TKL_RIPK1 (Receptor-interacting serine/threonine-protein kinase 1)

Total number of chains: 64
Active chains: 2
Uniprot: RIPK1_HUMAN
Kinase Domain Residues: 17 - 287
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 62 96.9% 9MZYB
DFGin BLAminus 2 3.1% AF-Q13546-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q13546-K1A 9 295 671.0 No_ligand No_ligand Active DFGin 6.204 12.705 BLAminus -129.12, 178.1 54.65, 73.26 -88.02, 18.3 301.61, 178.49 -64.81, -24.26 in-in in 8.977 Saltbr-in 3.052 HRD-in -69.0, -42.39 67.33, -15.98 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.29, 164.8 APE9-dihe-na 130.89, 168.49 APE8-dihe-in -70.97, 123.72 APE8-rot-in 292.25 APE67-dihe-in -61.63, -30.08 -50.94, -39.95 APE12-dist-in 10.818 APE11-dist-in 10.754 APE10-dist-in 6.862 APE9-dist-in 3.972 None None None AF2 -1.0 1.0 1.0 A 287 287 0 0 0 0 [[17, 287]] 1.0 AF-Q13546-K1 TKL_RIPK1_HUMAN TKL 1.9e-72 249.9 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
AF-Q13546-K3A 9 295 671.0 No_ligand No_ligand Active DFGin 5.837 12.887 BLAminus -130.59, -174.12 48.33, 68.81 -85.84, 14.27 296.26, 178.68 -63.39, -27.62 in-in in 8.304 Saltbr-in 2.82 HRD-in -78.2, -45.02 68.62, -18.72 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 66.19, 172.06 APE9-dihe-na 99.33, 160.16 APE8-dihe-in -82.96, 124.72 APE8-rot-in 304.62 APE67-dihe-in -61.16, -28.1 -51.71, -41.19 APE12-dist-in 12.115 APE11-dist-in 9.902 APE10-dist-in 6.476 APE9-dist-in 3.666 None None None AF2 -1.0 1.0 1.0 A 287 287 0 0 0 0 [[17, 287]] 1.0 AF-Q13546-K3 TKL_RIPK1_HUMAN TKL 1.9e-72 249.9 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9Q31B 9 294 671.0 TME:301,A1CNU:302 Allosteric,Type3 Inactive DFGout 13.907 8.435 BBAminus -122.3, 171.3 -132.12, 59.49 -65.75, -30.4 296.2, 168.06 -75.45, -4.09 out-out out 14.183 Saltbr-out 12.204 HRD-in -71.01, -56.22 86.95, -20.08 out-out-out SNCooo out-out ActLoopNT-out 6.165 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -10.33 APE8-dihe-out -68.5, -12.13 APE8-rot-out 74.7 APE67-dihe-in -66.49, -21.33 -107.69, -0.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.182 C34A,C127A,C233A,C240A None None XRAY 2.05 0.187 0.222 B 296 259 27 0 0 16 [[17, 287]] 1.0 9q31 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9MZZA 7 294 671.0 A1BU5:301 Type1 Inactive DFGout 12.906 8.715 BBAminus -129.63, 157.79 -122.97, 63.36 -71.61, -28.69 296.96, 167.53 -66.19, -18.77 out-out out 13.414 Saltbr-out 10.753 HRD-in -66.17, -54.55 84.95, -22.88 out-out-out SNCooo out-out ActLoopNT-out 5.944 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 55.12 APE8-dihe-in -81.45, 160.26 APE8-rot-out 213.74 APE67-dihe-in -62.06, -27.36 -115.15, 1.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.424 None None None XRAY 2.68 0.229 0.272 A 288 266 22 0 0 14 [[17, 287]] 1.0 9mzz TKL_RIPK1_HUMAN TKL 1.1e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6C3EB 10 294 671.0 EJY:301 Type1 Inactive DFGout 13.853 9.226 BBAminus -116.62, 174.57 -131.85, 80.64 -72.81, -17.51 298.12, 175.84 -94.34, 1.78 out-out out 14.462 Saltbr-out 17.006 HRD-out -82.33, 120.46 -88.8, -8.87 out-out-out SNCooo out-out ActLoopNT-out 6.27 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -120.03 APE8-dihe-out -65.57, -36.52 APE8-rot-out 49.13 APE67-dihe-in -61.78, -28.81 -54.71, -27.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.515 None None None XRAY 2.6 0.261 0.307 B 297 259 26 0 0 19 [[17, 287]] 1.0 6c3e TKL_RIPK1_HUMAN TKL 1.7e-72 250.1 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
7XMKA 10 294 671.0 GO4:302 Type1 Inactive DFGout 14.566 8.917 BBAminus -123.53, 170.12 -132.83, 80.16 -69.11, -37.98 267.13, 51.14 -88.09, 8.79 out-out out 14.13 Saltbr-out 13.763 HRD-in -66.74, -55.27 80.48, -10.35 out-out-out SNCooo out-out ActLoopNT-out 5.212 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 133.69 APE8-dihe-in -71.43, 147.44 APE8-rot-out 180.12 APE67-dihe-in -60.43, -25.11 -113.51, 9.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.397 C34A,C127A,C233A,C240A None None XRAY 2.376 0.226 0.259 A 294 261 24 0 0 15 [[17, 287]] 1.0 7xmk TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
7XMKB 9 294 671.0 GO4:302 Type1 Inactive DFGout 14.479 8.979 BBAminus -123.49, 170.35 -133.98, 80.58 -68.99, -35.08 268.96, 57.09 -84.15, 9.54 out-out out 13.824 Saltbr-out 13.099 HRD-in -65.91, -54.46 77.59, -10.23 out-out-out SNCooo out-out ActLoopNT-out 5.618 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 144.44 APE8-rot-out 176.95 APE67-dihe-in -63.72, -23.7 -112.01, 7.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.376 0.226 0.259 B 294 250 36 0 0 20 [[17, 287]] 1.0 7xmk TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
7YDXB 9 294 671.0 3CI:301 Type1 Inactive DFGout 14.602 8.383 BBAminus -129.45, 168.05 -133.42, 71.29 -64.35, -31.44 269.57, 74.24 -88.81, 4.64 out-out out 14.411 Saltbr-out 15.121 HRD-in -60.14, -49.78 80.05, -9.86 out-out-out SNCooo out-out ActLoopNT-out 5.16 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 69.92 APE8-dihe-in -67.98, 146.88 APE8-rot-out 204.7 APE67-dihe-in -69.75, -16.77 -115.61, 4.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.582 C34A,C127A,C233A,C240A None None XRAY 2.642 0.263 0.289 B 294 261 25 0 0 16 [[17, 287]] 1.0 7ydx TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
8I2NA 7 294 671.0 O4U:301 Type1 Inactive DFGout 14.587 9.878 BBAminus -132.39, 179.54 -138.91, 72.44 -59.66, -22.13 308.47, 178.68 -72.09, -21.19 out-out out 14.38 Saltbr-out 12.621 HRD-out -74.72, 150.84 -121.92, -0.64 out-out-out SNCooo out-out ActLoopNT-out 7.305 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 165.9 APE9-dihe-na 80.3, -2.56 APE8-dihe-out -86.5, -17.61 APE8-rot-out 67.69 APE67-dihe-in -64.62, -33.64 -56.41, -33.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.835 APE9-dist-out 10.973 C34A,C127A,C233A,C240A None None XRAY 2.29 0.217 0.245 A 294 274 14 0 0 10 [[17, 287]] 1.0 8i2n TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
5HX6B 9 294 671.0 65U:301 Type1 Inactive DFGout 13.916 9.524 BBAminus -110.33, 176.91 -138.5, 63.24 -70.63, -22.24 306.2, 1.53 -89.49, 7.38 out-out out 14.222 Saltbr-out 14.511 HRD-in -62.53, -53.57 75.95, -13.27 out-out-out SNCooo out-out ActLoopNT-out 6.156 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 167.39 APE8-rot-out 197.13 APE67-dihe-in -59.57, -25.55 -49.67, -46.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.23 0.202 0.248 B 303 264 22 0 0 12 [[17, 287]] 1.0 5hx6 TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
5TX5B 9 294 671.0 7MJ:301 Type1 Inactive DFGout 13.936 9.778 BBAminus -107.86, 177.34 -143.22, 66.7 -65.05, -25.5 304.4, 177.19 -82.39, -1.78 out-out out 14.348 Saltbr-out 14.996 HRD-in -56.67, -58.95 81.43, -20.64 out-out-out SNCooo out-out ActLoopNT-out 6.368 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 177.76 APE8-rot-out 196.13 APE67-dihe-in -61.28, -27.72 -46.44, -48.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.56 0.2 0.24 B 303 263 23 0 0 12 [[17, 287]] 1.0 5tx5 TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6OCQA 8 294 671.0 M5J:301 Type1 Inactive DFGout 13.653 8.906 BBAminus -128.08, 163.08 -123.42, 80.61 -79.57, -27.16 295.98, 0.26 -76.2, -0.13 out-out out 12.997 Saltbr-out 12.431 HRD-in -71.99, -45.34 74.31, -14.54 out-out-out SNCooo out-out ActLoopNT-out 5.744 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 39.5 APE8-rot-out 183.76 APE67-dihe-in -61.04, -32.79 -60.66, -7.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.793 0.206 0.268 A 303 262 25 0 0 19 [[17, 287]] 1.0 6ocq TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6RLNB 7 294 671.0 K8K:301 Type1 Inactive DFGout 13.68 9.211 BBAminus -122.62, 157.76 -117.85, 60.6 -61.69, -26.3 309.99, 176.45 -89.62, -1.51 out-out out 14.378 Saltbr-out 13.751 HRD-in -57.19, -49.72 76.89, -15.47 out-out-out SNCooo out-out ActLoopNT-out 5.779 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -31.37 APE8-rot-out 180.31 APE67-dihe-in -67.2, -37.26 -87.9, 3.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.87 0.196 0.232 B 303 265 23 0 0 12 [[17, 287]] 1.0 6rln TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9GTGB 8 294 671.0 A1IPG:301,RCM:302 Type1,Type3 Inactive DFGout 13.883 8.731 BBAminus -133.16, 165.18 -135.72, 76.93 -76.72, -18.51 304.22, 175.37 -84.19, -9.82 out-out out 14.397 Saltbr-out 11.534 HRD-in -66.92, -59.7 80.95, -9.91 out-out-out SNCooo out-out ActLoopNT-out 5.26 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -59.54 APE8-dihe-out -101.61, -12.8 APE8-rot-out 94.63 APE67-dihe-in -61.15, -22.29 -56.15, -36.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.505 None None None XRAY 2.25 0.221 0.295 B 313 259 28 0 0 19 [[17, 287]] 1.0 9gtg TKL_RIPK1_HUMAN TKL 1.5e-72 250.2 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
4ITJA 8 294 671.0 1HX:301 Type2 Inactive DFGout 14.012 9.129 BBAminus -136.14, 158.72 -113.11, 65.66 -67.83, -29.38 295.84, 1.08 -82.31, 2.17 out-out out 13.793 Saltbr-out 12.11 HRD-in -65.33, -53.51 83.49, -21.7 out-out-out SNCooo out-out ActLoopNT-out 6.47 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 67.46 APE8-dihe-in -61.72, 146.74 APE8-rot-out 197.87 APE67-dihe-in -67.31, -25.57 -109.11, 4.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.622 C34A,C127A,C233A,C240A None None XRAY 1.8 0.189 0.222 A 294 261 26 0 0 18 [[17, 287]] 1.0 4itj TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
4ITJB 7 294 671.0 1HX:301 Type2 Inactive DFGout 14.086 9.431 BBAminus -128.78, 163.03 -112.89, 67.55 -67.91, -19.67 298.87, 2.73 -88.99, 2.64 out-out out 13.577 Saltbr-out 12.082 HRD-in -67.42, -52.94 85.17, -18.35 out-out-none SNCoon out-none ActLoopNT-out 6.388 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -9.31 APE8-rot-in 268.88 APE67-dihe-in -69.48, -22.39 -56.33, -37.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 1.8 0.189 0.222 B 294 276 12 0 0 12 [[17, 287]] 1.0 4itj TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
7YDXA 8 294 671.0 3CI:301 Type2 Inactive DFGout 14.593 8.699 BBAminus -127.96, 167.74 -132.63, 74.61 -64.12, -33.97 262.15, 49.78 -87.58, 5.94 out-out out 13.903 Saltbr-out 13.136 HRD-in -55.62, -57.21 80.87, -7.97 out-out-out SNCooo out-out ActLoopNT-out 5.528 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 71.58 APE8-dihe-in -69.49, 146.55 APE8-rot-out 180.25 APE67-dihe-in -69.54, -17.09 -118.24, 5.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8 C34A,C127A,C233A,C240A None None XRAY 2.642 0.263 0.289 A 294 271 16 0 0 11 [[17, 287]] 1.0 7ydx TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
8I2NB 7 294 671.0 O4U:301 Type2 Inactive DFGout 14.697 10.04 BBAminus -125.25, 179.41 -140.6, 77.45 -64.03, -29.8 306.36, 179.39 -76.08, -10.88 out-out out 14.345 Saltbr-out 12.273 HRD-out -90.28, 98.28 -71.05, -2.88 out-out-out SNCooo out-out ActLoopNT-out 6.768 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 36.59 APE9-dihe-na -60.07, -33.91 APE8-dihe-out -70.17, -30.34 APE8-rot-out 44.28 APE67-dihe-in -58.09, -33.7 -66.92, -25.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.43 APE9-dist-out 13.084 C34A,C127A,C233A,C240A None None XRAY 2.29 0.217 0.245 B 294 263 25 0 0 16 [[17, 287]] 1.0 8i2n TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
7FD0A 9 294 671.0 3IU:401 Type2 Inactive DFGout 14.147 9.863 BBAminus -118.78, 165.25 -119.42, 61.37 -68.29, -26.6 305.34, 1.7 -75.63, -10.82 out-out out 14.584 Saltbr-out 13.566 HRD-in -72.87, -53.55 82.11, -10.83 out-out-none SNCoon out-none ActLoopNT-out 5.991 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.08, -27.07 999.0, -28.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.0 0.233 0.266 A 297 266 20 0 0 20 [[17, 287]] 1.0 7fd0 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
7FD0B 10 294 671.0 3IU:401 Type2 Inactive DFGout 13.641 10.172 BBAminus -125.85, 169.01 -129.26, 63.88 -69.87, -20.1 302.68, 1.48 -85.28, -1.37 out-out out 14.318 Saltbr-out 12.849 HRD-in -72.21, -55.04 81.07, -12.7 out-out-out SNCooo out-out ActLoopNT-out 6.207 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -37.05 APE8-dihe-out -74.66, -10.1 APE8-rot-out 56.77 APE67-dihe-in -65.18, -19.85 -105.86, 4.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.537 C34A,C127A,C233A,C240A None None XRAY 2.0 0.233 0.266 B 297 257 28 0 0 19 [[17, 287]] 1.0 7fd0 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
4NEUA 6 313 671.0 Q1A:402 Type2 Inactive DFGout 12.672 9.836 BBAminus -112.8, 174.68 -146.72, 69.35 -53.07, -37.43 279.43, 37.24 -96.17, -2.91 in-in in 7.386 Saltbr-in 2.717 HRD-in -71.48, -50.71 81.96, -8.55 in-out-none SNCion out-none ActLoopNT-out 11.764 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 161.65 APE8-dihe-in -102.31, 130.16 APE8-rot-in 319.78 APE67-dihe-in -63.34, -19.2 -49.9, -51.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.532 None None None XRAY 2.57 0.183 0.235 A 333 286 22 0 0 22 [[17, 287]] 1.0 4neu TKL_RIPK1_HUMAN TKL 3.3e-72 249.3 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
4NEUB 7 310 671.0 Q1A:401 Type2 Inactive DFGout 12.473 10.181 BBAminus -120.35, 176.55 -145.51, 75.92 -65.87, -32.05 283.58, 47.98 -94.04, 3.71 in-in in 8.152 Saltbr-in 2.531 HRD-in -74.16, -53.45 78.14, -4.58 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.39 APE8-rot-none 999.0 APE67-dihe-in -83.39, -7.69 -97.82, 22.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.57 0.183 0.235 B 333 268 32 0 0 29 [[17, 287]] 1.0 4neu TKL_RIPK1_HUMAN TKL 3.3e-72 249.3 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9MZYA 8 294 671.0 A1BU6:301 Type3 Inactive DFGout 13.417 8.594 BBAminus -121.56, 163.73 -131.53, 69.41 -69.13, -26.9 298.04, 169.8 -86.04, 2.22 out-out out 14.107 Saltbr-out 12.369 HRD-in -64.46, -51.93 74.85, -2.94 out-out-out SNCooo out-out ActLoopNT-out 5.757 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -38.39 APE8-dihe-out -63.39, -46.19 APE8-rot-out 52.35 APE67-dihe-in -66.56, -26.22 -73.65, -15.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.629 None None None XRAY 2.32 0.242 0.315 A 287 266 21 0 0 11 [[17, 287]] 1.0 9mzy TKL_RIPK1_HUMAN TKL 1.1e-72 250.7 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9MZYB 8 294 671.0 A1BU6:301 Type3 Inactive DFGout 13.256 8.174 BBAminus -120.1, 168.45 -128.87, 68.39 -67.18, -24.35 298.87, 170.09 -81.57, -2.83 out-out out 13.682 Saltbr-out 12.765 HRD-in -64.72, -49.57 76.17, -4.64 out-out-out SNCooo out-out ActLoopNT-out 5.393 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -55.1 APE8-dihe-out -64.67, -43.51 APE8-rot-in 298.41 APE67-dihe-in -63.01, -29.76 -69.62, -21.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.549 None None None XRAY 2.32 0.242 0.315 B 287 276 11 0 0 7 [[17, 287]] 1.0 9mzy TKL_RIPK1_HUMAN TKL 1.1e-72 250.7 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9MZZB 7 294 671.0 A1BU5:301 Type3 Inactive DFGout 12.91 8.093 BBAminus -123.12, 159.01 -125.1, 65.1 -71.49, -24.77 295.21, 165.65 -63.79, -21.88 out-out out 13.71 Saltbr-out 11.064 HRD-in -62.15, -53.84 85.81, -19.41 out-out-out SNCooo out-out ActLoopNT-out 5.831 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -52.81 APE8-dihe-out -60.77, -43.31 APE8-rot-out 60.81 APE67-dihe-in -60.82, -28.84 -40.61, -46.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.225 None None None XRAY 2.68 0.229 0.272 B 288 273 15 0 0 11 [[17, 287]] 1.0 9mzz TKL_RIPK1_HUMAN TKL 1.1e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9MZXA 6 294 671.0 A1BU4:301 Type3 Inactive DFGout 13.155 8.608 BBAminus -120.41, 164.67 -130.16, 69.77 -71.17, -32.11 302.55, 177.42 -76.49, -1.63 out-out out 13.684 Saltbr-out 12.721 HRD-in -65.64, -50.76 75.88, -9.5 out-out-out SNCooo out-out ActLoopNT-out 5.537 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 34.89 APE8-dihe-in -83.2, 116.64 APE8-rot-out 186.76 APE67-dihe-in -69.05, -25.68 -94.99, 5.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.474 None None None XRAY 2.53 0.217 0.263 A 289 265 24 0 0 17 [[17, 287]] 1.0 9mzx TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9MZXB 6 294 671.0 A1BU4:301 Type3 Inactive DFGout 13.385 8.604 BBAminus -119.33, 165.52 -131.66, 72.61 -71.75, -33.33 299.78, 172.5 -85.72, 10.29 out-out out 13.591 Saltbr-out 12.641 HRD-in -65.63, -49.62 75.8, -10.44 out-out-out SNCooo out-out ActLoopNT-out 5.433 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.61 APE8-dihe-in -77.58, 125.06 APE8-rot-out 189.43 APE67-dihe-in -65.68, -27.84 -90.79, 1.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.082 None None None XRAY 2.53 0.217 0.263 B 289 268 21 0 0 11 [[17, 287]] 1.0 9mzx TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6C3EA 9 293 671.0 EJY:301 Type3 Inactive DFGout 13.211 8.704 BBAminus -130.6, 166.87 -129.4, 74.2 -68.21, -19.66 307.39, 166.79 -86.61, -13.09 out-out out 13.511 Saltbr-out 13.358 HRD-out -69.12, 116.26 -89.73, 2.91 out-out-out SNCooo out-out ActLoopNT-out 5.346 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -66.6 APE8-dihe-out -78.73, -34.83 APE8-rot-out 76.27 APE67-dihe-in -63.09, -35.77 -52.34, -36.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.672 None None None XRAY 2.6 0.261 0.307 A 297 258 27 0 0 17 [[17, 287]] 1.0 6c3e TKL_RIPK1_HUMAN TKL 1.7e-72 250.1 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
4ITHA 8 294 671.0 RCM:307 Type3 Inactive DFGout 14.111 8.042 BBAminus -124.73, 172.6 -138.48, 68.81 -68.88, -22.32 295.59, 2.39 -91.07, 2.58 out-out out 13.598 Saltbr-out 12.965 HRD-in -65.52, -52.94 79.64, -21.46 out-out-out SNCooo out-out ActLoopNT-out 5.125 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.47 APE8-dihe-in -73.02, 143.29 APE8-rot-in 249.4 APE67-dihe-in -62.29, -27.12 -114.9, 22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.706 C34A,C127A,C233A,C240A None None XRAY 2.25 0.222 0.247 A 294 247 40 0 0 19 [[17, 287]] 1.0 4ith TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
4ITHB 7 294 671.0 RCM:307 Type3 Inactive DFGout 13.911 7.88 BBAminus -124.36, 170.84 -137.49, 67.98 -68.97, -21.27 308.9, 171.62 -88.43, 4.67 out-out out 13.671 Saltbr-out 12.354 HRD-in -66.08, -61.08 99.79, -41.26 out-out-out SNCooo out-out ActLoopNT-out 5.287 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.33 APE8-dihe-out -80.2, -0.81 APE8-rot-out 76.21 APE67-dihe-in -69.94, -29.23 -70.53, -20.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.372 C34A,C127A,C233A,C240A None None XRAY 2.25 0.222 0.247 B 294 270 18 0 0 12 [[17, 287]] 1.0 4ith TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
4ITIA 8 294 671.0 1HW:301 Type3 Inactive DFGout 14.809 7.536 BBAminus -119.39, 171.24 -131.64, 70.92 -77.19, -1.86 301.33, 175.38 -111.16, 12.31 out-out out 14.461 Saltbr-out 12.021 HRD-in -63.67, -39.02 58.78, 3.1 out-out-out SNCooo out-out ActLoopNT-out 5.063 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 135.54 APE9-dihe-na -28.2, -40.78 APE8-dihe-out -49.5, 2.2 APE8-rot-out 126.42 APE67-dihe-in -74.62, -10.45 -88.53, -16.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.612 APE9-dist-out 11.919 C34A,C127A,C233A,C240A None None XRAY 2.86 0.229 0.267 A 294 272 15 0 0 10 [[17, 287]] 1.0 4iti TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
4ITIB 7 294 671.0 1HW:301 Type3 Inactive DFGout 15.287 8.279 BBAminus -133.02, 174.0 -136.87, 74.76 -71.37, -1.88 298.09, 0.08 -118.72, 6.02 out-out out 14.736 Saltbr-out 12.105 HRD-in -67.98, -50.79 78.94, -25.18 out-out-out SNCooo out-out ActLoopNT-out 5.029 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.75 APE8-dihe-out -48.23, -36.55 APE8-rot-out 178.41 APE67-dihe-in -64.1, -17.64 -60.59, -39.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.503 C34A,C127A,C233A,C240A None None XRAY 2.86 0.229 0.267 B 294 270 18 0 0 11 [[17, 287]] 1.0 4iti TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6NYHA 8 294 671.0 L8D:301 Type3 Inactive DFGout 13.435 9.94 BBAminus -117.53, 173.88 -134.6, 59.12 -68.75, -26.25 307.46, 178.63 -80.82, 2.01 out-out out 14.527 Saltbr-out 12.436 HRD-in -67.92, -54.26 77.85, -10.18 out-out-out SNCooo out-out ActLoopNT-out 6.112 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -22.11 APE8-dihe-in -70.09, 140.73 APE8-rot-out 198.89 APE67-dihe-in -52.04, -30.58 -103.66, -3.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.748 C34A,C127A,C233A,C240A None None XRAY 2.1 0.206 0.246 A 296 265 22 0 0 12 [[17, 287]] 1.0 6nyh TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6NYHB 11 294 671.0 L8D:301 Type3 Inactive DFGout 13.932 9.865 BBAminus -122.04, 173.92 -132.13, 59.75 -67.23, -24.7 302.43, 2.51 -86.8, 3.14 out-out out 14.458 Saltbr-out 12.191 HRD-in -67.08, -53.83 81.99, -19.6 out-out-out SNCooo out-out ActLoopNT-out 6.207 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -85.36 APE8-dihe-in -72.43, 144.74 APE8-rot-out 184.05 APE67-dihe-in -66.66, -21.12 -105.82, 2.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.774 C34A,C127A,C233A,C240A None None XRAY 2.1 0.206 0.246 B 296 246 38 0 0 18 [[17, 287]] 1.0 6nyh TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9Q31A 7 294 671.0 A1CNU:301 Type3 Inactive DFGout 13.735 8.23 BBAminus -120.57, 170.34 -130.15, 58.16 -63.68, -22.9 293.63, 177.4 -82.91, 0.44 out-out out 13.869 Saltbr-out 11.761 HRD-in -67.33, -55.79 80.06, -9.46 out-out-out SNCooo out-out ActLoopNT-out 6.088 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.72 APE8-rot-out 187.62 APE67-dihe-in -62.14, -27.07 -101.34, -1.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.05 0.187 0.222 A 296 269 19 0 0 12 [[17, 287]] 1.0 9q31 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9Q32A 6 293 671.0 A1CNV:301 Type3 Inactive DFGout 14.528 8.226 BBAminus -121.4, 167.22 -125.99, 62.31 -66.66, -26.07 287.26, 169.09 -79.79, -0.98 out-out out 14.14 Saltbr-out 12.229 HRD-in -66.73, -48.33 74.89, -10.1 out-out-out SNCooo out-out ActLoopNT-out 5.546 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 27.12 APE8-dihe-in -71.54, 159.66 APE8-rot-out 185.13 APE67-dihe-in -62.84, -25.84 -113.42, -0.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.855 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 A 296 266 22 0 0 12 [[17, 287]] 1.0 9q32 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9Q32B 8 294 671.0 A1CNV:301 Type3 Inactive DFGout 14.34 8.34 BBAminus -125.85, 168.27 -125.45, 64.08 -70.16, -25.81 289.07, 162.55 -79.65, -1.07 out-out out 14.45 Saltbr-out 13.417 HRD-in -68.2, -50.31 78.72, -10.28 out-out-out SNCooo out-out ActLoopNT-out 5.817 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.67 APE8-rot-out 168.75 APE67-dihe-in -63.25, -31.84 -91.02, 4.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 B 296 251 36 0 0 18 [[17, 287]] 1.0 9q32 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9Q32C 6 293 671.0 A1CNV:301 Type3 Inactive DFGout 14.46 8.281 BBAminus -120.28, 170.4 -126.9, 54.43 -63.55, -25.46 293.16, 167.28 -77.54, -4.89 out-out out 13.586 Saltbr-out 12.769 HRD-in -69.24, -48.43 74.25, -12.6 out-out-out SNCooo out-out ActLoopNT-out 6.023 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -164.99 APE8-dihe-in -75.87, 151.54 APE8-rot-out 168.79 APE67-dihe-in -61.95, -25.0 -103.03, -0.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.6 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 C 296 259 29 0 0 17 [[17, 287]] 1.0 9q32 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9Q32D 8 294 671.0 A1CNV:301 Type3 Inactive DFGout 14.457 8.195 BBAminus -119.22, 172.55 -131.06, 63.91 -69.23, -20.15 294.44, 171.06 -85.09, -1.42 out-none out 14.021 Saltbr-none 999.0 HRD-in -82.45, -48.15 73.95, -16.29 none-out-out SNCnoo out-out ActLoopNT-out 5.764 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 25.84 APE8-dihe-in -75.4, 152.13 APE8-rot-out 189.23 APE67-dihe-in -64.73, -21.38 -109.94, 2.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.29 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 D 296 250 37 0 0 19 [[17, 287]] 1.0 9q32 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
7FCZA 10 294 671.0 3IF:301 Type3 Inactive DFGout 13.865 10.379 BBAminus -121.61, 171.92 -133.79, 66.08 -70.41, -22.3 302.99, 177.02 -85.6, 3.29 out-out out 15.002 Saltbr-out 12.85 HRD-in -69.8, -48.63 73.26, -13.72 out-out-out SNCooo out-out ActLoopNT-out 6.074 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 77.72 APE8-dihe-in -67.19, 127.43 APE8-rot-in 294.95 APE67-dihe-in -62.33, -29.47 -101.92, 1.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.476 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 A 297 248 37 0 0 18 [[17, 287]] 1.0 7fcz TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
7FCZB 7 294 671.0 3IF:301 Type3 Inactive DFGout 13.913 10.028 BBAminus -118.21, 174.22 -136.13, 64.53 -68.29, -24.74 303.09, 178.58 -83.09, -0.43 out-out out 14.189 Saltbr-out 12.575 HRD-in -73.47, -53.47 80.61, -17.48 out-out-out SNCooo out-out ActLoopNT-out 6.139 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.37 APE8-dihe-in -64.4, 143.44 APE8-rot-out 179.16 APE67-dihe-in -62.08, -29.26 -100.06, -1.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.634 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 B 297 263 25 0 0 17 [[17, 287]] 1.0 7fcz TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9HY8A 8 294 671.0 A1IX7:301 Type3 Inactive DFGout 12.981 9.596 BBAminus -141.13, 164.94 -130.11, 66.18 -66.58, -24.49 309.73, 7.18 -84.28, -2.51 out-out out 14.033 Saltbr-out 11.772 HRD-out -86.53, 114.22 -72.4, -38.91 out-out-out SNCooo out-out ActLoopNT-out 6.11 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 77.03 APE8-dihe-out -67.08, -34.07 APE8-rot-out 196.53 APE67-dihe-in -68.73, -30.32 -60.21, -30.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.808 None None None XRAY 2.98 0.23 0.295 A 297 260 27 0 0 18 [[17, 287]] 1.0 9hy8 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9HY8B 7 294 671.0 1HX:305 Type3 Inactive DFGout 13.904 9.078 BBAminus -137.15, 163.21 -126.56, 62.14 -66.56, -24.08 304.02, 3.22 -81.88, 1.19 out-out out 13.745 Saltbr-out 12.321 HRD-out -85.29, 111.77 -72.25, -38.63 out-out-out SNCooo out-out ActLoopNT-out 6.114 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -35.46 APE8-rot-out 195.34 APE67-dihe-in -63.95, -33.12 -61.2, -31.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.98 0.23 0.295 B 297 271 17 0 0 12 [[17, 287]] 1.0 9hy8 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9HY9A 10 294 671.0 A1IX9:301 Type3 Inactive DFGout 12.864 9.725 BBAminus -132.24, 163.44 -119.98, 69.92 -71.64, -30.92 302.3, 2.93 -73.75, -3.09 out-out out 14.314 Saltbr-out 11.313 HRD-in -66.75, -56.07 86.01, -13.31 out-out-out SNCooo out-out ActLoopNT-out 6.04 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -51.61 APE8-dihe-out -64.18, -21.53 APE8-rot-out 61.29 APE67-dihe-in -61.96, -24.09 -103.08, -2.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.198 C34A,C127A,C233A,C240A None None XRAY 2.29 0.219 0.275 A 297 251 34 0 0 18 [[17, 287]] 1.0 9hy9 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9HY9B 8 294 671.0 A1IX9:301 Type3 Inactive DFGout 14.034 9.477 BBAminus -133.17, 165.69 -124.95, 70.39 -65.88, -32.58 304.79, 2.82 -81.7, 4.58 out-out out 14.395 Saltbr-out 11.494 HRD-in -67.55, -54.35 91.32, -11.86 out-out-out SNCooo out-out ActLoopNT-out 6.175 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 166.85 APE8-dihe-in -57.79, 140.57 APE8-rot-out 188.52 APE67-dihe-in -62.67, -21.78 -100.89, 3.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.311 C34A,C127A,C233A,C240A None None XRAY 2.29 0.219 0.275 B 297 265 22 0 0 13 [[17, 287]] 1.0 9hy9 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6C4DA 8 294 671.0 EJP:1100 Type3 Inactive DFGout 15.126 10.11 BBAminus -117.56, 178.71 -149.43, 73.24 -69.95, -18.38 305.75, 179.55 -101.55, 7.83 out-out out 16.257 Saltbr-out 16.566 HRD-in -55.77, -51.03 80.27, -34.22 out-out-out SNCooo out-out ActLoopNT-out 5.595 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -159.93 APE8-dihe-in -106.53, 126.83 APE8-rot-in 321.17 APE67-dihe-in -67.47, -17.91 -88.44, 5.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.641 None None None XRAY 2.52 0.246 0.296 A 297 267 20 0 0 13 [[17, 287]] 1.0 6c4d TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6C4DB 7 294 671.0 EJP:1100 Type3 Inactive DFGout 14.902 9.997 BBAminus -109.17, 170.78 -134.96, 67.82 -67.04, -23.45 302.04, 179.31 -86.78, -0.45 out-out out 13.971 Saltbr-out 13.274 HRD-in -58.83, -55.33 81.23, -6.46 out-out-out SNCooo out-out ActLoopNT-out 6.208 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 135.34 APE8-dihe-in -76.56, 126.03 APE8-rot-in 339.29 APE67-dihe-in -57.69, -33.16 -79.19, -15.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.114 None None None XRAY 2.52 0.246 0.296 B 297 266 22 0 0 16 [[17, 287]] 1.0 6c4d TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6C4DC 10 294 671.0 EJP:1100 Type3 Inactive DFGout 13.888 9.719 BBAminus -117.68, 178.27 -141.12, 66.69 -63.91, -32.83 304.36, 1.77 -82.22, -7.01 out-out out 14.002 Saltbr-out 13.724 HRD-out -79.05, 115.27 -95.69, 8.59 out-out-out SNCooo out-out ActLoopNT-out 5.708 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 161.35 APE8-dihe-in -80.27, 139.4 APE8-rot-in 352.11 APE67-dihe-in -58.83, -30.61 -90.66, -17.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.716 None None None XRAY 2.52 0.246 0.296 C 297 258 27 0 0 18 [[17, 287]] 1.0 6c4d TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6C4DD 5 293 671.0 EJP:1100 Type3 Inactive DFGout 14.579 10.057 BBAminus -117.58, 172.01 -139.03, 81.37 -72.34, -39.58 302.56, 173.11 -76.31, -0.83 out-out out 15.418 Saltbr-out 15.949 HRD-out -76.11, 120.54 -93.07, -33.93 out-out-out SNCooo out-out ActLoopNT-out 5.708 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -89.51 APE8-dihe-in -75.78, 153.21 APE8-rot-out 63.53 APE67-dihe-in -63.87, -30.91 -109.82, 5.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.301 None None None XRAY 2.52 0.246 0.296 D 297 266 23 0 0 16 [[17, 287]] 1.0 6c4d TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
5HX6A 10 294 671.0 65U:301 Type3 Inactive DFGout 13.746 10.081 BBAminus -114.15, 174.66 -134.73, 71.48 -75.96, -22.44 306.17, 175.84 -90.96, 8.33 out-out out 15.167 Saltbr-out 14.396 HRD-in -69.31, -54.37 72.33, -26.98 out-out-out SNCooo out-out ActLoopNT-out 5.818 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.42 APE8-dihe-in -113.81, 128.35 APE8-rot-in 307.51 APE67-dihe-in -68.28, -25.41 -91.99, -10.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.926 C34A,C127A,C233A,C240A None None XRAY 2.23 0.202 0.248 A 303 259 26 0 0 18 [[17, 287]] 1.0 5hx6 TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
5TX5A 10 294 671.0 7MJ:301 Type3 Inactive DFGout 13.573 10.201 BBAminus -116.16, 171.57 -130.87, 63.14 -69.82, -14.33 312.94, 168.86 -98.42, 6.27 out-out out 14.845 Saltbr-out 14.379 HRD-in -66.81, -51.24 62.33, -1.21 out-out-out SNCooo out-out ActLoopNT-out 6.13 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 119.73 APE8-dihe-in -110.36, 127.1 APE8-rot-in 310.57 APE67-dihe-in -70.3, -28.6 -100.12, 4.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.291 C34A,C127A,C233A,C240A None None XRAY 2.56 0.2 0.24 A 303 259 26 0 0 18 [[17, 287]] 1.0 5tx5 TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6HHOA 8 294 671.0 G4W:301 Type3 Inactive DFGout 13.67 9.694 BBAminus -115.24, 164.48 -126.66, 62.71 -63.79, -26.65 296.63, 179.45 -87.49, 3.26 out-out out 14.208 Saltbr-out 13.017 HRD-in -59.4, -57.1 78.79, -22.09 out-out-out SNCooo out-out ActLoopNT-out 6.209 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.3 APE8-dihe-in -93.04, 144.83 APE8-rot-out 195.71 APE67-dihe-in -65.11, -26.33 -104.41, -2.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.244 C34A,C127A,C233A,C240A None None XRAY 3.49 0.209 0.227 A 303 273 14 0 0 11 [[17, 287]] 1.0 6hho TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6HHOB 7 294 671.0 G4W:301 Type3 Inactive DFGout 13.824 9.442 BBAminus -119.74, 167.8 -136.07, 70.92 -69.13, -25.22 303.5, 11.26 -79.53, -4.81 out-out out 14.318 Saltbr-out 12.609 HRD-in -55.52, -56.34 83.4, -19.29 out-out-none SNCoon out-none ActLoopNT-out 6.05 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -34.12 APE8-rot-in 325.58 APE67-dihe-in -55.64, -31.82 -55.9, -39.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 3.49 0.209 0.227 B 303 266 22 0 0 12 [[17, 287]] 1.0 6hho TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6OCQB 7 294 671.0 M5J:301 Type3 Inactive DFGout 13.012 8.057 BBAminus -130.11, 162.38 -122.52, 81.31 -82.7, -15.44 293.68, 160.97 -87.37, 2.43 out-out out 13.636 Saltbr-out 13.611 HRD-in -64.49, -53.65 73.55, -4.84 out-out-out SNCooo out-out ActLoopNT-out 5.464 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -23.86 APE8-rot-out 173.0 APE67-dihe-in -61.59, -15.49 -61.5, -24.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.793 0.206 0.268 B 303 274 14 0 0 12 [[17, 287]] 1.0 6ocq TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6R5FA 9 294 671.0 JSW:301 Type3 Inactive DFGout 13.955 9.481 BBAminus -112.95, 165.41 -130.42, 63.72 -66.93, -21.93 297.24, 0.02 -91.89, 5.73 out-out out 14.529 Saltbr-out 13.191 HRD-in -56.51, -60.39 80.9, -22.8 out-out-out SNCooo out-out ActLoopNT-out 5.924 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.38 APE8-rot-out 178.71 APE67-dihe-in -64.62, -25.33 -74.5, -6.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 A 303 252 34 0 0 16 [[17, 287]] 1.0 6r5f TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6R5FB 10 294 671.0 JSW:301 Type3 Inactive DFGout 13.78 9.691 BBAminus -117.91, 170.03 -135.39, 68.26 -70.88, -17.07 303.86, 8.01 -86.89, -7.53 out-out out 14.147 Saltbr-out 14.183 HRD-in -58.11, -56.03 90.31, -47.38 out-out-out SNCooo out-out ActLoopNT-out 6.22 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.8 APE8-dihe-in -110.24, 128.64 APE8-rot-out 54.88 APE67-dihe-in -53.24, -34.36 -61.38, -32.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.919 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 B 303 256 29 0 0 17 [[17, 287]] 1.0 6r5f TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6R5FC 9 294 671.0 JSW:301 Type3 Inactive DFGout 13.993 9.934 BBAminus -129.98, 154.77 -113.58, 87.15 -77.89, -25.03 313.32, 1.4 -85.25, 0.11 out-out out 14.529 Saltbr-out 15.039 HRD-in -68.31, -36.48 72.06, -57.73 out-out-out SNCooo out-out ActLoopNT-out 5.739 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -139.85 APE8-dihe-in -109.8, 132.44 APE8-rot-out 61.03 APE67-dihe-in -41.51, -34.43 -97.85, -8.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.153 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 C 303 253 33 0 0 16 [[17, 287]] 1.0 6r5f TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6R5FD 11 294 671.0 JSW:301 Type3 Inactive DFGout 14.45 9.248 BBAminus -142.39, 170.94 -125.26, 78.91 -70.36, -35.3 283.29, 144.33 -66.46, -23.13 out-out out 15.019 Saltbr-out 16.123 HRD-in -59.61, -37.57 70.15, -52.85 out-out-out SNCooo out-out ActLoopNT-out 6.06 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 119.22 APE8-dihe-in -103.39, 137.53 APE8-rot-out 189.96 APE67-dihe-in -50.68, -36.72 -90.03, -10.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.433 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 D 303 250 34 0 0 17 [[17, 287]] 1.0 6r5f TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6RLNA 8 294 671.0 K8K:301 Type3 Inactive DFGout 13.828 9.344 BBAminus -121.93, 164.11 -127.72, 59.44 -57.14, -30.4 302.07, 177.27 -86.63, -0.56 out-out out 14.464 Saltbr-out 13.169 HRD-in -55.19, -50.82 78.22, -37.5 out-out-out SNCooo out-out ActLoopNT-out 5.952 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.07 APE8-dihe-in -87.79, 130.01 APE8-rot-in 299.1 APE67-dihe-in -57.83, -39.09 -99.26, -10.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.716 C34A,C127A,C233A,C240A None None XRAY 2.87 0.196 0.232 A 303 266 21 0 0 11 [[17, 287]] 1.0 6rln TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6NW2A 8 294 671.0 L4Y:301 Type3 Inactive DFGout 13.608 9.512 BBAminus -126.76, 173.12 -134.47, 72.41 -77.05, -17.16 300.87, 12.85 -87.44, 3.81 out-out out 13.794 Saltbr-out 12.048 HRD-in -68.25, -50.83 78.22, -14.78 out-out-none SNCoon out-none ActLoopNT-out 6.312 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 149.64 APE8-rot-in 298.28 APE67-dihe-in -63.58, -21.18 -59.6, -37.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.212 0.261 A 310 260 27 0 0 12 [[17, 287]] 1.0 6nw2 TKL_RIPK1_HUMAN TKL 1.5e-72 250.3 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
6NW2B 11 294 671.0 L4Y:301 Type3 Inactive DFGout 13.716 9.993 BBAminus -122.99, 177.91 -138.58, 64.6 -73.14, -19.26 303.52, 11.16 -82.07, -0.78 out-out out 14.265 Saltbr-out 13.612 HRD-in -71.79, -51.87 81.67, -16.37 out-out-out SNCooo out-out ActLoopNT-out 6.279 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -16.93 APE8-dihe-out -77.38, -12.49 APE8-rot-out 198.5 APE67-dihe-in -68.62, -19.61 -107.28, 7.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.491 None None None XRAY 2.0 0.212 0.261 B 310 246 38 0 0 18 [[17, 287]] 1.0 6nw2 TKL_RIPK1_HUMAN TKL 1.5e-72 250.3 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9GTYA 8 294 671.0 RCM:301 Type3 Inactive DFGout 13.983 8.222 BBAminus -123.34, 171.31 -137.95, 64.52 -61.74, -25.38 305.36, 176.3 -90.28, 0.66 out-out out 13.752 Saltbr-out 13.245 HRD-in -64.08, -57.67 81.97, -22.12 out-out-out SNCooo out-out ActLoopNT-out 5.227 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -14.17 APE8-dihe-out -79.25, -21.69 APE8-rot-out 51.22 APE67-dihe-in -62.86, -31.23 -89.57, 1.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.816 C34A,C127A,C233A,C240A None None XRAY 2.145 0.251 0.294 A 313 253 34 0 0 19 [[17, 287]] 1.0 9gty TKL_RIPK1_HUMAN TKL 1.5e-72 250.2 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9GTGA 8 294 671.0 RCM:301,A1IPG:302 Type3,Type1 Inactive DFGout 14.048 8.733 BBAminus -120.7, 174.19 -140.11, 66.75 -72.21, -11.93 303.8, 178.39 -100.67, 0.92 out-out out 13.5 Saltbr-out 12.1 HRD-in -70.04, -46.73 71.98, -13.03 out-out-out SNCooo out-out ActLoopNT-out 5.099 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -38.11 APE8-dihe-out -53.85, -42.8 APE8-rot-out 59.02 APE67-dihe-in -64.33, -16.83 -85.43, -11.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.86 None None None XRAY 2.25 0.221 0.295 A 313 259 28 0 0 19 [[17, 287]] 1.0 9gtg TKL_RIPK1_HUMAN TKL 1.5e-72 250.2 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
9GTYB 8 294 671.0 RCM:301,A1IKX:302 Type3,Type1 Inactive DFGout 14.159 8.454 BBAminus -123.21, 170.66 -136.75, 64.56 -61.45, -25.1 304.25, 174.68 -90.93, 0.86 out-out out 13.932 Saltbr-out 13.354 HRD-in -64.37, -58.12 82.38, -22.95 out-out-out SNCooo out-out ActLoopNT-out 5.203 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -12.75 APE8-dihe-out -78.82, -22.72 APE8-rot-out 50.86 APE67-dihe-in -62.42, -30.84 -90.02, 1.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.905 C34A,C127A,C233A,C240A None None XRAY 2.145 0.251 0.294 B 313 259 28 0 0 19 [[17, 287]] 1.0 9gty TKL_RIPK1_HUMAN TKL 1.5e-72 250.2 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1

TKL_RIPK1 (Receptor-interacting serine/threonine-protein kinase 1)

Total number of chains: 64
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 62 96.9% 9MZYB
DFGin BLAminus 2 3.1% AF-Q13546-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RIPK1_HUMAN AF-Q13546-K1A Q13546 9 295 671.0 No_ligand No_ligand Active DFGin 6.204 12.705 BLAminus -129.12, 178.1 54.65, 73.26 -88.02, 18.3 301.61, 178.49 -64.81, -24.26 in-in in 8.977 Saltbr-in 3.052 HRD-in -69.0, -42.39 67.33, -15.98 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.29, 164.8 APE9-dihe-na 130.89, 168.49 APE8-dihe-in -70.97, 123.72 APE8-rot-in 292.25 APE67-dihe-in -61.63, -30.08 -50.94, -39.95 APE12-dist-in 10.818 APE11-dist-in 10.754 APE10-dist-in 6.862 APE9-dist-in 3.972 None None None AF2 -1.0 1.0 1.0 A 287 287 0 0 0 0 [[17, 287]] 1.0 AF-Q13546-K1 Homo sapiens TKL_RIPK1_HUMAN TKL 1.9e-72 249.9 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN AF-Q13546-K3A Q13546 9 295 671.0 No_ligand No_ligand Active DFGin 5.837 12.887 BLAminus -130.59, -174.12 48.33, 68.81 -85.84, 14.27 296.26, 178.68 -63.39, -27.62 in-in in 8.304 Saltbr-in 2.82 HRD-in -78.2, -45.02 68.62, -18.72 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 66.19, 172.06 APE9-dihe-na 99.33, 160.16 APE8-dihe-in -82.96, 124.72 APE8-rot-in 304.62 APE67-dihe-in -61.16, -28.1 -51.71, -41.19 APE12-dist-in 12.115 APE11-dist-in 9.902 APE10-dist-in 6.476 APE9-dist-in 3.666 None None None AF2 -1.0 1.0 1.0 A 287 287 0 0 0 0 [[17, 287]] 1.0 AF-Q13546-K3 Homo sapiens TKL_RIPK1_HUMAN TKL 1.9e-72 249.9 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9Q31B Q13546 9 294 671.0 TME:301,A1CNU:302 Allosteric,Type3 Inactive DFGout 13.907 8.435 BBAminus -122.3, 171.3 -132.12, 59.49 -65.75, -30.4 296.2, 168.06 -75.45, -4.09 out-out out 14.183 Saltbr-out 12.204 HRD-in -71.01, -56.22 86.95, -20.08 out-out-out SNCooo out-out ActLoopNT-out 6.165 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -10.33 APE8-dihe-out -68.5, -12.13 APE8-rot-out 74.7 APE67-dihe-in -66.49, -21.33 -107.69, -0.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.182 C34A,C127A,C233A,C240A None None XRAY 2.05 0.187 0.222 B 296 259 27 0 0 16 [[17, 287]] 1.0 9q31 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9MZZA Q13546 7 294 671.0 A1BU5:301 Type1 Inactive DFGout 12.906 8.715 BBAminus -129.63, 157.79 -122.97, 63.36 -71.61, -28.69 296.96, 167.53 -66.19, -18.77 out-out out 13.414 Saltbr-out 10.753 HRD-in -66.17, -54.55 84.95, -22.88 out-out-out SNCooo out-out ActLoopNT-out 5.944 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 55.12 APE8-dihe-in -81.45, 160.26 APE8-rot-out 213.74 APE67-dihe-in -62.06, -27.36 -115.15, 1.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.424 None None None XRAY 2.68 0.229 0.272 A 288 266 22 0 0 14 [[17, 287]] 1.0 9mzz Homo sapiens TKL_RIPK1_HUMAN TKL 1.1e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6C3EB Q13546 10 294 671.0 EJY:301 Type1 Inactive DFGout 13.853 9.226 BBAminus -116.62, 174.57 -131.85, 80.64 -72.81, -17.51 298.12, 175.84 -94.34, 1.78 out-out out 14.462 Saltbr-out 17.006 HRD-out -82.33, 120.46 -88.8, -8.87 out-out-out SNCooo out-out ActLoopNT-out 6.27 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -120.03 APE8-dihe-out -65.57, -36.52 APE8-rot-out 49.13 APE67-dihe-in -61.78, -28.81 -54.71, -27.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.515 None None None XRAY 2.6 0.261 0.307 B 297 259 26 0 0 19 [[17, 287]] 1.0 6c3e Homo sapiens TKL_RIPK1_HUMAN TKL 1.7e-72 250.1 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 7XMKA Q13546 10 294 671.0 GO4:302 Type1 Inactive DFGout 14.566 8.917 BBAminus -123.53, 170.12 -132.83, 80.16 -69.11, -37.98 267.13, 51.14 -88.09, 8.79 out-out out 14.13 Saltbr-out 13.763 HRD-in -66.74, -55.27 80.48, -10.35 out-out-out SNCooo out-out ActLoopNT-out 5.212 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 133.69 APE8-dihe-in -71.43, 147.44 APE8-rot-out 180.12 APE67-dihe-in -60.43, -25.11 -113.51, 9.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.397 C34A,C127A,C233A,C240A None None XRAY 2.376 0.226 0.259 A 294 261 24 0 0 15 [[17, 287]] 1.0 7xmk Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 7XMKB Q13546 9 294 671.0 GO4:302 Type1 Inactive DFGout 14.479 8.979 BBAminus -123.49, 170.35 -133.98, 80.58 -68.99, -35.08 268.96, 57.09 -84.15, 9.54 out-out out 13.824 Saltbr-out 13.099 HRD-in -65.91, -54.46 77.59, -10.23 out-out-out SNCooo out-out ActLoopNT-out 5.618 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 144.44 APE8-rot-out 176.95 APE67-dihe-in -63.72, -23.7 -112.01, 7.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.376 0.226 0.259 B 294 250 36 0 0 20 [[17, 287]] 1.0 7xmk Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 7YDXB Q13546 9 294 671.0 3CI:301 Type1 Inactive DFGout 14.602 8.383 BBAminus -129.45, 168.05 -133.42, 71.29 -64.35, -31.44 269.57, 74.24 -88.81, 4.64 out-out out 14.411 Saltbr-out 15.121 HRD-in -60.14, -49.78 80.05, -9.86 out-out-out SNCooo out-out ActLoopNT-out 5.16 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 69.92 APE8-dihe-in -67.98, 146.88 APE8-rot-out 204.7 APE67-dihe-in -69.75, -16.77 -115.61, 4.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.582 C34A,C127A,C233A,C240A None None XRAY 2.642 0.263 0.289 B 294 261 25 0 0 16 [[17, 287]] 1.0 7ydx Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 8I2NA Q13546 7 294 671.0 O4U:301 Type1 Inactive DFGout 14.587 9.878 BBAminus -132.39, 179.54 -138.91, 72.44 -59.66, -22.13 308.47, 178.68 -72.09, -21.19 out-out out 14.38 Saltbr-out 12.621 HRD-out -74.72, 150.84 -121.92, -0.64 out-out-out SNCooo out-out ActLoopNT-out 7.305 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 165.9 APE9-dihe-na 80.3, -2.56 APE8-dihe-out -86.5, -17.61 APE8-rot-out 67.69 APE67-dihe-in -64.62, -33.64 -56.41, -33.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.835 APE9-dist-out 10.973 C34A,C127A,C233A,C240A None None XRAY 2.29 0.217 0.245 A 294 274 14 0 0 10 [[17, 287]] 1.0 8i2n Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 5HX6B Q13546 9 294 671.0 65U:301 Type1 Inactive DFGout 13.916 9.524 BBAminus -110.33, 176.91 -138.5, 63.24 -70.63, -22.24 306.2, 1.53 -89.49, 7.38 out-out out 14.222 Saltbr-out 14.511 HRD-in -62.53, -53.57 75.95, -13.27 out-out-out SNCooo out-out ActLoopNT-out 6.156 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 167.39 APE8-rot-out 197.13 APE67-dihe-in -59.57, -25.55 -49.67, -46.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.23 0.202 0.248 B 303 264 22 0 0 12 [[17, 287]] 1.0 5hx6 Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 5TX5B Q13546 9 294 671.0 7MJ:301 Type1 Inactive DFGout 13.936 9.778 BBAminus -107.86, 177.34 -143.22, 66.7 -65.05, -25.5 304.4, 177.19 -82.39, -1.78 out-out out 14.348 Saltbr-out 14.996 HRD-in -56.67, -58.95 81.43, -20.64 out-out-out SNCooo out-out ActLoopNT-out 6.368 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 177.76 APE8-rot-out 196.13 APE67-dihe-in -61.28, -27.72 -46.44, -48.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.56 0.2 0.24 B 303 263 23 0 0 12 [[17, 287]] 1.0 5tx5 Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6OCQA Q13546 8 294 671.0 M5J:301 Type1 Inactive DFGout 13.653 8.906 BBAminus -128.08, 163.08 -123.42, 80.61 -79.57, -27.16 295.98, 0.26 -76.2, -0.13 out-out out 12.997 Saltbr-out 12.431 HRD-in -71.99, -45.34 74.31, -14.54 out-out-out SNCooo out-out ActLoopNT-out 5.744 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 39.5 APE8-rot-out 183.76 APE67-dihe-in -61.04, -32.79 -60.66, -7.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.793 0.206 0.268 A 303 262 25 0 0 19 [[17, 287]] 1.0 6ocq Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6RLNB Q13546 7 294 671.0 K8K:301 Type1 Inactive DFGout 13.68 9.211 BBAminus -122.62, 157.76 -117.85, 60.6 -61.69, -26.3 309.99, 176.45 -89.62, -1.51 out-out out 14.378 Saltbr-out 13.751 HRD-in -57.19, -49.72 76.89, -15.47 out-out-out SNCooo out-out ActLoopNT-out 5.779 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -31.37 APE8-rot-out 180.31 APE67-dihe-in -67.2, -37.26 -87.9, 3.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.87 0.196 0.232 B 303 265 23 0 0 12 [[17, 287]] 1.0 6rln Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9GTGB Q13546 8 294 671.0 A1IPG:301,RCM:302 Type1,Type3 Inactive DFGout 13.883 8.731 BBAminus -133.16, 165.18 -135.72, 76.93 -76.72, -18.51 304.22, 175.37 -84.19, -9.82 out-out out 14.397 Saltbr-out 11.534 HRD-in -66.92, -59.7 80.95, -9.91 out-out-out SNCooo out-out ActLoopNT-out 5.26 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -59.54 APE8-dihe-out -101.61, -12.8 APE8-rot-out 94.63 APE67-dihe-in -61.15, -22.29 -56.15, -36.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.505 None None None XRAY 2.25 0.221 0.295 B 313 259 28 0 0 19 [[17, 287]] 1.0 9gtg Homo sapiens TKL_RIPK1_HUMAN TKL 1.5e-72 250.2 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 4ITJA Q13546 8 294 671.0 1HX:301 Type2 Inactive DFGout 14.012 9.129 BBAminus -136.14, 158.72 -113.11, 65.66 -67.83, -29.38 295.84, 1.08 -82.31, 2.17 out-out out 13.793 Saltbr-out 12.11 HRD-in -65.33, -53.51 83.49, -21.7 out-out-out SNCooo out-out ActLoopNT-out 6.47 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 67.46 APE8-dihe-in -61.72, 146.74 APE8-rot-out 197.87 APE67-dihe-in -67.31, -25.57 -109.11, 4.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.622 C34A,C127A,C233A,C240A None None XRAY 1.8 0.189 0.222 A 294 261 26 0 0 18 [[17, 287]] 1.0 4itj Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 4ITJB Q13546 7 294 671.0 1HX:301 Type2 Inactive DFGout 14.086 9.431 BBAminus -128.78, 163.03 -112.89, 67.55 -67.91, -19.67 298.87, 2.73 -88.99, 2.64 out-out out 13.577 Saltbr-out 12.082 HRD-in -67.42, -52.94 85.17, -18.35 out-out-none SNCoon out-none ActLoopNT-out 6.388 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -9.31 APE8-rot-in 268.88 APE67-dihe-in -69.48, -22.39 -56.33, -37.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 1.8 0.189 0.222 B 294 276 12 0 0 12 [[17, 287]] 1.0 4itj Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 7YDXA Q13546 8 294 671.0 3CI:301 Type2 Inactive DFGout 14.593 8.699 BBAminus -127.96, 167.74 -132.63, 74.61 -64.12, -33.97 262.15, 49.78 -87.58, 5.94 out-out out 13.903 Saltbr-out 13.136 HRD-in -55.62, -57.21 80.87, -7.97 out-out-out SNCooo out-out ActLoopNT-out 5.528 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 71.58 APE8-dihe-in -69.49, 146.55 APE8-rot-out 180.25 APE67-dihe-in -69.54, -17.09 -118.24, 5.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8 C34A,C127A,C233A,C240A None None XRAY 2.642 0.263 0.289 A 294 271 16 0 0 11 [[17, 287]] 1.0 7ydx Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 8I2NB Q13546 7 294 671.0 O4U:301 Type2 Inactive DFGout 14.697 10.04 BBAminus -125.25, 179.41 -140.6, 77.45 -64.03, -29.8 306.36, 179.39 -76.08, -10.88 out-out out 14.345 Saltbr-out 12.273 HRD-out -90.28, 98.28 -71.05, -2.88 out-out-out SNCooo out-out ActLoopNT-out 6.768 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 36.59 APE9-dihe-na -60.07, -33.91 APE8-dihe-out -70.17, -30.34 APE8-rot-out 44.28 APE67-dihe-in -58.09, -33.7 -66.92, -25.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.43 APE9-dist-out 13.084 C34A,C127A,C233A,C240A None None XRAY 2.29 0.217 0.245 B 294 263 25 0 0 16 [[17, 287]] 1.0 8i2n Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 7FD0A Q13546 9 294 671.0 3IU:401 Type2 Inactive DFGout 14.147 9.863 BBAminus -118.78, 165.25 -119.42, 61.37 -68.29, -26.6 305.34, 1.7 -75.63, -10.82 out-out out 14.584 Saltbr-out 13.566 HRD-in -72.87, -53.55 82.11, -10.83 out-out-none SNCoon out-none ActLoopNT-out 5.991 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.08, -27.07 999.0, -28.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.0 0.233 0.266 A 297 266 20 0 0 20 [[17, 287]] 1.0 7fd0 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 7FD0B Q13546 10 294 671.0 3IU:401 Type2 Inactive DFGout 13.641 10.172 BBAminus -125.85, 169.01 -129.26, 63.88 -69.87, -20.1 302.68, 1.48 -85.28, -1.37 out-out out 14.318 Saltbr-out 12.849 HRD-in -72.21, -55.04 81.07, -12.7 out-out-out SNCooo out-out ActLoopNT-out 6.207 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -37.05 APE8-dihe-out -74.66, -10.1 APE8-rot-out 56.77 APE67-dihe-in -65.18, -19.85 -105.86, 4.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.537 C34A,C127A,C233A,C240A None None XRAY 2.0 0.233 0.266 B 297 257 28 0 0 19 [[17, 287]] 1.0 7fd0 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 4NEUA Q13546 6 313 671.0 Q1A:402 Type2 Inactive DFGout 12.672 9.836 BBAminus -112.8, 174.68 -146.72, 69.35 -53.07, -37.43 279.43, 37.24 -96.17, -2.91 in-in in 7.386 Saltbr-in 2.717 HRD-in -71.48, -50.71 81.96, -8.55 in-out-none SNCion out-none ActLoopNT-out 11.764 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 161.65 APE8-dihe-in -102.31, 130.16 APE8-rot-in 319.78 APE67-dihe-in -63.34, -19.2 -49.9, -51.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.532 None None None XRAY 2.57 0.183 0.235 A 333 286 22 0 0 22 [[17, 287]] 1.0 4neu Homo sapiens TKL_RIPK1_HUMAN TKL 3.3e-72 249.3 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 4NEUB Q13546 7 310 671.0 Q1A:401 Type2 Inactive DFGout 12.473 10.181 BBAminus -120.35, 176.55 -145.51, 75.92 -65.87, -32.05 283.58, 47.98 -94.04, 3.71 in-in in 8.152 Saltbr-in 2.531 HRD-in -74.16, -53.45 78.14, -4.58 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.39 APE8-rot-none 999.0 APE67-dihe-in -83.39, -7.69 -97.82, 22.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.57 0.183 0.235 B 333 268 32 0 0 29 [[17, 287]] 1.0 4neu Homo sapiens TKL_RIPK1_HUMAN TKL 3.3e-72 249.3 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9MZYA Q13546 8 294 671.0 A1BU6:301 Type3 Inactive DFGout 13.417 8.594 BBAminus -121.56, 163.73 -131.53, 69.41 -69.13, -26.9 298.04, 169.8 -86.04, 2.22 out-out out 14.107 Saltbr-out 12.369 HRD-in -64.46, -51.93 74.85, -2.94 out-out-out SNCooo out-out ActLoopNT-out 5.757 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -38.39 APE8-dihe-out -63.39, -46.19 APE8-rot-out 52.35 APE67-dihe-in -66.56, -26.22 -73.65, -15.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.629 None None None XRAY 2.32 0.242 0.315 A 287 266 21 0 0 11 [[17, 287]] 1.0 9mzy Homo sapiens TKL_RIPK1_HUMAN TKL 1.1e-72 250.7 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9MZYB Q13546 8 294 671.0 A1BU6:301 Type3 Inactive DFGout 13.256 8.174 BBAminus -120.1, 168.45 -128.87, 68.39 -67.18, -24.35 298.87, 170.09 -81.57, -2.83 out-out out 13.682 Saltbr-out 12.765 HRD-in -64.72, -49.57 76.17, -4.64 out-out-out SNCooo out-out ActLoopNT-out 5.393 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -55.1 APE8-dihe-out -64.67, -43.51 APE8-rot-in 298.41 APE67-dihe-in -63.01, -29.76 -69.62, -21.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.549 None None None XRAY 2.32 0.242 0.315 B 287 276 11 0 0 7 [[17, 287]] 1.0 9mzy Homo sapiens TKL_RIPK1_HUMAN TKL 1.1e-72 250.7 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9MZZB Q13546 7 294 671.0 A1BU5:301 Type3 Inactive DFGout 12.91 8.093 BBAminus -123.12, 159.01 -125.1, 65.1 -71.49, -24.77 295.21, 165.65 -63.79, -21.88 out-out out 13.71 Saltbr-out 11.064 HRD-in -62.15, -53.84 85.81, -19.41 out-out-out SNCooo out-out ActLoopNT-out 5.831 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -52.81 APE8-dihe-out -60.77, -43.31 APE8-rot-out 60.81 APE67-dihe-in -60.82, -28.84 -40.61, -46.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.225 None None None XRAY 2.68 0.229 0.272 B 288 273 15 0 0 11 [[17, 287]] 1.0 9mzz Homo sapiens TKL_RIPK1_HUMAN TKL 1.1e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9MZXA Q13546 6 294 671.0 A1BU4:301 Type3 Inactive DFGout 13.155 8.608 BBAminus -120.41, 164.67 -130.16, 69.77 -71.17, -32.11 302.55, 177.42 -76.49, -1.63 out-out out 13.684 Saltbr-out 12.721 HRD-in -65.64, -50.76 75.88, -9.5 out-out-out SNCooo out-out ActLoopNT-out 5.537 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 34.89 APE8-dihe-in -83.2, 116.64 APE8-rot-out 186.76 APE67-dihe-in -69.05, -25.68 -94.99, 5.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.474 None None None XRAY 2.53 0.217 0.263 A 289 265 24 0 0 17 [[17, 287]] 1.0 9mzx Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9MZXB Q13546 6 294 671.0 A1BU4:301 Type3 Inactive DFGout 13.385 8.604 BBAminus -119.33, 165.52 -131.66, 72.61 -71.75, -33.33 299.78, 172.5 -85.72, 10.29 out-out out 13.591 Saltbr-out 12.641 HRD-in -65.63, -49.62 75.8, -10.44 out-out-out SNCooo out-out ActLoopNT-out 5.433 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.61 APE8-dihe-in -77.58, 125.06 APE8-rot-out 189.43 APE67-dihe-in -65.68, -27.84 -90.79, 1.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.082 None None None XRAY 2.53 0.217 0.263 B 289 268 21 0 0 11 [[17, 287]] 1.0 9mzx Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6C3EA Q13546 9 293 671.0 EJY:301 Type3 Inactive DFGout 13.211 8.704 BBAminus -130.6, 166.87 -129.4, 74.2 -68.21, -19.66 307.39, 166.79 -86.61, -13.09 out-out out 13.511 Saltbr-out 13.358 HRD-out -69.12, 116.26 -89.73, 2.91 out-out-out SNCooo out-out ActLoopNT-out 5.346 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -66.6 APE8-dihe-out -78.73, -34.83 APE8-rot-out 76.27 APE67-dihe-in -63.09, -35.77 -52.34, -36.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.672 None None None XRAY 2.6 0.261 0.307 A 297 258 27 0 0 17 [[17, 287]] 1.0 6c3e Homo sapiens TKL_RIPK1_HUMAN TKL 1.7e-72 250.1 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 4ITHA Q13546 8 294 671.0 RCM:307 Type3 Inactive DFGout 14.111 8.042 BBAminus -124.73, 172.6 -138.48, 68.81 -68.88, -22.32 295.59, 2.39 -91.07, 2.58 out-out out 13.598 Saltbr-out 12.965 HRD-in -65.52, -52.94 79.64, -21.46 out-out-out SNCooo out-out ActLoopNT-out 5.125 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.47 APE8-dihe-in -73.02, 143.29 APE8-rot-in 249.4 APE67-dihe-in -62.29, -27.12 -114.9, 22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.706 C34A,C127A,C233A,C240A None None XRAY 2.25 0.222 0.247 A 294 247 40 0 0 19 [[17, 287]] 1.0 4ith Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 4ITHB Q13546 7 294 671.0 RCM:307 Type3 Inactive DFGout 13.911 7.88 BBAminus -124.36, 170.84 -137.49, 67.98 -68.97, -21.27 308.9, 171.62 -88.43, 4.67 out-out out 13.671 Saltbr-out 12.354 HRD-in -66.08, -61.08 99.79, -41.26 out-out-out SNCooo out-out ActLoopNT-out 5.287 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.33 APE8-dihe-out -80.2, -0.81 APE8-rot-out 76.21 APE67-dihe-in -69.94, -29.23 -70.53, -20.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.372 C34A,C127A,C233A,C240A None None XRAY 2.25 0.222 0.247 B 294 270 18 0 0 12 [[17, 287]] 1.0 4ith Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 4ITIA Q13546 8 294 671.0 1HW:301 Type3 Inactive DFGout 14.809 7.536 BBAminus -119.39, 171.24 -131.64, 70.92 -77.19, -1.86 301.33, 175.38 -111.16, 12.31 out-out out 14.461 Saltbr-out 12.021 HRD-in -63.67, -39.02 58.78, 3.1 out-out-out SNCooo out-out ActLoopNT-out 5.063 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 135.54 APE9-dihe-na -28.2, -40.78 APE8-dihe-out -49.5, 2.2 APE8-rot-out 126.42 APE67-dihe-in -74.62, -10.45 -88.53, -16.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.612 APE9-dist-out 11.919 C34A,C127A,C233A,C240A None None XRAY 2.86 0.229 0.267 A 294 272 15 0 0 10 [[17, 287]] 1.0 4iti Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 4ITIB Q13546 7 294 671.0 1HW:301 Type3 Inactive DFGout 15.287 8.279 BBAminus -133.02, 174.0 -136.87, 74.76 -71.37, -1.88 298.09, 0.08 -118.72, 6.02 out-out out 14.736 Saltbr-out 12.105 HRD-in -67.98, -50.79 78.94, -25.18 out-out-out SNCooo out-out ActLoopNT-out 5.029 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.75 APE8-dihe-out -48.23, -36.55 APE8-rot-out 178.41 APE67-dihe-in -64.1, -17.64 -60.59, -39.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.503 C34A,C127A,C233A,C240A None None XRAY 2.86 0.229 0.267 B 294 270 18 0 0 11 [[17, 287]] 1.0 4iti Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6NYHA Q13546 8 294 671.0 L8D:301 Type3 Inactive DFGout 13.435 9.94 BBAminus -117.53, 173.88 -134.6, 59.12 -68.75, -26.25 307.46, 178.63 -80.82, 2.01 out-out out 14.527 Saltbr-out 12.436 HRD-in -67.92, -54.26 77.85, -10.18 out-out-out SNCooo out-out ActLoopNT-out 6.112 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -22.11 APE8-dihe-in -70.09, 140.73 APE8-rot-out 198.89 APE67-dihe-in -52.04, -30.58 -103.66, -3.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.748 C34A,C127A,C233A,C240A None None XRAY 2.1 0.206 0.246 A 296 265 22 0 0 12 [[17, 287]] 1.0 6nyh Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6NYHB Q13546 11 294 671.0 L8D:301 Type3 Inactive DFGout 13.932 9.865 BBAminus -122.04, 173.92 -132.13, 59.75 -67.23, -24.7 302.43, 2.51 -86.8, 3.14 out-out out 14.458 Saltbr-out 12.191 HRD-in -67.08, -53.83 81.99, -19.6 out-out-out SNCooo out-out ActLoopNT-out 6.207 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -85.36 APE8-dihe-in -72.43, 144.74 APE8-rot-out 184.05 APE67-dihe-in -66.66, -21.12 -105.82, 2.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.774 C34A,C127A,C233A,C240A None None XRAY 2.1 0.206 0.246 B 296 246 38 0 0 18 [[17, 287]] 1.0 6nyh Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9Q31A Q13546 7 294 671.0 A1CNU:301 Type3 Inactive DFGout 13.735 8.23 BBAminus -120.57, 170.34 -130.15, 58.16 -63.68, -22.9 293.63, 177.4 -82.91, 0.44 out-out out 13.869 Saltbr-out 11.761 HRD-in -67.33, -55.79 80.06, -9.46 out-out-out SNCooo out-out ActLoopNT-out 6.088 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.72 APE8-rot-out 187.62 APE67-dihe-in -62.14, -27.07 -101.34, -1.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.05 0.187 0.222 A 296 269 19 0 0 12 [[17, 287]] 1.0 9q31 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9Q32A Q13546 6 293 671.0 A1CNV:301 Type3 Inactive DFGout 14.528 8.226 BBAminus -121.4, 167.22 -125.99, 62.31 -66.66, -26.07 287.26, 169.09 -79.79, -0.98 out-out out 14.14 Saltbr-out 12.229 HRD-in -66.73, -48.33 74.89, -10.1 out-out-out SNCooo out-out ActLoopNT-out 5.546 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 27.12 APE8-dihe-in -71.54, 159.66 APE8-rot-out 185.13 APE67-dihe-in -62.84, -25.84 -113.42, -0.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.855 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 A 296 266 22 0 0 12 [[17, 287]] 1.0 9q32 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9Q32B Q13546 8 294 671.0 A1CNV:301 Type3 Inactive DFGout 14.34 8.34 BBAminus -125.85, 168.27 -125.45, 64.08 -70.16, -25.81 289.07, 162.55 -79.65, -1.07 out-out out 14.45 Saltbr-out 13.417 HRD-in -68.2, -50.31 78.72, -10.28 out-out-out SNCooo out-out ActLoopNT-out 5.817 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.67 APE8-rot-out 168.75 APE67-dihe-in -63.25, -31.84 -91.02, 4.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 B 296 251 36 0 0 18 [[17, 287]] 1.0 9q32 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9Q32C Q13546 6 293 671.0 A1CNV:301 Type3 Inactive DFGout 14.46 8.281 BBAminus -120.28, 170.4 -126.9, 54.43 -63.55, -25.46 293.16, 167.28 -77.54, -4.89 out-out out 13.586 Saltbr-out 12.769 HRD-in -69.24, -48.43 74.25, -12.6 out-out-out SNCooo out-out ActLoopNT-out 6.023 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -164.99 APE8-dihe-in -75.87, 151.54 APE8-rot-out 168.79 APE67-dihe-in -61.95, -25.0 -103.03, -0.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.6 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 C 296 259 29 0 0 17 [[17, 287]] 1.0 9q32 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9Q32D Q13546 8 294 671.0 A1CNV:301 Type3 Inactive DFGout 14.457 8.195 BBAminus -119.22, 172.55 -131.06, 63.91 -69.23, -20.15 294.44, 171.06 -85.09, -1.42 out-none out 14.021 Saltbr-none 999.0 HRD-in -82.45, -48.15 73.95, -16.29 none-out-out SNCnoo out-out ActLoopNT-out 5.764 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 25.84 APE8-dihe-in -75.4, 152.13 APE8-rot-out 189.23 APE67-dihe-in -64.73, -21.38 -109.94, 2.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.29 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 D 296 250 37 0 0 19 [[17, 287]] 1.0 9q32 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 7FCZA Q13546 10 294 671.0 3IF:301 Type3 Inactive DFGout 13.865 10.379 BBAminus -121.61, 171.92 -133.79, 66.08 -70.41, -22.3 302.99, 177.02 -85.6, 3.29 out-out out 15.002 Saltbr-out 12.85 HRD-in -69.8, -48.63 73.26, -13.72 out-out-out SNCooo out-out ActLoopNT-out 6.074 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 77.72 APE8-dihe-in -67.19, 127.43 APE8-rot-in 294.95 APE67-dihe-in -62.33, -29.47 -101.92, 1.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.476 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 A 297 248 37 0 0 18 [[17, 287]] 1.0 7fcz Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 7FCZB Q13546 7 294 671.0 3IF:301 Type3 Inactive DFGout 13.913 10.028 BBAminus -118.21, 174.22 -136.13, 64.53 -68.29, -24.74 303.09, 178.58 -83.09, -0.43 out-out out 14.189 Saltbr-out 12.575 HRD-in -73.47, -53.47 80.61, -17.48 out-out-out SNCooo out-out ActLoopNT-out 6.139 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.37 APE8-dihe-in -64.4, 143.44 APE8-rot-out 179.16 APE67-dihe-in -62.08, -29.26 -100.06, -1.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.634 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 B 297 263 25 0 0 17 [[17, 287]] 1.0 7fcz Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9HY8A Q13546 8 294 671.0 A1IX7:301 Type3 Inactive DFGout 12.981 9.596 BBAminus -141.13, 164.94 -130.11, 66.18 -66.58, -24.49 309.73, 7.18 -84.28, -2.51 out-out out 14.033 Saltbr-out 11.772 HRD-out -86.53, 114.22 -72.4, -38.91 out-out-out SNCooo out-out ActLoopNT-out 6.11 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 77.03 APE8-dihe-out -67.08, -34.07 APE8-rot-out 196.53 APE67-dihe-in -68.73, -30.32 -60.21, -30.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.808 None None None XRAY 2.98 0.23 0.295 A 297 260 27 0 0 18 [[17, 287]] 1.0 9hy8 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9HY8B Q13546 7 294 671.0 1HX:305 Type3 Inactive DFGout 13.904 9.078 BBAminus -137.15, 163.21 -126.56, 62.14 -66.56, -24.08 304.02, 3.22 -81.88, 1.19 out-out out 13.745 Saltbr-out 12.321 HRD-out -85.29, 111.77 -72.25, -38.63 out-out-out SNCooo out-out ActLoopNT-out 6.114 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -35.46 APE8-rot-out 195.34 APE67-dihe-in -63.95, -33.12 -61.2, -31.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.98 0.23 0.295 B 297 271 17 0 0 12 [[17, 287]] 1.0 9hy8 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9HY9A Q13546 10 294 671.0 A1IX9:301 Type3 Inactive DFGout 12.864 9.725 BBAminus -132.24, 163.44 -119.98, 69.92 -71.64, -30.92 302.3, 2.93 -73.75, -3.09 out-out out 14.314 Saltbr-out 11.313 HRD-in -66.75, -56.07 86.01, -13.31 out-out-out SNCooo out-out ActLoopNT-out 6.04 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -51.61 APE8-dihe-out -64.18, -21.53 APE8-rot-out 61.29 APE67-dihe-in -61.96, -24.09 -103.08, -2.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.198 C34A,C127A,C233A,C240A None None XRAY 2.29 0.219 0.275 A 297 251 34 0 0 18 [[17, 287]] 1.0 9hy9 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9HY9B Q13546 8 294 671.0 A1IX9:301 Type3 Inactive DFGout 14.034 9.477 BBAminus -133.17, 165.69 -124.95, 70.39 -65.88, -32.58 304.79, 2.82 -81.7, 4.58 out-out out 14.395 Saltbr-out 11.494 HRD-in -67.55, -54.35 91.32, -11.86 out-out-out SNCooo out-out ActLoopNT-out 6.175 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 166.85 APE8-dihe-in -57.79, 140.57 APE8-rot-out 188.52 APE67-dihe-in -62.67, -21.78 -100.89, 3.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.311 C34A,C127A,C233A,C240A None None XRAY 2.29 0.219 0.275 B 297 265 22 0 0 13 [[17, 287]] 1.0 9hy9 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6C4DA Q13546 8 294 671.0 EJP:1100 Type3 Inactive DFGout 15.126 10.11 BBAminus -117.56, 178.71 -149.43, 73.24 -69.95, -18.38 305.75, 179.55 -101.55, 7.83 out-out out 16.257 Saltbr-out 16.566 HRD-in -55.77, -51.03 80.27, -34.22 out-out-out SNCooo out-out ActLoopNT-out 5.595 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -159.93 APE8-dihe-in -106.53, 126.83 APE8-rot-in 321.17 APE67-dihe-in -67.47, -17.91 -88.44, 5.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.641 None None None XRAY 2.52 0.246 0.296 A 297 267 20 0 0 13 [[17, 287]] 1.0 6c4d Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6C4DB Q13546 7 294 671.0 EJP:1100 Type3 Inactive DFGout 14.902 9.997 BBAminus -109.17, 170.78 -134.96, 67.82 -67.04, -23.45 302.04, 179.31 -86.78, -0.45 out-out out 13.971 Saltbr-out 13.274 HRD-in -58.83, -55.33 81.23, -6.46 out-out-out SNCooo out-out ActLoopNT-out 6.208 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 135.34 APE8-dihe-in -76.56, 126.03 APE8-rot-in 339.29 APE67-dihe-in -57.69, -33.16 -79.19, -15.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.114 None None None XRAY 2.52 0.246 0.296 B 297 266 22 0 0 16 [[17, 287]] 1.0 6c4d Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6C4DC Q13546 10 294 671.0 EJP:1100 Type3 Inactive DFGout 13.888 9.719 BBAminus -117.68, 178.27 -141.12, 66.69 -63.91, -32.83 304.36, 1.77 -82.22, -7.01 out-out out 14.002 Saltbr-out 13.724 HRD-out -79.05, 115.27 -95.69, 8.59 out-out-out SNCooo out-out ActLoopNT-out 5.708 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 161.35 APE8-dihe-in -80.27, 139.4 APE8-rot-in 352.11 APE67-dihe-in -58.83, -30.61 -90.66, -17.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.716 None None None XRAY 2.52 0.246 0.296 C 297 258 27 0 0 18 [[17, 287]] 1.0 6c4d Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6C4DD Q13546 5 293 671.0 EJP:1100 Type3 Inactive DFGout 14.579 10.057 BBAminus -117.58, 172.01 -139.03, 81.37 -72.34, -39.58 302.56, 173.11 -76.31, -0.83 out-out out 15.418 Saltbr-out 15.949 HRD-out -76.11, 120.54 -93.07, -33.93 out-out-out SNCooo out-out ActLoopNT-out 5.708 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -89.51 APE8-dihe-in -75.78, 153.21 APE8-rot-out 63.53 APE67-dihe-in -63.87, -30.91 -109.82, 5.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.301 None None None XRAY 2.52 0.246 0.296 D 297 266 23 0 0 16 [[17, 287]] 1.0 6c4d Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 5HX6A Q13546 10 294 671.0 65U:301 Type3 Inactive DFGout 13.746 10.081 BBAminus -114.15, 174.66 -134.73, 71.48 -75.96, -22.44 306.17, 175.84 -90.96, 8.33 out-out out 15.167 Saltbr-out 14.396 HRD-in -69.31, -54.37 72.33, -26.98 out-out-out SNCooo out-out ActLoopNT-out 5.818 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.42 APE8-dihe-in -113.81, 128.35 APE8-rot-in 307.51 APE67-dihe-in -68.28, -25.41 -91.99, -10.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.926 C34A,C127A,C233A,C240A None None XRAY 2.23 0.202 0.248 A 303 259 26 0 0 18 [[17, 287]] 1.0 5hx6 Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 5TX5A Q13546 10 294 671.0 7MJ:301 Type3 Inactive DFGout 13.573 10.201 BBAminus -116.16, 171.57 -130.87, 63.14 -69.82, -14.33 312.94, 168.86 -98.42, 6.27 out-out out 14.845 Saltbr-out 14.379 HRD-in -66.81, -51.24 62.33, -1.21 out-out-out SNCooo out-out ActLoopNT-out 6.13 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 119.73 APE8-dihe-in -110.36, 127.1 APE8-rot-in 310.57 APE67-dihe-in -70.3, -28.6 -100.12, 4.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.291 C34A,C127A,C233A,C240A None None XRAY 2.56 0.2 0.24 A 303 259 26 0 0 18 [[17, 287]] 1.0 5tx5 Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6HHOA Q13546 8 294 671.0 G4W:301 Type3 Inactive DFGout 13.67 9.694 BBAminus -115.24, 164.48 -126.66, 62.71 -63.79, -26.65 296.63, 179.45 -87.49, 3.26 out-out out 14.208 Saltbr-out 13.017 HRD-in -59.4, -57.1 78.79, -22.09 out-out-out SNCooo out-out ActLoopNT-out 6.209 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.3 APE8-dihe-in -93.04, 144.83 APE8-rot-out 195.71 APE67-dihe-in -65.11, -26.33 -104.41, -2.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.244 C34A,C127A,C233A,C240A None None XRAY 3.49 0.209 0.227 A 303 273 14 0 0 11 [[17, 287]] 1.0 6hho Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6HHOB Q13546 7 294 671.0 G4W:301 Type3 Inactive DFGout 13.824 9.442 BBAminus -119.74, 167.8 -136.07, 70.92 -69.13, -25.22 303.5, 11.26 -79.53, -4.81 out-out out 14.318 Saltbr-out 12.609 HRD-in -55.52, -56.34 83.4, -19.29 out-out-none SNCoon out-none ActLoopNT-out 6.05 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -34.12 APE8-rot-in 325.58 APE67-dihe-in -55.64, -31.82 -55.9, -39.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 3.49 0.209 0.227 B 303 266 22 0 0 12 [[17, 287]] 1.0 6hho Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6OCQB Q13546 7 294 671.0 M5J:301 Type3 Inactive DFGout 13.012 8.057 BBAminus -130.11, 162.38 -122.52, 81.31 -82.7, -15.44 293.68, 160.97 -87.37, 2.43 out-out out 13.636 Saltbr-out 13.611 HRD-in -64.49, -53.65 73.55, -4.84 out-out-out SNCooo out-out ActLoopNT-out 5.464 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -23.86 APE8-rot-out 173.0 APE67-dihe-in -61.59, -15.49 -61.5, -24.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.793 0.206 0.268 B 303 274 14 0 0 12 [[17, 287]] 1.0 6ocq Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6R5FA Q13546 9 294 671.0 JSW:301 Type3 Inactive DFGout 13.955 9.481 BBAminus -112.95, 165.41 -130.42, 63.72 -66.93, -21.93 297.24, 0.02 -91.89, 5.73 out-out out 14.529 Saltbr-out 13.191 HRD-in -56.51, -60.39 80.9, -22.8 out-out-out SNCooo out-out ActLoopNT-out 5.924 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.38 APE8-rot-out 178.71 APE67-dihe-in -64.62, -25.33 -74.5, -6.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 A 303 252 34 0 0 16 [[17, 287]] 1.0 6r5f Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6R5FB Q13546 10 294 671.0 JSW:301 Type3 Inactive DFGout 13.78 9.691 BBAminus -117.91, 170.03 -135.39, 68.26 -70.88, -17.07 303.86, 8.01 -86.89, -7.53 out-out out 14.147 Saltbr-out 14.183 HRD-in -58.11, -56.03 90.31, -47.38 out-out-out SNCooo out-out ActLoopNT-out 6.22 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.8 APE8-dihe-in -110.24, 128.64 APE8-rot-out 54.88 APE67-dihe-in -53.24, -34.36 -61.38, -32.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.919 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 B 303 256 29 0 0 17 [[17, 287]] 1.0 6r5f Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6R5FC Q13546 9 294 671.0 JSW:301 Type3 Inactive DFGout 13.993 9.934 BBAminus -129.98, 154.77 -113.58, 87.15 -77.89, -25.03 313.32, 1.4 -85.25, 0.11 out-out out 14.529 Saltbr-out 15.039 HRD-in -68.31, -36.48 72.06, -57.73 out-out-out SNCooo out-out ActLoopNT-out 5.739 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -139.85 APE8-dihe-in -109.8, 132.44 APE8-rot-out 61.03 APE67-dihe-in -41.51, -34.43 -97.85, -8.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.153 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 C 303 253 33 0 0 16 [[17, 287]] 1.0 6r5f Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6R5FD Q13546 11 294 671.0 JSW:301 Type3 Inactive DFGout 14.45 9.248 BBAminus -142.39, 170.94 -125.26, 78.91 -70.36, -35.3 283.29, 144.33 -66.46, -23.13 out-out out 15.019 Saltbr-out 16.123 HRD-in -59.61, -37.57 70.15, -52.85 out-out-out SNCooo out-out ActLoopNT-out 6.06 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 119.22 APE8-dihe-in -103.39, 137.53 APE8-rot-out 189.96 APE67-dihe-in -50.68, -36.72 -90.03, -10.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.433 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 D 303 250 34 0 0 17 [[17, 287]] 1.0 6r5f Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6RLNA Q13546 8 294 671.0 K8K:301 Type3 Inactive DFGout 13.828 9.344 BBAminus -121.93, 164.11 -127.72, 59.44 -57.14, -30.4 302.07, 177.27 -86.63, -0.56 out-out out 14.464 Saltbr-out 13.169 HRD-in -55.19, -50.82 78.22, -37.5 out-out-out SNCooo out-out ActLoopNT-out 5.952 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.07 APE8-dihe-in -87.79, 130.01 APE8-rot-in 299.1 APE67-dihe-in -57.83, -39.09 -99.26, -10.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.716 C34A,C127A,C233A,C240A None None XRAY 2.87 0.196 0.232 A 303 266 21 0 0 11 [[17, 287]] 1.0 6rln Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6NW2A Q13546 8 294 671.0 L4Y:301 Type3 Inactive DFGout 13.608 9.512 BBAminus -126.76, 173.12 -134.47, 72.41 -77.05, -17.16 300.87, 12.85 -87.44, 3.81 out-out out 13.794 Saltbr-out 12.048 HRD-in -68.25, -50.83 78.22, -14.78 out-out-none SNCoon out-none ActLoopNT-out 6.312 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 149.64 APE8-rot-in 298.28 APE67-dihe-in -63.58, -21.18 -59.6, -37.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.212 0.261 A 310 260 27 0 0 12 [[17, 287]] 1.0 6nw2 Homo sapiens TKL_RIPK1_HUMAN TKL 1.5e-72 250.3 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 6NW2B Q13546 11 294 671.0 L4Y:301 Type3 Inactive DFGout 13.716 9.993 BBAminus -122.99, 177.91 -138.58, 64.6 -73.14, -19.26 303.52, 11.16 -82.07, -0.78 out-out out 14.265 Saltbr-out 13.612 HRD-in -71.79, -51.87 81.67, -16.37 out-out-out SNCooo out-out ActLoopNT-out 6.279 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -16.93 APE8-dihe-out -77.38, -12.49 APE8-rot-out 198.5 APE67-dihe-in -68.62, -19.61 -107.28, 7.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.491 None None None XRAY 2.0 0.212 0.261 B 310 246 38 0 0 18 [[17, 287]] 1.0 6nw2 Homo sapiens TKL_RIPK1_HUMAN TKL 1.5e-72 250.3 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9GTYA Q13546 8 294 671.0 RCM:301 Type3 Inactive DFGout 13.983 8.222 BBAminus -123.34, 171.31 -137.95, 64.52 -61.74, -25.38 305.36, 176.3 -90.28, 0.66 out-out out 13.752 Saltbr-out 13.245 HRD-in -64.08, -57.67 81.97, -22.12 out-out-out SNCooo out-out ActLoopNT-out 5.227 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -14.17 APE8-dihe-out -79.25, -21.69 APE8-rot-out 51.22 APE67-dihe-in -62.86, -31.23 -89.57, 1.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.816 C34A,C127A,C233A,C240A None None XRAY 2.145 0.251 0.294 A 313 253 34 0 0 19 [[17, 287]] 1.0 9gty Homo sapiens TKL_RIPK1_HUMAN TKL 1.5e-72 250.2 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9GTGA Q13546 8 294 671.0 RCM:301,A1IPG:302 Type3,Type1 Inactive DFGout 14.048 8.733 BBAminus -120.7, 174.19 -140.11, 66.75 -72.21, -11.93 303.8, 178.39 -100.67, 0.92 out-out out 13.5 Saltbr-out 12.1 HRD-in -70.04, -46.73 71.98, -13.03 out-out-out SNCooo out-out ActLoopNT-out 5.099 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -38.11 APE8-dihe-out -53.85, -42.8 APE8-rot-out 59.02 APE67-dihe-in -64.33, -16.83 -85.43, -11.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.86 None None None XRAY 2.25 0.221 0.295 A 313 259 28 0 0 19 [[17, 287]] 1.0 9gtg Homo sapiens TKL_RIPK1_HUMAN TKL 1.5e-72 250.2 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
RIPK1_HUMAN 9GTYB Q13546 8 294 671.0 RCM:301,A1IKX:302 Type3,Type1 Inactive DFGout 14.159 8.454 BBAminus -123.21, 170.66 -136.75, 64.56 -61.45, -25.1 304.25, 174.68 -90.93, 0.86 out-out out 13.932 Saltbr-out 13.354 HRD-in -64.37, -58.12 82.38, -22.95 out-out-out SNCooo out-out ActLoopNT-out 5.203 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -12.75 APE8-dihe-out -78.82, -22.72 APE8-rot-out 50.86 APE67-dihe-in -62.42, -30.84 -90.02, 1.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.905 C34A,C127A,C233A,C240A None None XRAY 2.145 0.251 0.294 B 313 259 28 0 0 19 [[17, 287]] 1.0 9gty Homo sapiens TKL_RIPK1_HUMAN TKL 1.5e-72 250.2 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1

TKL_RIPK1 (Receptor-interacting serine/threonine-protein kinase 1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name