OTHER_TBK1 (Serine/threonine-protein kinase TBK1)

Total number of chains: 27
Active chains: 5
Uniprot: TBK1_HUMAN
Kinase Domain Residues: 7 - 304
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 33.3% AF-Q9UHD2-K1A
DFGin BLBplus 9 33.3% 4IWOA
DFGin None 9 33.3% 6RSUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q9UHD2-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 312 0 None None Serine/threonine-protein kinase TBK1
AF-Q9UHD2-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 312 0 None None Serine/threonine-protein kinase TBK1
4EUUA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BX7 Type1 2 - 307 0 SEP172 D135N Serine/threonine-protein kinase TBK1
4EUUB 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BX7 Type1 2 - 307 0 SEP172 D135N Serine/threonine-protein kinase TBK1
4IW0A 4.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BX7 Type1 2 - 657 0 SEP172 D135N Serine/threonine-protein kinase TBK1
4EUTA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo BX7 Type1 2 - 385 0 None D135N Serine/threonine-protein kinase TBK1
4EUTB 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo BX7 Type1 2 - 385 0 None D135N Serine/threonine-protein kinase TBK1
6O8BA 3.4 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_oiii BX7 Type1 2 - 656 0 None D135N,S172E Serine/threonine-protein kinase TBK1
6O8BB 3.4 Inactive DFGin‑BLAminus in-in out-in nonTYR APEdihe_aaiii APEdist_iiii BX7 Type1 2 - 654 0 None D135N,S172E Serine/threonine-protein kinase TBK1
6NT9A 3.3 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 1 - 658 0 None D135N Serine/threonine-protein kinase TBK1
6NT9B 3.3 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 1 - 658 0 None D135N Serine/threonine-protein kinase TBK1
5W5VA 3.645 Inactive DFGin‑BLBplus out-out none-none nonTYR APEdihe_aannn APEdist_nnnn ANW Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1
6BODA 3.197 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn E0P Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1
6RSTA 3.29 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aaiii APEdist_nnni KHQ Type1 2 - 657 0 None None Serine/threonine-protein kinase TBK1
4IWOA 2.61 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aaiii APEdist_nnni 1H4 Type1 2 - 657 0 None S172A Serine/threonine-protein kinase TBK1
4IM0A 2.4 Inactive DFGin‑BLBplus out-out none-none nonTYR APEdihe_aanni APEdist_nnnn 1FV Type1 1 - 657 0 None D135N Serine/threonine-protein kinase TBK1
4IM2A 2.5 Inactive DFGin‑BLBplus out-out none-none nonTYR APEdihe_aanni APEdist_nnnn BX7 Type1 1 - 657 0 None D135N Serine/threonine-protein kinase TBK1
4IM3A 3.342 Inactive DFGin‑BLBplus out-out none-none nonTYR APEdihe_aannn APEdist_nnnn BX7 Type1 1 - 657 0 None D135N Serine/threonine-protein kinase TBK1
6BNYA 3.341 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn E0M Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1
6BOEA 3.598 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni E0S Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1
6CQ0A 3.19 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno F8M Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1
6CQ4A 3.2 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni F8P Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1
6CQ5A 3.354 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn F8S Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1
6RSRA 3.15 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni KHT Type1 2 - 657 0 None None Serine/threonine-protein kinase TBK1
6RSUA 2.75 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni KJB Type1 2 - 657 0 None None Serine/threonine-protein kinase TBK1
4IWPA 3.065 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni BX7 Type1 2 - 657 0 None S172A Serine/threonine-protein kinase TBK1
4IWQA 3.0 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni 1FV Type1 2 - 657 0 None S172A Serine/threonine-protein kinase TBK1

OTHER_TBK1 (Serine/threonine-protein kinase TBK1)

Total number of chains: 31
Active chains: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 11 35.5% 6O8CA
DFGin BLAminus 9 29.0% AF-Q9UHD2-K1A
DFGin None 9 29.0% 6RSUA
DFGin BLAplus 2 6.5% 4JLCA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TBK1_HUMAN AF-Q9UHD2-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 312 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN AF-Q9UHD2-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 312 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 4EUUA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BX7 Type1 2 - 307 0 SEP172 D135N Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 4EUUB 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BX7 Type1 2 - 307 0 SEP172 D135N Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 4IW0A 4.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BX7 Type1 2 - 657 0 SEP172 D135N Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 4EUTA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo BX7 Type1 2 - 385 0 None D135N Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 4EUTB 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo BX7 Type1 2 - 385 0 None D135N Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 6O8BA 3.4 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_oiii BX7 Type1 2 - 656 0 None D135N,S172E Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 6O8BB 3.4 Inactive DFGin‑BLAminus in-in out-in nonTYR APEdihe_aaiii APEdist_iiii BX7 Type1 2 - 654 0 None D135N,S172E Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 6NT9A 3.3 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 1 - 658 0 None D135N Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 6NT9B 3.3 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 1 - 658 0 None D135N Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 5W5VA 3.645 Inactive DFGin‑BLBplus out-out none-none nonTYR APEdihe_aannn APEdist_nnnn ANW Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 6BODA 3.197 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn E0P Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 6RSTA 3.29 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aaiii APEdist_nnni KHQ Type1 2 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 4IWOA 2.61 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aaiii APEdist_nnni 1H4 Type1 2 - 657 0 None S172A Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 4IM0A 2.4 Inactive DFGin‑BLBplus out-out none-none nonTYR APEdihe_aanni APEdist_nnnn 1FV Type1 1 - 657 0 None D135N Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 4IM2A 2.5 Inactive DFGin‑BLBplus out-out none-none nonTYR APEdihe_aanni APEdist_nnnn BX7 Type1 1 - 657 0 None D135N Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 4IM3A 3.342 Inactive DFGin‑BLBplus out-out none-none nonTYR APEdihe_aannn APEdist_nnnn BX7 Type1 1 - 657 0 None D135N Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 6BNYA 3.341 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn E0M Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 6BOEA 3.598 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni E0S Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 6CQ0A 3.19 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno F8M Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 6CQ4A 3.2 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni F8P Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 6CQ5A 3.354 Inactive DFGin‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn F8S Type1 1 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 6RSRA 3.15 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni KHT Type1 2 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 6RSUA 2.75 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni KJB Type1 2 - 657 0 None None Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 4IWPA 3.065 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni BX7 Type1 2 - 657 0 None S172A Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_HUMAN 4IWQA 3.0 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aaiii APEdist_nnni 1FV Type1 2 - 657 0 None S172A Serine/threonine-protein kinase TBK1 Homo sapiens
TBK1_MOUSE 4JL9A 3.1 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_nnno BX7 Type1 2 - 656 0 None None Serine/threonine-protein kinase TBK1 Mus musculus
TBK1_MOUSE 4JLCA 3.0 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_nnno SU6 Type1 2 - 656 0 None None Serine/threonine-protein kinase TBK1 Mus musculus
TBK1_MOUSE 6O8CA 3.17 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aanoo APEdist_nnnn BX7 Type1 2 - 651 0 None S172A Serine/threonine-protein kinase TBK1 Mus musculus
TBK1_MOUSE 6O8CB 3.17 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaoio APEdist_nnno BX7 Type1 2 - 653 0 None S172A Serine/threonine-protein kinase TBK1 Mus musculus

OTHER_TBK1 (Serine/threonine-protein kinase TBK1)

Total number of chains: 4
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 2 50.0% 4JLCA
DFGin BLBplus 2 50.0% 6O8CA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TBK1_MOUSE 4JL9A 3.1 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_nnno BX7 Type1 2 - 656 0 None None Serine/threonine-protein kinase TBK1 Mus musculus
TBK1_MOUSE 4JLCA 3.0 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_nnno SU6 Type1 2 - 656 0 None None Serine/threonine-protein kinase TBK1 Mus musculus
TBK1_MOUSE 6O8CA 3.17 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aanoo APEdist_nnnn BX7 Type1 2 - 651 0 None S172A Serine/threonine-protein kinase TBK1 Mus musculus
TBK1_MOUSE 6O8CB 3.17 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaoio APEdist_nnno BX7 Type1 2 - 653 0 None S172A Serine/threonine-protein kinase TBK1 Mus musculus