TKL_MAP3K21 (Mitogen-activated protein kinase kinase kinase 21)

Total number of chains: 3
Active chains: 2
Uniprot: M3K21_HUMAN
Kinase Domain Residues: 124 - 400
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% AF-Q5TCX8-K1A
DFGin BLBplus 1 33.3% 4UYAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q5TCX8-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 116 - 408 0 None None Mitogen-activated protein kinase kinase kinase 21
AF-Q5TCX8-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 116 - 408 0 None None Mitogen-activated protein kinase kinase kinase 21
4UYAA 2.8 Inactive DFGin‑BLBplus in-none none-none nonTYR APEdihe_aanni APEdist_nnnn AGS ATPlike 115 - 437 0 None A214G,S303A,T307A Mitogen-activated protein kinase kinase kinase 21

TKL_MAP3K21 (Mitogen-activated protein kinase kinase kinase 21)

Total number of chains: 3
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% AF-Q5TCX8-K1A
DFGin BLBplus 1 33.3% 4UYAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
M3K21_HUMAN AF-Q5TCX8-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 116 - 408 0 None None Mitogen-activated protein kinase kinase kinase 21 Homo sapiens
M3K21_HUMAN AF-Q5TCX8-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 116 - 408 0 None None Mitogen-activated protein kinase kinase kinase 21 Homo sapiens
M3K21_HUMAN 4UYAA 2.8 Inactive DFGin‑BLBplus in-none none-none nonTYR APEdihe_aanni APEdist_nnnn AGS ATPlike 115 - 437 0 None A214G,S303A,T307A Mitogen-activated protein kinase kinase kinase 21 Homo sapiens

TKL_MAP3K21 (Mitogen-activated protein kinase kinase kinase 21)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism