TKL_MAP3K21 (Mitogen-activated protein kinase kinase kinase 21)

Total number of chains: 3
Active chains: 2
Uniprot: M3K21_HUMAN
Kinase Domain Residues: 124 - 400
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% AF-Q5TCX8-K1A
DFGin BLBplus 1 33.3% 4UYAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K21 AF-Q5TCX8-K1A Q5TCX8 116 408 1036.0 No_ligand No_ligand Active DFGin 6.8565 13.7702 BLAminus -137.8, 179.2 64.21, 74.44 -93.98, 15.29 291.96, 83.23 -59.47, -32.22 in-in in 7.8031 Saltbr-in 2.7483 HRD-in -72.9, -43.99 67.26, -5.47 in-in-in SNCiii in-in ActLoopNT-in 2.8715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.84, 156.0 APE9-dihe-na 104.92, 178.79 APE8-dihe-in -87.45, 121.61 APE8-rot-in 309.97 APE67-dihe-in -64.85, -13.63 -50.09, -43.56 APE12-dist-in 9.6326 APE11-dist-in 11.3246 APE10-dist-in 5.7458 APE9-dist-in 3.7953 None None None AF2 -1.0 1.0 1.0 A 293.0 293.0 0 26 26 0 [[124, 400]] 1.0 AF-Q5TCX8-K1 TKL_MAP3K21_HUMAN TKL 2.8e-89 305.1 1.0 266.0 266.0 288 289 290 292 294 151 171 175 260 262 261 263.0 326 314 309 308 307 306 305 304 303 201 Mitogen-activated protein kinase kinase kinase 21
MAP3K21 AF-Q5TCX8-K3A Q5TCX8 116 408 1036.0 No_ligand No_ligand Active DFGin 6.6845 13.9451 BLAminus -139.56, -177.6 62.94, 60.12 -78.74, 13.97 292.95, 84.51 -60.76, -33.19 in-in in 8.3547 Saltbr-in 2.7092 HRD-in -73.48, -42.53 66.33, -5.8 in-in-in SNCiii in-in ActLoopNT-in 2.9065 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.95, 151.46 APE9-dihe-na 129.24, 175.81 APE8-dihe-in -88.59, 126.05 APE8-rot-in 307.51 APE67-dihe-in -66.8, -15.03 -49.23, -47.33 APE12-dist-in 8.7882 APE11-dist-in 11.0775 APE10-dist-in 5.3733 APE9-dist-in 3.1857 None None None AF2 -1.0 1.0 1.0 A 293.0 293.0 0 26 26 0 [[124, 400]] 1.0 AF-Q5TCX8-K3 TKL_MAP3K21_HUMAN TKL 2.8e-89 305.1 1.0 266.0 266.0 288 289 290 292 294 151 171 175 260 262 261 263.0 326 314 309 308 307 306 305 304 303 201 Mitogen-activated protein kinase kinase kinase 21
MAP3K21 4UYAA Q5TCX8 115 437 1036.0 AGS:1438 ATPlike Inactive DFGin 6.4628 13.9984 BLBplus -133.24, 174.99 55.83, 68.25 -140.94, 164.55 55.9, 82.39 72.5, 999.0 in-none in 9.8853 Saltbr-none 999.0 HRD-in -81.83, -51.37 74.29, 7.17 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -67.17 APE8-rot-none 999.0 APE67-dihe-in -51.82, -45.19 -73.69, -16.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 A214G,S303A,T307A None None XRAY 2.8 0.204 0.261 A 340.0 274.0 29 26 11 15 [[124, 400]] 1.0 4uya TKL_MAP3K21_HUMAN TKL 1.2e-89 306.3 1.0 266.0 266.0 288 289 290 292 294 151 171 175 260 262 261 263.0 326 314 309 308 307 306 305 304 303 201 Mitogen-activated protein kinase kinase kinase 21

TKL_MAP3K21 (Mitogen-activated protein kinase kinase kinase 21)

Total number of chains: 3
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% AF-Q5TCX8-K1A
DFGin BLBplus 1 33.3% 4UYAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K21 M3K21_HUMAN AF-Q5TCX8-K1A Q5TCX8 116 408 1036.0 No_ligand No_ligand Active DFGin 6.8565 13.7702 BLAminus -137.8, 179.2 64.21, 74.44 -93.98, 15.29 291.96, 83.23 -59.47, -32.22 in-in in 7.8031 Saltbr-in 2.7483 HRD-in -72.9, -43.99 67.26, -5.47 in-in-in SNCiii in-in ActLoopNT-in 2.8715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.84, 156.0 APE9-dihe-na 104.92, 178.79 APE8-dihe-in -87.45, 121.61 APE8-rot-in 309.97 APE67-dihe-in -64.85, -13.63 -50.09, -43.56 APE12-dist-in 9.6326 APE11-dist-in 11.3246 APE10-dist-in 5.7458 APE9-dist-in 3.7953 None None None AF2 -1.0 1.0 1.0 A 293.0 293.0 0 26 26 0 [[124, 400]] 1.0 AF-Q5TCX8-K1 Homo sapiens TKL_MAP3K21_HUMAN TKL 2.8e-89 305.1 1.0 266.0 266.0 288 289 290 292 294 151 171 175 260 262 261 263.0 326 314 309 308 307 306 305 304 303 201 Mitogen-activated protein kinase kinase kinase 21
MAP3K21 M3K21_HUMAN AF-Q5TCX8-K3A Q5TCX8 116 408 1036.0 No_ligand No_ligand Active DFGin 6.6845 13.9451 BLAminus -139.56, -177.6 62.94, 60.12 -78.74, 13.97 292.95, 84.51 -60.76, -33.19 in-in in 8.3547 Saltbr-in 2.7092 HRD-in -73.48, -42.53 66.33, -5.8 in-in-in SNCiii in-in ActLoopNT-in 2.9065 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.95, 151.46 APE9-dihe-na 129.24, 175.81 APE8-dihe-in -88.59, 126.05 APE8-rot-in 307.51 APE67-dihe-in -66.8, -15.03 -49.23, -47.33 APE12-dist-in 8.7882 APE11-dist-in 11.0775 APE10-dist-in 5.3733 APE9-dist-in 3.1857 None None None AF2 -1.0 1.0 1.0 A 293.0 293.0 0 26 26 0 [[124, 400]] 1.0 AF-Q5TCX8-K3 Homo sapiens TKL_MAP3K21_HUMAN TKL 2.8e-89 305.1 1.0 266.0 266.0 288 289 290 292 294 151 171 175 260 262 261 263.0 326 314 309 308 307 306 305 304 303 201 Mitogen-activated protein kinase kinase kinase 21
MAP3K21 M3K21_HUMAN 4UYAA Q5TCX8 115 437 1036.0 AGS:1438 ATPlike Inactive DFGin 6.4628 13.9984 BLBplus -133.24, 174.99 55.83, 68.25 -140.94, 164.55 55.9, 82.39 72.5, 999.0 in-none in 9.8853 Saltbr-none 999.0 HRD-in -81.83, -51.37 74.29, 7.17 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -67.17 APE8-rot-none 999.0 APE67-dihe-in -51.82, -45.19 -73.69, -16.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 A214G,S303A,T307A None None XRAY 2.8 0.204 0.261 A 340.0 274.0 29 26 11 15 [[124, 400]] 1.0 4uya Homo sapiens TKL_MAP3K21_HUMAN TKL 1.2e-89 306.3 1.0 266.0 266.0 288 289 290 292 294 151 171 175 260 262 261 263.0 326 314 309 308 307 306 305 304 303 201 Mitogen-activated protein kinase kinase kinase 21

TKL_MAP3K21 (Mitogen-activated protein kinase kinase kinase 21)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name