CMGC_MAPK13 (Mitogen-activated protein kinase 13)

Total number of chains: 11
Active chains: 4
Uniprot: MK13_HUMAN
Kinase Domain Residues: 25 - 308
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 5 45.5% 8X23A
DFGin BLAminus 4 36.4% AF-O15264-K1A
DFGout BBAminus 1 9.1% 4EYJA
DFGout None 1 9.1% 5EKNA

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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-O15264-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 316 0 None None Mitogen-activated protein kinase 13
AF-O15264-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 316 0 None None Mitogen-activated protein kinase 13
4MYGA 2.594 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 15 - 351 0 TPO180,PTR182 None Mitogen-activated protein kinase 13
4MYGB 2.594 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 15 - 351 0 TPO180,PTR182 None Mitogen-activated protein kinase 13
8X23A 1.5 Inactive DFGin‑BLBplus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 1 - 351 0 None None Mitogen-activated protein kinase 13
4YNOA 1.7 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 2 - 351 0 None None Mitogen-activated protein kinase 13
3COIA 2.09 Inactive DFGin‑BLBplus in-out out-out nonTYR APEdihe_aaooo APEdist_nnoo No_ligand No_ligand 2 - 351 0 None None Mitogen-activated protein kinase 13
4EYMA 2.353 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nooo 0RX Type1 2 - 351 0 None None Mitogen-activated protein kinase 13
5EKOA 2.0 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_oooo N17 Type1 2 - 351 0 None None Mitogen-activated protein kinase 13
4EYJA 2.102 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno N61 Type2 2 - 351 0 None None Mitogen-activated protein kinase 13
5EKNA 2.594 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno N58 Type2 2 - 351 0 None None Mitogen-activated protein kinase 13

CMGC_MAPK13 (Mitogen-activated protein kinase 13)

Total number of chains: 11
Active chains: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 5 45.5% 8X23A
DFGin BLAminus 4 36.4% AF-O15264-K1A
DFGout BBAminus 1 9.1% 4EYJA
DFGout None 1 9.1% 5EKNA

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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
MK13_HUMAN AF-O15264-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 316 0 None None Mitogen-activated protein kinase 13 Homo sapiens
MK13_HUMAN AF-O15264-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 17 - 316 0 None None Mitogen-activated protein kinase 13 Homo sapiens
MK13_HUMAN 4MYGA 2.594 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 15 - 351 0 TPO180,PTR182 None Mitogen-activated protein kinase 13 Homo sapiens
MK13_HUMAN 4MYGB 2.594 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 15 - 351 0 TPO180,PTR182 None Mitogen-activated protein kinase 13 Homo sapiens
MK13_HUMAN 8X23A 1.5 Inactive DFGin‑BLBplus in-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 1 - 351 0 None None Mitogen-activated protein kinase 13 Homo sapiens
MK13_HUMAN 4YNOA 1.7 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 2 - 351 0 None None Mitogen-activated protein kinase 13 Homo sapiens
MK13_HUMAN 3COIA 2.09 Inactive DFGin‑BLBplus in-out out-out nonTYR APEdihe_aaooo APEdist_nnoo No_ligand No_ligand 2 - 351 0 None None Mitogen-activated protein kinase 13 Homo sapiens
MK13_HUMAN 4EYMA 2.353 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nooo 0RX Type1 2 - 351 0 None None Mitogen-activated protein kinase 13 Homo sapiens
MK13_HUMAN 5EKOA 2.0 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_oooo N17 Type1 2 - 351 0 None None Mitogen-activated protein kinase 13 Homo sapiens
MK13_HUMAN 4EYJA 2.102 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno N61 Type2 2 - 351 0 None None Mitogen-activated protein kinase 13 Homo sapiens
MK13_HUMAN 5EKNA 2.594 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno N58 Type2 2 - 351 0 None None Mitogen-activated protein kinase 13 Homo sapiens

CMGC_MAPK13 (Mitogen-activated protein kinase 13)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism