CMGC_MAPK6 (Mitogen-activated protein kinase 6)

Total number of chains: 14
Active chains: 2
Uniprot: MK06_HUMAN
Kinase Domain Residues: 20 - 316
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 64.3% AF-Q16659-K1A
DFGinter None 3 21.4% 6YLCD
DFGin None 1 7.1% 7AQBB
DFGout None 1 7.1% 6YLCA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAPK6 AF-Q16659-K1A Q16659 12 324 721.0 No_ligand No_ligand Active DFGin 6.4022 14.2617 BLAminus -136.26, -168.64 53.45, 78.56 -88.17, 18.62 289.12, 80.2 -59.84, -33.12 in-in in 9.0675 Saltbr-in 2.6725 HRD-in -71.99, -48.36 66.26, -0.31 in-in-in SNCiii in-in ActLoopNT-in 2.8383 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -70.93, 34.39 APE9-dihe-na -75.94, 146.57 APE8-dihe-in -52.46, 123.79 APE8-rot-in 300.96 APE67-dihe-in -70.23, -19.06 -45.96, -46.84 APE12-dist-in 12.2138 APE11-dist-in 9.2187 APE10-dist-in 6.8702 APE9-dist-in 3.6629 None None None AF2 -1.0 1.0 1.0 A 313.0 313.0 0 31 31 0 [[20, 316]] 1.0 AF-Q16659-K1 CMGC_MAPK6_HUMAN CMGC 2e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 AF-Q16659-K3A Q16659 12 324 721.0 No_ligand No_ligand Active DFGin 6.1587 13.9739 BLAminus -138.4, -165.97 55.41, 66.08 -78.56, 16.63 290.35, 82.89 -59.77, -28.22 in-in in 9.1237 Saltbr-in 2.6654 HRD-in -75.92, -47.44 64.11, 7.45 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.26, -29.12 APE9-dihe-na -91.1, 145.63 APE8-dihe-in -50.81, 126.25 APE8-rot-in 300.71 APE67-dihe-in -67.83, -19.2 -51.45, -41.59 APE12-dist-in 12.4332 APE11-dist-in 10.4238 APE10-dist-in 6.1341 APE9-dist-in 3.4357 None None None AF2 -1.0 1.0 1.0 A 313.0 313.0 0 31 31 0 [[20, 316]] 1.0 AF-Q16659-K3 CMGC_MAPK6_HUMAN CMGC 2e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 6YLLB Q16659 46 321 721.0 No_ligand No_ligand Inactive DFGin 6.7592 15.7141 BLAminus -144.43, -171.34 49.58, 48.98 -55.81, 94.87 277.22, 86.3 -99.33, 999.0 out-out out 10.3859 Saltbr-out 5.6125 HRD-in -71.0, -33.77 70.49, -18.47 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -126.25, -11.05 APE9-dihe-na -93.56, 123.9 APE8-dihe-in -90.53, 132.04 APE8-rot-out 29.76 APE67-dihe-in -50.98, -28.12 -88.59, -6.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.0092 L290V None None XRAY 2.89 0.246 0.263 B 319.0 245.0 57 31 18 13 [[20, 316]] 1.0 6yll CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 7AQBA Q16659 13 320 721.0 No_ligand No_ligand Inactive DFGin 6.5561 15.0505 BLAminus -130.12, -171.25 52.63, 72.87 -85.41, 18.73 285.15, 82.5 -37.73, -47.91 in-in in 9.3956 Saltbr-in 2.7386 HRD-in -77.51, -52.75 79.92, -8.04 in-in-out SNCiio in-out ActLoopNT-in 2.9415 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -100.57, -5.85 APE9-dihe-na -90.27, 119.86 APE8-dihe-in -69.52, 144.0 APE8-rot-out 59.11 APE67-dihe-in -66.08, -28.82 -93.81, -12.78 APE12-dist-in 13.4628 APE11-dist-out 14.438 APE10-dist-out 11.5363 APE9-dist-out 8.1276 None None None XRAY 2.25 0.224 0.258 A 320.0 294.0 14 31 24 7 [[20, 316]] 1.0 7aqb CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 6YKYB Q16659 16 321 721.0 OWQ:401 Type1 Inactive DFGin 6.8725 14.2286 BLAminus -135.65, -169.72 45.42, 80.57 -90.98, 22.97 284.21, 94.98 -60.5, -31.54 in-in in 8.7443 Saltbr-in 2.8495 HRD-in -66.3, -53.61 73.11, -7.16 in-in-out SNCiio in-out ActLoopNT-in 2.8661 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -96.55, -13.52 APE9-dihe-na -75.9, 130.43 APE8-dihe-in -63.69, 130.13 APE8-rot-out 187.19 APE67-dihe-in -51.35, -29.03 -93.29, -25.17 APE12-dist-in 12.9772 APE11-dist-out 14.7509 APE10-dist-out 12.447 APE9-dist-out 8.0297 L290V None None XRAY 2.52 0.201 0.251 B 319.0 289.0 17 31 25 6 [[20, 316]] 1.0 6yky CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 6YKYC Q16659 13 319 721.0 OWQ:401 Type1 Inactive DFGin 7.1599 14.3615 BLAminus -137.66, -169.84 51.29, 73.15 -89.7, 25.97 286.65, 85.33 -69.13, -22.91 in-in in 9.2334 Saltbr-in 3.5041 HRD-out -71.5, 121.99 -108.85, 12.23 in-in-out SNCiio in-out ActLoopNT-in 2.9474 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.49, -28.13 APE9-dihe-na -81.97, 142.27 APE8-dihe-in -81.41, 134.9 APE8-rot-out 190.32 APE67-dihe-in -48.11, -35.02 -84.72, -21.61 APE12-dist-out 15.1533 APE11-dist-out 16.4251 APE10-dist-out 13.2714 APE9-dist-out 9.0914 L290V None None XRAY 2.52 0.201 0.251 C 319.0 283.0 24 31 22 9 [[20, 316]] 1.0 6yky CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 6YLCB Q16659 16 321 721.0 OXW:401 Type1 Inactive DFGin 6.7967 14.2788 BLAminus -125.47, -168.68 42.86, 82.65 -93.69, 23.37 291.11, 93.75 -53.16, -50.09 in-in in 8.719 Saltbr-in 3.2794 HRD-in -63.05, -51.72 72.3, 3.6 in-in-out SNCiio in-out ActLoopNT-in 2.7728 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -96.03, -12.43 APE9-dihe-na -75.76, 134.51 APE8-dihe-in -70.2, 126.66 APE8-rot-out 200.77 APE67-dihe-in -64.74, -18.73 -95.85, -14.57 APE12-dist-in 12.6654 APE11-dist-out 14.5735 APE10-dist-out 12.3734 APE9-dist-out 8.1606 L290V None None XRAY 2.43 0.191 0.231 B 319.0 292.0 14 31 25 6 [[20, 316]] 1.0 6ylc CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 6YLCC Q16659 14 319 721.0 OXW:401 Type1 Inactive DFGin 6.4218 15.0119 BLAminus -130.34, -162.17 45.83, 68.62 -75.11, -39.49 278.89, 76.75 -61.17, 999.0 in-in in 9.805 Saltbr-in 3.5091 HRD-out -86.12, 130.48 -108.15, 1.45 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -106.95, -16.91 APE9-dihe-na -101.07, 132.87 APE8-dihe-in -72.03, 129.29 APE8-rot-out 191.96 APE67-dihe-in -58.83, -26.46 -92.46, -7.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.9445 L290V None None XRAY 2.43 0.191 0.231 C 319.0 280.0 26 31 17 14 [[20, 316]] 1.0 6ylc CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 6YLLA Q16659 14 321 721.0 OYB:401 Type1 Inactive DFGin 6.4388 14.8006 BLAminus -130.84, -173.06 51.23, 80.61 -95.55, 30.17 290.86, 89.67 -62.82, -30.51 out-in out 10.0523 Saltbr-in 3.3166 HRD-in -71.38, -36.98 62.19, -2.2 in-in-out SNCiio in-out ActLoopNT-in 2.9603 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -75.76, -5.39 APE9-dihe-na -96.16, 143.08 APE8-dihe-in -88.39, 129.24 APE8-rot-out 58.25 APE67-dihe-in -53.29, -25.59 -91.11, -7.74 APE12-dist-in 12.4423 APE11-dist-out 14.1828 APE10-dist-out 11.7492 APE9-dist-out 8.5416 L290V None None XRAY 2.89 0.246 0.263 A 319.0 293.0 15 31 23 8 [[20, 316]] 1.0 6yll CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 7AQBB Q16659 21 320 721.0 No_ligand No_ligand Inactive DFGin 6.3975 15.2127 None -131.48, -173.72 49.63, 73.98 -75.43, 999.0 277.2, 75.11 999.0, 999.0 out-none out 12.9244 Saltbr-none 999.0 HRD-in -76.36, -53.27 81.32, -12.25 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -102.52, -6.95 APE9-dihe-na -95.53, 119.94 APE8-dihe-in -80.87, 140.54 APE8-rot-out 180.68 APE67-dihe-in -60.55, -29.29 -99.38, 0.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8091 None None None XRAY 2.25 0.224 0.258 B 320.0 274.0 27 31 17 14 [[20, 316]] 1.0 7aqb CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 6YKYA Q16659 18 319 721.0 OWQ:401 Type1 Inactive DFGinter 8.8272 5.0031 None -71.78, 144.73 -71.1, -32.64 -79.99, 115.19 311.82, 124.02 127.81, -16.19 in-out in 9.8118 Saltbr-out 8.1302 HRD-out -111.51, 110.19 -70.61, -5.41 out-out-out SNCooo out-out ActLoopNT-out 5.2412 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -91.65, 9.39 APE9-dihe-na -95.19, 123.93 APE8-dihe-in -73.44, 137.77 APE8-rot-out 188.34 APE67-dihe-in -47.48, -36.76 -86.99, -20.14 APE12-dist-out 18.6512 APE11-dist-out 20.1967 APE10-dist-out 17.8407 APE9-dist-out 8.26 L290V None None XRAY 2.52 0.201 0.251 A 319.0 281.0 21 31 22 9 [[20, 316]] 1.0 6yky CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 6YKYD Q16659 14 321 721.0 OWQ:401 Type1 Inactive DFGinter 10.4826 4.7833 None -79.21, 142.3 -63.95, -30.02 -82.92, 88.96 326.01, 122.38 148.68, -14.44 out-out out 13.3289 Saltbr-out 11.7551 HRD-out -97.47, 116.92 -79.67, -2.76 out-out-out SNCooo out-out ActLoopNT-out 5.2458 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.9, -29.99 APE9-dihe-na -87.22, 152.15 APE8-dihe-in -86.08, 134.07 APE8-rot-out 192.13 APE67-dihe-in -46.65, -35.13 -86.31, -21.98 APE12-dist-out 20.0761 APE11-dist-out 21.3843 APE10-dist-out 18.1317 APE9-dist-out 8.9379 L290V None None XRAY 2.52 0.201 0.251 D 319.0 301.0 7 31 31 0 [[20, 316]] 1.0 6yky CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 6YLCD Q16659 13 321 721.0 OXW:401 Type1 Inactive DFGinter 9.8338 4.9935 None -68.6, 151.66 -80.4, -20.68 -82.11, 114.82 290.44, 97.57 115.85, -9.5 out-out out 13.3472 Saltbr-out 9.8532 HRD-out -103.81, 118.3 -82.36, -0.96 out-out-out SNCooo out-out ActLoopNT-out 5.3623 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.61, -26.31 APE9-dihe-na -98.13, 139.46 APE8-dihe-in -69.39, 130.27 APE8-rot-out 191.58 APE67-dihe-in -59.56, -27.81 -93.33, -5.47 APE12-dist-out 19.9869 APE11-dist-out 21.3886 APE10-dist-out 18.1959 APE9-dist-out 9.0553 L290V None None XRAY 2.43 0.191 0.231 D 319.0 303.0 6 31 31 0 [[20, 316]] 1.0 6ylc CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 6YLCA Q16659 15 320 721.0 OXW:401 Type1 Inactive DFGout 13.422 10.8869 None -63.11, 142.83 -70.72, -29.36 -71.04, 124.71 163.01, 86.26 111.55, -16.92 in-out in 9.8391 Saltbr-out 6.3887 HRD-out -107.02, 114.83 -80.4, -3.12 out-out-out SNCooo out-out ActLoopNT-out 5.4805 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -95.42, -2.84 APE9-dihe-na -87.07, 131.04 APE8-dihe-in -71.05, 130.36 APE8-rot-in 321.94 APE67-dihe-in -59.79, -18.51 -109.19, -10.05 APE12-dist-out 18.7485 APE11-dist-out 20.4554 APE10-dist-out 18.1685 APE9-dist-out 8.796 L290V None None XRAY 2.43 0.191 0.231 A 319.0 282.0 24 31 22 9 [[20, 316]] 1.0 6ylc CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6

CMGC_MAPK6 (Mitogen-activated protein kinase 6)

Total number of chains: 14
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 64.3% AF-Q16659-K1A
DFGinter None 3 21.4% 6YLCD
DFGin None 1 7.1% 7AQBB
DFGout None 1 7.1% 6YLCA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAPK6 MK06_HUMAN AF-Q16659-K1A Q16659 12 324 721.0 No_ligand No_ligand Active DFGin 6.4022 14.2617 BLAminus -136.26, -168.64 53.45, 78.56 -88.17, 18.62 289.12, 80.2 -59.84, -33.12 in-in in 9.0675 Saltbr-in 2.6725 HRD-in -71.99, -48.36 66.26, -0.31 in-in-in SNCiii in-in ActLoopNT-in 2.8383 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -70.93, 34.39 APE9-dihe-na -75.94, 146.57 APE8-dihe-in -52.46, 123.79 APE8-rot-in 300.96 APE67-dihe-in -70.23, -19.06 -45.96, -46.84 APE12-dist-in 12.2138 APE11-dist-in 9.2187 APE10-dist-in 6.8702 APE9-dist-in 3.6629 None None None AF2 -1.0 1.0 1.0 A 313.0 313.0 0 31 31 0 [[20, 316]] 1.0 AF-Q16659-K1 Homo sapiens CMGC_MAPK6_HUMAN CMGC 2e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 MK06_HUMAN AF-Q16659-K3A Q16659 12 324 721.0 No_ligand No_ligand Active DFGin 6.1587 13.9739 BLAminus -138.4, -165.97 55.41, 66.08 -78.56, 16.63 290.35, 82.89 -59.77, -28.22 in-in in 9.1237 Saltbr-in 2.6654 HRD-in -75.92, -47.44 64.11, 7.45 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.26, -29.12 APE9-dihe-na -91.1, 145.63 APE8-dihe-in -50.81, 126.25 APE8-rot-in 300.71 APE67-dihe-in -67.83, -19.2 -51.45, -41.59 APE12-dist-in 12.4332 APE11-dist-in 10.4238 APE10-dist-in 6.1341 APE9-dist-in 3.4357 None None None AF2 -1.0 1.0 1.0 A 313.0 313.0 0 31 31 0 [[20, 316]] 1.0 AF-Q16659-K3 Homo sapiens CMGC_MAPK6_HUMAN CMGC 2e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 MK06_HUMAN 6YLLB Q16659 46 321 721.0 No_ligand No_ligand Inactive DFGin 6.7592 15.7141 BLAminus -144.43, -171.34 49.58, 48.98 -55.81, 94.87 277.22, 86.3 -99.33, 999.0 out-out out 10.3859 Saltbr-out 5.6125 HRD-in -71.0, -33.77 70.49, -18.47 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -126.25, -11.05 APE9-dihe-na -93.56, 123.9 APE8-dihe-in -90.53, 132.04 APE8-rot-out 29.76 APE67-dihe-in -50.98, -28.12 -88.59, -6.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.0092 L290V None None XRAY 2.89 0.246 0.263 B 319.0 245.0 57 31 18 13 [[20, 316]] 1.0 6yll Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 MK06_HUMAN 7AQBA Q16659 13 320 721.0 No_ligand No_ligand Inactive DFGin 6.5561 15.0505 BLAminus -130.12, -171.25 52.63, 72.87 -85.41, 18.73 285.15, 82.5 -37.73, -47.91 in-in in 9.3956 Saltbr-in 2.7386 HRD-in -77.51, -52.75 79.92, -8.04 in-in-out SNCiio in-out ActLoopNT-in 2.9415 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -100.57, -5.85 APE9-dihe-na -90.27, 119.86 APE8-dihe-in -69.52, 144.0 APE8-rot-out 59.11 APE67-dihe-in -66.08, -28.82 -93.81, -12.78 APE12-dist-in 13.4628 APE11-dist-out 14.438 APE10-dist-out 11.5363 APE9-dist-out 8.1276 None None None XRAY 2.25 0.224 0.258 A 320.0 294.0 14 31 24 7 [[20, 316]] 1.0 7aqb Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 MK06_HUMAN 6YKYB Q16659 16 321 721.0 OWQ:401 Type1 Inactive DFGin 6.8725 14.2286 BLAminus -135.65, -169.72 45.42, 80.57 -90.98, 22.97 284.21, 94.98 -60.5, -31.54 in-in in 8.7443 Saltbr-in 2.8495 HRD-in -66.3, -53.61 73.11, -7.16 in-in-out SNCiio in-out ActLoopNT-in 2.8661 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -96.55, -13.52 APE9-dihe-na -75.9, 130.43 APE8-dihe-in -63.69, 130.13 APE8-rot-out 187.19 APE67-dihe-in -51.35, -29.03 -93.29, -25.17 APE12-dist-in 12.9772 APE11-dist-out 14.7509 APE10-dist-out 12.447 APE9-dist-out 8.0297 L290V None None XRAY 2.52 0.201 0.251 B 319.0 289.0 17 31 25 6 [[20, 316]] 1.0 6yky Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 MK06_HUMAN 6YKYC Q16659 13 319 721.0 OWQ:401 Type1 Inactive DFGin 7.1599 14.3615 BLAminus -137.66, -169.84 51.29, 73.15 -89.7, 25.97 286.65, 85.33 -69.13, -22.91 in-in in 9.2334 Saltbr-in 3.5041 HRD-out -71.5, 121.99 -108.85, 12.23 in-in-out SNCiio in-out ActLoopNT-in 2.9474 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.49, -28.13 APE9-dihe-na -81.97, 142.27 APE8-dihe-in -81.41, 134.9 APE8-rot-out 190.32 APE67-dihe-in -48.11, -35.02 -84.72, -21.61 APE12-dist-out 15.1533 APE11-dist-out 16.4251 APE10-dist-out 13.2714 APE9-dist-out 9.0914 L290V None None XRAY 2.52 0.201 0.251 C 319.0 283.0 24 31 22 9 [[20, 316]] 1.0 6yky Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 MK06_HUMAN 6YLCB Q16659 16 321 721.0 OXW:401 Type1 Inactive DFGin 6.7967 14.2788 BLAminus -125.47, -168.68 42.86, 82.65 -93.69, 23.37 291.11, 93.75 -53.16, -50.09 in-in in 8.719 Saltbr-in 3.2794 HRD-in -63.05, -51.72 72.3, 3.6 in-in-out SNCiio in-out ActLoopNT-in 2.7728 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -96.03, -12.43 APE9-dihe-na -75.76, 134.51 APE8-dihe-in -70.2, 126.66 APE8-rot-out 200.77 APE67-dihe-in -64.74, -18.73 -95.85, -14.57 APE12-dist-in 12.6654 APE11-dist-out 14.5735 APE10-dist-out 12.3734 APE9-dist-out 8.1606 L290V None None XRAY 2.43 0.191 0.231 B 319.0 292.0 14 31 25 6 [[20, 316]] 1.0 6ylc Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 MK06_HUMAN 6YLCC Q16659 14 319 721.0 OXW:401 Type1 Inactive DFGin 6.4218 15.0119 BLAminus -130.34, -162.17 45.83, 68.62 -75.11, -39.49 278.89, 76.75 -61.17, 999.0 in-in in 9.805 Saltbr-in 3.5091 HRD-out -86.12, 130.48 -108.15, 1.45 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -106.95, -16.91 APE9-dihe-na -101.07, 132.87 APE8-dihe-in -72.03, 129.29 APE8-rot-out 191.96 APE67-dihe-in -58.83, -26.46 -92.46, -7.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.9445 L290V None None XRAY 2.43 0.191 0.231 C 319.0 280.0 26 31 17 14 [[20, 316]] 1.0 6ylc Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 MK06_HUMAN 6YLLA Q16659 14 321 721.0 OYB:401 Type1 Inactive DFGin 6.4388 14.8006 BLAminus -130.84, -173.06 51.23, 80.61 -95.55, 30.17 290.86, 89.67 -62.82, -30.51 out-in out 10.0523 Saltbr-in 3.3166 HRD-in -71.38, -36.98 62.19, -2.2 in-in-out SNCiio in-out ActLoopNT-in 2.9603 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -75.76, -5.39 APE9-dihe-na -96.16, 143.08 APE8-dihe-in -88.39, 129.24 APE8-rot-out 58.25 APE67-dihe-in -53.29, -25.59 -91.11, -7.74 APE12-dist-in 12.4423 APE11-dist-out 14.1828 APE10-dist-out 11.7492 APE9-dist-out 8.5416 L290V None None XRAY 2.89 0.246 0.263 A 319.0 293.0 15 31 23 8 [[20, 316]] 1.0 6yll Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 MK06_HUMAN 7AQBB Q16659 21 320 721.0 No_ligand No_ligand Inactive DFGin 6.3975 15.2127 None -131.48, -173.72 49.63, 73.98 -75.43, 999.0 277.2, 75.11 999.0, 999.0 out-none out 12.9244 Saltbr-none 999.0 HRD-in -76.36, -53.27 81.32, -12.25 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -102.52, -6.95 APE9-dihe-na -95.53, 119.94 APE8-dihe-in -80.87, 140.54 APE8-rot-out 180.68 APE67-dihe-in -60.55, -29.29 -99.38, 0.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8091 None None None XRAY 2.25 0.224 0.258 B 320.0 274.0 27 31 17 14 [[20, 316]] 1.0 7aqb Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 MK06_HUMAN 6YKYA Q16659 18 319 721.0 OWQ:401 Type1 Inactive DFGinter 8.8272 5.0031 None -71.78, 144.73 -71.1, -32.64 -79.99, 115.19 311.82, 124.02 127.81, -16.19 in-out in 9.8118 Saltbr-out 8.1302 HRD-out -111.51, 110.19 -70.61, -5.41 out-out-out SNCooo out-out ActLoopNT-out 5.2412 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -91.65, 9.39 APE9-dihe-na -95.19, 123.93 APE8-dihe-in -73.44, 137.77 APE8-rot-out 188.34 APE67-dihe-in -47.48, -36.76 -86.99, -20.14 APE12-dist-out 18.6512 APE11-dist-out 20.1967 APE10-dist-out 17.8407 APE9-dist-out 8.26 L290V None None XRAY 2.52 0.201 0.251 A 319.0 281.0 21 31 22 9 [[20, 316]] 1.0 6yky Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 MK06_HUMAN 6YKYD Q16659 14 321 721.0 OWQ:401 Type1 Inactive DFGinter 10.4826 4.7833 None -79.21, 142.3 -63.95, -30.02 -82.92, 88.96 326.01, 122.38 148.68, -14.44 out-out out 13.3289 Saltbr-out 11.7551 HRD-out -97.47, 116.92 -79.67, -2.76 out-out-out SNCooo out-out ActLoopNT-out 5.2458 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.9, -29.99 APE9-dihe-na -87.22, 152.15 APE8-dihe-in -86.08, 134.07 APE8-rot-out 192.13 APE67-dihe-in -46.65, -35.13 -86.31, -21.98 APE12-dist-out 20.0761 APE11-dist-out 21.3843 APE10-dist-out 18.1317 APE9-dist-out 8.9379 L290V None None XRAY 2.52 0.201 0.251 D 319.0 301.0 7 31 31 0 [[20, 316]] 1.0 6yky Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 MK06_HUMAN 6YLCD Q16659 13 321 721.0 OXW:401 Type1 Inactive DFGinter 9.8338 4.9935 None -68.6, 151.66 -80.4, -20.68 -82.11, 114.82 290.44, 97.57 115.85, -9.5 out-out out 13.3472 Saltbr-out 9.8532 HRD-out -103.81, 118.3 -82.36, -0.96 out-out-out SNCooo out-out ActLoopNT-out 5.3623 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.61, -26.31 APE9-dihe-na -98.13, 139.46 APE8-dihe-in -69.39, 130.27 APE8-rot-out 191.58 APE67-dihe-in -59.56, -27.81 -93.33, -5.47 APE12-dist-out 19.9869 APE11-dist-out 21.3886 APE10-dist-out 18.1959 APE9-dist-out 9.0553 L290V None None XRAY 2.43 0.191 0.231 D 319.0 303.0 6 31 31 0 [[20, 316]] 1.0 6ylc Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
MAPK6 MK06_HUMAN 6YLCA Q16659 15 320 721.0 OXW:401 Type1 Inactive DFGout 13.422 10.8869 None -63.11, 142.83 -70.72, -29.36 -71.04, 124.71 163.01, 86.26 111.55, -16.92 in-out in 9.8391 Saltbr-out 6.3887 HRD-out -107.02, 114.83 -80.4, -3.12 out-out-out SNCooo out-out ActLoopNT-out 5.4805 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -95.42, -2.84 APE9-dihe-na -87.07, 131.04 APE8-dihe-in -71.05, 130.36 APE8-rot-in 321.94 APE67-dihe-in -59.79, -18.51 -109.19, -10.05 APE12-dist-out 18.7485 APE11-dist-out 20.4554 APE10-dist-out 18.1685 APE9-dist-out 8.796 L290V None None XRAY 2.43 0.191 0.231 A 319.0 282.0 24 31 22 9 [[20, 316]] 1.0 6ylc Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1.0 301.0 301.0 170 171 172 174 176 49 65 69 149 151 150 152.0 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6

CMGC_MAPK6 (Mitogen-activated protein kinase 6)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name