CAMK_MARK2 (Serine/threonine-protein kinase MARK2)

Total number of chains: 14
Active chains: 2
Uniprot: MARK2_HUMAN
Kinase Domain Residues: 53 - 304
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 7 50.0% AF-Q7KZI7-K1A
DFGin ABAminus 3 21.4% 3IECB
DFGin None 3 21.4% 5KZ8A
None None 1 7.1% 5KZ7B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MARK2 AF-Q7KZI7-K1A Q7KZI7 45 312 788.0 No_ligand No_ligand Active DFGin 6.6175 14.4592 BLAminus -124.25, 176.28 57.12, 73.23 -81.85, 16.44 288.16, 80.98 -61.95, -29.5 in-in in 9.397 Saltbr-in 2.6783 HRD-in -79.11, -48.82 65.67, 0.61 in-in-in SNCiii in-in ActLoopNT-in 2.9158 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.73, 161.68 APE9-dihe-na 92.79, 171.11 APE8-dihe-in -68.76, 130.08 APE8-rot-in 283.89 APE67-dihe-in -65.41, -22.04 -52.41, -39.4 APE12-dist-in 8.6095 APE11-dist-in 10.9407 APE10-dist-in 5.1346 APE9-dist-in 3.4925 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[53, 304]] 1.0 AF-Q7KZI7-K1 CAMK_MARK2_HUMAN CAMK 4.6e-97 330.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 AF-Q7KZI7-K3A Q7KZI7 45 312 788.0 No_ligand No_ligand Active DFGin 6.3343 14.4625 BLAminus -124.9, 174.85 53.99, 75.54 -78.47, 15.52 286.14, 85.13 -59.73, -27.22 in-in in 9.3771 Saltbr-in 2.681 HRD-in -85.93, -45.9 63.51, 12.19 in-in-in SNCiii in-in ActLoopNT-in 2.8974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.31, 179.02 APE9-dihe-na 100.33, 167.6 APE8-dihe-in -78.21, 124.32 APE8-rot-in 298.84 APE67-dihe-in -65.56, -21.76 -51.27, -39.62 APE12-dist-in 8.2298 APE11-dist-in 11.191 APE10-dist-in 5.6798 APE9-dist-in 3.2548 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[53, 304]] 1.0 AF-Q7KZI7-K3 CAMK_MARK2_HUMAN CAMK 4.6e-97 330.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 3IECB Q7KZI7 49 363 788.0 No_ligand No_ligand Inactive DFGin 6.6322 15.2369 ABAminus -111.73, -54.57 -113.89, 100.97 -96.49, 26.5 288.68, 76.63 -60.73, -30.69 out-out out 10.3563 Saltbr-out 3.9972 HRD-in -81.53, -52.44 69.82, 3.23 out-in-in SNCoii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.14, 141.67 APE9-dihe-na 179.56, -168.84 APE8-dihe-in -115.03, 122.65 APE8-rot-in 293.99 APE67-dihe-in -69.55, -18.44 -52.49, -39.54 APE12-dist-in 8.2426 APE11-dist-in 11.317 APE10-dist-in 5.5854 APE9-dist-in 3.8316 R146W None None XRAY 2.2 0.206 0.248 B 319.0 313.0 2 27 27 0 [[53, 304]] 1.0 3iec CAMK_MARK2_HUMAN CAMK 5.9e-96 326.7 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 3IECD Q7KZI7 49 363 788.0 No_ligand No_ligand Inactive DFGin 6.6627 14.9192 ABAminus -112.97, -65.92 -95.58, 101.96 -91.56, 23.33 290.31, 80.0 -68.23, -21.37 out-in out 10.1541 Saltbr-in 2.9799 HRD-in -83.43, -51.45 66.36, 9.68 in-in-in SNCiii in-in ActLoopNT-in 2.9781 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.06, 150.19 APE9-dihe-na 170.56, -174.15 APE8-dihe-in -111.23, 125.42 APE8-rot-in 296.56 APE67-dihe-in -61.05, -25.35 -49.37, -46.53 APE12-dist-in 8.0544 APE11-dist-in 11.2118 APE10-dist-in 5.5606 APE9-dist-in 3.8872 R146W None None XRAY 2.2 0.206 0.248 D 319.0 311.0 4 27 27 0 [[53, 304]] 1.0 3iec CAMK_MARK2_HUMAN CAMK 5.9e-96 326.7 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 5EAKB Q7KZI7 51 363 788.0 24R:1000 Type1 Inactive DFGin 7.4165 14.7687 ABAminus -115.0, -64.33 -99.01, 103.92 -95.29, 15.09 281.93, 90.95 -107.62, 171.78 in-in in 8.6207 Saltbr-in 2.742 HRD-in -62.14, -44.87 64.0, 0.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 97.33 APE9-dihe-na -131.91, 57.79 APE8-dihe-out -101.72, -28.4 APE8-rot-out 49.14 APE67-dihe-in -62.46, -16.48 -45.02, -56.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.8555 APE9-dist-out 12.0578 None None None XRAY 2.8 0.198 0.254 B 328.0 300.0 13 27 14 13 [[53, 304]] 1.0 5eak CAMK_MARK2_HUMAN CAMK 9.4e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 3IECA Q7KZI7 49 363 788.0 No_ligand No_ligand Inactive DFGin 6.641 15.3771 BLAminus -126.48, 175.49 61.88, 79.23 -90.99, 24.6 291.84, 73.92 -64.94, -23.61 out-out out 10.3941 Saltbr-out 3.8204 HRD-in -80.72, -52.71 72.09, -1.3 out-in-in SNCoii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.64, 146.3 APE9-dihe-na 174.61, -164.25 APE8-dihe-in -117.64, 127.54 APE8-rot-in 308.22 APE67-dihe-in -65.81, -20.25 -46.09, -50.93 APE12-dist-in 8.6591 APE11-dist-in 11.3383 APE10-dist-in 5.6931 APE9-dist-in 3.752 R146W None None XRAY 2.2 0.206 0.248 A 319.0 311.0 4 27 27 0 [[53, 304]] 1.0 3iec CAMK_MARK2_HUMAN CAMK 5.9e-96 326.7 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 3IECC Q7KZI7 49 363 788.0 No_ligand No_ligand Inactive DFGin 6.5451 14.989 BLAminus -129.05, 171.44 70.18, 76.84 -94.18, 29.05 290.27, 77.72 -70.46, -25.82 out-out out 10.0931 Saltbr-out 3.7212 HRD-in -79.35, -55.6 72.39, -0.34 out-in-in SNCoii in-in ActLoopNT-in 2.9206 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.75, 147.4 APE9-dihe-na 171.59, -162.23 APE8-dihe-in -122.69, 124.24 APE8-rot-in 294.26 APE67-dihe-in -71.7, -12.49 -45.56, -49.08 APE12-dist-in 8.5114 APE11-dist-in 11.3259 APE10-dist-in 5.6521 APE9-dist-in 3.7882 R146W None None XRAY 2.2 0.206 0.248 C 319.0 311.0 4 27 27 0 [[53, 304]] 1.0 3iec CAMK_MARK2_HUMAN CAMK 5.9e-96 326.7 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 5EAKA Q7KZI7 47 362 788.0 24R:1000 Type1 Inactive DFGin 7.3244 14.5039 BLAminus -137.46, 144.64 77.77, 96.6 -106.75, 35.54 294.98, 75.52 -129.15, 17.91 in-in in 8.7428 Saltbr-in 2.7925 HRD-in -76.52, -44.94 75.05, -11.1 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nioo APE10-dihe-na -71.03, -34.99 APE9-dihe-na -84.28, -40.83 APE8-dihe-out -54.27, -59.88 APE8-rot-out 164.87 APE67-dihe-in -67.03, -8.26 -47.53, -48.52 APE12-dist-none 999.0 APE11-dist-in 11.7375 APE10-dist-out 13.6019 APE9-dist-out 11.5385 None None None XRAY 2.8 0.198 0.254 A 328.0 305.0 11 27 16 11 [[53, 304]] 1.0 5eak CAMK_MARK2_HUMAN CAMK 9.4e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 8TXYA Q7KZI7 48 363 788.0 SJ0:403 Type1 Inactive DFGin 7.771 16.0803 BLAminus -130.34, 171.06 66.32, 92.69 -116.41, 35.91 282.62, 80.32 152.7, -23.26 in-out in 9.8337 Saltbr-out 6.2376 HRD-in -65.71, -52.56 70.64, -3.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -66.12, -34.52 APE9-dihe-na -131.17, 15.38 APE8-dihe-out -71.17, -44.57 APE8-rot-in 290.0 APE67-dihe-in -63.53, -17.52 -56.17, -38.22 APE12-dist-in 8.369 APE11-dist-in 12.5258 APE10-dist-out 13.8257 APE9-dist-out 11.3998 I59L,K66V,V81I,L97I,V113I,M129T,S133K,G134N,S197G None None XRAY 2.1 0.241 0.267 A 317.0 305.0 11 27 16 11 [[53, 304]] 1.0 8txy CAMK_MARK2_HUMAN CAMK 2.1e-95 324.9 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 8TXYB Q7KZI7 47 363 788.0 SJ0:402 Type1 Inactive DFGin 7.6317 16.4739 BLAminus -131.24, 168.82 67.77, 87.06 -109.29, 36.63 283.39, 79.6 152.71, 999.0 out-out out 10.0769 Saltbr-out 3.7188 HRD-in -65.54, -52.35 70.44, -3.82 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -82.92, -38.19 APE9-dihe-na -125.48, 4.04 APE8-dihe-out -73.83, -43.45 APE8-rot-out 195.03 APE67-dihe-in -63.18, -17.94 -57.03, -37.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.413 I59L,K66V,V81I,L97I,V113I,M129T,S133K,G134N,S197G None None XRAY 2.1 0.241 0.267 B 317.0 305.0 12 27 15 12 [[53, 304]] 1.0 8txy CAMK_MARK2_HUMAN CAMK 2.1e-95 324.9 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 5KZ7A Q7KZI7 48 363 788.0 6Z2:401 Type1 Inactive DFGin 6.1798 15.1923 None -66.59, -98.89 -137.2, 177.34 -105.99, 0.84 306.21, 67.89 -39.62, 999.0 in-out in 9.3332 Saltbr-out 3.9373 HRD-in -57.93, -35.05 64.12, -16.36 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -56.94 APE8-rot-out 193.16 APE67-dihe-in -59.38, -16.94 -59.8, -39.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.226 0.293 A 346.0 296.0 20 27 11 16 [[53, 304]] 1.0 5kz7 CAMK_MARK2_HUMAN CAMK 1.1e-96 329.1 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 5KZ8A Q7KZI7 48 363 788.0 6Z5:401 Type1 Inactive DFGin 6.6608 14.8467 None -66.62, -138.3 -110.24, 161.57 -113.14, 60.74 323.38, 77.32 145.61, 999.0 in-out in 9.5893 Saltbr-out 4.8664 HRD-in -68.17, -39.88 60.26, -10.16 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 142.11 APE9-dihe-na -96.01, 39.12 APE8-dihe-out -76.41, -33.97 APE8-rot-out 180.16 APE67-dihe-in -71.46, -15.13 -73.47, -29.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5634 None None None XRAY 3.21 0.222 0.29 A 346.0 302.0 14 27 13 14 [[53, 304]] 1.0 5kz8 CAMK_MARK2_HUMAN CAMK 1.1e-96 329.1 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 5KZ8B Q7KZI7 48 363 788.0 6Z5:401 Type1 Inactive DFGin 7.4263 15.8016 None -67.43, 142.07 -36.53, 154.18 -125.77, 99.94 7.04, 147.55 143.09, 999.0 in-out in 9.6021 Saltbr-out 4.8858 HRD-in -66.11, -40.74 54.9, 7.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -66.07 APE8-rot-out 193.35 APE67-dihe-in -71.07, -14.96 -58.24, -27.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.21 0.222 0.29 B 346.0 300.0 16 27 11 16 [[53, 304]] 1.0 5kz8 CAMK_MARK2_HUMAN CAMK 1.1e-96 329.1 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 5KZ7B Q7KZI7 48 363 788.0 6Z2:401 Type1 Inactive None 999.0 999.0 None -120.55, 164.19 69.13, 152.42 -169.56, 4.25 999.0, 999.0 -153.62, 999.0 in-out in 9.232 Saltbr-out 4.0514 HRD-in -60.44, -40.64 55.6, 2.04 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -57.96 APE8-rot-out 194.36 APE67-dihe-in -59.11, -16.52 -60.34, -38.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.226 0.293 B 346.0 296.0 20 27 11 16 [[53, 304]] 1.0 5kz7 CAMK_MARK2_HUMAN CAMK 1.1e-96 329.1 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2

CAMK_MARK2 (Serine/threonine-protein kinase MARK2)

Total number of chains: 30
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 30.0% AF-Q7KZI7-K1A
DFGin None 9 30.0% 2WZJA
None None 9 30.0% 1Y8GA
DFGin ABAminus 3 10.0% 3IECB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MARK2 MARK2_HUMAN AF-Q7KZI7-K1A Q7KZI7 45 312 788.0 No_ligand No_ligand Active DFGin 6.6175 14.4592 BLAminus -124.25, 176.28 57.12, 73.23 -81.85, 16.44 288.16, 80.98 -61.95, -29.5 in-in in 9.397 Saltbr-in 2.6783 HRD-in -79.11, -48.82 65.67, 0.61 in-in-in SNCiii in-in ActLoopNT-in 2.9158 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.73, 161.68 APE9-dihe-na 92.79, 171.11 APE8-dihe-in -68.76, 130.08 APE8-rot-in 283.89 APE67-dihe-in -65.41, -22.04 -52.41, -39.4 APE12-dist-in 8.6095 APE11-dist-in 10.9407 APE10-dist-in 5.1346 APE9-dist-in 3.4925 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[53, 304]] 1.0 AF-Q7KZI7-K1 Homo sapiens CAMK_MARK2_HUMAN CAMK 4.6e-97 330.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_HUMAN AF-Q7KZI7-K3A Q7KZI7 45 312 788.0 No_ligand No_ligand Active DFGin 6.3343 14.4625 BLAminus -124.9, 174.85 53.99, 75.54 -78.47, 15.52 286.14, 85.13 -59.73, -27.22 in-in in 9.3771 Saltbr-in 2.681 HRD-in -85.93, -45.9 63.51, 12.19 in-in-in SNCiii in-in ActLoopNT-in 2.8974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.31, 179.02 APE9-dihe-na 100.33, 167.6 APE8-dihe-in -78.21, 124.32 APE8-rot-in 298.84 APE67-dihe-in -65.56, -21.76 -51.27, -39.62 APE12-dist-in 8.2298 APE11-dist-in 11.191 APE10-dist-in 5.6798 APE9-dist-in 3.2548 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[53, 304]] 1.0 AF-Q7KZI7-K3 Homo sapiens CAMK_MARK2_HUMAN CAMK 4.6e-97 330.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_HUMAN 3IECB Q7KZI7 49 363 788.0 No_ligand No_ligand Inactive DFGin 6.6322 15.2369 ABAminus -111.73, -54.57 -113.89, 100.97 -96.49, 26.5 288.68, 76.63 -60.73, -30.69 out-out out 10.3563 Saltbr-out 3.9972 HRD-in -81.53, -52.44 69.82, 3.23 out-in-in SNCoii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.14, 141.67 APE9-dihe-na 179.56, -168.84 APE8-dihe-in -115.03, 122.65 APE8-rot-in 293.99 APE67-dihe-in -69.55, -18.44 -52.49, -39.54 APE12-dist-in 8.2426 APE11-dist-in 11.317 APE10-dist-in 5.5854 APE9-dist-in 3.8316 R146W None None XRAY 2.2 0.206 0.248 B 319.0 313.0 2 27 27 0 [[53, 304]] 1.0 3iec Homo sapiens CAMK_MARK2_HUMAN CAMK 5.9e-96 326.7 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_HUMAN 3IECD Q7KZI7 49 363 788.0 No_ligand No_ligand Inactive DFGin 6.6627 14.9192 ABAminus -112.97, -65.92 -95.58, 101.96 -91.56, 23.33 290.31, 80.0 -68.23, -21.37 out-in out 10.1541 Saltbr-in 2.9799 HRD-in -83.43, -51.45 66.36, 9.68 in-in-in SNCiii in-in ActLoopNT-in 2.9781 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.06, 150.19 APE9-dihe-na 170.56, -174.15 APE8-dihe-in -111.23, 125.42 APE8-rot-in 296.56 APE67-dihe-in -61.05, -25.35 -49.37, -46.53 APE12-dist-in 8.0544 APE11-dist-in 11.2118 APE10-dist-in 5.5606 APE9-dist-in 3.8872 R146W None None XRAY 2.2 0.206 0.248 D 319.0 311.0 4 27 27 0 [[53, 304]] 1.0 3iec Homo sapiens CAMK_MARK2_HUMAN CAMK 5.9e-96 326.7 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_HUMAN 5EAKB Q7KZI7 51 363 788.0 24R:1000 Type1 Inactive DFGin 7.4165 14.7687 ABAminus -115.0, -64.33 -99.01, 103.92 -95.29, 15.09 281.93, 90.95 -107.62, 171.78 in-in in 8.6207 Saltbr-in 2.742 HRD-in -62.14, -44.87 64.0, 0.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 97.33 APE9-dihe-na -131.91, 57.79 APE8-dihe-out -101.72, -28.4 APE8-rot-out 49.14 APE67-dihe-in -62.46, -16.48 -45.02, -56.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.8555 APE9-dist-out 12.0578 None None None XRAY 2.8 0.198 0.254 B 328.0 300.0 13 27 14 13 [[53, 304]] 1.0 5eak Homo sapiens CAMK_MARK2_HUMAN CAMK 9.4e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_HUMAN 3IECA Q7KZI7 49 363 788.0 No_ligand No_ligand Inactive DFGin 6.641 15.3771 BLAminus -126.48, 175.49 61.88, 79.23 -90.99, 24.6 291.84, 73.92 -64.94, -23.61 out-out out 10.3941 Saltbr-out 3.8204 HRD-in -80.72, -52.71 72.09, -1.3 out-in-in SNCoii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.64, 146.3 APE9-dihe-na 174.61, -164.25 APE8-dihe-in -117.64, 127.54 APE8-rot-in 308.22 APE67-dihe-in -65.81, -20.25 -46.09, -50.93 APE12-dist-in 8.6591 APE11-dist-in 11.3383 APE10-dist-in 5.6931 APE9-dist-in 3.752 R146W None None XRAY 2.2 0.206 0.248 A 319.0 311.0 4 27 27 0 [[53, 304]] 1.0 3iec Homo sapiens CAMK_MARK2_HUMAN CAMK 5.9e-96 326.7 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_HUMAN 3IECC Q7KZI7 49 363 788.0 No_ligand No_ligand Inactive DFGin 6.5451 14.989 BLAminus -129.05, 171.44 70.18, 76.84 -94.18, 29.05 290.27, 77.72 -70.46, -25.82 out-out out 10.0931 Saltbr-out 3.7212 HRD-in -79.35, -55.6 72.39, -0.34 out-in-in SNCoii in-in ActLoopNT-in 2.9206 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.75, 147.4 APE9-dihe-na 171.59, -162.23 APE8-dihe-in -122.69, 124.24 APE8-rot-in 294.26 APE67-dihe-in -71.7, -12.49 -45.56, -49.08 APE12-dist-in 8.5114 APE11-dist-in 11.3259 APE10-dist-in 5.6521 APE9-dist-in 3.7882 R146W None None XRAY 2.2 0.206 0.248 C 319.0 311.0 4 27 27 0 [[53, 304]] 1.0 3iec Homo sapiens CAMK_MARK2_HUMAN CAMK 5.9e-96 326.7 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_HUMAN 5EAKA Q7KZI7 47 362 788.0 24R:1000 Type1 Inactive DFGin 7.3244 14.5039 BLAminus -137.46, 144.64 77.77, 96.6 -106.75, 35.54 294.98, 75.52 -129.15, 17.91 in-in in 8.7428 Saltbr-in 2.7925 HRD-in -76.52, -44.94 75.05, -11.1 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nioo APE10-dihe-na -71.03, -34.99 APE9-dihe-na -84.28, -40.83 APE8-dihe-out -54.27, -59.88 APE8-rot-out 164.87 APE67-dihe-in -67.03, -8.26 -47.53, -48.52 APE12-dist-none 999.0 APE11-dist-in 11.7375 APE10-dist-out 13.6019 APE9-dist-out 11.5385 None None None XRAY 2.8 0.198 0.254 A 328.0 305.0 11 27 16 11 [[53, 304]] 1.0 5eak Homo sapiens CAMK_MARK2_HUMAN CAMK 9.4e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_HUMAN 8TXYA Q7KZI7 48 363 788.0 SJ0:403 Type1 Inactive DFGin 7.771 16.0803 BLAminus -130.34, 171.06 66.32, 92.69 -116.41, 35.91 282.62, 80.32 152.7, -23.26 in-out in 9.8337 Saltbr-out 6.2376 HRD-in -65.71, -52.56 70.64, -3.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -66.12, -34.52 APE9-dihe-na -131.17, 15.38 APE8-dihe-out -71.17, -44.57 APE8-rot-in 290.0 APE67-dihe-in -63.53, -17.52 -56.17, -38.22 APE12-dist-in 8.369 APE11-dist-in 12.5258 APE10-dist-out 13.8257 APE9-dist-out 11.3998 I59L,K66V,V81I,L97I,V113I,M129T,S133K,G134N,S197G None None XRAY 2.1 0.241 0.267 A 317.0 305.0 11 27 16 11 [[53, 304]] 1.0 8txy Homo sapiens CAMK_MARK2_HUMAN CAMK 2.1e-95 324.9 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_HUMAN 8TXYB Q7KZI7 47 363 788.0 SJ0:402 Type1 Inactive DFGin 7.6317 16.4739 BLAminus -131.24, 168.82 67.77, 87.06 -109.29, 36.63 283.39, 79.6 152.71, 999.0 out-out out 10.0769 Saltbr-out 3.7188 HRD-in -65.54, -52.35 70.44, -3.82 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -82.92, -38.19 APE9-dihe-na -125.48, 4.04 APE8-dihe-out -73.83, -43.45 APE8-rot-out 195.03 APE67-dihe-in -63.18, -17.94 -57.03, -37.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.413 I59L,K66V,V81I,L97I,V113I,M129T,S133K,G134N,S197G None None XRAY 2.1 0.241 0.267 B 317.0 305.0 12 27 15 12 [[53, 304]] 1.0 8txy Homo sapiens CAMK_MARK2_HUMAN CAMK 2.1e-95 324.9 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_HUMAN 5KZ7A Q7KZI7 48 363 788.0 6Z2:401 Type1 Inactive DFGin 6.1798 15.1923 None -66.59, -98.89 -137.2, 177.34 -105.99, 0.84 306.21, 67.89 -39.62, 999.0 in-out in 9.3332 Saltbr-out 3.9373 HRD-in -57.93, -35.05 64.12, -16.36 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -56.94 APE8-rot-out 193.16 APE67-dihe-in -59.38, -16.94 -59.8, -39.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.226 0.293 A 346.0 296.0 20 27 11 16 [[53, 304]] 1.0 5kz7 Homo sapiens CAMK_MARK2_HUMAN CAMK 1.1e-96 329.1 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_HUMAN 5KZ8A Q7KZI7 48 363 788.0 6Z5:401 Type1 Inactive DFGin 6.6608 14.8467 None -66.62, -138.3 -110.24, 161.57 -113.14, 60.74 323.38, 77.32 145.61, 999.0 in-out in 9.5893 Saltbr-out 4.8664 HRD-in -68.17, -39.88 60.26, -10.16 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 142.11 APE9-dihe-na -96.01, 39.12 APE8-dihe-out -76.41, -33.97 APE8-rot-out 180.16 APE67-dihe-in -71.46, -15.13 -73.47, -29.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5634 None None None XRAY 3.21 0.222 0.29 A 346.0 302.0 14 27 13 14 [[53, 304]] 1.0 5kz8 Homo sapiens CAMK_MARK2_HUMAN CAMK 1.1e-96 329.1 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_HUMAN 5KZ8B Q7KZI7 48 363 788.0 6Z5:401 Type1 Inactive DFGin 7.4263 15.8016 None -67.43, 142.07 -36.53, 154.18 -125.77, 99.94 7.04, 147.55 143.09, 999.0 in-out in 9.6021 Saltbr-out 4.8858 HRD-in -66.11, -40.74 54.9, 7.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -66.07 APE8-rot-out 193.35 APE67-dihe-in -71.07, -14.96 -58.24, -27.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.21 0.222 0.29 B 346.0 300.0 16 27 11 16 [[53, 304]] 1.0 5kz8 Homo sapiens CAMK_MARK2_HUMAN CAMK 1.1e-96 329.1 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_HUMAN 5KZ7B Q7KZI7 48 363 788.0 6Z2:401 Type1 Inactive None 999.0 999.0 None -120.55, 164.19 69.13, 152.42 -169.56, 4.25 999.0, 999.0 -153.62, 999.0 in-out in 9.232 Saltbr-out 4.0514 HRD-in -60.44, -40.64 55.6, 2.04 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -57.96 APE8-rot-out 194.36 APE67-dihe-in -59.11, -16.52 -60.34, -38.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.226 0.293 B 346.0 296.0 20 27 11 16 [[53, 304]] 1.0 5kz7 Homo sapiens CAMK_MARK2_HUMAN CAMK 1.1e-96 329.1 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2WZJC O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.4193 19.2161 BLAminus -108.57, 167.32 72.45, 27.49 -76.07, -43.56 240.74, 110.71 -97.91, -81.36 out-none out 11.356 Saltbr-none 999.0 HRD-in -82.61, -50.33 75.14, -8.42 none-out-out SNCnoo out-out ActLoopNT-out 13.4303 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -51.82, 125.48 APE9-dihe-na 91.1, -16.67 APE8-dihe-out -69.68, -47.69 APE8-rot-in 299.91 APE67-dihe-in -68.57, -10.67 -60.33, -36.15 APE12-dist-out 17.8525 APE11-dist-out 15.6437 APE10-dist-out 16.7637 APE9-dist-out 10.6164 K82R,T208E None None XRAY 2.786 0.182 0.246 C 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2WZJD O08679 46 363 722.0 No_ligand No_ligand Inactive DFGin 10.884 19.011 BLAminus -111.12, 157.59 76.03, 27.22 -72.96, -31.06 251.16, 131.35 -108.17, -95.74 out-none out 11.0927 Saltbr-none 999.0 HRD-in -63.69, -47.12 71.54, 1.01 none-out-out SNCnoo out-out ActLoopNT-out 13.1789 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -46.11, 129.38 APE9-dihe-na 75.73, -2.05 APE8-dihe-out -70.84, -49.06 APE8-rot-in 271.18 APE67-dihe-in -60.37, -15.06 -50.52, -50.12 APE12-dist-out 17.5946 APE11-dist-out 15.8073 APE10-dist-out 17.2199 APE9-dist-out 11.1078 K82R,T208E None None XRAY 2.786 0.182 0.246 D 327.0 313.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2R0IA O08679 48 363 722.0 No_ligand No_ligand Inactive DFGin 7.1773 15.9104 None -110.07, 163.19 70.79, 104.32 -114.32, 999.0 271.35, 82.41 999.0, 999.0 in-in in 9.8103 Saltbr-in 2.9222 HRD-in -72.72, -53.9 78.71, -16.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 32.87 APE8-dihe-out -80.28, -35.43 APE8-rot-out 33.61 APE67-dihe-in -54.73, -18.4 -55.05, -40.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5684 E318A None None XRAY 2.202 0.194 0.239 A 327.0 300.0 16 27 11 16 [[53, 304]] 1.0 2r0i Rattus norvegicus CAMK_MARK2_RAT CAMK 9.3e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2R0IB O08679 48 363 722.0 No_ligand No_ligand Inactive DFGin 7.288 15.7457 None -106.65, 164.03 58.05, 102.65 -104.54, 999.0 278.98, 72.06 999.0, 999.0 in-in in 9.6682 Saltbr-in 3.0026 HRD-in -63.83, -55.97 76.75, -7.74 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 34.5 APE8-dihe-out -80.07, -37.66 APE8-rot-out 40.75 APE67-dihe-in -61.42, -16.77 -41.08, -47.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.655 E318A None None XRAY 2.202 0.194 0.239 B 327.0 300.0 16 27 11 16 [[53, 304]] 1.0 2r0i Rattus norvegicus CAMK_MARK2_RAT CAMK 9.3e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2WZJA O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.2964 19.4429 None -98.71, 167.47 67.78, 27.22 -75.76, -39.27 231.0, 117.88 -107.13, -80.77 out-none out 11.1414 Saltbr-none 999.0 HRD-in -75.15, -47.64 70.01, -6.03 none-out-out SNCnoo out-out ActLoopNT-out 13.503 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -55.72, 133.56 APE9-dihe-na 78.12, -13.87 APE8-dihe-out -67.74, -43.04 APE8-rot-in 291.97 APE67-dihe-in -62.19, -15.93 -58.96, -43.73 APE12-dist-out 17.5862 APE11-dist-out 15.426 APE10-dist-out 16.7267 APE9-dist-out 10.8809 K82R,T208E None None XRAY 2.786 0.182 0.246 A 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2WZJB O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.655 19.1179 None -108.74, 166.92 70.33, 31.17 -81.88, -31.63 237.8, 118.28 -103.58, -84.38 out-none out 11.2946 Saltbr-none 999.0 HRD-in -73.51, -48.16 74.26, -7.23 none-out-out SNCnoo out-out ActLoopNT-out 13.3405 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -55.83, 119.56 APE9-dihe-na 97.8, -31.81 APE8-dihe-out -52.01, -40.59 APE8-rot-in 301.14 APE67-dihe-in -59.16, -17.79 -69.83, -40.48 APE12-dist-out 17.7834 APE11-dist-out 15.6951 APE10-dist-out 17.0451 APE9-dist-out 10.6569 K82R,T208E None None XRAY 2.786 0.182 0.246 B 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2WZJE O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.7278 19.4523 None -122.21, 167.3 70.37, 14.54 -64.86, -52.55 239.49, 125.08 -92.23, -103.55 out-none out 11.2743 Saltbr-none 999.0 HRD-in -71.5, -43.46 73.23, -7.58 none-out-out SNCnoo out-out ActLoopNT-out 13.576 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -54.24, 120.43 APE9-dihe-na 88.28, -0.67 APE8-dihe-out -78.27, -40.76 APE8-rot-in 286.92 APE67-dihe-in -59.78, -9.34 -58.65, -47.75 APE12-dist-out 18.0861 APE11-dist-out 15.9972 APE10-dist-out 17.2602 APE9-dist-out 11.1331 K82R,T208E None None XRAY 2.786 0.182 0.246 E 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2WZJF O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.4161 19.3297 None -128.0, 171.74 60.39, 39.11 -82.16, -33.66 235.83, 116.83 -109.02, -81.73 out-none out 11.4062 Saltbr-none 999.0 HRD-in -70.32, -50.59 74.66, -7.6 none-out-out SNCnoo out-out ActLoopNT-out 13.3181 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -47.39, 112.51 APE9-dihe-na 95.61, -12.53 APE8-dihe-out -65.97, -50.18 APE8-rot-in 297.4 APE67-dihe-in -68.54, -20.61 -50.47, -43.86 APE12-dist-out 17.1694 APE11-dist-out 15.1773 APE10-dist-out 16.4228 APE9-dist-out 10.9122 K82R,T208E None None XRAY 2.786 0.182 0.246 F 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1ZMUA O08679 51 363 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -110.93, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.7133 Saltbr-out 5.1442 HRD-in -66.3, -21.12 55.7, -17.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -92.46 APE8-dihe-out -99.53, -9.62 APE8-rot-out 82.29 APE67-dihe-in -67.22, -13.92 -69.62, -36.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0549 None None None XRAY 2.9 0.199 0.27 A 327.0 293.0 20 27 9 18 [[53, 304]] 1.0 1zmu Rattus norvegicus CAMK_MARK2_RAT CAMK 9.3e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1ZMUB O08679 48 363 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -111.91, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.5785 Saltbr-in 3.2947 HRD-in -66.9, -28.52 59.29, -16.8 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -88.6 APE8-dihe-out -98.24, -16.16 APE8-rot-out 52.45 APE67-dihe-in -69.87, -14.61 -45.77, -52.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.1138 None None None XRAY 2.9 0.199 0.27 B 327.0 296.0 20 27 9 18 [[53, 304]] 1.0 1zmu Rattus norvegicus CAMK_MARK2_RAT CAMK 9.3e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1Y8GA O08679 49 363 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -101.35, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.9483 Saltbr-out 7.3126 HRD-in -83.11, -47.27 80.28, -24.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na -63.72, 131.09 APE9-dihe-na 66.7, -8.37 APE8-dihe-out -70.73, -45.84 APE8-rot-none 999.0 APE67-dihe-in -60.4, -15.18 -59.08, -36.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.5878 T208A,S212A None MSE104,MSE129,MSE147,MSE187,MSE273,MSE299,MSE304,MSE332,MSE335,MSE355 XRAY 2.501 0.201 0.268 A 327.0 302.0 13 27 14 13 [[53, 304]] 1.0 1y8g Rattus norvegicus CAMK_MARK2_RAT CAMK 9.6e-96 326.0 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1Y8GB O08679 48 362 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -84.5, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.8765 Saltbr-out 6.4056 HRD-in -81.43, -43.68 78.13, -20.61 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na -60.63, 122.75 APE9-dihe-na 56.66, 27.13 APE8-dihe-out -91.16, -55.23 APE8-rot-none 999.0 APE67-dihe-in -58.8, -20.32 -54.78, -33.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6486 T208A,S212A None MSE104,MSE129,MSE147,MSE187,MSE273,MSE299,MSE304,MSE332,MSE335,MSE355 XRAY 2.501 0.201 0.268 B 327.0 302.0 13 27 14 13 [[53, 304]] 1.0 1y8g Rattus norvegicus CAMK_MARK2_RAT CAMK 9.6e-96 326.0 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1ZMWA O08679 49 363 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -81.79, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.9679 Saltbr-out 7.6194 HRD-in -77.86, -54.11 85.28, -27.67 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na -61.19, 134.13 APE9-dihe-na 74.24, -14.63 APE8-dihe-out -70.23, -50.36 APE8-rot-none 999.0 APE67-dihe-in -52.18, -24.46 -60.64, -36.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.4404 T208A,S212A None None XRAY 2.802 0.206 0.262 A 327.0 302.0 13 27 14 13 [[53, 304]] 1.0 1zmw Rattus norvegicus CAMK_MARK2_RAT CAMK 9.6e-96 326.0 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1ZMWB O08679 48 362 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -70.63, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.0809 Saltbr-out 6.6336 HRD-in -84.6, -49.82 84.27, -21.87 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na -55.25, 128.58 APE9-dihe-na 65.37, -2.9 APE8-dihe-out -61.83, -60.15 APE8-rot-none 999.0 APE67-dihe-in -53.54, -26.77 -59.74, -37.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.4596 T208A,S212A None None XRAY 2.802 0.206 0.262 B 327.0 302.0 13 27 14 13 [[53, 304]] 1.0 1zmw Rattus norvegicus CAMK_MARK2_RAT CAMK 9.6e-96 326.0 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1ZMVA O08679 51 363 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -133.61, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 10.4007 Saltbr-none 999.0 HRD-in -52.05, -30.76 61.97, -17.5 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -10.03 APE8-dihe-out -81.81, -34.31 APE8-rot-out 102.27 APE67-dihe-in -63.87, -12.21 -48.98, -44.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2014 K82R None None XRAY 3.105 0.202 0.251 A 327.0 293.0 20 27 9 18 [[53, 304]] 1.0 1zmv Rattus norvegicus CAMK_MARK2_RAT CAMK 1.3e-95 325.6 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1ZMVB O08679 48 363 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -121.98, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 10.4756 Saltbr-none 999.0 HRD-in -53.15, -34.52 68.06, -17.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -12.39 APE8-dihe-out -78.89, -39.15 APE8-rot-out 116.12 APE67-dihe-in -66.45, -9.37 -45.99, -45.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0825 K82R None None XRAY 3.105 0.202 0.251 B 327.0 296.0 20 27 9 18 [[53, 304]] 1.0 1zmv Rattus norvegicus CAMK_MARK2_RAT CAMK 1.3e-95 325.6 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2

CAMK_MARK2 (Serine/threonine-protein kinase MARK2)

Total number of chains: 16
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
None None 8 50.0% 1Y8GA
DFGin None 6 37.5% 2WZJA
DFGin BLAminus 2 12.5% 2WZJC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MARK2 MARK2_RAT 2WZJC O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.4193 19.2161 BLAminus -108.57, 167.32 72.45, 27.49 -76.07, -43.56 240.74, 110.71 -97.91, -81.36 out-none out 11.356 Saltbr-none 999.0 HRD-in -82.61, -50.33 75.14, -8.42 none-out-out SNCnoo out-out ActLoopNT-out 13.4303 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -51.82, 125.48 APE9-dihe-na 91.1, -16.67 APE8-dihe-out -69.68, -47.69 APE8-rot-in 299.91 APE67-dihe-in -68.57, -10.67 -60.33, -36.15 APE12-dist-out 17.8525 APE11-dist-out 15.6437 APE10-dist-out 16.7637 APE9-dist-out 10.6164 K82R,T208E None None XRAY 2.786 0.182 0.246 C 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2WZJD O08679 46 363 722.0 No_ligand No_ligand Inactive DFGin 10.884 19.011 BLAminus -111.12, 157.59 76.03, 27.22 -72.96, -31.06 251.16, 131.35 -108.17, -95.74 out-none out 11.0927 Saltbr-none 999.0 HRD-in -63.69, -47.12 71.54, 1.01 none-out-out SNCnoo out-out ActLoopNT-out 13.1789 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -46.11, 129.38 APE9-dihe-na 75.73, -2.05 APE8-dihe-out -70.84, -49.06 APE8-rot-in 271.18 APE67-dihe-in -60.37, -15.06 -50.52, -50.12 APE12-dist-out 17.5946 APE11-dist-out 15.8073 APE10-dist-out 17.2199 APE9-dist-out 11.1078 K82R,T208E None None XRAY 2.786 0.182 0.246 D 327.0 313.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2R0IA O08679 48 363 722.0 No_ligand No_ligand Inactive DFGin 7.1773 15.9104 None -110.07, 163.19 70.79, 104.32 -114.32, 999.0 271.35, 82.41 999.0, 999.0 in-in in 9.8103 Saltbr-in 2.9222 HRD-in -72.72, -53.9 78.71, -16.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 32.87 APE8-dihe-out -80.28, -35.43 APE8-rot-out 33.61 APE67-dihe-in -54.73, -18.4 -55.05, -40.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5684 E318A None None XRAY 2.202 0.194 0.239 A 327.0 300.0 16 27 11 16 [[53, 304]] 1.0 2r0i Rattus norvegicus CAMK_MARK2_RAT CAMK 9.3e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2R0IB O08679 48 363 722.0 No_ligand No_ligand Inactive DFGin 7.288 15.7457 None -106.65, 164.03 58.05, 102.65 -104.54, 999.0 278.98, 72.06 999.0, 999.0 in-in in 9.6682 Saltbr-in 3.0026 HRD-in -63.83, -55.97 76.75, -7.74 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 34.5 APE8-dihe-out -80.07, -37.66 APE8-rot-out 40.75 APE67-dihe-in -61.42, -16.77 -41.08, -47.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.655 E318A None None XRAY 2.202 0.194 0.239 B 327.0 300.0 16 27 11 16 [[53, 304]] 1.0 2r0i Rattus norvegicus CAMK_MARK2_RAT CAMK 9.3e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2WZJA O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.2964 19.4429 None -98.71, 167.47 67.78, 27.22 -75.76, -39.27 231.0, 117.88 -107.13, -80.77 out-none out 11.1414 Saltbr-none 999.0 HRD-in -75.15, -47.64 70.01, -6.03 none-out-out SNCnoo out-out ActLoopNT-out 13.503 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -55.72, 133.56 APE9-dihe-na 78.12, -13.87 APE8-dihe-out -67.74, -43.04 APE8-rot-in 291.97 APE67-dihe-in -62.19, -15.93 -58.96, -43.73 APE12-dist-out 17.5862 APE11-dist-out 15.426 APE10-dist-out 16.7267 APE9-dist-out 10.8809 K82R,T208E None None XRAY 2.786 0.182 0.246 A 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2WZJB O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.655 19.1179 None -108.74, 166.92 70.33, 31.17 -81.88, -31.63 237.8, 118.28 -103.58, -84.38 out-none out 11.2946 Saltbr-none 999.0 HRD-in -73.51, -48.16 74.26, -7.23 none-out-out SNCnoo out-out ActLoopNT-out 13.3405 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -55.83, 119.56 APE9-dihe-na 97.8, -31.81 APE8-dihe-out -52.01, -40.59 APE8-rot-in 301.14 APE67-dihe-in -59.16, -17.79 -69.83, -40.48 APE12-dist-out 17.7834 APE11-dist-out 15.6951 APE10-dist-out 17.0451 APE9-dist-out 10.6569 K82R,T208E None None XRAY 2.786 0.182 0.246 B 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2WZJE O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.7278 19.4523 None -122.21, 167.3 70.37, 14.54 -64.86, -52.55 239.49, 125.08 -92.23, -103.55 out-none out 11.2743 Saltbr-none 999.0 HRD-in -71.5, -43.46 73.23, -7.58 none-out-out SNCnoo out-out ActLoopNT-out 13.576 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -54.24, 120.43 APE9-dihe-na 88.28, -0.67 APE8-dihe-out -78.27, -40.76 APE8-rot-in 286.92 APE67-dihe-in -59.78, -9.34 -58.65, -47.75 APE12-dist-out 18.0861 APE11-dist-out 15.9972 APE10-dist-out 17.2602 APE9-dist-out 11.1331 K82R,T208E None None XRAY 2.786 0.182 0.246 E 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 2WZJF O08679 49 363 722.0 No_ligand No_ligand Inactive DFGin 10.4161 19.3297 None -128.0, 171.74 60.39, 39.11 -82.16, -33.66 235.83, 116.83 -109.02, -81.73 out-none out 11.4062 Saltbr-none 999.0 HRD-in -70.32, -50.59 74.66, -7.6 none-out-out SNCnoo out-out ActLoopNT-out 13.3181 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -47.39, 112.51 APE9-dihe-na 95.61, -12.53 APE8-dihe-out -65.97, -50.18 APE8-rot-in 297.4 APE67-dihe-in -68.54, -20.61 -50.47, -43.86 APE12-dist-out 17.1694 APE11-dist-out 15.1773 APE10-dist-out 16.4228 APE9-dist-out 10.9122 K82R,T208E None None XRAY 2.786 0.182 0.246 F 327.0 310.0 5 27 27 0 [[53, 304]] 1.0 2wzj Rattus norvegicus CAMK_MARK2_RAT CAMK 3e-95 324.4 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1ZMUA O08679 51 363 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -110.93, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.7133 Saltbr-out 5.1442 HRD-in -66.3, -21.12 55.7, -17.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -92.46 APE8-dihe-out -99.53, -9.62 APE8-rot-out 82.29 APE67-dihe-in -67.22, -13.92 -69.62, -36.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0549 None None None XRAY 2.9 0.199 0.27 A 327.0 293.0 20 27 9 18 [[53, 304]] 1.0 1zmu Rattus norvegicus CAMK_MARK2_RAT CAMK 9.3e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1ZMUB O08679 48 363 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -111.91, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.5785 Saltbr-in 3.2947 HRD-in -66.9, -28.52 59.29, -16.8 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -88.6 APE8-dihe-out -98.24, -16.16 APE8-rot-out 52.45 APE67-dihe-in -69.87, -14.61 -45.77, -52.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.1138 None None None XRAY 2.9 0.199 0.27 B 327.0 296.0 20 27 9 18 [[53, 304]] 1.0 1zmu Rattus norvegicus CAMK_MARK2_RAT CAMK 9.3e-97 329.3 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1Y8GA O08679 49 363 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -101.35, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.9483 Saltbr-out 7.3126 HRD-in -83.11, -47.27 80.28, -24.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na -63.72, 131.09 APE9-dihe-na 66.7, -8.37 APE8-dihe-out -70.73, -45.84 APE8-rot-none 999.0 APE67-dihe-in -60.4, -15.18 -59.08, -36.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.5878 T208A,S212A None MSE104,MSE129,MSE147,MSE187,MSE273,MSE299,MSE304,MSE332,MSE335,MSE355 XRAY 2.501 0.201 0.268 A 327.0 302.0 13 27 14 13 [[53, 304]] 1.0 1y8g Rattus norvegicus CAMK_MARK2_RAT CAMK 9.6e-96 326.0 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1Y8GB O08679 48 362 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -84.5, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.8765 Saltbr-out 6.4056 HRD-in -81.43, -43.68 78.13, -20.61 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na -60.63, 122.75 APE9-dihe-na 56.66, 27.13 APE8-dihe-out -91.16, -55.23 APE8-rot-none 999.0 APE67-dihe-in -58.8, -20.32 -54.78, -33.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6486 T208A,S212A None MSE104,MSE129,MSE147,MSE187,MSE273,MSE299,MSE304,MSE332,MSE335,MSE355 XRAY 2.501 0.201 0.268 B 327.0 302.0 13 27 14 13 [[53, 304]] 1.0 1y8g Rattus norvegicus CAMK_MARK2_RAT CAMK 9.6e-96 326.0 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1ZMWA O08679 49 363 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -81.79, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.9679 Saltbr-out 7.6194 HRD-in -77.86, -54.11 85.28, -27.67 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na -61.19, 134.13 APE9-dihe-na 74.24, -14.63 APE8-dihe-out -70.23, -50.36 APE8-rot-none 999.0 APE67-dihe-in -52.18, -24.46 -60.64, -36.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.4404 T208A,S212A None None XRAY 2.802 0.206 0.262 A 327.0 302.0 13 27 14 13 [[53, 304]] 1.0 1zmw Rattus norvegicus CAMK_MARK2_RAT CAMK 9.6e-96 326.0 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1ZMWB O08679 48 362 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -70.63, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.0809 Saltbr-out 6.6336 HRD-in -84.6, -49.82 84.27, -21.87 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na -55.25, 128.58 APE9-dihe-na 65.37, -2.9 APE8-dihe-out -61.83, -60.15 APE8-rot-none 999.0 APE67-dihe-in -53.54, -26.77 -59.74, -37.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.4596 T208A,S212A None None XRAY 2.802 0.206 0.262 B 327.0 302.0 13 27 14 13 [[53, 304]] 1.0 1zmw Rattus norvegicus CAMK_MARK2_RAT CAMK 9.6e-96 326.0 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1ZMVA O08679 51 363 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -133.61, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 10.4007 Saltbr-none 999.0 HRD-in -52.05, -30.76 61.97, -17.5 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -10.03 APE8-dihe-out -81.81, -34.31 APE8-rot-out 102.27 APE67-dihe-in -63.87, -12.21 -48.98, -44.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2014 K82R None None XRAY 3.105 0.202 0.251 A 327.0 293.0 20 27 9 18 [[53, 304]] 1.0 1zmv Rattus norvegicus CAMK_MARK2_RAT CAMK 1.3e-95 325.6 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
MARK2 MARK2_RAT 1ZMVB O08679 48 363 722.0 No_ligand No_ligand Inactive None 999.0 999.0 None -121.98, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 10.4756 Saltbr-none 999.0 HRD-in -53.15, -34.52 68.06, -17.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -12.39 APE8-dihe-out -78.89, -39.15 APE8-rot-out 116.12 APE67-dihe-in -66.45, -9.37 -45.99, -45.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0825 K82R None None XRAY 3.105 0.202 0.251 B 327.0 296.0 20 27 9 18 [[53, 304]] 1.0 1zmv Rattus norvegicus CAMK_MARK2_RAT CAMK 1.3e-95 325.6 1.0 256.0 256.0 192 193 194 196 198 82 100 104 172 174 173 175.0 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2