 na-na na 15.697 Saltbr-na 16.634 HRD-in -46.05, -59.08 77.01, 5.2 na-out-out SNCaoo out-out ActLoopNT-out 8.488 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -63.73, -5.16 APE9-dihe-na -108.36, -10.27 APE8-dihe-out -119.29, -38.77 APE8-rot-na 65.49 APE67-dihe-in -52.63, -18.08 -55.59, -49.23 APE12-dist-out 18.45 APE11-dist-out 19.25 APE10-dist-out 20.27 APE9-dist-out 23.34 None None None XRAY 2.5 0.237 0.326 A 327 307 6 0 0 0 [[102, 367]] 1.0 8yp5 STE_MAP2K4_HUMAN STE 7.1e-86 293.8 4 257 254 246 247 248 250 252 131 148 152 226 228 227 229 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K6 MP2K6_HUMAN 9M1ZA P52564 38 334 334.0 1FM:401 Type1 Inactive DFGout 11.933 4.631 None DFGAsp-rot-out 178.9628, -91.3647 71.3242, 94.1839 291.2652, 79.0242 -71.4538, -43.3449 248.5577, 165.2259 75.6023, 32.1336 na-na na 13.935 Saltbr-na 12.209 HRD-out -111.1084, 144.9129 -151.7313, 112.3143 na-out-out SNCaoo out-out ActLoopNT-out 11.334 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_iooo APE10-dihe-na -134.2664, 165.3226 APE9-dihe-na -92.6312, 93.314 APE8-dihe-out -156.4065, -89.0885 APE8-rot-na 38.2549 APE67-dihe-out -100.3067, 92.8873 -133.9085, 128.2028 APE12-dist-in 13.264 APE11-dist-out 17.265 APE10-dist-out 15.413 APE9-dist-out 16.533 None None None XRAY 3.0 0.277 0.332 A 340 288 9 0 0 9 [[53, 314]] 1.0 9m1z STE_MAP2K6_HUMAN STE 4.9e-85 291.0 3 257 255 196 197 198 200 202 82 99 103 176 178 177 179 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 9M1ZB P52564 38 333 334.0 1FM:401 Type1 Inactive DFGout 15.202 10.188 None DFGAsp-rot-out -97.1674, 164.1216 -147.7518, 165.0884 278.942, 89.4945 -171.6292, 137.862 56.1611, 97.1833 -82.3991, 150.1732 na-na na 13.353 Saltbr-na 13.239 HRD-out 70.1522, 145.6304 -151.0907, 32.2226 na-out-out SNCaoo out-out ActLoopNT-out 15.567 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_oooo APE10-dihe-na -98.806, -80.0387 APE9-dihe-na -174.3012, 78.772 APE8-dihe-in -153.4455, 170.7568 APE8-rot-na 270.8737 APE67-dihe-out -96.3894, 108.4122 -42.9803, 112.7162 APE12-dist-out 15.14 APE11-dist-out 17.608 APE10-dist-out 16.397 APE9-dist-out 15.991 None None None XRAY 3.0 0.277 0.332 B 340 287 9 0 0 9 [[53, 314]] 1.0 9m1z STE_MAP2K6_HUMAN STE 4.9e-85 291.0 3 257 255 196 197 198 200 202 82 99 103 176 178 177 179 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 9M1ZC P52564 38 334 334.0 1FM:401 Type1 Inactive DFGout 12.934 7.104 None DFGAsp-rot-out -48.865, -59.6011 64.38, 90.8772 283.3601, 0.2319 -64.4975, -42.5734 213.3427, 80.2205 60.2646, 38.3761 na-na na 12.488 Saltbr-na 12.859 HRD-out -85.1393, 141.6794 -77.2266, -30.3563 na-out-out SNCaoo out-out ActLoopNT-out 9.959 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -64.2055, -49.8113 APE9-dihe-na 62.9588, 37.7652 APE8-dihe-out -56.5728, -42.5281 APE8-rot-na 35.77 APE67-dihe-out -105.6613, 97.833 -133.5618, 122.2334 APE12-dist-out 14.163 APE11-dist-out 17.31 APE10-dist-out 17.41 APE9-dist-out 14.696 None None None XRAY 3.0 0.277 0.332 C 340 289 8 0 0 8 [[53, 314]] 1.0 9m1z STE_MAP2K6_HUMAN STE 4.9e-85 291.0 3 257 255 196 197 198 200 202 82 99 103 176 178 177 179 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 9M1ZD P52564 38 334 334.0 1FM:401 Type1 Inactive DFGout 11.828 7.297 None DFGAsp-rot-out -67.0691, -96.4763 71.9757, 102.5391 292.3689, -55.1051 -115.964, -67.2621 39.1774, 47.7176 82.9965, 151.0151 na-na na 14.547 Saltbr-na 17.017 HRD-out -125.4739, 133.0295 -116.7752, 134.0743 na-out-out SNCaoo out-out ActLoopNT-out 10.756 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_iooo APE10-dihe-na -157.5576, -178.3003 APE9-dihe-na -97.4057, 90.579 APE8-dihe-out -148.4737, -93.1771 APE8-rot-na 53.2646 APE67-dihe-out -102.447, 101.4874 -139.5895, 141.5729 APE12-dist-in 13.806 APE11-dist-out 17.439 APE10-dist-out 16.315 APE9-dist-out 16.728 None None None XRAY 3.0 0.277 0.332 D 340 289 8 0 0 8 [[53, 314]] 1.0 9m1z STE_MAP2K6_HUMAN STE 4.9e-85 291.0 3 257 255 196 197 198 200 202 82 99 103 176 178 177 179 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K7 MP2K7_HUMAN 3WZUA O14733 104 402 419.0 1FM:60600 Type1 Inactive DFGout 11.799 6.654 None DFGAsp-rot-out -93.22, 113.48 -84.76, 103.03 33.67, -13.61 -136.57, -104.81 215.37, 93.4 104.1, 999.0 na-na na 999.0 Saltbr-na 999.0 HRD-out -25.62, 111.55 -64.83, -46.46 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, -69.55 APE9-dihe-na -125.65, -59.15 APE8-dihe-out -72.37, 11.48 APE8-rot-na 285.95 APE67-dihe-in -63.78, -33.54 -102.86, -19.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.324 None None None XRAY 3.01 0.24 0.322 A 324 270 29 0 0 14 [[120, 380]] 1.0 3wzu STE_MAP2K7_HUMAN STE 3e-80 275.3 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 4GS6A O43318 31 496 606.0 1FM:60611 Type1 Inactive DFGin 5.5 14.173 BLBminus DFGAsp-rot-out -129.67, -179.57 41.4, 77.08 242.98, -67.53 -68.75, 133.58 312.58, 158.89 -63.49, 999.0 in-in in 8.366 Saltbr-in 2.861 HRD-in -70.16, -52.0 72.73, -10.07 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -28.33 APE8-dihe-out -87.29, -1.72 APE8-rot-in 306.53 APE67-dihe-in -64.56, -22.41 -54.21, -34.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.847 None None None XRAY 2.2 0.223 0.245 A 315 260 13 0 0 13 [[36, 286]] 1.0 4gs6 TKL_MAP3K7_HUMAN TKL 4.2e-74 255.4 2 266 265 174 175 176 178 180 63 77 81 153 155 154 156 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7

Ligand: 1FM

Total number of chains: 8
Active chains: 0
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 5 62.5% 9M1ZC
DFGin BLAminus 1 12.5% 3W55A
DFGin BLBminus 1 12.5% 4GS6A
DFGin BLBplus 1 12.5% 8YP5A
All chains
Pymol session (all) Pymol script (all)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK1 MK01_HUMAN 3W55A P28482 11 357 360.0 1FM:401 Type1 Inactive DFGin 6.845 15.311 BLAminus DFGAsp-rot-in -114.5, 159.86 66.42, 121.73 211.71, -54.89 -134.68, 25.56 281.37, 73.75 -67.05, -27.15 in-in in 9.766 Saltbr-in 3.328 HRD-in -73.73, -41.19 69.72, -22.0 in-in-out SNCiio in-out ActLoopNT-in 3.245 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, 108.71 APE9-dihe-na 148.35, -177.22 APE8-dihe-out -15.28, -98.64 APE8-rot-out 164.29 APE67-dihe-out -92.01, -3.61 134.93, -62.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.006 APE9-dist-out 7.367 None None None XRAY 3.0 0.277 0.281 A 368 335 12 0 0 12 [[25, 313]] 1.0 3w55 Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
STE MAP2K4 MP2K4_HUMAN 8YP5A P45985 80 392 399.0 1FM:501 Type1 Inactive DFGin 7.519 13.76 BLBplus DFGAsp-rot-out -152.08, 177.39 57.94, 27.43 281.52, -47.29 -91.01, 160.87 50.54, 97.87 71.82, -120.11 na-na na 15.697 Saltbr-na 16.634 HRD-in -46.05, -59.08 77.01, 5.2 na-out-out SNCaoo out-out ActLoopNT-out 8.488 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -63.73, -5.16 APE9-dihe-na -108.36, -10.27 APE8-dihe-out -119.29, -38.77 APE8-rot-na 65.49 APE67-dihe-in -52.63, -18.08 -55.59, -49.23 APE12-dist-out 18.45 APE11-dist-out 19.25 APE10-dist-out 20.27 APE9-dist-out 23.34 None None None XRAY 2.5 0.237 0.326 A 327 307 6 0 0 0 [[102, 367]] 1.0 8yp5 Homo sapiens STE_MAP2K4_HUMAN STE 7.1e-86 293.8 4 257 254 246 247 248 250 252 131 148 152 226 228 227 229 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K6 MP2K6_HUMAN 9M1ZA P52564 38 334 334.0 1FM:401 Type1 Inactive DFGout 11.933 4.631 None DFGAsp-rot-out 178.9628, -91.3647 71.3242, 94.1839 291.2652, 79.0242 -71.4538, -43.3449 248.5577, 165.2259 75.6023, 32.1336 na-na na 13.935 Saltbr-na 12.209 HRD-out -111.1084, 144.9129 -151.7313, 112.3143 na-out-out SNCaoo out-out ActLoopNT-out 11.334 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_iooo APE10-dihe-na -134.2664, 165.3226 APE9-dihe-na -92.6312, 93.314 APE8-dihe-out -156.4065, -89.0885 APE8-rot-na 38.2549 APE67-dihe-out -100.3067, 92.8873 -133.9085, 128.2028 APE12-dist-in 13.264 APE11-dist-out 17.265 APE10-dist-out 15.413 APE9-dist-out 16.533 None None None XRAY 3.0 0.277 0.332 A 340 288 9 0 0 9 [[53, 314]] 1.0 9m1z Homo sapiens STE_MAP2K6_HUMAN STE 4.9e-85 291.0 3 257 255 196 197 198 200 202 82 99 103 176 178 177 179 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 9M1ZB P52564 38 333 334.0 1FM:401 Type1 Inactive DFGout 15.202 10.188 None DFGAsp-rot-out -97.1674, 164.1216 -147.7518, 165.0884 278.942, 89.4945 -171.6292, 137.862 56.1611, 97.1833 -82.3991, 150.1732 na-na na 13.353 Saltbr-na 13.239 HRD-out 70.1522, 145.6304 -151.0907, 32.2226 na-out-out SNCaoo out-out ActLoopNT-out 15.567 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_oooo APE10-dihe-na -98.806, -80.0387 APE9-dihe-na -174.3012, 78.772 APE8-dihe-in -153.4455, 170.7568 APE8-rot-na 270.8737 APE67-dihe-out -96.3894, 108.4122 -42.9803, 112.7162 APE12-dist-out 15.14 APE11-dist-out 17.608 APE10-dist-out 16.397 APE9-dist-out 15.991 None None None XRAY 3.0 0.277 0.332 B 340 287 9 0 0 9 [[53, 314]] 1.0 9m1z Homo sapiens STE_MAP2K6_HUMAN STE 4.9e-85 291.0 3 257 255 196 197 198 200 202 82 99 103 176 178 177 179 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 9M1ZC P52564 38 334 334.0 1FM:401 Type1 Inactive DFGout 12.934 7.104 None DFGAsp-rot-out -48.865, -59.6011 64.38, 90.8772 283.3601, 0.2319 -64.4975, -42.5734 213.3427, 80.2205 60.2646, 38.3761 na-na na 12.488 Saltbr-na 12.859 HRD-out -85.1393, 141.6794 -77.2266, -30.3563 na-out-out SNCaoo out-out ActLoopNT-out 9.959 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -64.2055, -49.8113 APE9-dihe-na 62.9588, 37.7652 APE8-dihe-out -56.5728, -42.5281 APE8-rot-na 35.77 APE67-dihe-out -105.6613, 97.833 -133.5618, 122.2334 APE12-dist-out 14.163 APE11-dist-out 17.31 APE10-dist-out 17.41 APE9-dist-out 14.696 None None None XRAY 3.0 0.277 0.332 C 340 289 8 0 0 8 [[53, 314]] 1.0 9m1z Homo sapiens STE_MAP2K6_HUMAN STE 4.9e-85 291.0 3 257 255 196 197 198 200 202 82 99 103 176 178 177 179 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 9M1ZD P52564 38 334 334.0 1FM:401 Type1 Inactive DFGout 11.828 7.297 None DFGAsp-rot-out -67.0691, -96.4763 71.9757, 102.5391 292.3689, -55.1051 -115.964, -67.2621 39.1774, 47.7176 82.9965, 151.0151 na-na na 14.547 Saltbr-na 17.017 HRD-out -125.4739, 133.0295 -116.7752, 134.0743 na-out-out SNCaoo out-out ActLoopNT-out 10.756 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_iooo APE10-dihe-na -157.5576, -178.3003 APE9-dihe-na -97.4057, 90.579 APE8-dihe-out -148.4737, -93.1771 APE8-rot-na 53.2646 APE67-dihe-out -102.447, 101.4874 -139.5895, 141.5729 APE12-dist-in 13.806 APE11-dist-out 17.439 APE10-dist-out 16.315 APE9-dist-out 16.728 None None None XRAY 3.0 0.277 0.332 D 340 289 8 0 0 8 [[53, 314]] 1.0 9m1z Homo sapiens STE_MAP2K6_HUMAN STE 4.9e-85 291.0 3 257 255 196 197 198 200 202 82 99 103 176 178 177 179 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K7 MP2K7_HUMAN 3WZUA O14733 104 402 419.0 1FM:60600 Type1 Inactive DFGout 11.799 6.654 None DFGAsp-rot-out -93.22, 113.48 -84.76, 103.03 33.67, -13.61 -136.57, -104.81 215.37, 93.4 104.1, 999.0 na-na na 999.0 Saltbr-na 999.0 HRD-out -25.62, 111.55 -64.83, -46.46 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, -69.55 APE9-dihe-na -125.65, -59.15 APE8-dihe-out -72.37, 11.48 APE8-rot-na 285.95 APE67-dihe-in -63.78, -33.54 -102.86, -19.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.324 None None None XRAY 3.01 0.24 0.322 A 324 270 29 0 0 14 [[120, 380]] 1.0 3wzu Homo sapiens STE_MAP2K7_HUMAN STE 3e-80 275.3 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 4GS6A O43318 31 496 606.0 1FM:60611 Type1 Inactive DFGin 5.5 14.173 BLBminus DFGAsp-rot-out -129.67, -179.57 41.4, 77.08 242.98, -67.53 -68.75, 133.58 312.58, 158.89 -63.49, 999.0 in-in in 8.366 Saltbr-in 2.861 HRD-in -70.16, -52.0 72.73, -10.07 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -28.33 APE8-dihe-out -87.29, -1.72 APE8-rot-in 306.53 APE67-dihe-in -64.56, -22.41 -54.21, -34.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.847 None None None XRAY 2.2 0.223 0.245 A 315 260 13 0 0 13 [[36, 286]] 1.0 4gs6 Homo sapiens TKL_MAP3K7_HUMAN TKL 4.2e-74 255.4 2 266 265 174 175 176 178 180 63 77 81 153 155 154 156 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7

Ligand: 1FM

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name