STE_STK3 (Serine/threonine-protein kinase 3)

Total number of chains: 17
Active chains: 2
Family: STE
Uniprot: STK3_HUMAN
Kinase Domain Residues: 27 - 278
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 8 47.1% 4LGDA
DFGin BLAminus 5 29.4% AF-Q13188-K1A
DFGin ABAminus 1 5.9% 5DH3B
DFGin BLAplus 1 5.9% 6AO5A
DFGin None 1 5.9% 4LG4F
None None 1 5.9% 4LG4D
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q13188-K1A 19 286 491.0 No_ligand No_ligand Active DFGin 6.028 14.597 BLAminus -135.04, 169.56 63.03, 75.37 -87.0, 11.61 290.14, 89.45 -63.13, -18.34 in-in in 9.13 Saltbr-in 2.642 HRD-in -70.59, -40.17 65.78, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.97, 156.29 APE9-dihe-na 125.13, 171.28 APE8-dihe-in -76.48, 123.55 APE8-rot-in 305.35 APE67-dihe-in -70.86, -20.72 -44.44, -46.2 APE12-dist-in 8.717 APE11-dist-in 11.818 APE10-dist-in 6.005 APE9-dist-in 3.265 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[27, 278]] 1.0 AF-Q13188-K1 STE_STK3_HUMAN STE 1.6e-101 345.0 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
AF-Q13188-K3A 19 286 491.0 No_ligand No_ligand Active DFGin 5.962 14.291 BLAminus -138.23, 170.92 62.61, 74.96 -87.3, 10.06 291.0, 89.98 -61.46, -22.56 in-in in 9.0 Saltbr-in 2.654 HRD-in -73.67, -41.85 67.4, -9.51 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.87, 148.49 APE9-dihe-na 135.56, 174.98 APE8-dihe-in -80.15, 124.18 APE8-rot-in 303.72 APE67-dihe-in -70.58, -21.97 -43.1, -47.82 APE12-dist-in 8.884 APE11-dist-in 11.687 APE10-dist-in 5.969 APE9-dist-in 3.273 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[27, 278]] 1.0 AF-Q13188-K3 STE_STK3_HUMAN STE 1.6e-101 345.0 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
5DH3B 18 302 491.0 5BS:401 Type1 Inactive DFGin 5.786 14.82 ABAminus -107.93, -47.86 -103.07, 119.05 -112.25, 18.06 290.67, 93.25 -61.59, -41.21 out-in out 10.137 Saltbr-in 3.208 HRD-in -63.36, -51.22 81.92, -5.45 in-in-in SNCiii in-in ActLoopNT-in 2.712 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.17, 161.15 APE9-dihe-na 132.06, -164.99 APE8-dihe-in -104.21, 128.47 APE8-rot-in 313.02 APE67-dihe-in -62.35, -41.65 -60.99, -39.89 APE12-dist-in 8.878 APE11-dist-in 11.407 APE10-dist-in 5.827 APE9-dist-in 3.665 None TPO174,TPO180 TPO174,TPO180 XRAY 2.468 0.213 0.247 B 315 285 0 0 0 0 [[27, 278]] 1.0 5dh3 STE_STK3_HUMAN STE 2.8e-101 344.2 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
8A66A 24 303 491.0 5BS:60501 Type1 Inactive DFGin 6.232 14.662 BLAminus -139.57, 162.57 72.11, 84.59 -98.16, 23.52 293.51, 92.3 -65.59, -22.75 in-in in 9.559 Saltbr-in 2.736 HRD-in -65.32, -44.41 72.25, -5.9 in-in-out SNCiio in-out ActLoopNT-in 2.838 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -147.11, 158.64 APE9-dihe-na 124.6, -157.27 APE8-dihe-in -114.81, 122.93 APE8-rot-out 43.78 APE67-dihe-in -62.92, -24.25 -35.94, -56.9 APE12-dist-in 8.68 APE11-dist-in 11.823 APE10-dist-in 5.983 APE9-dist-in 3.53 None TPO180 TPO180 XRAY 1.901 0.22 0.258 A 298 275 5 0 0 1 [[27, 278]] 1.0 8a66 STE_STK3_HUMAN STE 2.3e-101 344.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
8A66B 18 304 491.0 5BS:60501 Type1 Inactive DFGin 6.229 14.491 BLAminus -139.08, 162.57 69.6, 85.67 -96.89, 21.95 294.07, 84.34 -63.47, -19.34 in-in in 9.514 Saltbr-in 2.883 HRD-in -65.79, -48.59 72.98, -4.76 in-in-out SNCiio in-out ActLoopNT-in 2.832 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -146.04, 152.12 APE9-dihe-na 134.76, -156.35 APE8-dihe-in -108.07, 116.58 APE8-rot-out 42.21 APE67-dihe-in -60.0, -23.48 -33.57, -55.3 APE12-dist-in 8.605 APE11-dist-in 11.752 APE10-dist-in 5.981 APE9-dist-in 3.41 None TPO174,TPO180,TPO268 TPO174,TPO180,TPO268 XRAY 1.901 0.22 0.258 B 298 282 5 0 0 0 [[27, 278]] 1.0 8a66 STE_STK3_HUMAN STE 2.3e-101 344.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
5DH3A 19 307 491.0 5BS:401 Type1 Inactive DFGin 5.947 14.614 BLAminus -145.26, 166.53 56.21, 58.22 -79.02, 55.98 309.22, 59.68 -65.37, -40.98 out-out out 10.158 Saltbr-out 3.889 HRD-in -64.99, -53.25 81.51, -5.49 out-in-in SNCoii in-in ActLoopNT-in 2.818 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.11, 158.66 APE9-dihe-na 133.82, -164.61 APE8-dihe-in -99.88, 125.54 APE8-rot-in 317.53 APE67-dihe-in -61.6, -38.71 -57.46, -40.82 APE12-dist-in 8.882 APE11-dist-in 11.36 APE10-dist-in 5.773 APE9-dist-in 3.388 None TPO174,TPO180 TPO174,TPO180 XRAY 2.468 0.213 0.247 A 315 289 0 0 0 0 [[27, 278]] 1.0 5dh3 STE_STK3_HUMAN STE 2.8e-101 344.2 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
6AO5A 28 488 491.0 ANP:501 ATPlike Inactive DFGin 5.762 13.255 BLAplus -144.87, 157.4 64.61, 76.09 -109.93, -46.63 13.82, 108.09 -89.31, 27.29 out-out out 12.908 Saltbr-out 12.116 HRD-in -60.56, -48.36 76.32, -35.33 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nooo APE10-dihe-na -164.34, 157.95 APE9-dihe-na -118.75, -167.2 APE8-dihe-in -63.94, 121.38 APE8-rot-out 166.95 APE67-dihe-out -86.4, -39.81 -115.82, 59.17 APE12-dist-none 999.0 APE11-dist-out 17.895 APE10-dist-out 16.152 APE9-dist-out 11.062 D146N None None XRAY 2.955 0.236 0.256 A 362 321 27 0 0 12 [[27, 278]] 1.0 6ao5 STE_STK3_HUMAN STE 3.6e-100 340.7 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
4LGDA 16 488 491.0 ANP:501 ATPlike Inactive DFGin 6.018 17.02 BLBminus -145.52, -179.3 43.95, 67.54 -70.27, 152.23 281.57, 44.13 -80.59, 163.91 out-out out 10.889 Saltbr-out 5.794 HRD-in -73.7, -41.12 68.58, 5.1 out-out-out SNCooo out-out ActLoopNT-out 8.717 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -60.16, -34.45 APE9-dihe-na -67.84, -18.95 APE8-dihe-in -138.32, 78.16 APE8-rot-in 307.08 APE67-dihe-in -67.01, -21.51 -99.04, 14.35 APE12-dist-in 12.457 APE11-dist-in 10.195 APE10-dist-out 15.269 APE9-dist-out 12.752 D146N None None XRAY 3.05 0.202 0.244 A 378 350 0 0 0 0 [[27, 278]] 1.0 4lgd STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
4LGDB 10 488 491.0 ANP:501 ATPlike Inactive DFGin 6.16 16.692 BLBminus -138.64, 169.86 44.76, 62.12 -62.36, 151.89 285.61, 26.54 -88.9, 160.74 out-out out 10.736 Saltbr-out 6.022 HRD-in -77.36, -41.29 64.17, 12.1 out-out-out SNCooo out-out ActLoopNT-out 9.006 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -74.54, -22.15 APE9-dihe-na -64.82, -19.37 APE8-dihe-in -144.49, 84.11 APE8-rot-in 305.11 APE67-dihe-in -63.85, -34.86 -100.76, 15.67 APE12-dist-in 12.595 APE11-dist-in 10.253 APE10-dist-out 15.046 APE9-dist-out 12.722 D146N None None XRAY 3.05 0.202 0.244 B 378 350 0 0 0 0 [[27, 278]] 1.0 4lgd STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
4LGDC 12 490 491.0 ANP:501 ATPlike Inactive DFGin 6.359 17.118 BLBminus -149.78, 166.61 51.14, 65.46 -62.65, 153.33 284.02, 26.74 -77.49, 169.34 out-out out 10.55 Saltbr-out 5.611 HRD-in -72.97, -46.37 72.83, -1.88 out-out-out SNCooo out-out ActLoopNT-out 9.037 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -57.36, -33.07 APE9-dihe-na -66.61, -18.79 APE8-dihe-in -138.0, 80.15 APE8-rot-in 301.29 APE67-dihe-in -70.28, -28.9 -100.7, 15.38 APE12-dist-in 12.447 APE11-dist-in 10.03 APE10-dist-out 15.197 APE9-dist-out 12.67 D146N None None XRAY 3.05 0.202 0.244 C 378 349 7 0 0 0 [[27, 278]] 1.0 4lgd STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
4LGDD 11 489 491.0 ANP:501 ATPlike Inactive DFGin 6.268 16.891 BLBminus -143.39, 170.34 44.57, 62.98 -62.31, 161.36 279.47, 45.38 -101.43, 151.87 out-out out 10.794 Saltbr-out 6.287 HRD-in -67.38, -41.94 64.94, 10.19 out-out-out SNCooo out-out ActLoopNT-out 8.791 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -65.98, -30.48 APE9-dihe-na -65.09, -18.33 APE8-dihe-in -145.24, 79.51 APE8-rot-in 304.52 APE67-dihe-in -64.33, -26.69 -98.63, 11.94 APE12-dist-in 12.433 APE11-dist-in 10.306 APE10-dist-out 15.377 APE9-dist-out 12.751 D146N None None XRAY 3.05 0.202 0.244 D 378 338 0 0 0 0 [[27, 278]] 1.0 4lgd STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
4LG4A 18 308 491.0 No_ligand No_ligand Inactive DFGin 6.432 16.709 BLBminus -149.12, 171.46 46.69, 61.4 -60.75, 152.52 291.15, 39.97 -79.18, 173.35 out-out out 10.108 Saltbr-out 4.074 HRD-in -76.71, -50.91 85.64, -28.8 out-out-out SNCooo out-out ActLoopNT-out 9.203 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -62.56, -37.12 APE9-dihe-na -57.6, -19.4 APE8-dihe-in -131.0, 81.65 APE8-rot-in 305.42 APE67-dihe-in -65.11, -24.08 -99.22, 5.56 APE12-dist-in 11.633 APE11-dist-in 9.26 APE10-dist-out 14.084 APE9-dist-out 12.417 D146N None None XRAY 2.42 0.194 0.231 A 299 289 2 0 0 0 [[27, 278]] 1.0 4lg4 STE_STK3_HUMAN STE 1.9e-100 341.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
4LG4B 18 308 491.0 No_ligand No_ligand Inactive DFGin 5.314 14.731 BLBminus -140.21, 165.65 51.04, 86.72 -80.54, 176.1 305.81, 78.15 -53.27, 999.0 out-out out 10.695 Saltbr-out 5.399 HRD-in -69.34, -48.39 74.3, -6.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -68.75, -29.95 APE9-dihe-na -83.67, -6.62 APE8-dihe-out -47.16, -50.18 APE8-rot-in 302.82 APE67-dihe-in -50.74, -37.0 -61.88, -26.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.24 D146N None None XRAY 2.42 0.194 0.231 B 299 284 7 0 0 4 [[27, 278]] 1.0 4lg4 STE_STK3_HUMAN STE 1.9e-100 341.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
4LG4C 18 307 491.0 No_ligand No_ligand Inactive DFGin 6.226 16.418 BLBminus -145.61, 169.46 51.28, 57.2 -59.23, 151.18 287.92, 51.76 -86.76, 150.02 in-in in 9.911 Saltbr-in 3.44 HRD-in -75.35, -49.3 83.39, -19.28 in-out-out SNCioo out-out ActLoopNT-out 9.193 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -63.35, -30.69 APE9-dihe-na -66.56, -23.25 APE8-dihe-in -134.1, 75.91 APE8-rot-out 66.24 APE67-dihe-in -62.05, -27.19 -90.36, 7.85 APE12-dist-in 11.691 APE11-dist-in 9.722 APE10-dist-out 14.664 APE9-dist-out 12.281 D146N None None XRAY 2.42 0.194 0.231 C 299 288 2 0 0 0 [[27, 278]] 1.0 4lg4 STE_STK3_HUMAN STE 1.9e-100 341.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
4LG4E 18 308 491.0 No_ligand No_ligand Inactive DFGin 6.263 16.204 BLBminus -130.31, 173.17 47.8, 59.45 -58.92, 151.45 279.66, 80.29 -84.51, 152.04 out-out out 10.135 Saltbr-out 4.21 HRD-in -72.01, -47.83 74.71, -8.47 out-out-out SNCooo out-out ActLoopNT-out 8.91 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -71.15, -28.45 APE9-dihe-na -67.18, -21.74 APE8-dihe-in -127.36, 70.14 APE8-rot-in 309.85 APE67-dihe-in -69.41, -34.62 -90.13, 14.25 APE12-dist-in 11.192 APE11-dist-in 9.221 APE10-dist-out 14.066 APE9-dist-out 12.293 D146N None None XRAY 2.42 0.194 0.231 E 299 275 16 0 0 6 [[27, 278]] 1.0 4lg4 STE_STK3_HUMAN STE 1.9e-100 341.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
4LG4F 18 310 491.0 No_ligand No_ligand Inactive DFGin 4.8 15.191 None -138.38, 162.54 47.11, 83.6 -66.57, 999.0 302.94, 84.23 999.0, 999.0 out-out out 10.79 Saltbr-out 6.42 HRD-in -72.45, -47.39 76.74, -5.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -102.3 APE8-dihe-in -134.65, 156.4 APE8-rot-out 45.22 APE67-dihe-in -63.77, -27.55 -98.01, 1.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.121 D146N None None XRAY 2.42 0.194 0.231 F 299 276 17 0 0 17 [[27, 278]] 1.0 4lg4 STE_STK3_HUMAN STE 1.9e-100 341.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
4LG4D 26 308 491.0 No_ligand No_ligand Inactive None 999.0 999.0 None -138.74, -179.79 -96.29, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.335 Saltbr-out 5.21 HRD-in -73.23, -47.35 79.5, -18.38 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -41.57 APE8-dihe-in -147.49, 145.83 APE8-rot-out 185.09 APE67-dihe-in -63.59, -23.02 -102.14, -5.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.516 D146N None None XRAY 2.42 0.194 0.231 D 299 250 33 0 0 18 [[27, 278]] 1.0 4lg4 STE_STK3_HUMAN STE 1.9e-100 341.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3

STE_STK3 (Serine/threonine-protein kinase 3)

Total number of chains: 17
Active chains: 2
Family: STE
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 8 47.1% 4LGDA
DFGin BLAminus 5 29.4% AF-Q13188-K1A
DFGin ABAminus 1 5.9% 5DH3B
DFGin BLAplus 1 5.9% 6AO5A
DFGin None 1 5.9% 4LG4F
None None 1 5.9% 4LG4D
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STK3_HUMAN AF-Q13188-K1A Q13188 19 286 491.0 No_ligand No_ligand Active DFGin 6.028 14.597 BLAminus -135.04, 169.56 63.03, 75.37 -87.0, 11.61 290.14, 89.45 -63.13, -18.34 in-in in 9.13 Saltbr-in 2.642 HRD-in -70.59, -40.17 65.78, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.97, 156.29 APE9-dihe-na 125.13, 171.28 APE8-dihe-in -76.48, 123.55 APE8-rot-in 305.35 APE67-dihe-in -70.86, -20.72 -44.44, -46.2 APE12-dist-in 8.717 APE11-dist-in 11.818 APE10-dist-in 6.005 APE9-dist-in 3.265 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[27, 278]] 1.0 AF-Q13188-K1 Homo sapiens STE_STK3_HUMAN STE 1.6e-101 345.0 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN AF-Q13188-K3A Q13188 19 286 491.0 No_ligand No_ligand Active DFGin 5.962 14.291 BLAminus -138.23, 170.92 62.61, 74.96 -87.3, 10.06 291.0, 89.98 -61.46, -22.56 in-in in 9.0 Saltbr-in 2.654 HRD-in -73.67, -41.85 67.4, -9.51 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.87, 148.49 APE9-dihe-na 135.56, 174.98 APE8-dihe-in -80.15, 124.18 APE8-rot-in 303.72 APE67-dihe-in -70.58, -21.97 -43.1, -47.82 APE12-dist-in 8.884 APE11-dist-in 11.687 APE10-dist-in 5.969 APE9-dist-in 3.273 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[27, 278]] 1.0 AF-Q13188-K3 Homo sapiens STE_STK3_HUMAN STE 1.6e-101 345.0 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 5DH3B Q13188 18 302 491.0 5BS:401 Type1 Inactive DFGin 5.786 14.82 ABAminus -107.93, -47.86 -103.07, 119.05 -112.25, 18.06 290.67, 93.25 -61.59, -41.21 out-in out 10.137 Saltbr-in 3.208 HRD-in -63.36, -51.22 81.92, -5.45 in-in-in SNCiii in-in ActLoopNT-in 2.712 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.17, 161.15 APE9-dihe-na 132.06, -164.99 APE8-dihe-in -104.21, 128.47 APE8-rot-in 313.02 APE67-dihe-in -62.35, -41.65 -60.99, -39.89 APE12-dist-in 8.878 APE11-dist-in 11.407 APE10-dist-in 5.827 APE9-dist-in 3.665 None TPO174,TPO180 TPO174,TPO180 XRAY 2.468 0.213 0.247 B 315 285 0 0 0 0 [[27, 278]] 1.0 5dh3 Homo sapiens STE_STK3_HUMAN STE 2.8e-101 344.2 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 8A66A Q13188 24 303 491.0 5BS:60501 Type1 Inactive DFGin 6.232 14.662 BLAminus -139.57, 162.57 72.11, 84.59 -98.16, 23.52 293.51, 92.3 -65.59, -22.75 in-in in 9.559 Saltbr-in 2.736 HRD-in -65.32, -44.41 72.25, -5.9 in-in-out SNCiio in-out ActLoopNT-in 2.838 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -147.11, 158.64 APE9-dihe-na 124.6, -157.27 APE8-dihe-in -114.81, 122.93 APE8-rot-out 43.78 APE67-dihe-in -62.92, -24.25 -35.94, -56.9 APE12-dist-in 8.68 APE11-dist-in 11.823 APE10-dist-in 5.983 APE9-dist-in 3.53 None TPO180 TPO180 XRAY 1.901 0.22 0.258 A 298 275 5 0 0 1 [[27, 278]] 1.0 8a66 Homo sapiens STE_STK3_HUMAN STE 2.3e-101 344.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 8A66B Q13188 18 304 491.0 5BS:60501 Type1 Inactive DFGin 6.229 14.491 BLAminus -139.08, 162.57 69.6, 85.67 -96.89, 21.95 294.07, 84.34 -63.47, -19.34 in-in in 9.514 Saltbr-in 2.883 HRD-in -65.79, -48.59 72.98, -4.76 in-in-out SNCiio in-out ActLoopNT-in 2.832 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -146.04, 152.12 APE9-dihe-na 134.76, -156.35 APE8-dihe-in -108.07, 116.58 APE8-rot-out 42.21 APE67-dihe-in -60.0, -23.48 -33.57, -55.3 APE12-dist-in 8.605 APE11-dist-in 11.752 APE10-dist-in 5.981 APE9-dist-in 3.41 None TPO174,TPO180,TPO268 TPO174,TPO180,TPO268 XRAY 1.901 0.22 0.258 B 298 282 5 0 0 0 [[27, 278]] 1.0 8a66 Homo sapiens STE_STK3_HUMAN STE 2.3e-101 344.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 5DH3A Q13188 19 307 491.0 5BS:401 Type1 Inactive DFGin 5.947 14.614 BLAminus -145.26, 166.53 56.21, 58.22 -79.02, 55.98 309.22, 59.68 -65.37, -40.98 out-out out 10.158 Saltbr-out 3.889 HRD-in -64.99, -53.25 81.51, -5.49 out-in-in SNCoii in-in ActLoopNT-in 2.818 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.11, 158.66 APE9-dihe-na 133.82, -164.61 APE8-dihe-in -99.88, 125.54 APE8-rot-in 317.53 APE67-dihe-in -61.6, -38.71 -57.46, -40.82 APE12-dist-in 8.882 APE11-dist-in 11.36 APE10-dist-in 5.773 APE9-dist-in 3.388 None TPO174,TPO180 TPO174,TPO180 XRAY 2.468 0.213 0.247 A 315 289 0 0 0 0 [[27, 278]] 1.0 5dh3 Homo sapiens STE_STK3_HUMAN STE 2.8e-101 344.2 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 6AO5A Q13188 28 488 491.0 ANP:501 ATPlike Inactive DFGin 5.762 13.255 BLAplus -144.87, 157.4 64.61, 76.09 -109.93, -46.63 13.82, 108.09 -89.31, 27.29 out-out out 12.908 Saltbr-out 12.116 HRD-in -60.56, -48.36 76.32, -35.33 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nooo APE10-dihe-na -164.34, 157.95 APE9-dihe-na -118.75, -167.2 APE8-dihe-in -63.94, 121.38 APE8-rot-out 166.95 APE67-dihe-out -86.4, -39.81 -115.82, 59.17 APE12-dist-none 999.0 APE11-dist-out 17.895 APE10-dist-out 16.152 APE9-dist-out 11.062 D146N None None XRAY 2.955 0.236 0.256 A 362 321 27 0 0 12 [[27, 278]] 1.0 6ao5 Homo sapiens STE_STK3_HUMAN STE 3.6e-100 340.7 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 4LGDA Q13188 16 488 491.0 ANP:501 ATPlike Inactive DFGin 6.018 17.02 BLBminus -145.52, -179.3 43.95, 67.54 -70.27, 152.23 281.57, 44.13 -80.59, 163.91 out-out out 10.889 Saltbr-out 5.794 HRD-in -73.7, -41.12 68.58, 5.1 out-out-out SNCooo out-out ActLoopNT-out 8.717 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -60.16, -34.45 APE9-dihe-na -67.84, -18.95 APE8-dihe-in -138.32, 78.16 APE8-rot-in 307.08 APE67-dihe-in -67.01, -21.51 -99.04, 14.35 APE12-dist-in 12.457 APE11-dist-in 10.195 APE10-dist-out 15.269 APE9-dist-out 12.752 D146N None None XRAY 3.05 0.202 0.244 A 378 350 0 0 0 0 [[27, 278]] 1.0 4lgd Homo sapiens STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 4LGDB Q13188 10 488 491.0 ANP:501 ATPlike Inactive DFGin 6.16 16.692 BLBminus -138.64, 169.86 44.76, 62.12 -62.36, 151.89 285.61, 26.54 -88.9, 160.74 out-out out 10.736 Saltbr-out 6.022 HRD-in -77.36, -41.29 64.17, 12.1 out-out-out SNCooo out-out ActLoopNT-out 9.006 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -74.54, -22.15 APE9-dihe-na -64.82, -19.37 APE8-dihe-in -144.49, 84.11 APE8-rot-in 305.11 APE67-dihe-in -63.85, -34.86 -100.76, 15.67 APE12-dist-in 12.595 APE11-dist-in 10.253 APE10-dist-out 15.046 APE9-dist-out 12.722 D146N None None XRAY 3.05 0.202 0.244 B 378 350 0 0 0 0 [[27, 278]] 1.0 4lgd Homo sapiens STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 4LGDC Q13188 12 490 491.0 ANP:501 ATPlike Inactive DFGin 6.359 17.118 BLBminus -149.78, 166.61 51.14, 65.46 -62.65, 153.33 284.02, 26.74 -77.49, 169.34 out-out out 10.55 Saltbr-out 5.611 HRD-in -72.97, -46.37 72.83, -1.88 out-out-out SNCooo out-out ActLoopNT-out 9.037 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -57.36, -33.07 APE9-dihe-na -66.61, -18.79 APE8-dihe-in -138.0, 80.15 APE8-rot-in 301.29 APE67-dihe-in -70.28, -28.9 -100.7, 15.38 APE12-dist-in 12.447 APE11-dist-in 10.03 APE10-dist-out 15.197 APE9-dist-out 12.67 D146N None None XRAY 3.05 0.202 0.244 C 378 349 7 0 0 0 [[27, 278]] 1.0 4lgd Homo sapiens STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 4LGDD Q13188 11 489 491.0 ANP:501 ATPlike Inactive DFGin 6.268 16.891 BLBminus -143.39, 170.34 44.57, 62.98 -62.31, 161.36 279.47, 45.38 -101.43, 151.87 out-out out 10.794 Saltbr-out 6.287 HRD-in -67.38, -41.94 64.94, 10.19 out-out-out SNCooo out-out ActLoopNT-out 8.791 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -65.98, -30.48 APE9-dihe-na -65.09, -18.33 APE8-dihe-in -145.24, 79.51 APE8-rot-in 304.52 APE67-dihe-in -64.33, -26.69 -98.63, 11.94 APE12-dist-in 12.433 APE11-dist-in 10.306 APE10-dist-out 15.377 APE9-dist-out 12.751 D146N None None XRAY 3.05 0.202 0.244 D 378 338 0 0 0 0 [[27, 278]] 1.0 4lgd Homo sapiens STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 4LG4A Q13188 18 308 491.0 No_ligand No_ligand Inactive DFGin 6.432 16.709 BLBminus -149.12, 171.46 46.69, 61.4 -60.75, 152.52 291.15, 39.97 -79.18, 173.35 out-out out 10.108 Saltbr-out 4.074 HRD-in -76.71, -50.91 85.64, -28.8 out-out-out SNCooo out-out ActLoopNT-out 9.203 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -62.56, -37.12 APE9-dihe-na -57.6, -19.4 APE8-dihe-in -131.0, 81.65 APE8-rot-in 305.42 APE67-dihe-in -65.11, -24.08 -99.22, 5.56 APE12-dist-in 11.633 APE11-dist-in 9.26 APE10-dist-out 14.084 APE9-dist-out 12.417 D146N None None XRAY 2.42 0.194 0.231 A 299 289 2 0 0 0 [[27, 278]] 1.0 4lg4 Homo sapiens STE_STK3_HUMAN STE 1.9e-100 341.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 4LG4B Q13188 18 308 491.0 No_ligand No_ligand Inactive DFGin 5.314 14.731 BLBminus -140.21, 165.65 51.04, 86.72 -80.54, 176.1 305.81, 78.15 -53.27, 999.0 out-out out 10.695 Saltbr-out 5.399 HRD-in -69.34, -48.39 74.3, -6.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -68.75, -29.95 APE9-dihe-na -83.67, -6.62 APE8-dihe-out -47.16, -50.18 APE8-rot-in 302.82 APE67-dihe-in -50.74, -37.0 -61.88, -26.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.24 D146N None None XRAY 2.42 0.194 0.231 B 299 284 7 0 0 4 [[27, 278]] 1.0 4lg4 Homo sapiens STE_STK3_HUMAN STE 1.9e-100 341.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 4LG4C Q13188 18 307 491.0 No_ligand No_ligand Inactive DFGin 6.226 16.418 BLBminus -145.61, 169.46 51.28, 57.2 -59.23, 151.18 287.92, 51.76 -86.76, 150.02 in-in in 9.911 Saltbr-in 3.44 HRD-in -75.35, -49.3 83.39, -19.28 in-out-out SNCioo out-out ActLoopNT-out 9.193 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -63.35, -30.69 APE9-dihe-na -66.56, -23.25 APE8-dihe-in -134.1, 75.91 APE8-rot-out 66.24 APE67-dihe-in -62.05, -27.19 -90.36, 7.85 APE12-dist-in 11.691 APE11-dist-in 9.722 APE10-dist-out 14.664 APE9-dist-out 12.281 D146N None None XRAY 2.42 0.194 0.231 C 299 288 2 0 0 0 [[27, 278]] 1.0 4lg4 Homo sapiens STE_STK3_HUMAN STE 1.9e-100 341.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 4LG4E Q13188 18 308 491.0 No_ligand No_ligand Inactive DFGin 6.263 16.204 BLBminus -130.31, 173.17 47.8, 59.45 -58.92, 151.45 279.66, 80.29 -84.51, 152.04 out-out out 10.135 Saltbr-out 4.21 HRD-in -72.01, -47.83 74.71, -8.47 out-out-out SNCooo out-out ActLoopNT-out 8.91 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -71.15, -28.45 APE9-dihe-na -67.18, -21.74 APE8-dihe-in -127.36, 70.14 APE8-rot-in 309.85 APE67-dihe-in -69.41, -34.62 -90.13, 14.25 APE12-dist-in 11.192 APE11-dist-in 9.221 APE10-dist-out 14.066 APE9-dist-out 12.293 D146N None None XRAY 2.42 0.194 0.231 E 299 275 16 0 0 6 [[27, 278]] 1.0 4lg4 Homo sapiens STE_STK3_HUMAN STE 1.9e-100 341.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 4LG4F Q13188 18 310 491.0 No_ligand No_ligand Inactive DFGin 4.8 15.191 None -138.38, 162.54 47.11, 83.6 -66.57, 999.0 302.94, 84.23 999.0, 999.0 out-out out 10.79 Saltbr-out 6.42 HRD-in -72.45, -47.39 76.74, -5.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -102.3 APE8-dihe-in -134.65, 156.4 APE8-rot-out 45.22 APE67-dihe-in -63.77, -27.55 -98.01, 1.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.121 D146N None None XRAY 2.42 0.194 0.231 F 299 276 17 0 0 17 [[27, 278]] 1.0 4lg4 Homo sapiens STE_STK3_HUMAN STE 1.9e-100 341.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STK3_HUMAN 4LG4D Q13188 26 308 491.0 No_ligand No_ligand Inactive None 999.0 999.0 None -138.74, -179.79 -96.29, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.335 Saltbr-out 5.21 HRD-in -73.23, -47.35 79.5, -18.38 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -41.57 APE8-dihe-in -147.49, 145.83 APE8-rot-out 185.09 APE67-dihe-in -63.59, -23.02 -102.14, -5.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.516 D146N None None XRAY 2.42 0.194 0.231 D 299 250 33 0 0 18 [[27, 278]] 1.0 4lg4 Homo sapiens STE_STK3_HUMAN STE 1.9e-100 341.5 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3

STE_STK3 (Serine/threonine-protein kinase 3)

Total number of chains: 0
Active chains: 0
Family: STE
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name