CAMK_MARK2 (Serine/threonine-protein kinase MARK2)

Total number of chains: 14
Active chains: 2
Uniprot: MARK2_HUMAN
Kinase Domain Residues: 53 - 304
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 7 50.0% AF-Q7KZI7-K1A
DFGin ABAminus 3 21.4% 3IECB
DFGin None 3 21.4% 5KZ8A
None None 1 7.1% 5KZ7B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q7KZI7-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 45 - 312 0 None None Serine/threonine-protein kinase MARK2
AF-Q7KZI7-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 45 - 312 0 None None Serine/threonine-protein kinase MARK2
3IECB 2.2 Inactive DFGin‑ABAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 49 - 363 0 None R146W Serine/threonine-protein kinase MARK2
3IECD 2.2 Inactive DFGin‑ABAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 49 - 363 0 None R146W Serine/threonine-protein kinase MARK2
5EAKB 2.8 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaooi APEdist_nnoo 24R Type1 51 - 363 0 None None Serine/threonine-protein kinase MARK2
3IECA 2.2 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 49 - 363 0 None R146W Serine/threonine-protein kinase MARK2
3IECC 2.2 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 49 - 363 0 None R146W Serine/threonine-protein kinase MARK2
5EAKA 2.8 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaooi APEdist_nioo 24R Type1 47 - 362 0 None None Serine/threonine-protein kinase MARK2
8TXYA 2.1 Inactive DFGin‑BLAminus in-out none-out nonTYR APEdihe_aaoii APEdist_iioo SJ0 Type1 48 - 363 0 None I59L,K66V,V81I,L97I,V113I,M129T,S133K,G134N,S197G Serine/threonine-protein kinase MARK2
8TXYB 2.1 Inactive DFGin‑BLAminus out-out none-out nonTYR APEdihe_aaooi APEdist_nnno SJ0 Type1 47 - 363 0 None I59L,K66V,V81I,L97I,V113I,M129T,S133K,G134N,S197G Serine/threonine-protein kinase MARK2
5KZ7A 3.2 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 6Z2 Type1 48 - 363 0 None None Serine/threonine-protein kinase MARK2
5KZ8A 3.21 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno 6Z5 Type1 48 - 363 0 None None Serine/threonine-protein kinase MARK2
5KZ8B 3.21 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 6Z5 Type1 48 - 363 0 None None Serine/threonine-protein kinase MARK2
5KZ7B 3.2 Inactive None‑None in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 6Z2 Type1 48 - 363 0 None None Serine/threonine-protein kinase MARK2

CAMK_MARK2 (Serine/threonine-protein kinase MARK2)

Total number of chains: 30
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 30.0% AF-Q7KZI7-K1A
DFGin None 9 30.0% 2WZJA
None None 9 30.0% 1Y8GA
DFGin ABAminus 3 10.0% 3IECB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
MARK2_HUMAN AF-Q7KZI7-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 45 - 312 0 None None Serine/threonine-protein kinase MARK2 Homo sapiens
MARK2_HUMAN AF-Q7KZI7-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 45 - 312 0 None None Serine/threonine-protein kinase MARK2 Homo sapiens
MARK2_HUMAN 3IECB 2.2 Inactive DFGin‑ABAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 49 - 363 0 None R146W Serine/threonine-protein kinase MARK2 Homo sapiens
MARK2_HUMAN 3IECD 2.2 Inactive DFGin‑ABAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 49 - 363 0 None R146W Serine/threonine-protein kinase MARK2 Homo sapiens
MARK2_HUMAN 5EAKB 2.8 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaooi APEdist_nnoo 24R Type1 51 - 363 0 None None Serine/threonine-protein kinase MARK2 Homo sapiens
MARK2_HUMAN 3IECA 2.2 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 49 - 363 0 None R146W Serine/threonine-protein kinase MARK2 Homo sapiens
MARK2_HUMAN 3IECC 2.2 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 49 - 363 0 None R146W Serine/threonine-protein kinase MARK2 Homo sapiens
MARK2_HUMAN 5EAKA 2.8 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaooi APEdist_nioo 24R Type1 47 - 362 0 None None Serine/threonine-protein kinase MARK2 Homo sapiens
MARK2_HUMAN 8TXYA 2.1 Inactive DFGin‑BLAminus in-out none-out nonTYR APEdihe_aaoii APEdist_iioo SJ0 Type1 48 - 363 0 None I59L,K66V,V81I,L97I,V113I,M129T,S133K,G134N,S197G Serine/threonine-protein kinase MARK2 Homo sapiens
MARK2_HUMAN 8TXYB 2.1 Inactive DFGin‑BLAminus out-out none-out nonTYR APEdihe_aaooi APEdist_nnno SJ0 Type1 47 - 363 0 None I59L,K66V,V81I,L97I,V113I,M129T,S133K,G134N,S197G Serine/threonine-protein kinase MARK2 Homo sapiens
MARK2_HUMAN 5KZ7A 3.2 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 6Z2 Type1 48 - 363 0 None None Serine/threonine-protein kinase MARK2 Homo sapiens
MARK2_HUMAN 5KZ8A 3.21 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno 6Z5 Type1 48 - 363 0 None None Serine/threonine-protein kinase MARK2 Homo sapiens
MARK2_HUMAN 5KZ8B 3.21 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 6Z5 Type1 48 - 363 0 None None Serine/threonine-protein kinase MARK2 Homo sapiens
MARK2_HUMAN 5KZ7B 3.2 Inactive None‑None in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 6Z2 Type1 48 - 363 0 None None Serine/threonine-protein kinase MARK2 Homo sapiens
MARK2_RAT 2WZJC 2.786 Inactive DFGin‑BLAminus out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 2WZJD 2.786 Inactive DFGin‑BLAminus out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 46 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 2R0IA 2.202 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 48 - 363 0 None E318A Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 2R0IB 2.202 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 48 - 363 0 None E318A Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 2WZJA 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 2WZJB 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 2WZJE 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 2WZJF 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1ZMUA 2.9 Inactive None‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 51 - 363 0 None None Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1ZMUB 2.9 Inactive None‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 48 - 363 0 None None Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1Y8GA 2.501 Inactive None‑None in-out none-out nonTYR APEdihe_aaoni APEdist_nnno No_ligand No_ligand 49 - 363 0 None T208A,S212A Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1Y8GB 2.501 Inactive None‑None in-out none-out nonTYR APEdihe_aaoni APEdist_nnno No_ligand No_ligand 48 - 362 0 None T208A,S212A Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1ZMWA 2.802 Inactive None‑None in-out none-out nonTYR APEdihe_aaoni APEdist_nnno No_ligand No_ligand 49 - 363 0 None T208A,S212A Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1ZMWB 2.802 Inactive None‑None out-out none-out nonTYR APEdihe_aaoni APEdist_nnno No_ligand No_ligand 48 - 362 0 None T208A,S212A Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1ZMVA 3.105 Inactive None‑None out-none none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 51 - 363 0 None K82R Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1ZMVB 3.105 Inactive None‑None out-none none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 48 - 363 0 None K82R Serine/threonine-protein kinase MARK2 Rattus norvegicus

CAMK_MARK2 (Serine/threonine-protein kinase MARK2)

Total number of chains: 16
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
None None 8 50.0% 1Y8GA
DFGin None 6 37.5% 2WZJA
DFGin BLAminus 2 12.5% 2WZJC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
MARK2_RAT 2WZJC 2.786 Inactive DFGin‑BLAminus out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 2WZJD 2.786 Inactive DFGin‑BLAminus out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 46 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 2R0IA 2.202 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 48 - 363 0 None E318A Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 2R0IB 2.202 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 48 - 363 0 None E318A Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 2WZJA 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 2WZJB 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 2WZJE 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 2WZJF 2.786 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 49 - 363 0 None K82R,T208E Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1ZMUA 2.9 Inactive None‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 51 - 363 0 None None Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1ZMUB 2.9 Inactive None‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 48 - 363 0 None None Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1Y8GA 2.501 Inactive None‑None in-out none-out nonTYR APEdihe_aaoni APEdist_nnno No_ligand No_ligand 49 - 363 0 None T208A,S212A Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1Y8GB 2.501 Inactive None‑None in-out none-out nonTYR APEdihe_aaoni APEdist_nnno No_ligand No_ligand 48 - 362 0 None T208A,S212A Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1ZMWA 2.802 Inactive None‑None in-out none-out nonTYR APEdihe_aaoni APEdist_nnno No_ligand No_ligand 49 - 363 0 None T208A,S212A Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1ZMWB 2.802 Inactive None‑None out-out none-out nonTYR APEdihe_aaoni APEdist_nnno No_ligand No_ligand 48 - 362 0 None T208A,S212A Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1ZMVA 3.105 Inactive None‑None out-none none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 51 - 363 0 None K82R Serine/threonine-protein kinase MARK2 Rattus norvegicus
MARK2_RAT 1ZMVB 3.105 Inactive None‑None out-none none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 48 - 363 0 None K82R Serine/threonine-protein kinase MARK2 Rattus norvegicus