TKL_LIMK2 (LIM domain kinase 2)

Total number of chains: 16
Active chains: 2
Uniprot: LIMK2_HUMAN
Kinase Domain Residues: 331 - 603
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 8 50.0% 8WSWA
DFGout BBAminus 5 31.2% 7QHGA
DFGin BLAminus 2 12.5% AF-P53671-K1A
DFGout None 1 6.2% 5NXDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P53671-K1A 323 611 638.0 No_ligand No_ligand Active DFGin 6.511 13.736 BLAminus -134.75, 175.62 57.17, 86.12 -93.67, 14.29 301.98, 99.12 -59.64, -26.69 in-in in 8.092 Saltbr-in 2.678 HRD-in -72.66, -48.28 64.19, -3.0 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -147.49, 164.32 APE9-dihe-na 96.07, 174.47 APE8-dihe-in -73.12, 124.78 APE8-rot-na 189.54 APE67-dihe-in -70.32, -25.23 -54.49, -28.96 APE12-dist-in 9.09 APE11-dist-in 11.36 APE10-dist-in 5.624 APE9-dist-in 3.67 None None None AF2 -1.0 1.0 1.0 A 289 289 0 0 0 0 [[331, 603]] 1.0 AF-P53671-K1 TKL_LIMK2_HUMAN TKL 5.7e-77 264.8 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
AF-P53671-K3A 323 611 638.0 No_ligand No_ligand Active DFGin 6.264 13.809 BLAminus -130.27, -175.29 58.97, 58.85 -75.83, 12.84 306.94, 98.49 -58.49, -35.4 in-in in 7.69 Saltbr-in 2.696 HRD-in -74.5, -47.78 65.54, -4.55 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -148.69, 159.52 APE9-dihe-na 98.04, 172.75 APE8-dihe-in -73.22, 126.58 APE8-rot-na 186.23 APE67-dihe-in -69.63, -30.61 -59.8, -23.94 APE12-dist-in 9.121 APE11-dist-in 11.143 APE10-dist-in 5.404 APE9-dist-in 3.693 None None None AF2 -1.0 1.0 1.0 A 289 289 0 0 0 0 [[331, 603]] 1.0 AF-P53671-K3 TKL_LIMK2_HUMAN TKL 5.7e-77 264.8 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
8WSWA 330 632 638.0 LH0:701 Type1 Inactive DFGin 6.224 13.083 BLBplus -143.86, 164.67 66.05, 45.45 -99.55, 149.37 45.26, 77.07 128.31, -28.75 out-out out 15.585 Saltbr-out 13.7 HRD-in -62.1, -64.33 86.32, -11.58 out-out-out SNCooo out-out ActLoopNT-out 10.36 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -144.43, 115.19 APE9-dihe-na 97.95, -174.87 APE8-dihe-in -74.35, 110.98 APE8-rot-na 35.75 APE67-dihe-in -80.15, -5.25 -93.18, 6.59 APE12-dist-out 14.469 APE11-dist-in 12.786 APE10-dist-out 13.139 APE9-dist-out 11.546 None None None XRAY 2.5 0.212 0.256 A 303 281 22 0 0 22 [[331, 603]] 1.0 8wsw TKL_LIMK2_HUMAN TKL 6.8e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
8WSWB 330 632 638.0 LH0:701 Type1 Inactive DFGin 6.196 13.02 BLBplus -144.33, 164.55 66.39, 44.42 -99.91, 149.51 45.77, 76.85 127.25, -28.39 out-out out 15.547 Saltbr-out 14.029 HRD-in -62.31, -64.15 86.83, -11.17 out-out-out SNCooo out-out ActLoopNT-out 10.339 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -145.0, 114.92 APE9-dihe-na 99.06, -178.29 APE8-dihe-in -72.51, 110.69 APE8-rot-na 34.98 APE67-dihe-in -80.47, -5.7 -93.47, 6.74 APE12-dist-out 14.456 APE11-dist-in 12.815 APE10-dist-out 13.029 APE9-dist-out 11.391 None None None XRAY 2.5 0.212 0.256 B 303 281 22 0 0 22 [[331, 603]] 1.0 8wsw TKL_LIMK2_HUMAN TKL 6.8e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
8WSWC 330 632 638.0 LH0:701 Type1 Inactive DFGin 6.206 13.056 BLBplus -143.75, 164.15 66.94, 45.19 -100.18, 150.72 45.03, 76.69 126.96, -28.24 out-out out 15.583 Saltbr-out 13.805 HRD-in -62.29, -64.05 86.34, -11.59 out-out-out SNCooo out-out ActLoopNT-out 10.322 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -138.85, 0.68 APE9-dihe-na -100.32, -174.72 APE8-dihe-in -60.21, 114.43 APE8-rot-na 201.59 APE67-dihe-in -78.75, 1.25 -92.38, 7.31 APE12-dist-out 14.393 APE11-dist-in 12.854 APE10-dist-out 13.326 APE9-dist-out 10.579 None None None XRAY 2.5 0.212 0.256 C 303 281 22 0 0 22 [[331, 603]] 1.0 8wsw TKL_LIMK2_HUMAN TKL 6.8e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
8WSWD 330 632 638.0 LH0:701 Type1 Inactive DFGin 6.171 12.986 BLBplus -144.42, 164.29 66.67, 44.97 -99.33, 148.78 44.58, 76.12 128.82, -27.92 out-out out 15.501 Saltbr-out 13.888 HRD-in -63.12, -64.04 86.22, -11.79 out-out-out SNCooo out-out ActLoopNT-out 10.34 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -139.44, -0.07 APE9-dihe-na -100.72, -173.49 APE8-dihe-in -61.82, 114.37 APE8-rot-na 201.16 APE67-dihe-in -77.38, -2.64 -91.99, 7.01 APE12-dist-out 14.416 APE11-dist-in 12.796 APE10-dist-out 13.073 APE9-dist-out 10.399 None None None XRAY 2.5 0.212 0.256 D 303 281 22 0 0 22 [[331, 603]] 1.0 8wsw TKL_LIMK2_HUMAN TKL 6.8e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
8S3XA 334 631 638.0 A1H41:701 Type1 Inactive DFGin 5.968 12.403 BLBplus -144.26, 168.7 62.94, 31.05 -79.6, 145.9 45.8, 92.76 123.71, -30.5 out-none out 14.884 Saltbr-none 999.0 HRD-in -63.88, -62.21 88.2, -18.53 none-out-out SNCnoo out-out ActLoopNT-out 10.354 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -127.59, 120.27 APE9-dihe-na 104.21, -135.23 APE8-dihe-in -76.76, 84.76 APE8-rot-na 300.32 APE67-dihe-in -90.86, 2.54 -87.78, -14.33 APE12-dist-out 14.295 APE11-dist-in 12.733 APE10-dist-out 12.36 APE9-dist-out 11.23 None None None XRAY 2.59 0.241 0.287 A 305 268 33 0 0 21 [[331, 603]] 1.0 8s3x TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
8S3XB 330 631 638.0 A1H41:701 Type1 Inactive DFGin 5.823 12.34 BLBplus -140.47, 174.67 57.06, 33.75 -83.23, 147.94 48.1, 85.96 121.47, -43.89 out-none out 15.197 Saltbr-none 999.0 HRD-in -65.42, -53.26 80.26, -11.88 none-out-out SNCnoo out-out ActLoopNT-out 10.382 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -134.6, 126.18 APE9-dihe-na 102.32, -143.25 APE8-dihe-in -76.94, 86.92 APE8-rot-na 318.29 APE67-dihe-in -93.48, 5.12 -82.1, -10.72 APE12-dist-out 14.42 APE11-dist-in 12.563 APE10-dist-out 12.432 APE9-dist-out 11.2 None None None XRAY 2.59 0.241 0.287 B 305 275 26 0 0 24 [[331, 603]] 1.0 8s3x TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
8S3XC 330 631 638.0 A1H41:701 Type1 Inactive DFGin 5.626 12.148 BLBplus -137.5, 171.28 65.93, 29.0 -85.35, 149.91 49.85, 78.23 113.39, -24.66 out-out out 14.454 Saltbr-out 11.614 HRD-in -65.26, -56.37 85.12, -14.69 out-out-out SNCooo out-out ActLoopNT-out 10.308 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -130.28, 119.65 APE9-dihe-na 112.63, -103.47 APE8-dihe-in -105.17, 77.25 APE8-rot-na 290.31 APE67-dihe-in -73.22, -12.55 -89.24, -18.87 APE12-dist-out 14.43 APE11-dist-in 12.605 APE10-dist-out 12.503 APE9-dist-out 11.316 None None None XRAY 2.59 0.241 0.287 C 305 273 27 0 0 25 [[331, 603]] 1.0 8s3x TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
8S3XD 331 631 638.0 A1H41:701 Type1 Inactive DFGin 5.988 12.294 BLBplus -146.38, 170.29 65.22, 26.89 -76.65, 149.04 41.28, 82.37 119.61, -16.8 out-none out 15.112 Saltbr-none 999.0 HRD-in -63.2, -53.54 81.77, -12.2 none-out-out SNCnoo out-out ActLoopNT-out 10.364 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -128.93, 122.05 APE9-dihe-na 107.92, -105.9 APE8-dihe-in -103.55, 77.8 APE8-rot-na 295.03 APE67-dihe-in -72.5, -18.88 -85.85, -21.49 APE12-dist-out 14.413 APE11-dist-in 12.628 APE10-dist-out 12.411 APE9-dist-out 11.468 None None None XRAY 2.59 0.241 0.287 D 305 263 36 0 0 26 [[331, 603]] 1.0 8s3x TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
7QHGA 330 632 638.0 T3B:60701 Type2 Inactive DFGout 17.106 11.746 BBAminus -120.68, -179.95 -148.07, 82.27 -63.69, -35.06 297.46, 151.72 -95.03, 6.19 out-out out 15.901 Saltbr-out 14.972 HRD-in -69.22, -58.45 80.73, -9.42 out-out-out SNCooo out-out ActLoopNT-out 4.415 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooo APE10-dihe-na -132.96, 150.13 APE9-dihe-na 122.11, -127.07 APE8-dihe-in -121.56, 98.92 APE8-rot-na 291.42 APE67-dihe-in -67.87, -23.41 -89.26, 16.88 APE12-dist-out 19.149 APE11-dist-out 16.283 APE10-dist-out 16.046 APE9-dist-out 11.184 None None None XRAY 1.45 0.166 0.177 A 305 282 21 0 0 21 [[331, 603]] 1.0 7qhg TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
7QHGB 330 632 638.0 T3B:60701 Type2 Inactive DFGout 17.212 12.137 BBAminus -115.77, 177.7 -145.12, 83.29 -66.87, -32.88 299.11, 134.99 -99.0, 8.98 out-out out 15.637 Saltbr-out 15.229 HRD-in -68.94, -54.88 80.26, -12.53 out-out-out SNCooo out-out ActLoopNT-out 4.417 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_iooo APE10-dihe-na -153.58, 152.19 APE9-dihe-na 72.86, 27.01 APE8-dihe-out 69.41, 81.19 APE8-rot-na 313.41 APE67-dihe-out -61.53, -27.57 -82.37, 89.51 APE12-dist-in 12.499 APE11-dist-out 14.623 APE10-dist-out 14.118 APE9-dist-out 12.649 None None None XRAY 1.45 0.166 0.177 B 305 281 22 0 0 22 [[331, 603]] 1.0 7qhg TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
4TPTA 330 631 638.0 35H:701 Type3 Inactive DFGout 16.096 11.142 BBAminus -114.59, 179.84 -146.01, 83.03 -70.78, -31.53 290.09, 109.97 -82.43, -2.78 out-out out 15.862 Saltbr-out 16.376 HRD-in -70.45, -54.99 74.1, -7.22 out-out-out SNCooo out-out ActLoopNT-out 4.568 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -135.17, 156.48 APE9-dihe-na 121.28, -168.66 APE8-dihe-in -107.67, 124.96 APE8-rot-na 184.54 APE67-dihe-in -64.31, -24.66 -54.17, -26.81 APE12-dist-in 12.014 APE11-dist-out 14.643 APE10-dist-out 8.775 APE9-dist-in 3.89 None None None XRAY 2.6 0.223 0.274 A 303 279 23 0 0 23 [[331, 603]] 1.0 4tpt TKL_LIMK2_HUMAN TKL 6.8e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
4TPTB 330 632 638.0 35H:701 Type3 Inactive DFGout 16.355 11.034 BBAminus -130.75, -177.01 -149.57, 73.72 -61.92, -29.69 288.54, 113.54 -95.75, 7.29 out-out out 15.844 Saltbr-out 15.526 HRD-in -72.14, -56.53 86.02, -32.37 out-out-out SNCooo out-out ActLoopNT-out 4.602 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -134.67, 147.66 APE9-dihe-na 124.79, 175.82 APE8-dihe-in -86.47, 130.25 APE8-rot-na 184.44 APE67-dihe-in -70.78, -18.97 -49.94, -29.41 APE12-dist-in 12.536 APE11-dist-out 14.694 APE10-dist-out 8.83 APE9-dist-in 4.468 None None None XRAY 2.6 0.223 0.274 B 303 277 26 0 0 26 [[331, 603]] 1.0 4tpt TKL_LIMK2_HUMAN TKL 6.8e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
5NXDB 330 632 638.0 9D8:701 Type3 Inactive DFGout 15.929 9.622 BBAminus -120.85, -179.43 -146.81, 73.71 -62.47, -25.15 278.45, 45.25 -102.04, 2.18 out-out out 15.912 Saltbr-out 15.763 HRD-in -73.52, -53.98 77.3, -13.62 out-out-none SNCoon out-none ActLoopNT-out 4.503 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.09, -26.34 999.0, 50.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.197 0.23 B 305 271 32 0 0 32 [[331, 603]] 1.0 5nxd TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
5NXDA 330 632 638.0 9D8:701 Type3 Inactive DFGout 18.215 8.199 None -133.95, 177.46 -146.72, 77.25 -55.91, -32.79 190.69, 79.33 -96.52, 3.25 out-out out 16.007 Saltbr-out 14.828 HRD-in -75.21, -55.71 76.14, -4.58 out-out-none SNCoon out-none ActLoopNT-out 4.382 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.14, -25.71 999.0, -20.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.197 0.23 A 305 271 32 0 0 32 [[331, 603]] 1.0 5nxd TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2

TKL_LIMK2 (LIM domain kinase 2)

Total number of chains: 16
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 8 50.0% 8WSWA
DFGout BBAminus 5 31.2% 7QHGA
DFGin BLAminus 2 12.5% AF-P53671-K1A
DFGout None 1 6.2% 5NXDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
LIMK2_HUMAN AF-P53671-K1A P53671 323 611 638.0 No_ligand No_ligand Active DFGin 6.511 13.736 BLAminus -134.75, 175.62 57.17, 86.12 -93.67, 14.29 301.98, 99.12 -59.64, -26.69 in-in in 8.092 Saltbr-in 2.678 HRD-in -72.66, -48.28 64.19, -3.0 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -147.49, 164.32 APE9-dihe-na 96.07, 174.47 APE8-dihe-in -73.12, 124.78 APE8-rot-na 189.54 APE67-dihe-in -70.32, -25.23 -54.49, -28.96 APE12-dist-in 9.09 APE11-dist-in 11.36 APE10-dist-in 5.624 APE9-dist-in 3.67 None None None AF2 -1.0 1.0 1.0 A 289 289 0 0 0 0 [[331, 603]] 1.0 AF-P53671-K1 Homo sapiens TKL_LIMK2_HUMAN TKL 5.7e-77 264.8 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN AF-P53671-K3A P53671 323 611 638.0 No_ligand No_ligand Active DFGin 6.264 13.809 BLAminus -130.27, -175.29 58.97, 58.85 -75.83, 12.84 306.94, 98.49 -58.49, -35.4 in-in in 7.69 Saltbr-in 2.696 HRD-in -74.5, -47.78 65.54, -4.55 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -148.69, 159.52 APE9-dihe-na 98.04, 172.75 APE8-dihe-in -73.22, 126.58 APE8-rot-na 186.23 APE67-dihe-in -69.63, -30.61 -59.8, -23.94 APE12-dist-in 9.121 APE11-dist-in 11.143 APE10-dist-in 5.404 APE9-dist-in 3.693 None None None AF2 -1.0 1.0 1.0 A 289 289 0 0 0 0 [[331, 603]] 1.0 AF-P53671-K3 Homo sapiens TKL_LIMK2_HUMAN TKL 5.7e-77 264.8 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN 8WSWA P53671 330 632 638.0 LH0:701 Type1 Inactive DFGin 6.224 13.083 BLBplus -143.86, 164.67 66.05, 45.45 -99.55, 149.37 45.26, 77.07 128.31, -28.75 out-out out 15.585 Saltbr-out 13.7 HRD-in -62.1, -64.33 86.32, -11.58 out-out-out SNCooo out-out ActLoopNT-out 10.36 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -144.43, 115.19 APE9-dihe-na 97.95, -174.87 APE8-dihe-in -74.35, 110.98 APE8-rot-na 35.75 APE67-dihe-in -80.15, -5.25 -93.18, 6.59 APE12-dist-out 14.469 APE11-dist-in 12.786 APE10-dist-out 13.139 APE9-dist-out 11.546 None None None XRAY 2.5 0.212 0.256 A 303 281 22 0 0 22 [[331, 603]] 1.0 8wsw Homo sapiens TKL_LIMK2_HUMAN TKL 6.8e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN 8WSWB P53671 330 632 638.0 LH0:701 Type1 Inactive DFGin 6.196 13.02 BLBplus -144.33, 164.55 66.39, 44.42 -99.91, 149.51 45.77, 76.85 127.25, -28.39 out-out out 15.547 Saltbr-out 14.029 HRD-in -62.31, -64.15 86.83, -11.17 out-out-out SNCooo out-out ActLoopNT-out 10.339 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -145.0, 114.92 APE9-dihe-na 99.06, -178.29 APE8-dihe-in -72.51, 110.69 APE8-rot-na 34.98 APE67-dihe-in -80.47, -5.7 -93.47, 6.74 APE12-dist-out 14.456 APE11-dist-in 12.815 APE10-dist-out 13.029 APE9-dist-out 11.391 None None None XRAY 2.5 0.212 0.256 B 303 281 22 0 0 22 [[331, 603]] 1.0 8wsw Homo sapiens TKL_LIMK2_HUMAN TKL 6.8e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN 8WSWC P53671 330 632 638.0 LH0:701 Type1 Inactive DFGin 6.206 13.056 BLBplus -143.75, 164.15 66.94, 45.19 -100.18, 150.72 45.03, 76.69 126.96, -28.24 out-out out 15.583 Saltbr-out 13.805 HRD-in -62.29, -64.05 86.34, -11.59 out-out-out SNCooo out-out ActLoopNT-out 10.322 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -138.85, 0.68 APE9-dihe-na -100.32, -174.72 APE8-dihe-in -60.21, 114.43 APE8-rot-na 201.59 APE67-dihe-in -78.75, 1.25 -92.38, 7.31 APE12-dist-out 14.393 APE11-dist-in 12.854 APE10-dist-out 13.326 APE9-dist-out 10.579 None None None XRAY 2.5 0.212 0.256 C 303 281 22 0 0 22 [[331, 603]] 1.0 8wsw Homo sapiens TKL_LIMK2_HUMAN TKL 6.8e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN 8WSWD P53671 330 632 638.0 LH0:701 Type1 Inactive DFGin 6.171 12.986 BLBplus -144.42, 164.29 66.67, 44.97 -99.33, 148.78 44.58, 76.12 128.82, -27.92 out-out out 15.501 Saltbr-out 13.888 HRD-in -63.12, -64.04 86.22, -11.79 out-out-out SNCooo out-out ActLoopNT-out 10.34 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -139.44, -0.07 APE9-dihe-na -100.72, -173.49 APE8-dihe-in -61.82, 114.37 APE8-rot-na 201.16 APE67-dihe-in -77.38, -2.64 -91.99, 7.01 APE12-dist-out 14.416 APE11-dist-in 12.796 APE10-dist-out 13.073 APE9-dist-out 10.399 None None None XRAY 2.5 0.212 0.256 D 303 281 22 0 0 22 [[331, 603]] 1.0 8wsw Homo sapiens TKL_LIMK2_HUMAN TKL 6.8e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN 8S3XA P53671 334 631 638.0 A1H41:701 Type1 Inactive DFGin 5.968 12.403 BLBplus -144.26, 168.7 62.94, 31.05 -79.6, 145.9 45.8, 92.76 123.71, -30.5 out-none out 14.884 Saltbr-none 999.0 HRD-in -63.88, -62.21 88.2, -18.53 none-out-out SNCnoo out-out ActLoopNT-out 10.354 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -127.59, 120.27 APE9-dihe-na 104.21, -135.23 APE8-dihe-in -76.76, 84.76 APE8-rot-na 300.32 APE67-dihe-in -90.86, 2.54 -87.78, -14.33 APE12-dist-out 14.295 APE11-dist-in 12.733 APE10-dist-out 12.36 APE9-dist-out 11.23 None None None XRAY 2.59 0.241 0.287 A 305 268 33 0 0 21 [[331, 603]] 1.0 8s3x Homo sapiens TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN 8S3XB P53671 330 631 638.0 A1H41:701 Type1 Inactive DFGin 5.823 12.34 BLBplus -140.47, 174.67 57.06, 33.75 -83.23, 147.94 48.1, 85.96 121.47, -43.89 out-none out 15.197 Saltbr-none 999.0 HRD-in -65.42, -53.26 80.26, -11.88 none-out-out SNCnoo out-out ActLoopNT-out 10.382 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -134.6, 126.18 APE9-dihe-na 102.32, -143.25 APE8-dihe-in -76.94, 86.92 APE8-rot-na 318.29 APE67-dihe-in -93.48, 5.12 -82.1, -10.72 APE12-dist-out 14.42 APE11-dist-in 12.563 APE10-dist-out 12.432 APE9-dist-out 11.2 None None None XRAY 2.59 0.241 0.287 B 305 275 26 0 0 24 [[331, 603]] 1.0 8s3x Homo sapiens TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN 8S3XC P53671 330 631 638.0 A1H41:701 Type1 Inactive DFGin 5.626 12.148 BLBplus -137.5, 171.28 65.93, 29.0 -85.35, 149.91 49.85, 78.23 113.39, -24.66 out-out out 14.454 Saltbr-out 11.614 HRD-in -65.26, -56.37 85.12, -14.69 out-out-out SNCooo out-out ActLoopNT-out 10.308 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -130.28, 119.65 APE9-dihe-na 112.63, -103.47 APE8-dihe-in -105.17, 77.25 APE8-rot-na 290.31 APE67-dihe-in -73.22, -12.55 -89.24, -18.87 APE12-dist-out 14.43 APE11-dist-in 12.605 APE10-dist-out 12.503 APE9-dist-out 11.316 None None None XRAY 2.59 0.241 0.287 C 305 273 27 0 0 25 [[331, 603]] 1.0 8s3x Homo sapiens TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN 8S3XD P53671 331 631 638.0 A1H41:701 Type1 Inactive DFGin 5.988 12.294 BLBplus -146.38, 170.29 65.22, 26.89 -76.65, 149.04 41.28, 82.37 119.61, -16.8 out-none out 15.112 Saltbr-none 999.0 HRD-in -63.2, -53.54 81.77, -12.2 none-out-out SNCnoo out-out ActLoopNT-out 10.364 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -128.93, 122.05 APE9-dihe-na 107.92, -105.9 APE8-dihe-in -103.55, 77.8 APE8-rot-na 295.03 APE67-dihe-in -72.5, -18.88 -85.85, -21.49 APE12-dist-out 14.413 APE11-dist-in 12.628 APE10-dist-out 12.411 APE9-dist-out 11.468 None None None XRAY 2.59 0.241 0.287 D 305 263 36 0 0 26 [[331, 603]] 1.0 8s3x Homo sapiens TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN 7QHGA P53671 330 632 638.0 T3B:60701 Type2 Inactive DFGout 17.106 11.746 BBAminus -120.68, -179.95 -148.07, 82.27 -63.69, -35.06 297.46, 151.72 -95.03, 6.19 out-out out 15.901 Saltbr-out 14.972 HRD-in -69.22, -58.45 80.73, -9.42 out-out-out SNCooo out-out ActLoopNT-out 4.415 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooo APE10-dihe-na -132.96, 150.13 APE9-dihe-na 122.11, -127.07 APE8-dihe-in -121.56, 98.92 APE8-rot-na 291.42 APE67-dihe-in -67.87, -23.41 -89.26, 16.88 APE12-dist-out 19.149 APE11-dist-out 16.283 APE10-dist-out 16.046 APE9-dist-out 11.184 None None None XRAY 1.45 0.166 0.177 A 305 282 21 0 0 21 [[331, 603]] 1.0 7qhg Homo sapiens TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN 7QHGB P53671 330 632 638.0 T3B:60701 Type2 Inactive DFGout 17.212 12.137 BBAminus -115.77, 177.7 -145.12, 83.29 -66.87, -32.88 299.11, 134.99 -99.0, 8.98 out-out out 15.637 Saltbr-out 15.229 HRD-in -68.94, -54.88 80.26, -12.53 out-out-out SNCooo out-out ActLoopNT-out 4.417 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_iooo APE10-dihe-na -153.58, 152.19 APE9-dihe-na 72.86, 27.01 APE8-dihe-out 69.41, 81.19 APE8-rot-na 313.41 APE67-dihe-out -61.53, -27.57 -82.37, 89.51 APE12-dist-in 12.499 APE11-dist-out 14.623 APE10-dist-out 14.118 APE9-dist-out 12.649 None None None XRAY 1.45 0.166 0.177 B 305 281 22 0 0 22 [[331, 603]] 1.0 7qhg Homo sapiens TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN 4TPTA P53671 330 631 638.0 35H:701 Type3 Inactive DFGout 16.096 11.142 BBAminus -114.59, 179.84 -146.01, 83.03 -70.78, -31.53 290.09, 109.97 -82.43, -2.78 out-out out 15.862 Saltbr-out 16.376 HRD-in -70.45, -54.99 74.1, -7.22 out-out-out SNCooo out-out ActLoopNT-out 4.568 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -135.17, 156.48 APE9-dihe-na 121.28, -168.66 APE8-dihe-in -107.67, 124.96 APE8-rot-na 184.54 APE67-dihe-in -64.31, -24.66 -54.17, -26.81 APE12-dist-in 12.014 APE11-dist-out 14.643 APE10-dist-out 8.775 APE9-dist-in 3.89 None None None XRAY 2.6 0.223 0.274 A 303 279 23 0 0 23 [[331, 603]] 1.0 4tpt Homo sapiens TKL_LIMK2_HUMAN TKL 6.8e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN 4TPTB P53671 330 632 638.0 35H:701 Type3 Inactive DFGout 16.355 11.034 BBAminus -130.75, -177.01 -149.57, 73.72 -61.92, -29.69 288.54, 113.54 -95.75, 7.29 out-out out 15.844 Saltbr-out 15.526 HRD-in -72.14, -56.53 86.02, -32.37 out-out-out SNCooo out-out ActLoopNT-out 4.602 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -134.67, 147.66 APE9-dihe-na 124.79, 175.82 APE8-dihe-in -86.47, 130.25 APE8-rot-na 184.44 APE67-dihe-in -70.78, -18.97 -49.94, -29.41 APE12-dist-in 12.536 APE11-dist-out 14.694 APE10-dist-out 8.83 APE9-dist-in 4.468 None None None XRAY 2.6 0.223 0.274 B 303 277 26 0 0 26 [[331, 603]] 1.0 4tpt Homo sapiens TKL_LIMK2_HUMAN TKL 6.8e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN 5NXDB P53671 330 632 638.0 9D8:701 Type3 Inactive DFGout 15.929 9.622 BBAminus -120.85, -179.43 -146.81, 73.71 -62.47, -25.15 278.45, 45.25 -102.04, 2.18 out-out out 15.912 Saltbr-out 15.763 HRD-in -73.52, -53.98 77.3, -13.62 out-out-none SNCoon out-none ActLoopNT-out 4.503 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.09, -26.34 999.0, 50.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.197 0.23 B 305 271 32 0 0 32 [[331, 603]] 1.0 5nxd Homo sapiens TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
LIMK2_HUMAN 5NXDA P53671 330 632 638.0 9D8:701 Type3 Inactive DFGout 18.215 8.199 None -133.95, 177.46 -146.72, 77.25 -55.91, -32.79 190.69, 79.33 -96.52, 3.25 out-out out 16.007 Saltbr-out 14.828 HRD-in -75.21, -55.71 76.14, -4.58 out-out-none SNCoon out-none ActLoopNT-out 4.382 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.14, -25.71 999.0, -20.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.197 0.23 A 305 271 32 0 0 32 [[331, 603]] 1.0 5nxd Homo sapiens TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2

TKL_LIMK2 (LIM domain kinase 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name