KinCore

CMGC_MAPK6 (Mitogen-activated protein kinase 6)

Total number of chains: 14

Active chains: 2

Uniprot: MK06_HUMAN

Kinase Domain Residues: 20 - 316

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	9	64.3%	AF-Q16659-K1A
DFGinter	None	3	21.4%	6YLCD
DFGin	None	1	7.1%	7AQBB
DFGout	None	1	7.1%	6YLCA

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PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein
AF-Q16659-K1A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	12 - 324	0	None	None	Mitogen-activated protein kinase 6
AF-Q16659-K3A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	12 - 324	0	None	None	Mitogen-activated protein kinase 6
6YLLB	2.89	Inactive	DFGin‑BLAminus	out-out	none-out	nonTYR	APEdihe_aaioi	APEdist_nnno	No_ligand	No_ligand	46 - 321	0	None	L290V	Mitogen-activated protein kinase 6
7AQBA	2.25	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaioi	APEdist_iooo	No_ligand	No_ligand	13 - 320	0	None	None	Mitogen-activated protein kinase 6
6YKYB	2.52	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaioi	APEdist_iooo	OWQ	Type1	16 - 321	0	None	L290V	Mitogen-activated protein kinase 6
6YKYC	2.52	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaioi	APEdist_oooo	OWQ	Type1	13 - 319	0	None	L290V	Mitogen-activated protein kinase 6
6YLCB	2.43	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaioi	APEdist_iooo	OXW	Type1	16 - 321	0	None	L290V	Mitogen-activated protein kinase 6
6YLCC	2.43	Inactive	DFGin‑BLAminus	in-in	none-out	nonTYR	APEdihe_aaioi	APEdist_nnno	OXW	Type1	14 - 319	0	None	L290V	Mitogen-activated protein kinase 6
6YLLA	2.89	Inactive	DFGin‑BLAminus	out-in	in-out	nonTYR	APEdihe_aaioi	APEdist_iooo	OYB	Type1	14 - 321	0	None	L290V	Mitogen-activated protein kinase 6
7AQBB	2.25	Inactive	DFGin‑None	out-none	none-out	nonTYR	APEdihe_aaioi	APEdist_nnno	No_ligand	No_ligand	21 - 320	0	None	None	Mitogen-activated protein kinase 6
6YKYA	2.52	Inactive	DFGinter‑None	in-out	out-out	nonTYR	APEdihe_aaioi	APEdist_oooo	OWQ	Type1	18 - 319	0	None	L290V	Mitogen-activated protein kinase 6
6YKYD	2.52	Inactive	DFGinter‑None	out-out	out-out	nonTYR	APEdihe_aaioi	APEdist_oooo	OWQ	Type1	14 - 321	0	None	L290V	Mitogen-activated protein kinase 6
6YLCD	2.43	Inactive	DFGinter‑None	out-out	out-out	nonTYR	APEdihe_aaioi	APEdist_oooo	OXW	Type1	13 - 321	0	None	L290V	Mitogen-activated protein kinase 6
6YLCA	2.43	Inactive	DFGout‑None	in-out	out-out	nonTYR	APEdihe_aaiii	APEdist_oooo	OXW	Type1	15 - 320	0	None	L290V	Mitogen-activated protein kinase 6

CMGC_MAPK6 (Mitogen-activated protein kinase 6)

Total number of chains: 14

Active chains: 2

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	9	64.3%	AF-Q16659-K1A
DFGinter	None	3	21.4%	6YLCD
DFGin	None	1	7.1%	7AQBB
DFGout	None	1	7.1%	6YLCA

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UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism
MK06_HUMAN	AF-Q16659-K1A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	12 - 324	0	None	None	Mitogen-activated protein kinase 6	Homo sapiens
MK06_HUMAN	AF-Q16659-K3A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	12 - 324	0	None	None	Mitogen-activated protein kinase 6	Homo sapiens
MK06_HUMAN	6YLLB	2.89	Inactive	DFGin‑BLAminus	out-out	none-out	nonTYR	APEdihe_aaioi	APEdist_nnno	No_ligand	No_ligand	46 - 321	0	None	L290V	Mitogen-activated protein kinase 6	Homo sapiens
MK06_HUMAN	7AQBA	2.25	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaioi	APEdist_iooo	No_ligand	No_ligand	13 - 320	0	None	None	Mitogen-activated protein kinase 6	Homo sapiens
MK06_HUMAN	6YKYB	2.52	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaioi	APEdist_iooo	OWQ	Type1	16 - 321	0	None	L290V	Mitogen-activated protein kinase 6	Homo sapiens
MK06_HUMAN	6YKYC	2.52	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaioi	APEdist_oooo	OWQ	Type1	13 - 319	0	None	L290V	Mitogen-activated protein kinase 6	Homo sapiens
MK06_HUMAN	6YLCB	2.43	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaioi	APEdist_iooo	OXW	Type1	16 - 321	0	None	L290V	Mitogen-activated protein kinase 6	Homo sapiens
MK06_HUMAN	6YLCC	2.43	Inactive	DFGin‑BLAminus	in-in	none-out	nonTYR	APEdihe_aaioi	APEdist_nnno	OXW	Type1	14 - 319	0	None	L290V	Mitogen-activated protein kinase 6	Homo sapiens
MK06_HUMAN	6YLLA	2.89	Inactive	DFGin‑BLAminus	out-in	in-out	nonTYR	APEdihe_aaioi	APEdist_iooo	OYB	Type1	14 - 321	0	None	L290V	Mitogen-activated protein kinase 6	Homo sapiens
MK06_HUMAN	7AQBB	2.25	Inactive	DFGin‑None	out-none	none-out	nonTYR	APEdihe_aaioi	APEdist_nnno	No_ligand	No_ligand	21 - 320	0	None	None	Mitogen-activated protein kinase 6	Homo sapiens
MK06_HUMAN	6YKYA	2.52	Inactive	DFGinter‑None	in-out	out-out	nonTYR	APEdihe_aaioi	APEdist_oooo	OWQ	Type1	18 - 319	0	None	L290V	Mitogen-activated protein kinase 6	Homo sapiens
MK06_HUMAN	6YKYD	2.52	Inactive	DFGinter‑None	out-out	out-out	nonTYR	APEdihe_aaioi	APEdist_oooo	OWQ	Type1	14 - 321	0	None	L290V	Mitogen-activated protein kinase 6	Homo sapiens
MK06_HUMAN	6YLCD	2.43	Inactive	DFGinter‑None	out-out	out-out	nonTYR	APEdihe_aaioi	APEdist_oooo	OXW	Type1	13 - 321	0	None	L290V	Mitogen-activated protein kinase 6	Homo sapiens
MK06_HUMAN	6YLCA	2.43	Inactive	DFGout‑None	in-out	out-out	nonTYR	APEdihe_aaiii	APEdist_oooo	OXW	Type1	15 - 320	0	None	L290V	Mitogen-activated protein kinase 6	Homo sapiens

CMGC_MAPK6 (Mitogen-activated protein kinase 6)

Total number of chains: 0

Active chains: 0

Spatial label	Dihedral label	Number of Chains	Percent	Representative

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UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism