TKL_MAP3K12 (Mitogen-activated protein kinase kinase kinase 12)

Total number of chains: 14
Active chains: 2
Uniprot: M3K12_HUMAN
Kinase Domain Residues: 125 - 366
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 10 71.4% 9CDYA
DFGin BLAminus 2 14.3% AF-Q12852-K1A
DFGin BLBminus 1 7.1% 5CENA
DFGin None 1 7.1% 9CDXA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K12 AF-Q12852-K1A Q12852 117 374 859.0 No_ligand No_ligand Active DFGin 6.4258 14.4038 BLAminus -135.37, 174.94 59.09, 75.76 -81.87, 15.15 290.24, 86.78 -63.45, -16.18 in-na in 9.0259 Saltbr-na 5.0805 HRD-in -74.58, -46.99 68.83, -6.59 na-in-in SNCaii in-in ActLoopNT-in 2.9293 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.29, 155.5 APE9-dihe-na 115.77, -178.15 APE8-dihe-in -101.06, 126.9 APE8-rot-in 306.9 APE67-dihe-in -65.79, -18.28 -46.31, -46.72 APE12-dist-in 8.8055 APE11-dist-in 11.076 APE10-dist-in 5.3824 APE9-dist-in 3.438 None None None AF2 -1.0 1.0 1.0 A 258.0 258.0 0 27 27 0 [[118, 372]] 1.0 AF-Q12852-K1 TKL_MAP3K12_HUMAN MAP3K123 8.4e-138 463.6 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 AF-Q12852-K3A Q12852 117 374 859.0 No_ligand No_ligand Active DFGin 6.2508 14.5575 BLAminus -140.65, -175.73 52.42, 68.88 -73.59, 9.91 294.28, 96.63 -59.3, -19.37 in-na in 9.0783 Saltbr-na 5.3305 HRD-in -74.8, -45.87 67.92, -9.13 na-in-in SNCaii in-in ActLoopNT-in 2.9232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.36, 146.36 APE9-dihe-na 105.87, -173.52 APE8-dihe-in -105.9, 126.7 APE8-rot-in 310.93 APE67-dihe-in -64.79, -18.86 -50.97, -43.69 APE12-dist-in 8.6823 APE11-dist-in 11.2814 APE10-dist-in 5.4772 APE9-dist-in 3.635 None None None AF2 -1.0 1.0 1.0 A 258.0 258.0 0 27 27 0 [[118, 372]] 1.0 AF-Q12852-K3 TKL_MAP3K12_HUMAN MAP3K123 8.4e-138 463.6 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 5CENA Q12852 117 397 859.0 No_ligand No_ligand Inactive DFGin 6.5711 14.5936 BLBminus -139.23, -167.03 41.89, 62.24 -59.37, 141.01 289.88, 76.49 -88.51, 171.86 out-na out 13.3249 Saltbr-na 13.8047 HRD-in -64.3, -49.81 77.36, -11.65 na-out-out SNCaoo out-out ActLoopNT-out 10.4378 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -66.46, -25.65 APE9-dihe-na -69.15, -23.11 APE8-dihe-out -120.04, 27.45 APE8-rot-out 47.83 APE67-dihe-in -54.85, -32.09 -61.13, -20.63 APE12-dist-in 12.7375 APE11-dist-in 10.7082 APE10-dist-out 16.415 APE9-dist-out 12.7049 None None None XRAY 1.7 0.187 0.225 A 300.0 281.0 0 27 27 0 [[118, 372]] 1.0 5cen TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 5CEOA Q12852 117 398 859.0 50D:501 Type1 Inactive DFGin 6.5971 14.0857 BLBplus -126.24, 175.81 67.12, 25.36 -93.94, 136.37 52.61, 92.25 91.51, 999.0 out-na out 13.8478 Saltbr-na 13.0081 HRD-in -63.27, -54.52 78.95, -16.59 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -68.21, -27.79 APE9-dihe-na -71.83, -28.25 APE8-dihe-out -98.1, -6.02 APE8-rot-out 179.22 APE67-dihe-in -62.76, -24.87 -51.91, -27.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2704 None None None XRAY 2.28 0.19 0.248 A 300.0 269.0 13 27 14 13 [[118, 372]] 1.0 5ceo TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 5CEPA Q12852 117 398 859.0 50E:501 Type1 Inactive DFGin 6.3848 14.1124 BLBplus -133.95, 176.37 61.43, 47.97 -122.18, 164.22 62.69, 87.15 70.44, 999.0 out-na out 13.9686 Saltbr-na 13.1355 HRD-in -62.94, -52.59 77.57, -18.56 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -70.69, -32.93 APE9-dihe-na -93.66, 31.57 APE8-dihe-out -146.83, -4.84 APE8-rot-out 193.07 APE67-dihe-in -54.11, -31.23 -68.11, -24.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1938 None None None XRAY 1.99 0.175 0.23 A 300.0 269.0 13 27 14 13 [[118, 372]] 1.0 5cep TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 5CEQA Q12852 117 398 859.0 50F:4000 Type1 Inactive DFGin 6.2846 14.1433 BLBplus -139.34, 175.24 65.23, 33.46 -103.17, 163.52 57.07, 90.2 71.88, 999.0 out-na out 13.9369 Saltbr-na 13.2447 HRD-in -61.44, -57.14 79.98, -14.5 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -71.43, -48.01 APE9-dihe-na -72.5, -0.08 APE8-dihe-out -118.56, -4.99 APE8-rot-out 184.08 APE67-dihe-in -55.04, -30.89 -63.03, -27.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1318 None None None XRAY 1.911 0.171 0.218 A 300.0 269.0 13 27 14 13 [[118, 372]] 1.0 5ceq TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 5VO1A Q12852 117 398 859.0 9FS:501 Type1 Inactive DFGin 6.2008 14.0511 BLBplus -138.68, 175.38 61.55, 50.37 -122.24, 158.95 63.32, 84.56 65.14, 999.0 out-na out 14.0538 Saltbr-na 13.4343 HRD-in -65.1, -50.88 77.35, -20.43 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -71.85, -31.45 APE9-dihe-na -88.8, -3.0 APE8-dihe-out -114.25, -4.42 APE8-rot-out 177.46 APE67-dihe-in -61.34, -27.27 -72.08, -17.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2292 None None None XRAY 2.45 0.17 0.243 A 300.0 269.0 13 27 14 13 [[118, 372]] 1.0 5vo1 TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 5VO2A Q12852 117 398 859.0 9FV:501 Type1 Inactive DFGin 6.2042 14.0707 BLBplus -140.2, 175.38 66.01, 45.19 -115.1, 135.02 57.8, 93.28 88.97, 999.0 out-na out 14.2643 Saltbr-na 13.3999 HRD-in -58.5, -58.5 85.4, -17.84 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -69.83, -27.32 APE9-dihe-na -81.44, -53.81 APE8-dihe-out -58.3, -15.18 APE8-rot-out 186.83 APE67-dihe-in -66.04, -30.04 -63.34, -10.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1348 None None None XRAY 2.96 0.174 0.264 A 300.0 269.0 13 27 14 13 [[118, 372]] 1.0 5vo2 TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 8OURA Q12852 118 396 859.0 W38:501 Type1 Inactive DFGin 6.4194 14.2172 BLBplus -138.96, 175.22 69.83, 31.48 -104.12, 155.29 58.86, 89.33 89.34, 999.0 out-na out 13.8002 Saltbr-na 13.736 HRD-in -67.45, -60.47 86.42, -18.11 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -53.88 APE8-dihe-out -134.6, 2.72 APE8-rot-out 48.27 APE67-dihe-in -59.1, -25.42 -64.53, -15.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2452 None None None XRAY 1.95 0.199 0.255 A 300.0 264.0 15 27 12 15 [[118, 372]] 1.0 8our TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 8OUSA Q12852 118 397 859.0 W3I:501 Type1 Inactive DFGin 6.6019 14.1668 BLBplus -144.35, 176.95 66.08, 42.85 -121.82, 148.93 60.13, 95.34 113.23, 999.0 out-na out 13.7283 Saltbr-na 13.501 HRD-in -75.3, -55.77 83.8, -19.58 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -65.63 APE8-dihe-out -124.8, 12.38 APE8-rot-out 39.55 APE67-dihe-in -59.47, -26.11 -78.96, -17.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.5449 None None None XRAY 2.2 0.183 0.252 A 300.0 265.0 15 27 12 15 [[118, 372]] 1.0 8ous TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 8OUTA Q12852 118 399 859.0 W3C:501 Type1 Inactive DFGin 6.428 14.0514 BLBplus -130.79, 171.93 63.86, 50.04 -121.25, 160.04 54.58, 85.39 75.27, 999.0 out-na out 14.0131 Saltbr-na 13.5461 HRD-in -62.32, -54.97 77.89, -23.21 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -67.75 APE8-dihe-out -118.99, 19.68 APE8-rot-out 66.66 APE67-dihe-in -61.06, -23.63 -71.31, -17.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7162 None None None XRAY 1.935 0.195 0.229 A 300.0 267.0 15 27 12 15 [[118, 372]] 1.0 8out TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 9CDYA Q12852 117 397 859.0 A1AZ8:501 Type1 Inactive DFGin 6.2934 13.9612 BLBplus -140.85, 173.29 70.22, 37.43 -109.99, 164.75 58.42, 92.35 116.78, 52.38 out-na out 13.6816 Saltbr-na 13.4972 HRD-in -66.42, -55.44 82.84, -15.63 na-out-out SNCaoo out-out ActLoopNT-out 10.4278 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -33.28 APE9-dihe-na -82.02, 24.26 APE8-dihe-out -138.17, -34.24 APE8-rot-out 201.2 APE67-dihe-in -63.23, -20.35 -75.74, -14.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.0209 APE9-dist-out 12.6886 None None None XRAY 1.5 0.206 0.24 A 300.0 274.0 7 27 20 7 [[118, 372]] 1.0 9cdy TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 8DEGA Q12852 117 398 859.0 SIQ:501 Type1 Inactive DFGin 6.4246 13.8592 BLBplus -140.72, 170.7 72.07, 23.55 -96.43, 164.97 62.07, 88.25 77.47, 999.0 out-na out 13.512 Saltbr-na 13.0375 HRD-in -55.29, -52.64 83.92, -34.8 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -65.94 APE8-dihe-out -122.31, 39.97 APE8-rot-out 58.58 APE67-dihe-in -59.47, -29.89 -89.13, -20.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.3129 None None None XRAY 2.79 0.251 0.297 A 322.0 267.0 15 27 12 15 [[118, 372]] 1.0 8deg TKL_MAP3K12_HUMAN MAP3K123 1.9e-137 462.5 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 9CDXA Q12852 117 397 859.0 A1AZP:501 Type1 Inactive DFGin 6.5428 13.646 None -140.44, 159.48 81.4, 17.88 -85.98, 999.0 46.51, 94.56 999.0, 999.0 out-na out 13.7947 Saltbr-na 13.5441 HRD-in -72.41, -54.6 86.63, -24.49 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -169.44 APE8-dihe-out -120.92, 37.67 APE8-rot-out 62.69 APE67-dihe-in -60.76, -27.81 -70.5, -18.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6787 None None None XRAY 2.38 0.234 0.284 A 300.0 265.0 16 27 11 16 [[118, 372]] 1.0 9cdx TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12

TKL_MAP3K12 (Mitogen-activated protein kinase kinase kinase 12)

Total number of chains: 14
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 10 71.4% 9CDYA
DFGin BLAminus 2 14.3% AF-Q12852-K1A
DFGin BLBminus 1 7.1% 5CENA
DFGin None 1 7.1% 9CDXA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K12 M3K12_HUMAN AF-Q12852-K1A Q12852 117 374 859.0 No_ligand No_ligand Active DFGin 6.4258 14.4038 BLAminus -135.37, 174.94 59.09, 75.76 -81.87, 15.15 290.24, 86.78 -63.45, -16.18 in-na in 9.0259 Saltbr-na 5.0805 HRD-in -74.58, -46.99 68.83, -6.59 na-in-in SNCaii in-in ActLoopNT-in 2.9293 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.29, 155.5 APE9-dihe-na 115.77, -178.15 APE8-dihe-in -101.06, 126.9 APE8-rot-in 306.9 APE67-dihe-in -65.79, -18.28 -46.31, -46.72 APE12-dist-in 8.8055 APE11-dist-in 11.076 APE10-dist-in 5.3824 APE9-dist-in 3.438 None None None AF2 -1.0 1.0 1.0 A 258.0 258.0 0 27 27 0 [[118, 372]] 1.0 AF-Q12852-K1 Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 8.4e-138 463.6 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 M3K12_HUMAN AF-Q12852-K3A Q12852 117 374 859.0 No_ligand No_ligand Active DFGin 6.2508 14.5575 BLAminus -140.65, -175.73 52.42, 68.88 -73.59, 9.91 294.28, 96.63 -59.3, -19.37 in-na in 9.0783 Saltbr-na 5.3305 HRD-in -74.8, -45.87 67.92, -9.13 na-in-in SNCaii in-in ActLoopNT-in 2.9232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.36, 146.36 APE9-dihe-na 105.87, -173.52 APE8-dihe-in -105.9, 126.7 APE8-rot-in 310.93 APE67-dihe-in -64.79, -18.86 -50.97, -43.69 APE12-dist-in 8.6823 APE11-dist-in 11.2814 APE10-dist-in 5.4772 APE9-dist-in 3.635 None None None AF2 -1.0 1.0 1.0 A 258.0 258.0 0 27 27 0 [[118, 372]] 1.0 AF-Q12852-K3 Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 8.4e-138 463.6 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 M3K12_HUMAN 5CENA Q12852 117 397 859.0 No_ligand No_ligand Inactive DFGin 6.5711 14.5936 BLBminus -139.23, -167.03 41.89, 62.24 -59.37, 141.01 289.88, 76.49 -88.51, 171.86 out-na out 13.3249 Saltbr-na 13.8047 HRD-in -64.3, -49.81 77.36, -11.65 na-out-out SNCaoo out-out ActLoopNT-out 10.4378 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -66.46, -25.65 APE9-dihe-na -69.15, -23.11 APE8-dihe-out -120.04, 27.45 APE8-rot-out 47.83 APE67-dihe-in -54.85, -32.09 -61.13, -20.63 APE12-dist-in 12.7375 APE11-dist-in 10.7082 APE10-dist-out 16.415 APE9-dist-out 12.7049 None None None XRAY 1.7 0.187 0.225 A 300.0 281.0 0 27 27 0 [[118, 372]] 1.0 5cen Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 M3K12_HUMAN 5CEOA Q12852 117 398 859.0 50D:501 Type1 Inactive DFGin 6.5971 14.0857 BLBplus -126.24, 175.81 67.12, 25.36 -93.94, 136.37 52.61, 92.25 91.51, 999.0 out-na out 13.8478 Saltbr-na 13.0081 HRD-in -63.27, -54.52 78.95, -16.59 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -68.21, -27.79 APE9-dihe-na -71.83, -28.25 APE8-dihe-out -98.1, -6.02 APE8-rot-out 179.22 APE67-dihe-in -62.76, -24.87 -51.91, -27.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2704 None None None XRAY 2.28 0.19 0.248 A 300.0 269.0 13 27 14 13 [[118, 372]] 1.0 5ceo Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 M3K12_HUMAN 5CEPA Q12852 117 398 859.0 50E:501 Type1 Inactive DFGin 6.3848 14.1124 BLBplus -133.95, 176.37 61.43, 47.97 -122.18, 164.22 62.69, 87.15 70.44, 999.0 out-na out 13.9686 Saltbr-na 13.1355 HRD-in -62.94, -52.59 77.57, -18.56 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -70.69, -32.93 APE9-dihe-na -93.66, 31.57 APE8-dihe-out -146.83, -4.84 APE8-rot-out 193.07 APE67-dihe-in -54.11, -31.23 -68.11, -24.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1938 None None None XRAY 1.99 0.175 0.23 A 300.0 269.0 13 27 14 13 [[118, 372]] 1.0 5cep Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 M3K12_HUMAN 5CEQA Q12852 117 398 859.0 50F:4000 Type1 Inactive DFGin 6.2846 14.1433 BLBplus -139.34, 175.24 65.23, 33.46 -103.17, 163.52 57.07, 90.2 71.88, 999.0 out-na out 13.9369 Saltbr-na 13.2447 HRD-in -61.44, -57.14 79.98, -14.5 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -71.43, -48.01 APE9-dihe-na -72.5, -0.08 APE8-dihe-out -118.56, -4.99 APE8-rot-out 184.08 APE67-dihe-in -55.04, -30.89 -63.03, -27.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1318 None None None XRAY 1.911 0.171 0.218 A 300.0 269.0 13 27 14 13 [[118, 372]] 1.0 5ceq Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 M3K12_HUMAN 5VO1A Q12852 117 398 859.0 9FS:501 Type1 Inactive DFGin 6.2008 14.0511 BLBplus -138.68, 175.38 61.55, 50.37 -122.24, 158.95 63.32, 84.56 65.14, 999.0 out-na out 14.0538 Saltbr-na 13.4343 HRD-in -65.1, -50.88 77.35, -20.43 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -71.85, -31.45 APE9-dihe-na -88.8, -3.0 APE8-dihe-out -114.25, -4.42 APE8-rot-out 177.46 APE67-dihe-in -61.34, -27.27 -72.08, -17.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2292 None None None XRAY 2.45 0.17 0.243 A 300.0 269.0 13 27 14 13 [[118, 372]] 1.0 5vo1 Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 M3K12_HUMAN 5VO2A Q12852 117 398 859.0 9FV:501 Type1 Inactive DFGin 6.2042 14.0707 BLBplus -140.2, 175.38 66.01, 45.19 -115.1, 135.02 57.8, 93.28 88.97, 999.0 out-na out 14.2643 Saltbr-na 13.3999 HRD-in -58.5, -58.5 85.4, -17.84 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -69.83, -27.32 APE9-dihe-na -81.44, -53.81 APE8-dihe-out -58.3, -15.18 APE8-rot-out 186.83 APE67-dihe-in -66.04, -30.04 -63.34, -10.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1348 None None None XRAY 2.96 0.174 0.264 A 300.0 269.0 13 27 14 13 [[118, 372]] 1.0 5vo2 Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 M3K12_HUMAN 8OURA Q12852 118 396 859.0 W38:501 Type1 Inactive DFGin 6.4194 14.2172 BLBplus -138.96, 175.22 69.83, 31.48 -104.12, 155.29 58.86, 89.33 89.34, 999.0 out-na out 13.8002 Saltbr-na 13.736 HRD-in -67.45, -60.47 86.42, -18.11 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -53.88 APE8-dihe-out -134.6, 2.72 APE8-rot-out 48.27 APE67-dihe-in -59.1, -25.42 -64.53, -15.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2452 None None None XRAY 1.95 0.199 0.255 A 300.0 264.0 15 27 12 15 [[118, 372]] 1.0 8our Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 M3K12_HUMAN 8OUSA Q12852 118 397 859.0 W3I:501 Type1 Inactive DFGin 6.6019 14.1668 BLBplus -144.35, 176.95 66.08, 42.85 -121.82, 148.93 60.13, 95.34 113.23, 999.0 out-na out 13.7283 Saltbr-na 13.501 HRD-in -75.3, -55.77 83.8, -19.58 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -65.63 APE8-dihe-out -124.8, 12.38 APE8-rot-out 39.55 APE67-dihe-in -59.47, -26.11 -78.96, -17.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.5449 None None None XRAY 2.2 0.183 0.252 A 300.0 265.0 15 27 12 15 [[118, 372]] 1.0 8ous Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 M3K12_HUMAN 8OUTA Q12852 118 399 859.0 W3C:501 Type1 Inactive DFGin 6.428 14.0514 BLBplus -130.79, 171.93 63.86, 50.04 -121.25, 160.04 54.58, 85.39 75.27, 999.0 out-na out 14.0131 Saltbr-na 13.5461 HRD-in -62.32, -54.97 77.89, -23.21 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -67.75 APE8-dihe-out -118.99, 19.68 APE8-rot-out 66.66 APE67-dihe-in -61.06, -23.63 -71.31, -17.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7162 None None None XRAY 1.935 0.195 0.229 A 300.0 267.0 15 27 12 15 [[118, 372]] 1.0 8out Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 M3K12_HUMAN 9CDYA Q12852 117 397 859.0 A1AZ8:501 Type1 Inactive DFGin 6.2934 13.9612 BLBplus -140.85, 173.29 70.22, 37.43 -109.99, 164.75 58.42, 92.35 116.78, 52.38 out-na out 13.6816 Saltbr-na 13.4972 HRD-in -66.42, -55.44 82.84, -15.63 na-out-out SNCaoo out-out ActLoopNT-out 10.4278 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -33.28 APE9-dihe-na -82.02, 24.26 APE8-dihe-out -138.17, -34.24 APE8-rot-out 201.2 APE67-dihe-in -63.23, -20.35 -75.74, -14.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.0209 APE9-dist-out 12.6886 None None None XRAY 1.5 0.206 0.24 A 300.0 274.0 7 27 20 7 [[118, 372]] 1.0 9cdy Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 M3K12_HUMAN 8DEGA Q12852 117 398 859.0 SIQ:501 Type1 Inactive DFGin 6.4246 13.8592 BLBplus -140.72, 170.7 72.07, 23.55 -96.43, 164.97 62.07, 88.25 77.47, 999.0 out-na out 13.512 Saltbr-na 13.0375 HRD-in -55.29, -52.64 83.92, -34.8 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -65.94 APE8-dihe-out -122.31, 39.97 APE8-rot-out 58.58 APE67-dihe-in -59.47, -29.89 -89.13, -20.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.3129 None None None XRAY 2.79 0.251 0.297 A 322.0 267.0 15 27 12 15 [[118, 372]] 1.0 8deg Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.9e-137 462.5 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
MAP3K12 M3K12_HUMAN 9CDXA Q12852 117 397 859.0 A1AZP:501 Type1 Inactive DFGin 6.5428 13.646 None -140.44, 159.48 81.4, 17.88 -85.98, 999.0 46.51, 94.56 999.0, 999.0 out-na out 13.7947 Saltbr-na 13.5441 HRD-in -72.41, -54.6 86.63, -24.49 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -169.44 APE8-dihe-out -120.92, 37.67 APE8-rot-out 62.69 APE67-dihe-in -60.76, -27.81 -70.5, -18.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6787 None None None XRAY 2.38 0.234 0.284 A 300.0 265.0 16 27 11 16 [[118, 372]] 1.0 9cdx Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12

TKL_MAP3K12 (Mitogen-activated protein kinase kinase kinase 12)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name