STE_MAP3K2 (Mitogen-activated protein kinase kinase kinase 2)

Total number of chains: 4
Active chains: 2
Uniprot: M3K2_HUMAN
Kinase Domain Residues: 356 - 616
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% AF-Q9Y2U5-K1A
DFGout BBAminus 1 25.0% 9P6AA
DFGout None 1 25.0% 9P6AB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K2 AF-Q9Y2U5-K1A Q9Y2U5 348 619 619.0 No_ligand No_ligand Active DFGin 7.1341 13.9995 BLAminus -124.32, 177.44 53.53, 89.34 -97.59, 13.67 288.12, 80.3 -60.17, -27.42 in-in in 9.1569 Saltbr-in 2.9475 HRD-in -78.12, -42.92 66.18, 5.77 in-in-in SNCiii in-in ActLoopNT-in 2.9449 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.31, 145.37 APE9-dihe-na 138.62, -179.74 APE8-dihe-in -90.88, 129.97 APE8-rot-in 305.09 APE67-dihe-in -72.4, -14.97 -41.24, -52.44 APE12-dist-in 9.0251 APE11-dist-in 11.787 APE10-dist-in 5.9845 APE9-dist-in 3.6693 None None None AF2 -1.0 1.0 1.0 A 272.0 272.0 0 31 31 0 [[356, 616]] 1.0 AF-Q9Y2U5-K1 STE_MAP3K2_HUMAN STE 1.3e-81 279.6 1.0 257.0 257.0 500 501 502 504 506 385 406 410 480 482 481 483.0 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2
MAP3K2 AF-Q9Y2U5-K3A Q9Y2U5 348 619 619.0 No_ligand No_ligand Active DFGin 6.991 14.2416 BLAminus -130.68, -179.91 52.53, 82.07 -91.88, 10.64 286.08, 82.78 -60.66, -30.44 in-in in 9.0586 Saltbr-in 2.9232 HRD-in -75.15, -42.49 67.78, 5.59 in-in-in SNCiii in-in ActLoopNT-in 2.9452 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.83, 137.17 APE9-dihe-na 137.58, -170.76 APE8-dihe-in -98.35, 128.43 APE8-rot-in 305.11 APE67-dihe-in -67.21, -11.56 -43.36, -54.08 APE12-dist-in 9.3598 APE11-dist-in 11.5753 APE10-dist-in 5.7113 APE9-dist-in 3.1794 None None None AF2 -1.0 1.0 1.0 A 272.0 272.0 0 31 31 0 [[356, 616]] 1.0 AF-Q9Y2U5-K3 STE_MAP3K2_HUMAN STE 1.3e-81 279.6 1.0 257.0 257.0 500 501 502 504 506 385 406 410 480 482 481 483.0 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2
MAP3K2 9P6AA Q9Y2U5 351 617 619.0 0LI:701 Type2 Inactive DFGout 14.1431 9.8906 BBAminus -146.02, -172.59 -157.95, 116.33 -87.88, -36.33 294.81, 102.45 -88.54, 36.79 in-in in 8.4578 Saltbr-in 2.5939 HRD-in -76.59, -52.31 80.62, -19.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.17, -51.62 APE9-dihe-na -96.01, 162.48 APE8-dihe-in -81.48, 131.06 APE8-rot-out 69.69 APE67-dihe-in -67.88, -22.22 -92.28, 3.15 APE12-dist-out 20.6817 APE11-dist-out 19.1439 APE10-dist-out 14.3088 APE9-dist-out 10.4562 None None None XRAY 2.4 0.228 0.246 A 299.0 253.0 14 31 17 14 [[356, 616]] 1.0 9p6a STE_MAP3K2_HUMAN STE 1.9e-81 279.1 1.0 257.0 257.0 500 501 502 504 506 385 406 410 480 482 481 483.0 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2
MAP3K2 9P6AB Q9Y2U5 347 618 619.0 0LI:701 Type2 Inactive DFGout 13.8018 9.7559 None -145.97, -173.02 -157.2, 114.58 -90.61, 158.12 297.06, 102.49 67.12, -99.7 in-in in 8.6308 Saltbr-in 2.7273 HRD-in -74.0, -48.74 85.04, -22.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -168.99 APE9-dihe-na -96.92, -27.66 APE8-dihe-in -82.09, 127.1 APE8-rot-out 70.19 APE67-dihe-in -70.58, -23.59 -96.42, -0.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6373 APE9-dist-out 10.7871 None None None XRAY 2.4 0.228 0.246 B 299.0 247.0 25 31 15 16 [[356, 616]] 1.0 9p6a STE_MAP3K2_HUMAN STE 1.9e-81 279.1 1.0 257.0 257.0 500 501 502 504 506 385 406 410 480 482 481 483.0 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2

STE_MAP3K2 (Mitogen-activated protein kinase kinase kinase 2)

Total number of chains: 4
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% AF-Q9Y2U5-K1A
DFGout BBAminus 1 25.0% 9P6AA
DFGout None 1 25.0% 9P6AB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K2 M3K2_HUMAN AF-Q9Y2U5-K1A Q9Y2U5 348 619 619.0 No_ligand No_ligand Active DFGin 7.1341 13.9995 BLAminus -124.32, 177.44 53.53, 89.34 -97.59, 13.67 288.12, 80.3 -60.17, -27.42 in-in in 9.1569 Saltbr-in 2.9475 HRD-in -78.12, -42.92 66.18, 5.77 in-in-in SNCiii in-in ActLoopNT-in 2.9449 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.31, 145.37 APE9-dihe-na 138.62, -179.74 APE8-dihe-in -90.88, 129.97 APE8-rot-in 305.09 APE67-dihe-in -72.4, -14.97 -41.24, -52.44 APE12-dist-in 9.0251 APE11-dist-in 11.787 APE10-dist-in 5.9845 APE9-dist-in 3.6693 None None None AF2 -1.0 1.0 1.0 A 272.0 272.0 0 31 31 0 [[356, 616]] 1.0 AF-Q9Y2U5-K1 Homo sapiens STE_MAP3K2_HUMAN STE 1.3e-81 279.6 1.0 257.0 257.0 500 501 502 504 506 385 406 410 480 482 481 483.0 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2
MAP3K2 M3K2_HUMAN AF-Q9Y2U5-K3A Q9Y2U5 348 619 619.0 No_ligand No_ligand Active DFGin 6.991 14.2416 BLAminus -130.68, -179.91 52.53, 82.07 -91.88, 10.64 286.08, 82.78 -60.66, -30.44 in-in in 9.0586 Saltbr-in 2.9232 HRD-in -75.15, -42.49 67.78, 5.59 in-in-in SNCiii in-in ActLoopNT-in 2.9452 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.83, 137.17 APE9-dihe-na 137.58, -170.76 APE8-dihe-in -98.35, 128.43 APE8-rot-in 305.11 APE67-dihe-in -67.21, -11.56 -43.36, -54.08 APE12-dist-in 9.3598 APE11-dist-in 11.5753 APE10-dist-in 5.7113 APE9-dist-in 3.1794 None None None AF2 -1.0 1.0 1.0 A 272.0 272.0 0 31 31 0 [[356, 616]] 1.0 AF-Q9Y2U5-K3 Homo sapiens STE_MAP3K2_HUMAN STE 1.3e-81 279.6 1.0 257.0 257.0 500 501 502 504 506 385 406 410 480 482 481 483.0 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2
MAP3K2 M3K2_HUMAN 9P6AA Q9Y2U5 351 617 619.0 0LI:701 Type2 Inactive DFGout 14.1431 9.8906 BBAminus -146.02, -172.59 -157.95, 116.33 -87.88, -36.33 294.81, 102.45 -88.54, 36.79 in-in in 8.4578 Saltbr-in 2.5939 HRD-in -76.59, -52.31 80.62, -19.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.17, -51.62 APE9-dihe-na -96.01, 162.48 APE8-dihe-in -81.48, 131.06 APE8-rot-out 69.69 APE67-dihe-in -67.88, -22.22 -92.28, 3.15 APE12-dist-out 20.6817 APE11-dist-out 19.1439 APE10-dist-out 14.3088 APE9-dist-out 10.4562 None None None XRAY 2.4 0.228 0.246 A 299.0 253.0 14 31 17 14 [[356, 616]] 1.0 9p6a Homo sapiens STE_MAP3K2_HUMAN STE 1.9e-81 279.1 1.0 257.0 257.0 500 501 502 504 506 385 406 410 480 482 481 483.0 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2
MAP3K2 M3K2_HUMAN 9P6AB Q9Y2U5 347 618 619.0 0LI:701 Type2 Inactive DFGout 13.8018 9.7559 None -145.97, -173.02 -157.2, 114.58 -90.61, 158.12 297.06, 102.49 67.12, -99.7 in-in in 8.6308 Saltbr-in 2.7273 HRD-in -74.0, -48.74 85.04, -22.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -168.99 APE9-dihe-na -96.92, -27.66 APE8-dihe-in -82.09, 127.1 APE8-rot-out 70.19 APE67-dihe-in -70.58, -23.59 -96.42, -0.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.6373 APE9-dist-out 10.7871 None None None XRAY 2.4 0.228 0.246 B 299.0 247.0 25 31 15 16 [[356, 616]] 1.0 9p6a Homo sapiens STE_MAP3K2_HUMAN STE 1.9e-81 279.1 1.0 257.0 257.0 500 501 502 504 506 385 406 410 480 482 481 483.0 543 531 526 525 524 523 522 521 520 438 Mitogen-activated protein kinase kinase kinase 2

STE_MAP3K2 (Mitogen-activated protein kinase kinase kinase 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name