TYR_EPHA2 (Ephrin type-A receptor 2)

Total number of chains: 81
Active chains: 2
Family: TYR
Uniprot: EPHA2_HUMAN
Kinase Domain Residues: 613 - 873
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 28 34.6% 5NKGA
DFGout BBAminus 23 28.4% 8BOKA
DFGin BLAminus 15 18.5% AF-P29317-K1A
DFGin ABAminus 8 9.9% 7KJBA
DFGout None 4 4.9% 5IA5A
DFGin None 3 3.7% 5IA1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P29317-K1A 605 881 976.0 No_ligand No_ligand Active DFGin 6.249 14.768 BLAminus -140.35, -178.11 60.68, 63.96 -83.01, 12.49 290.7, 90.65 -60.91, -32.34 in-in in 8.263 Saltbr-in 2.648 HRD-in -81.0, -41.9 68.37, -20.17 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.13, 136.01 APE9-dihe-in -119.41, 124.38 APE8-dihe-in -75.94, 80.27 APE8-rot-na 33.64 APE67-dihe-in -68.13, -20.7 -44.4, -43.02 APE12-dist-na 11.38 APE11-dist-na 9.019 APE10-dist-na 9.306 APE9-dist-in 6.356 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[613, 873]] 1.0 AF-P29317-K1 TYR_EPHA2_HUMAN TYR 3.8e-108 366.6 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
AF-P29317-K3A 605 881 976.0 No_ligand No_ligand Active DFGin 5.997 14.36 BLAminus -144.91, -177.93 57.46, 72.8 -83.35, 12.16 291.82, 92.9 -59.12, -31.93 in-in in 8.31 Saltbr-in 2.7 HRD-in -79.58, -45.38 67.22, -10.26 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.02, 141.9 APE9-dihe-in -124.72, 138.13 APE8-dihe-in -75.91, 74.67 APE8-rot-na 34.86 APE67-dihe-in -64.95, -18.37 -43.74, -45.38 APE12-dist-na 11.571 APE11-dist-na 9.239 APE10-dist-na 9.407 APE9-dist-in 5.997 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[613, 873]] 1.0 AF-P29317-K3 TYR_EPHA2_HUMAN TYR 3.8e-108 366.6 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
4TRLA 599 875 976.0 No_ligand No_ligand Inactive DFGin 5.578 14.734 ABAminus -135.74, -21.41 -117.74, 96.0 -97.73, 10.57 299.45, 103.05 -52.99, -46.17 in-in in 8.531 Saltbr-in 3.569 HRD-in -85.62, -43.31 69.59, 2.8 in-in-in SNCiii in-in ActLoopNT-in 3.017 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.67, 134.65 APE9-dihe-in -136.44, 149.6 APE8-dihe-in -75.27, 91.15 APE8-rot-na 24.33 APE67-dihe-in -65.44, -16.63 -52.52, -46.9 APE12-dist-na 11.134 APE11-dist-na 9.323 APE10-dist-na 9.342 APE9-dist-in 5.871 None PTR772 PTR772 XRAY 2.452 0.202 0.25 A 299 269 8 0 0 1 [[613, 873]] 1.0 4trl TYR_EPHA2_HUMAN TYR 5.1e-108 366.2 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
7KJBA 591 965 976.0 No_ligand No_ligand Inactive DFGin 5.637 14.959 ABAminus -132.91, -22.75 -108.93, 112.29 -125.99, 49.73 298.64, 106.94 -77.0, 170.81 in-in in 8.125 Saltbr-in 2.615 HRD-in -72.92, -40.78 73.25, -13.62 in-out-in SNCioi out-in ActLoopNT-out 9.463 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.09, 163.14 APE9-dihe-in -84.17, 117.21 APE8-dihe-in -72.3, 146.33 APE8-rot-na 29.14 APE67-dihe-in -70.22, -15.1 -63.86, -33.58 APE12-dist-na 13.61 APE11-dist-na 10.299 APE10-dist-na 11.883 APE9-dist-in 5.516 S897E,S901E None None XRAY 2.8 0.2 0.246 A 390 361 5 0 0 0 [[613, 873]] 1.0 7kjb TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NK0A 602 894 976.0 91E:1001 Type1 Inactive DFGin 5.783 15.305 ABAminus -130.11, -35.9 -103.1, 114.86 -114.18, 27.44 295.79, 97.0 -63.76, -27.15 in-in in 8.887 Saltbr-in 3.583 HRD-in -79.65, -46.58 73.85, -13.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 97.07 APE8-rot-na 324.81 APE67-dihe-in -78.99, -2.17 -57.91, -45.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.597 0.165 0.194 A 306 273 19 0 0 19 [[613, 873]] 1.0 5nk0 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NK8A 605 894 976.0 90Z:1001 Type1 Inactive DFGin 5.897 15.505 ABAminus -130.54, -47.65 -90.06, 119.53 -121.49, 17.1 287.64, 97.95 -115.78, 999.0 in-in in 8.887 Saltbr-in 3.328 HRD-in -77.39, -49.79 77.73, -13.27 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 131.74 APE8-rot-na 323.5 APE67-dihe-in -75.77, -1.63 -58.13, -47.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.761 0.168 0.206 A 306 266 24 0 0 20 [[613, 873]] 1.0 5nk8 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6FNHA 602 889 976.0 DXK:1001 Type1 Inactive DFGin 6.029 15.287 ABAminus -132.89, -13.6 -114.29, 112.91 -120.16, 34.85 297.73, 92.28 -68.77, 147.18 in-in in 8.571 Saltbr-in 2.524 HRD-in -71.64, -49.56 77.94, -13.05 in-out-in SNCioi out-in ActLoopNT-out 10.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.64, 136.2 APE9-dihe-in -91.95, 112.57 APE8-dihe-in -77.45, 142.7 APE8-rot-na 28.74 APE67-dihe-in -60.57, -18.72 -57.08, -38.55 APE12-dist-na 999.0 APE11-dist-na 8.383 APE10-dist-na 12.377 APE9-dist-in 5.447 None None None XRAY 1.379 0.206 0.221 A 306 277 11 0 0 10 [[613, 873]] 1.0 6fnh TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6FNHB 602 882 976.0 DXK:1001 Type1 Inactive DFGin 5.348 15.068 ABAminus -133.93, -15.74 -121.25, 119.84 -118.06, 28.52 301.16, 87.41 -78.43, -76.5 in-in in 8.252 Saltbr-in 2.341 HRD-in -74.5, -47.84 76.45, -12.42 in-out-out SNCioo out-out ActLoopNT-out 6.812 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 153.72 APE9-dihe-in -66.55, 140.49 APE8-dihe-in -67.49, 153.9 APE8-rot-na 28.58 APE67-dihe-in -75.86, -2.19 -123.09, -16.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.248 APE9-dist-out 8.953 None None None XRAY 1.379 0.206 0.221 B 306 271 10 0 0 7 [[613, 873]] 1.0 6fnh TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NK3A 601 888 976.0 92Q:1001 Type1.5_Back Inactive DFGin 5.888 14.932 ABAminus -127.77, -30.16 -98.66, 126.21 -132.36, 33.74 299.85, 97.19 -64.67, 145.97 in-in in 8.62 Saltbr-in 2.695 HRD-in -75.58, -45.96 75.19, -12.86 in-out-in SNCioi out-in ActLoopNT-out 10.261 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.51, 134.59 APE9-dihe-in -90.19, 122.73 APE8-dihe-in -78.28, 138.13 APE8-rot-na 5.98 APE67-dihe-in -79.02, -0.01 -52.35, -44.52 APE12-dist-na 999.0 APE11-dist-na 8.895 APE10-dist-na 12.725 APE9-dist-in 5.457 None None None XRAY 1.586 0.195 0.228 A 306 281 7 0 0 3 [[613, 873]] 1.0 5nk3 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
8QQYA 605 896 976.0 WT3:1001 Type1.5_Back Inactive DFGin 6.022 15.079 ABAminus -143.91, 11.32 -136.78, 112.13 -116.84, 31.35 294.32, 97.84 -60.55, 136.19 in-in in 8.788 Saltbr-in 2.491 HRD-in -70.11, -50.87 79.72, -17.4 in-out-none SNCion out-none ActLoopNT-out 10.219 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -77.4 APE9-dihe-in -90.42, 120.43 APE8-dihe-in -75.55, 139.11 APE8-rot-na 24.19 APE67-dihe-in -77.39, -3.79 -51.26, -47.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.291 APE9-dist-in 5.494 None None None XRAY 1.8 0.191 0.223 A 306 272 20 0 0 10 [[613, 873]] 1.0 8qqy TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
1MQBA 605 887 976.0 ANP:1000 ATPlike Inactive DFGin 5.712 14.924 BLAminus -127.53, -172.03 57.53, 74.63 -109.94, 122.74 306.64, 100.38 176.53, 104.78 in-out in 8.465 Saltbr-out 5.675 HRD-in -62.1, -45.48 77.42, -17.66 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -37.06 APE9-dihe-in -88.14, 119.95 APE8-dihe-in -73.81, 144.85 APE8-rot-na 33.04 APE67-dihe-in -82.72, 0.0 -54.3, -43.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.553 APE9-dist-in 5.598 None None None XRAY 2.3 0.237 0.288 A 333 263 20 0 0 17 [[613, 873]] 1.0 1mqb TYR_EPHA2_HUMAN TYR 7.4e-108 365.7 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
4P2KA 600 876 976.0 No_ligand No_ligand Inactive DFGin 5.081 15.914 BLAminus -128.03, -172.79 59.15, 70.41 -91.85, 18.3 285.75, 82.84 -52.48, -41.13 in-out in 9.616 Saltbr-out 3.937 HRD-in -82.58, -47.9 75.24, -8.53 out-in-in SNCoii in-in ActLoopNT-in 2.926 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.82, 138.44 APE9-dihe-in -127.64, 156.99 APE8-dihe-in -81.39, 86.24 APE8-rot-na 29.13 APE67-dihe-in -65.57, -17.39 -54.1, -43.92 APE12-dist-na 999.0 APE11-dist-na 9.807 APE10-dist-na 10.152 APE9-dist-in 6.06 None None None XRAY 1.499 0.174 0.19 A 299 259 18 0 0 12 [[613, 873]] 1.0 4p2k TYR_EPHA2_HUMAN TYR 5.1e-108 366.2 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5EK7A 586 875 976.0 No_ligand No_ligand Inactive DFGin 5.857 15.407 BLAminus -130.66, -168.3 62.02, 69.56 -99.82, 88.13 290.82, 97.38 -94.6, 141.73 in-in in 7.755 Saltbr-in 2.757 HRD-in -76.18, -45.92 76.67, -15.63 in-out-in SNCioi out-in ActLoopNT-out 8.587 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.13, 163.41 APE9-dihe-in -81.65, 120.12 APE8-dihe-in -73.73, 138.8 APE8-rot-na 25.17 APE67-dihe-in -54.48, -26.63 -56.76, -41.48 APE12-dist-na 14.613 APE11-dist-na 10.971 APE10-dist-na 12.398 APE9-dist-in 5.197 None None None XRAY 1.901 0.172 0.205 A 308 286 4 0 0 0 [[613, 873]] 1.0 5ek7 TYR_EPHA2_HUMAN TYR 5.7e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5EK7B 586 875 976.0 No_ligand No_ligand Inactive DFGin 5.745 15.21 BLAminus -126.54, -164.94 55.71, 72.14 -96.75, 90.29 295.56, 92.81 -90.82, 136.53 in-in in 7.701 Saltbr-in 2.668 HRD-in -71.96, -46.69 77.79, -18.08 in-out-in SNCioi out-in ActLoopNT-out 9.182 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.45, 153.41 APE9-dihe-in -80.92, 121.99 APE8-dihe-in -74.2, 138.52 APE8-rot-na 26.08 APE67-dihe-in -58.89, -22.57 -58.03, -38.86 APE12-dist-na 14.279 APE11-dist-na 10.507 APE10-dist-na 12.63 APE9-dist-in 5.186 None None None XRAY 1.901 0.172 0.205 B 308 286 4 0 0 0 [[613, 873]] 1.0 5ek7 TYR_EPHA2_HUMAN TYR 5.7e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
8BINA 605 887 976.0 QRR:1005 Type1 Inactive DFGin 6.096 14.933 BLAminus -129.12, -169.3 64.88, 80.64 -107.59, 25.53 298.43, 100.36 -53.06, 139.56 in-in in 8.256 Saltbr-in 2.838 HRD-in -74.83, -46.22 76.7, -15.63 in-out-in SNCioi out-in ActLoopNT-out 9.968 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.47, 132.16 APE9-dihe-in -87.88, 121.44 APE8-dihe-in -71.63, 137.09 APE8-rot-na 27.71 APE67-dihe-in -78.72, -2.32 -51.32, -46.75 APE12-dist-na 999.0 APE11-dist-na 9.181 APE10-dist-na 13.089 APE9-dist-in 5.405 None None None XRAY 1.5 0.134 0.171 A 306 264 19 0 0 9 [[613, 873]] 1.0 8bin TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
8BIOA 605 894 976.0 QRD:1012 Type1.5_Back Inactive DFGin 6.107 14.819 BLAminus -133.27, 178.5 74.5, 81.24 -109.91, 27.01 298.28, 105.83 -55.05, 138.71 in-in in 8.257 Saltbr-in 2.837 HRD-in -75.31, -47.53 77.61, -13.45 in-out-in SNCioi out-in ActLoopNT-out 9.765 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.13, 128.48 APE9-dihe-in -84.61, 123.83 APE8-dihe-in -73.7, 136.2 APE8-rot-na 29.88 APE67-dihe-in -81.02, -0.73 -50.92, -45.76 APE12-dist-na 999.0 APE11-dist-na 9.296 APE10-dist-na 13.21 APE9-dist-in 5.425 None None None XRAY 1.6 0.165 0.199 A 306 273 17 0 0 7 [[613, 873]] 1.0 8bio TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5I9WA 605 895 976.0 ANP:1001 ATPlike Inactive DFGin 6.244 15.281 BLBminus -125.95, -162.36 67.3, 57.63 -98.89, 156.85 294.37, 103.89 164.47, 175.48 in-in in 8.347 Saltbr-in 2.764 HRD-in -75.49, -48.49 78.15, -15.84 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.31 APE8-dihe-in -84.75, 145.17 APE8-rot-na 35.12 APE67-dihe-in -78.8, -3.01 -55.81, -43.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.342 None None None XRAY 1.359 0.17 0.18 A 306 267 24 0 0 18 [[613, 873]] 1.0 5i9w TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
7KJCA 590 976 976.0 ACP:61001 ATPlike Inactive DFGin 5.878 14.93 BLBminus -137.77, -170.41 70.81, 83.37 -119.58, 163.56 301.23, 100.14 146.26, -161.86 in-in in 8.355 Saltbr-in 3.032 HRD-in -75.87, -47.34 76.1, -11.46 in-out-none SNCion out-none ActLoopNT-out 9.669 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 107.51 APE9-dihe-in -145.96, 148.03 APE8-dihe-in -73.29, 89.61 APE8-rot-na 29.38 APE67-dihe-in -67.75, -13.33 -62.67, -32.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.547 APE9-dist-in 6.64 S901E None None XRAY 2.3 0.19 0.226 A 390 373 8 0 0 5 [[613, 873]] 1.0 7kjc TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
7KJCB 590 965 976.0 ACP:61002 ATPlike Inactive DFGin 5.963 15.204 BLBminus -132.91, -166.6 60.51, 83.21 -117.48, 163.92 299.39, 100.57 145.47, 999.0 in-in in 8.467 Saltbr-in 3.13 HRD-in -75.7, -46.49 74.32, -9.38 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 86.32 APE8-rot-na 29.03 APE67-dihe-in -66.96, -12.86 -66.13, -32.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 S901E None None XRAY 2.3 0.19 0.226 B 390 347 23 0 0 20 [[613, 873]] 1.0 7kjc TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
7KJAA 590 976 976.0 ACP:61002 ATPlike Inactive DFGin 5.763 14.769 BLBminus -129.59, -174.19 75.99, 88.0 -122.87, 170.51 304.47, 101.43 99.06, 999.0 in-in in 8.424 Saltbr-in 3.055 HRD-in -76.77, -48.29 79.69, -17.22 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.1 APE8-rot-na 32.23 APE67-dihe-in -70.25, -11.59 -65.39, -29.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.19 0.217 A 390 361 20 0 0 20 [[613, 873]] 1.0 7kja TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5I9XA 604 896 976.0 DB8:1001 Type1 Inactive DFGin 6.007 14.831 BLBminus -129.07, 177.72 76.64, 79.94 -112.75, 156.99 297.29, 98.79 146.97, -174.61 in-in in 8.09 Saltbr-in 3.299 HRD-in -74.57, -46.21 76.15, -16.23 in-out-in SNCioi out-in ActLoopNT-out 10.42 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.78, 113.1 APE9-dihe-in -147.01, 138.26 APE8-dihe-in -78.55, 92.56 APE8-rot-na 31.7 APE67-dihe-in -77.79, -2.98 -59.26, -48.48 APE12-dist-na 999.0 APE11-dist-na 14.091 APE10-dist-na 12.379 APE9-dist-in 6.799 None None None XRAY 1.427 0.166 0.182 A 306 284 9 0 0 4 [[613, 873]] 1.0 5i9x TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5I9YA 600 896 976.0 1N1:1001 Type1 Inactive DFGin 6.222 14.973 BLBminus -129.12, 177.86 73.14, 77.74 -114.09, 153.37 295.9, 102.04 147.64, -171.81 in-in in 8.257 Saltbr-in 2.774 HRD-in -75.07, -47.16 76.83, -16.24 in-out-none SNCion out-none ActLoopNT-out 10.459 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 139.34 APE8-rot-na 36.16 APE67-dihe-in -79.28, -3.2 -53.92, -45.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.228 0.164 0.179 A 306 287 10 0 0 7 [[613, 873]] 1.0 5i9y TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5I9ZA 604 896 976.0 627:1001 Type1 Inactive DFGin 6.395 15.025 BLBminus -135.15, -162.14 63.34, 62.38 -99.38, 153.95 296.28, 106.39 156.26, -159.7 in-in in 8.181 Saltbr-in 3.003 HRD-in -78.26, -45.75 77.15, -16.58 in-out-none SNCion out-none ActLoopNT-out 10.334 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.03 APE8-dihe-in -78.75, 94.25 APE8-rot-na 31.08 APE67-dihe-in -77.33, -1.49 -57.35, -48.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.695 None None None XRAY 1.698 0.162 0.2 A 306 273 20 0 0 14 [[613, 873]] 1.0 5i9z TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5IA0B 600 882 976.0 A5B:1001 Type1 Inactive DFGin 5.553 15.384 BLBminus -126.96, -156.55 64.03, 67.0 -103.77, 142.3 299.95, 99.48 123.44, 148.27 in-in in 8.085 Saltbr-in 3.23 HRD-in -74.38, -46.39 76.24, -14.79 in-out-none SNCion out-none ActLoopNT-out 10.837 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 107.19 APE8-dihe-in -66.68, 140.21 APE8-rot-na 27.23 APE67-dihe-in -76.07, -2.43 -63.36, -38.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.332 None None None XRAY 1.948 0.194 0.225 B 306 266 17 0 0 14 [[613, 873]] 1.0 5ia0 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5IA0C 600 890 976.0 A5B:1001 Type1 Inactive DFGin 6.339 15.027 BLBminus -132.95, -162.71 63.9, 70.2 -105.45, 159.62 303.48, 101.06 149.65, -160.59 in-in in 8.356 Saltbr-in 2.642 HRD-in -77.84, -43.14 69.2, -7.06 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 48.26 APE8-rot-na 27.02 APE67-dihe-in -80.71, 0.8 -57.19, -48.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.948 0.194 0.225 C 306 269 22 0 0 18 [[613, 873]] 1.0 5ia0 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5IA3A 602 896 976.0 P17:1001 Type1 Inactive DFGin 6.244 14.848 BLBminus -140.25, -177.97 75.12, 87.33 -118.87, 162.99 296.17, 108.02 122.4, -163.0 in-in in 8.321 Saltbr-in 2.649 HRD-in -77.68, -48.9 76.3, -15.94 in-out-none SNCion out-none ActLoopNT-out 9.267 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 154.55 APE8-dihe-in -79.35, 94.2 APE8-rot-na 29.88 APE67-dihe-in -64.17, -17.19 -57.49, -47.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.641 None None None XRAY 1.788 0.163 0.204 A 306 275 20 0 0 16 [[613, 873]] 1.0 5ia3 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NJZA 604 896 976.0 8ZH:1001 Type1 Inactive DFGin 6.204 14.895 BLBminus -137.86, -175.05 73.68, 71.15 -106.6, 164.44 297.85, 104.9 122.98, -167.74 in-in in 8.335 Saltbr-in 3.007 HRD-in -74.37, -49.77 78.18, -16.27 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.44 APE8-dihe-in -79.72, 92.34 APE8-rot-na 31.41 APE67-dihe-in -77.02, -1.86 -56.16, -49.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.798 None None None XRAY 1.768 0.165 0.199 A 306 273 20 0 0 17 [[613, 873]] 1.0 5njz TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NK1A 604 896 976.0 90N:1001 Type1 Inactive DFGin 6.261 15.096 BLBminus -137.04, -175.86 73.92, 78.56 -114.15, 154.72 297.57, 106.7 143.73, -170.99 in-in in 8.452 Saltbr-in 3.562 HRD-in -77.13, -47.81 78.79, -17.19 in-out-in SNCioi out-in ActLoopNT-out 10.255 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.69, 107.39 APE9-dihe-in -145.05, 145.15 APE8-dihe-in -80.73, 95.07 APE8-rot-na 28.79 APE67-dihe-in -77.06, -2.71 -57.34, -48.02 APE12-dist-na 999.0 APE11-dist-na 13.98 APE10-dist-na 12.27 APE9-dist-in 6.611 None None None XRAY 1.548 0.168 0.193 A 306 284 9 0 0 4 [[613, 873]] 1.0 5nk1 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NK2A 598 896 976.0 8ZZ:1001 Type1 Inactive DFGin 6.246 14.904 BLBminus -133.56, -173.1 72.69, 80.77 -116.74, 156.82 298.99, 102.92 143.26, -174.99 in-in in 8.21 Saltbr-in 2.846 HRD-in -74.93, -47.15 75.08, -14.22 in-out-in SNCioi out-in ActLoopNT-out 10.494 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.16, 114.72 APE9-dihe-in -143.31, 138.34 APE8-dihe-in -81.16, 89.97 APE8-rot-na 31.9 APE67-dihe-in -81.7, 0.84 -56.09, -45.98 APE12-dist-na 999.0 APE11-dist-na 13.865 APE10-dist-na 12.294 APE9-dist-in 6.761 None None None XRAY 1.649 0.158 0.189 A 306 290 9 0 0 4 [[613, 873]] 1.0 5nk2 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NK4A 601 896 976.0 90E:1001 Type1 Inactive DFGin 6.158 15.103 BLBminus -133.74, -169.69 69.8, 80.22 -113.59, 153.71 298.29, 106.67 147.72, -170.25 in-in in 8.314 Saltbr-in 3.251 HRD-in -74.87, -48.2 78.27, -18.05 in-out-in SNCioi out-in ActLoopNT-out 10.479 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.29, 110.29 APE9-dihe-in -136.95, 141.93 APE8-dihe-in -84.88, 89.59 APE8-rot-na 31.07 APE67-dihe-in -76.16, -4.97 -53.91, -49.3 APE12-dist-na 16.882 APE11-dist-na 13.682 APE10-dist-na 12.249 APE9-dist-in 6.763 None None None XRAY 1.45 0.17 0.197 A 306 290 6 0 0 0 [[613, 873]] 1.0 5nk4 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NK5A 605 896 976.0 90K:1001 Type1 Inactive DFGin 6.073 15.346 BLBminus -137.11, -168.25 74.71, 82.66 -124.01, 156.72 306.75, 105.61 -166.49, 154.07 in-in in 8.84 Saltbr-in 3.409 HRD-in -76.81, -44.59 72.07, -9.98 in-out-in SNCioi out-in ActLoopNT-out 5.007 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.29, 132.5 APE9-dihe-in -59.48, 116.97 APE8-dihe-in -52.03, 120.26 APE8-rot-na 332.57 APE67-dihe-in -73.79, -6.01 -69.09, -20.53 APE12-dist-na 11.958 APE11-dist-na 14.944 APE10-dist-na 17.706 APE9-dist-in 5.639 None None None XRAY 1.329 0.181 0.202 A 306 287 4 0 0 1 [[613, 873]] 1.0 5nk5 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NK6A 605 896 976.0 90W:1001 Type1 Inactive DFGin 6.158 15.114 BLBminus -127.42, -172.48 68.71, 79.04 -114.0, 154.12 297.13, 104.22 145.91, -174.06 in-out in 8.338 Saltbr-out 3.685 HRD-in -77.16, -48.59 77.69, -11.86 out-out-in SNCooi out-in ActLoopNT-out 10.439 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.47, 110.03 APE9-dihe-in -142.84, 150.69 APE8-dihe-in -85.6, 93.63 APE8-rot-na 31.14 APE67-dihe-in -66.03, -18.5 -55.72, -46.87 APE12-dist-na 16.087 APE11-dist-na 13.852 APE10-dist-na 12.323 APE9-dist-in 6.594 None None None XRAY 1.267 0.172 0.186 A 306 284 8 0 0 3 [[613, 873]] 1.0 5nk6 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NK7A 604 896 976.0 8ZZ:1001 Type1 Inactive DFGin 6.311 15.067 BLBminus -131.93, -179.62 72.17, 67.66 -104.91, 158.6 298.18, 102.85 143.87, -168.6 in-in in 8.255 Saltbr-in 2.855 HRD-in -78.48, -45.08 78.22, -20.49 in-out-in SNCioi out-in ActLoopNT-out 10.227 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.4, 104.21 APE9-dihe-in -139.82, 156.78 APE8-dihe-in -85.7, 99.4 APE8-rot-na 30.28 APE67-dihe-in -63.84, -18.12 -58.56, -47.79 APE12-dist-na 999.0 APE11-dist-na 13.79 APE10-dist-na 12.454 APE9-dist-in 6.508 None None None XRAY 1.889 0.171 0.2 A 306 284 9 0 0 4 [[613, 873]] 1.0 5nk7 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NK9A 605 896 976.0 912:1001 Type1 Inactive DFGin 6.242 15.128 BLBminus -137.77, -174.06 71.41, 79.64 -113.27, 155.81 297.43, 105.37 145.29, -173.1 in-out in 8.378 Saltbr-out 5.809 HRD-in -76.8, -48.27 77.51, -16.42 out-out-in SNCooi out-in ActLoopNT-out 10.401 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.34, 98.9 APE9-dihe-in -132.66, 143.35 APE8-dihe-in -81.24, 93.22 APE8-rot-na 31.4 APE67-dihe-in -65.79, -17.82 -56.45, -46.3 APE12-dist-na 999.0 APE11-dist-na 14.026 APE10-dist-na 12.389 APE9-dist-in 6.706 None None None XRAY 1.588 0.164 0.195 A 306 285 7 0 0 2 [[613, 873]] 1.0 5nk9 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NKBA 605 896 976.0 8ZT:1001 Type1 Inactive DFGin 6.287 14.993 BLBminus -131.88, -179.08 75.71, 70.28 -109.86, 150.89 296.07, 101.49 157.0, -166.21 in-in in 8.29 Saltbr-in 2.819 HRD-in -75.0, -44.6 73.88, -12.43 in-out-in SNCioi out-in ActLoopNT-out 10.373 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.59, 110.72 APE9-dihe-in -147.23, 154.27 APE8-dihe-in -91.23, 94.45 APE8-rot-na 33.34 APE67-dihe-in -69.82, -14.68 -57.35, -42.58 APE12-dist-na 999.0 APE11-dist-na 14.1 APE10-dist-na 12.336 APE9-dist-in 6.586 None None None XRAY 1.5 0.161 0.191 A 306 285 7 0 0 2 [[613, 873]] 1.0 5nkb TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NKCA 601 896 976.0 90T:1001 Type1 Inactive DFGin 6.093 14.967 BLBminus -135.22, -175.36 73.65, 77.68 -110.73, 155.72 298.14, 102.52 146.31, -171.29 in-in in 8.289 Saltbr-in 2.822 HRD-in -74.69, -46.81 76.81, -16.71 in-out-none SNCion out-none ActLoopNT-out 10.507 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 105.91 APE9-dihe-in -149.82, 161.92 APE8-dihe-in -87.79, 89.86 APE8-rot-na 31.31 APE67-dihe-in -77.76, -3.77 -54.19, -47.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.424 APE9-dist-in 6.627 None None None XRAY 1.448 0.162 0.191 A 306 286 10 0 0 5 [[613, 873]] 1.0 5nkc TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NKDA 600 896 976.0 91K:1001 Type1 Inactive DFGin 6.132 14.964 BLBminus -134.78, -176.82 73.76, 78.86 -113.54, 153.56 296.08, 104.15 146.36, -174.67 in-in in 8.26 Saltbr-in 2.732 HRD-in -77.14, -45.48 77.12, -16.83 in-out-in SNCioi out-in ActLoopNT-out 10.467 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.01, 117.41 APE9-dihe-in -145.83, 137.51 APE8-dihe-in -78.06, 86.38 APE8-rot-na 30.76 APE67-dihe-in -79.78, -1.96 -53.99, -48.84 APE12-dist-na 999.0 APE11-dist-na 14.179 APE10-dist-na 12.468 APE9-dist-in 6.855 None None None XRAY 1.408 0.186 0.224 A 306 287 10 0 0 4 [[613, 873]] 1.0 5nkd TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NKEA 605 896 976.0 90B:1001 Type1 Inactive DFGin 6.012 15.477 BLBminus -135.64, -171.02 68.87, 95.15 -133.04, 152.12 306.86, 107.41 -169.26, 153.03 in-in in 8.882 Saltbr-in 3.311 HRD-in -76.93, -45.55 75.92, -17.2 in-out-in SNCioi out-in ActLoopNT-out 5.045 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.7, 128.87 APE9-dihe-in -59.73, 120.77 APE8-dihe-in -54.03, 120.5 APE8-rot-na 332.36 APE67-dihe-in -73.93, -4.86 -69.21, -21.3 APE12-dist-na 11.897 APE11-dist-na 14.842 APE10-dist-na 17.564 APE9-dist-in 5.758 None None None XRAY 1.39 0.174 0.204 A 306 292 0 0 0 0 [[613, 873]] 1.0 5nke TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NKFA 605 896 976.0 8ZN:1001 Type1 Inactive DFGin 6.183 15.179 BLBminus -122.27, 177.83 72.21, 78.1 -114.07, 153.93 296.07, 102.17 145.36, -178.0 in-out in 8.364 Saltbr-out 3.743 HRD-in -74.66, -48.65 78.25, -15.54 out-out-in SNCooi out-in ActLoopNT-out 10.321 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.3, 108.22 APE9-dihe-in -143.18, 153.17 APE8-dihe-in -86.73, 90.35 APE8-rot-na 29.73 APE67-dihe-in -65.53, -16.38 -49.82, -51.37 APE12-dist-na 17.118 APE11-dist-na 13.933 APE10-dist-na 12.306 APE9-dist-in 6.58 None None None XRAY 1.099 0.171 0.187 A 306 291 1 0 0 0 [[613, 873]] 1.0 5nkf TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NKGA 605 896 976.0 8ZK:1001 Type1 Inactive DFGin 6.191 15.067 BLBminus -139.5, 179.31 75.9, 82.87 -116.7, 155.72 295.67, 109.55 146.37, 168.26 in-out in 8.42 Saltbr-out 3.808 HRD-in -76.37, -48.88 77.43, -18.77 out-out-in SNCooi out-in ActLoopNT-out 10.076 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.66, 108.62 APE9-dihe-in -143.07, 153.94 APE8-dihe-in -87.68, 91.58 APE8-rot-na 31.26 APE67-dihe-in -64.1, -16.04 -53.74, -48.31 APE12-dist-na 17.441 APE11-dist-na 14.179 APE10-dist-na 12.775 APE9-dist-in 6.551 None None None XRAY 1.1 0.172 0.19 A 306 292 0 0 0 0 [[613, 873]] 1.0 5nkg TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NKHA 601 895 976.0 8ZQ:1001 Type1 Inactive DFGin 5.923 15.358 BLBminus -132.2, -178.54 78.51, 82.02 -119.56, 155.37 305.48, 103.78 -164.13, 152.2 in-in in 8.906 Saltbr-in 3.322 HRD-in -76.4, -43.57 74.34, -17.58 in-out-in SNCioi out-in ActLoopNT-out 4.925 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.22, 130.18 APE9-dihe-in -62.58, 124.79 APE8-dihe-in -55.59, 120.89 APE8-rot-na 328.8 APE67-dihe-in -74.96, -2.98 -49.76, -43.38 APE12-dist-na 11.936 APE11-dist-na 14.877 APE10-dist-na 17.718 APE9-dist-in 5.752 None None None XRAY 1.29 0.171 0.196 A 306 295 0 0 0 0 [[613, 873]] 1.0 5nkh TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NKIA 604 896 976.0 8ZW:1001 Type1 Inactive DFGin 6.234 15.195 BLBminus -131.56, -168.05 65.37, 72.57 -104.34, 158.3 297.86, 102.98 178.28, 999.0 in-in in 8.441 Saltbr-in 3.243 HRD-in -76.06, -48.41 76.01, -12.4 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 71.21 APE8-rot-na 27.11 APE67-dihe-in -79.27, -3.33 -55.7, -45.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.675 0.162 0.189 A 306 268 25 0 0 20 [[613, 873]] 1.0 5nki TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
8BK0A 605 887 976.0 QJI:1007 Type1 Inactive DFGin 6.049 14.931 BLBminus -127.21, -168.15 68.67, 77.36 -114.53, 162.62 293.54, 106.47 142.52, -154.64 in-in in 8.193 Saltbr-in 2.968 HRD-in -70.96, -48.84 78.9, -18.22 in-out-none SNCion out-none ActLoopNT-out 9.874 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.88 APE8-dihe-in -76.9, 140.27 APE8-rot-na 31.9 APE67-dihe-in -78.19, -3.6 -52.58, -46.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.411 None None None XRAY 1.7 0.168 0.195 A 306 266 17 0 0 11 [[613, 873]] 1.0 8bk0 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5IA2A 598 888 976.0 L66:1001 Type1.5_Back Inactive DFGin 6.033 14.258 BLBminus -134.41, -178.14 76.73, 84.08 -119.06, 159.2 303.5, 118.54 144.3, -174.17 in-out in 8.4 Saltbr-out 3.691 HRD-in -77.24, -46.91 75.8, -16.93 out-out-in SNCooi out-in ActLoopNT-out 10.463 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.98, 106.86 APE9-dihe-in -142.72, 149.22 APE8-dihe-in -83.94, 92.51 APE8-rot-na 31.71 APE67-dihe-in -79.44, -1.75 -55.95, -46.88 APE12-dist-na 17.051 APE11-dist-na 14.007 APE10-dist-na 12.274 APE9-dist-in 6.581 None None None XRAY 1.619 0.164 0.199 A 306 287 4 0 0 0 [[613, 873]] 1.0 5ia2 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
4PDOA 590 875 976.0 No_ligand No_ligand Inactive DFGin 5.317 14.854 None -130.75, -10.88 -121.71, 138.39 -133.1, 999.0 295.74, 93.17 999.0, 999.0 in-out in 7.968 Saltbr-out 6.262 HRD-in -77.55, -48.01 73.27, -11.62 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.79, 137.86 APE9-dihe-in -135.53, 157.5 APE8-dihe-in -79.41, 83.0 APE8-rot-na 28.9 APE67-dihe-in -59.48, -20.71 -53.52, -46.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.493 None None None XRAY 2.104 0.162 0.184 A 299 261 25 0 0 18 [[613, 873]] 1.0 4pdo TYR_EPHA2_HUMAN TYR 5.1e-108 366.2 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
4PDOB 590 875 976.0 No_ligand No_ligand Inactive DFGin 5.288 14.897 None -129.53, -11.31 -121.1, 139.25 -134.72, 999.0 294.46, 94.17 999.0, 999.0 in-out in 7.965 Saltbr-out 6.373 HRD-in -76.29, -48.44 73.45, -12.19 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.42, 139.51 APE9-dihe-in -133.49, 157.9 APE8-dihe-in -78.68, 83.43 APE8-rot-na 28.65 APE67-dihe-in -60.39, -20.86 -55.6, -45.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.495 None None None XRAY 2.104 0.162 0.184 B 299 261 25 0 0 18 [[613, 873]] 1.0 4pdo TYR_EPHA2_HUMAN TYR 5.1e-108 366.2 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5IA1A 605 888 976.0 ZZL:1001 Type1 Inactive DFGin 5.104 13.44 None -130.45, -159.4 76.21, -65.85 93.22, -3.68 287.63, 98.57 73.71, -159.39 in-in in 8.825 Saltbr-in 3.231 HRD-in -77.12, -51.78 78.89, -19.53 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.06 APE8-dihe-in -70.6, 101.8 APE8-rot-na 29.53 APE67-dihe-in -68.76, -14.33 -55.26, -45.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.783 None None None XRAY 2.036 0.183 0.223 A 306 261 23 0 0 17 [[613, 873]] 1.0 5ia1 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
8XPVA 604 895 976.0 4Z5:1001 Type2 Inactive DFGout 13.269 10.955 BBAminus -137.16, -164.34 -163.18, 122.32 -110.97, 8.06 311.52, 123.3 90.13, 999.0 in-in in 8.833 Saltbr-in 2.927 HRD-in -72.87, -53.95 83.53, -16.47 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.99 APE8-dihe-in -73.48, 86.08 APE8-rot-na 30.77 APE67-dihe-in -77.0, -6.4 -53.93, -46.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.92 None None None XRAY 1.55 0.165 0.19 A 305 267 25 0 0 19 [[613, 873]] 1.0 8xpv TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6FNFA 606 894 976.0 DXH:1001 Type2 Inactive DFGout 12.992 10.763 BBAminus -140.4, -179.53 -150.33, 114.47 -94.22, -1.16 310.54, 140.88 68.04, 21.72 in-in in 8.425 Saltbr-in 3.357 HRD-in -74.62, -50.37 78.48, -11.76 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -19.2 APE8-rot-na 31.74 APE67-dihe-in -65.5, -24.37 -53.32, -41.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.556 0.234 0.273 A 306 267 22 0 0 18 [[613, 873]] 1.0 6fnf TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6FNGA 599 897 976.0 DWT:1001 Type2 Inactive DFGout 13.003 11.523 BBAminus -139.19, -178.13 -146.25, 108.94 -93.08, 5.13 304.04, 131.15 80.25, -172.1 in-in in 8.409 Saltbr-in 2.85 HRD-in -73.52, -50.78 77.08, -12.87 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -61.22 APE9-dihe-in -99.96, 115.38 APE8-dihe-in -66.87, 88.76 APE8-rot-na 27.3 APE67-dihe-in -78.4, -4.06 -49.48, -51.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.12 APE9-dist-in 6.332 None None None XRAY 1.038 0.173 0.187 A 306 277 22 0 0 17 [[613, 873]] 1.0 6fng TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6HESA 599 896 976.0 G0H:1000 Type2 Inactive DFGout 13.0 11.456 BBAminus -140.84, -179.28 -148.61, 107.36 -93.63, 13.04 308.75, 129.86 76.56, 172.95 in-in in 8.276 Saltbr-in 2.835 HRD-in -72.23, -50.85 77.43, -11.81 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 64.34 APE8-rot-na 34.36 APE67-dihe-in -76.07, -4.24 -50.4, -47.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.128 0.181 0.205 A 306 275 23 0 0 18 [[613, 873]] 1.0 6hes TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6HETA 605 896 976.0 G0Q:1000 Type2 Inactive DFGout 13.23 11.152 BBAminus -138.72, -176.67 -152.42, 107.94 -90.19, 0.51 304.31, 145.49 88.53, 172.85 in-in in 8.555 Saltbr-in 2.75 HRD-in -74.56, -51.23 78.24, -13.2 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.74 APE8-rot-na 27.35 APE67-dihe-in -63.24, -19.2 -50.37, -47.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.208 0.192 0.21 A 306 268 24 0 0 19 [[613, 873]] 1.0 6het TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6HEUA 600 896 976.0 G0N:1000 Type2 Inactive DFGout 13.428 11.471 BBAminus -135.37, -173.13 -154.17, 104.42 -83.48, -1.5 307.89, 130.83 75.25, 15.45 in-in in 8.38 Saltbr-in 2.617 HRD-in -73.51, -52.25 80.82, -12.69 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 56.49 APE8-rot-na 34.57 APE67-dihe-in -63.22, -18.27 -50.54, -48.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.719 0.187 0.225 A 306 275 22 0 0 18 [[613, 873]] 1.0 6heu TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6HEVA 600 896 976.0 G0K:1000 Type2 Inactive DFGout 13.304 11.423 BBAminus -139.38, 178.5 -146.09, 105.14 -84.2, -0.45 302.02, 143.7 68.6, 14.09 in-in in 8.373 Saltbr-in 2.733 HRD-in -75.0, -49.44 76.64, -12.46 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.11 APE8-dihe-in -74.12, 88.51 APE8-rot-na 28.82 APE67-dihe-in -64.32, -18.03 -52.58, -48.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.697 None None None XRAY 1.28 0.187 0.197 A 306 275 22 0 0 17 [[613, 873]] 1.0 6hev TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6HEWA 605 896 976.0 G0E:1000 Type2 Inactive DFGout 13.181 11.166 BBAminus -143.0, 179.38 -150.3, 109.84 -93.36, 9.05 309.09, 140.2 80.47, 175.4 in-in in 8.5 Saltbr-in 2.8 HRD-in -75.05, -52.39 79.11, -13.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -72.95, 126.24 APE9-dihe-in -78.88, 131.03 APE8-dihe-in -89.92, 64.71 APE8-rot-na 35.37 APE67-dihe-in -76.18, -3.26 -46.41, -49.44 APE12-dist-na 999.0 APE11-dist-na 5.025 APE10-dist-na 6.292 APE9-dist-out 8.409 None None None XRAY 1.268 0.198 0.221 A 306 272 20 0 0 15 [[613, 873]] 1.0 6hew TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6HEXA 605 896 976.0 G02:1000 Type2 Inactive DFGout 13.19 11.107 BBAminus -140.12, -179.23 -150.38, 108.51 -91.23, 6.14 306.43, 142.83 82.26, 175.38 in-in in 8.434 Saltbr-in 2.729 HRD-in -73.28, -51.82 76.62, -12.43 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.4 APE8-rot-na 27.11 APE67-dihe-in -75.77, -5.12 -48.76, -46.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.413 0.16 0.178 A 306 268 24 0 0 19 [[613, 873]] 1.0 6hex TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6HEYA 600 896 976.0 FZW:1000 Type2 Inactive DFGout 13.026 11.247 BBAminus -140.98, -179.53 -146.83, 106.44 -91.72, 6.73 307.31, 132.08 84.32, 173.9 in-in in 8.425 Saltbr-in 2.662 HRD-in -74.52, -50.25 76.22, -12.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 124.54 APE9-dihe-in -82.41, 126.93 APE8-dihe-in -86.56, 66.8 APE8-rot-na 34.65 APE67-dihe-in -78.59, -4.71 -51.51, -45.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.062 APE9-dist-out 8.408 None None None XRAY 1.367 0.181 0.2 A 306 277 20 0 0 16 [[613, 873]] 1.0 6hey TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6Q7BA 599 896 976.0 HO5:1001 Type2 Inactive DFGout 12.911 11.371 BBAminus -138.71, 179.79 -146.84, 106.31 -90.41, 8.47 305.19, 134.6 81.41, 173.29 in-in in 8.316 Saltbr-in 2.742 HRD-in -74.68, -51.31 81.87, -20.54 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -77.7, 125.36 APE9-dihe-in -78.21, 121.81 APE8-dihe-in -84.83, 65.52 APE8-rot-na 33.52 APE67-dihe-in -76.37, -3.64 -49.88, -47.8 APE12-dist-na 999.0 APE11-dist-na 4.932 APE10-dist-na 6.195 APE9-dist-out 8.418 None None None XRAY 1.009 0.187 0.203 A 306 279 19 0 0 15 [[613, 873]] 1.0 6q7b TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6Q7CA 599 896 976.0 HOK:1001 Type2 Inactive DFGout 12.917 11.472 BBAminus -137.38, 179.65 -145.57, 106.32 -90.51, 8.07 303.39, 136.77 80.89, 177.1 in-in in 8.294 Saltbr-in 2.781 HRD-in -74.02, -50.95 80.0, -17.56 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -79.99, 121.72 APE9-dihe-in -77.16, 123.54 APE8-dihe-in -85.16, 67.12 APE8-rot-na 34.38 APE67-dihe-in -74.23, -4.06 -53.67, -47.44 APE12-dist-na 999.0 APE11-dist-na 5.03 APE10-dist-na 5.916 APE9-dist-out 8.35 None None None XRAY 1.049 0.193 0.212 A 306 277 21 0 0 15 [[613, 873]] 1.0 6q7c TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6Q7DA 600 896 976.0 HOT:1001 Type2 Inactive DFGout 12.832 11.406 BBAminus -137.78, -179.53 -146.23, 105.84 -90.01, 2.59 301.41, 135.77 84.53, 167.57 in-in in 8.335 Saltbr-in 2.787 HRD-in -72.57, -51.45 80.18, -11.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.64 APE8-dihe-in -76.33, 60.43 APE8-rot-na 29.94 APE67-dihe-in -66.35, -17.6 -46.26, -47.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.508 None None None XRAY 0.978 0.186 0.207 A 306 275 22 0 0 18 [[613, 873]] 1.0 6q7d TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6Q7EA 601 896 976.0 HMW:1001 Type2 Inactive DFGout 13.062 11.271 BBAminus -140.13, 179.65 -147.61, 107.28 -87.46, 0.03 301.89, 137.22 84.61, 152.96 in-in in 8.443 Saltbr-in 2.906 HRD-in -73.62, -52.51 81.64, -19.01 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.8 APE8-rot-na 26.99 APE67-dihe-in -64.95, -18.36 -51.27, -48.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.059 0.193 0.211 A 306 272 24 0 0 19 [[613, 873]] 1.0 6q7e TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6Q7GA 601 896 976.0 HO8:1001 Type2 Inactive DFGout 12.842 11.429 BBAminus -139.0, -179.32 -148.27, 106.76 -89.38, 3.41 302.66, 137.0 79.39, 167.4 in-in in 8.405 Saltbr-in 2.922 HRD-in -75.44, -50.26 80.93, -17.54 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 63.75 APE8-rot-na 25.43 APE67-dihe-in -66.95, -18.43 -49.42, -45.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.047 0.187 0.201 A 306 273 23 0 0 19 [[613, 873]] 1.0 6q7g TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
8BM8A 605 895 976.0 QT1:1001 Type2 Inactive DFGout 13.299 11.216 BBAminus -138.05, -176.91 -152.31, 112.71 -97.62, -4.12 309.42, 141.33 100.15, -175.59 in-in in 8.546 Saltbr-in 2.901 HRD-in -70.96, -54.99 79.39, -13.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.88 APE8-dihe-in -86.8, 66.48 APE8-rot-na 40.84 APE67-dihe-in -67.76, -19.03 -49.33, -44.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.122 None None None XRAY 1.68 0.192 0.225 A 306 268 23 0 0 18 [[613, 873]] 1.0 8bm8 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
8BOCA 605 888 976.0 QUF:1001 Type2 Inactive DFGout 13.583 10.813 BBAminus -139.62, -179.28 -151.24, 106.28 -78.98, -6.2 302.64, 171.21 84.05, 5.79 in-in in 8.869 Saltbr-in 3.501 HRD-in -70.68, -54.7 83.35, -19.69 in-out-in SNCioi out-in ActLoopNT-out 12.248 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.53, 160.37 APE9-dihe-in -116.01, 148.45 APE8-dihe-in -79.02, 97.78 APE8-rot-na 34.23 APE67-dihe-in -77.84, -8.8 -56.96, -40.4 APE12-dist-na 12.844 APE11-dist-na 9.325 APE10-dist-na 7.892 APE9-dist-in 5.837 None None None XRAY 1.9 0.248 0.286 A 306 271 13 0 0 0 [[613, 873]] 1.0 8boc TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
8BODA 605 896 976.0 QTX:1001 Type2 Inactive DFGout 13.28 11.166 BBAminus -138.75, 179.02 -151.09, 111.94 -95.2, 7.92 310.36, 138.91 79.28, 170.08 in-in in 8.489 Saltbr-in 2.572 HRD-in -76.72, -52.83 81.46, -18.64 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.32 APE8-rot-na 30.12 APE67-dihe-in -67.2, -16.48 -51.99, -47.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.5 0.162 0.185 A 306 268 24 0 0 19 [[613, 873]] 1.0 8bod TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
8BOGA 600 895 976.0 QUU:1001 Type2 Inactive DFGout 13.093 11.42 BBAminus -138.29, -175.41 -154.02, 110.76 -96.23, 4.72 309.55, 133.75 85.69, 178.97 in-in in 8.614 Saltbr-in 2.847 HRD-in -73.76, -52.45 82.86, -19.49 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.24 APE8-rot-na 33.92 APE67-dihe-in -64.56, -20.52 -51.05, -44.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.47 0.167 0.18 A 306 272 24 0 0 19 [[613, 873]] 1.0 8bog TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
8BOHA 604 896 976.0 R0T:1001 Type2 Inactive DFGout 13.138 10.911 BBAminus -143.82, -179.68 -152.45, 109.89 -96.02, 6.95 308.25, 139.26 81.21, 175.48 in-in in 8.546 Saltbr-in 2.992 HRD-in -74.91, -51.04 79.04, -16.8 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.21 APE8-dihe-in -92.63, 66.3 APE8-rot-na 36.09 APE67-dihe-in -67.47, -18.74 -50.08, -43.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.392 None None None XRAY 1.42 0.159 0.174 A 306 269 24 0 0 18 [[613, 873]] 1.0 8boh TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
8BOIA 604 896 976.0 R0O:1001 Type2 Inactive DFGout 13.283 11.03 BBAminus -141.08, 178.02 -149.45, 111.25 -98.53, 10.32 311.85, 140.9 77.27, 174.45 in-in in 8.259 Saltbr-in 2.911 HRD-in -73.1, -59.86 86.83, -16.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.13 APE8-dihe-in -88.03, 63.64 APE8-rot-na 36.17 APE67-dihe-in -62.77, -20.16 -55.53, -44.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.527 None None None XRAY 1.63 0.181 0.211 A 306 269 24 0 0 18 [[613, 873]] 1.0 8boi TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
8BOKA 605 890 976.0 R0X:1001 Type2 Inactive DFGout 13.153 10.636 BBAminus -138.77, 176.95 -145.73, 113.78 -87.01, -5.08 300.46, 157.21 78.94, 15.26 in-in in 8.101 Saltbr-in 3.246 HRD-in -82.54, -50.07 77.02, -16.97 in-out-in SNCioi out-in ActLoopNT-out 12.259 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.81, 160.7 APE9-dihe-in -116.2, 148.85 APE8-dihe-in -81.74, 100.11 APE8-rot-na 33.49 APE67-dihe-in -73.77, -10.77 -53.43, -43.88 APE12-dist-na 12.757 APE11-dist-na 9.227 APE10-dist-na 7.959 APE9-dist-in 5.767 None None None XRAY 2.02 0.218 0.261 A 306 280 6 0 0 0 [[613, 873]] 1.0 8bok TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
8BOMA 605 896 976.0 QU6:1001 Type2 Inactive DFGout 13.014 11.156 BBAminus -139.26, -174.46 -155.4, 107.51 -92.71, 6.11 307.16, 139.18 85.39, 173.92 in-in in 8.461 Saltbr-in 2.829 HRD-in -74.01, -53.36 79.97, -17.68 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.93 APE8-rot-na 32.87 APE67-dihe-in -77.73, -3.9 -47.13, -48.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.12 0.164 0.177 A 306 267 25 0 0 19 [[613, 873]] 1.0 8bom TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5IA4A 605 877 976.0 88Z:1001 Type2 Inactive DFGout 13.811 6.305 None -141.42, 176.32 -148.43, 94.59 -58.84, -30.4 187.59, 75.41 105.04, 22.91 in-out in 9.571 Saltbr-out 4.687 HRD-in -75.95, -50.56 75.81, -10.01 out-out-in SNCooi out-in ActLoopNT-out 12.322 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.68, 164.18 APE9-dihe-in -115.64, 144.62 APE8-dihe-in -83.58, 93.81 APE8-rot-na 29.41 APE67-dihe-in -65.12, -16.72 -54.94, -46.13 APE12-dist-na 12.548 APE11-dist-na 8.981 APE10-dist-na 8.282 APE9-dist-in 5.911 None None None XRAY 1.797 0.19 0.226 A 306 269 4 0 0 0 [[613, 873]] 1.0 5ia4 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5IA5A 605 880 976.0 GV0:1001 Type2 Inactive DFGout 13.874 6.594 None -143.37, 173.19 -151.4, 82.68 -56.42, -33.09 175.63, 84.97 110.28, 32.23 in-out in 9.576 Saltbr-out 4.012 HRD-in -76.98, -49.24 77.2, -12.17 out-out-in SNCooi out-in ActLoopNT-out 12.64 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.87, 166.66 APE9-dihe-in -109.64, 133.43 APE8-dihe-in -81.98, 92.61 APE8-rot-na 30.46 APE67-dihe-in -66.59, -17.41 -56.37, -44.02 APE12-dist-na 12.683 APE11-dist-na 9.326 APE10-dist-na 8.565 APE9-dist-in 6.138 None None None XRAY 1.776 0.2 0.244 A 306 273 3 0 0 0 [[613, 873]] 1.0 5ia5 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6Q7FA 605 896 976.0 HNZ:1001 Type2 Inactive DFGout 15.869 13.943 None -134.18, 174.7 -157.39, 165.69 -81.97, -172.5 323.46, 97.9 -68.25, 999.0 in-in in 8.496 Saltbr-in 2.797 HRD-in -75.6, -51.64 79.09, -19.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 68.54 APE8-rot-na 24.65 APE67-dihe-in -62.45, -19.38 -49.67, -47.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.204 0.187 0.21 A 306 267 25 0 0 20 [[613, 873]] 1.0 6q7f TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
8BOFA 605 896 976.0 R3L:1001 Type2 Inactive DFGout 13.475 11.246 None -130.77, 177.3 -148.61, 101.8 -81.23, 999.0 310.93, 149.4 999.0, 999.0 in-in in 8.374 Saltbr-in 2.925 HRD-in -72.28, -52.52 79.68, -16.43 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 57.23 APE8-rot-na 32.04 APE67-dihe-in -64.32, -20.17 -51.23, -47.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.82 0.187 0.216 A 306 266 26 0 0 21 [[613, 873]] 1.0 8bof TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5I9VA 605 896 976.0 AGS:1001 ATPlike None DFGin 5.797 14.921 BLAminus -141.81, -171.65 57.06, 75.11 -93.17, 20.3 299.55, 97.8 -61.14, -30.9 in-in in 8.619 Saltbr-in 2.822 HRD-in -77.85, -47.75 76.63, -12.15 in-in-none SNCiin in-none ActLoopNT-in 2.918 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 136.3 APE9-dihe-in -111.36, 131.85 APE8-dihe-in -64.26, 123.12 APE8-rot-na 332.19 APE67-dihe-in -77.38, -2.66 -54.41, -44.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.712 APE9-dist-in 5.342 None None None XRAY 1.458 0.164 0.191 A 306 279 13 0 0 13 [[613, 873]] 1.0 5i9v TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
1MQBB 602 883 976.0 ANP:1001 ATPlike None DFGin 5.691 14.889 BLAminus -139.65, -173.77 51.28, 81.33 -92.67, 10.65 292.99, 95.58 -41.77, -44.65 in-in in 8.273 Saltbr-in 2.64 HRD-in -72.65, -50.06 79.19, -16.04 in-in-none SNCiin in-none ActLoopNT-in 2.992 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -50.3 APE9-dihe-in -134.32, 148.66 APE8-dihe-in -83.15, 83.63 APE8-rot-na 31.61 APE67-dihe-in -80.07, -2.61 -53.54, -47.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.328 APE9-dist-in 6.633 None None None XRAY 2.3 0.237 0.288 B 333 265 17 0 0 13 [[613, 873]] 1.0 1mqb TYR_EPHA2_HUMAN TYR 7.4e-108 365.7 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
7KJAB 590 965 976.0 ACP:61003 ATPlike None DFGin 5.95 15.319 BLAminus -132.83, -173.32 70.39, 83.56 -118.78, 24.56 302.85, 98.09 -89.22, 999.0 in-in in 8.607 Saltbr-in 3.165 HRD-in -76.56, -48.38 78.92, -16.95 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.75 APE8-rot-na 32.08 APE67-dihe-in -69.28, -11.58 -65.6, -29.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.19 0.217 B 390 349 22 0 0 20 [[613, 873]] 1.0 7kja TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5I9UA 601 894 976.0 No_ligand No_ligand None DFGin 6.103 15.089 BLAminus -130.24, -168.91 54.89, 69.82 -93.83, 19.72 297.56, 96.24 -63.4, -27.55 in-in in 9.022 Saltbr-in 3.201 HRD-in -78.67, -48.85 76.31, -6.88 in-in-none SNCiin in-none ActLoopNT-in 2.999 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.04 APE8-dihe-in -54.79, 128.06 APE8-rot-na 14.0 APE67-dihe-in -78.34, -2.47 -55.89, -42.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.492 None None None XRAY 1.889 0.166 0.224 A 306 281 13 0 0 13 [[613, 873]] 1.0 5i9u TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5IA0A 604 889 976.0 A5B:1001 Type1 None DFGin 5.75 15.225 BLAminus -131.01, -155.76 61.65, 69.41 -104.69, 91.97 299.22, 100.6 -172.83, 999.0 in-in in 7.988 Saltbr-in 3.057 HRD-in -80.45, -46.02 73.5, -13.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 103.13 APE8-dihe-in -95.39, 103.1 APE8-rot-na 22.72 APE67-dihe-in -72.64, -3.49 -61.44, -50.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.638 None None None XRAY 1.948 0.194 0.225 A 306 263 23 0 0 19 [[613, 873]] 1.0 5ia0 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
5NKAA 605 895 976.0 91H:1001 Type1 None DFGin 5.817 15.43 BLAminus -138.05, -167.81 59.6, 76.5 -90.38, 23.3 298.3, 92.95 -114.03, 999.0 in-in in 8.742 Saltbr-in 3.565 HRD-in -74.33, -47.29 74.19, -12.19 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -56.83 APE9-dihe-in -63.62, 121.18 APE8-dihe-in -54.7, 111.87 APE8-rot-na 330.09 APE67-dihe-in -75.86, -5.14 -47.88, -45.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.701 None None None XRAY 1.377 0.161 0.182 A 306 271 18 0 0 18 [[613, 873]] 1.0 5nka TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
6FNHC 600 890 976.0 DXK:1001 Type1 None DFGin 6.1 15.078 BLAminus -136.98, -166.98 54.47, 77.28 -106.75, 37.52 303.15, 87.48 -109.85, 171.74 in-in in 8.523 Saltbr-in 2.973 HRD-in -71.56, -48.37 75.35, -10.7 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.12 APE8-rot-na 34.55 APE67-dihe-in -53.44, -22.38 -49.0, -43.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.379 0.206 0.221 C 306 270 21 0 0 19 [[613, 873]] 1.0 6fnh TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2

TYR_EPHA2 (Ephrin type-A receptor 2)

Total number of chains: 81
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 28 34.6% 5NKGA
DFGout BBAminus 23 28.4% 8BOKA
DFGin BLAminus 15 18.5% AF-P29317-K1A
DFGin ABAminus 8 9.9% 7KJBA
DFGout None 4 4.9% 5IA5A
DFGin None 3 3.7% 5IA1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EPHA2_HUMAN AF-P29317-K1A P29317 605 881 976.0 No_ligand No_ligand Active DFGin 6.249 14.768 BLAminus -140.35, -178.11 60.68, 63.96 -83.01, 12.49 290.7, 90.65 -60.91, -32.34 in-in in 8.263 Saltbr-in 2.648 HRD-in -81.0, -41.9 68.37, -20.17 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.13, 136.01 APE9-dihe-in -119.41, 124.38 APE8-dihe-in -75.94, 80.27 APE8-rot-na 33.64 APE67-dihe-in -68.13, -20.7 -44.4, -43.02 APE12-dist-na 11.38 APE11-dist-na 9.019 APE10-dist-na 9.306 APE9-dist-in 6.356 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[613, 873]] 1.0 AF-P29317-K1 Homo sapiens TYR_EPHA2_HUMAN TYR 3.8e-108 366.6 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN AF-P29317-K3A P29317 605 881 976.0 No_ligand No_ligand Active DFGin 5.997 14.36 BLAminus -144.91, -177.93 57.46, 72.8 -83.35, 12.16 291.82, 92.9 -59.12, -31.93 in-in in 8.31 Saltbr-in 2.7 HRD-in -79.58, -45.38 67.22, -10.26 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.02, 141.9 APE9-dihe-in -124.72, 138.13 APE8-dihe-in -75.91, 74.67 APE8-rot-na 34.86 APE67-dihe-in -64.95, -18.37 -43.74, -45.38 APE12-dist-na 11.571 APE11-dist-na 9.239 APE10-dist-na 9.407 APE9-dist-in 5.997 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[613, 873]] 1.0 AF-P29317-K3 Homo sapiens TYR_EPHA2_HUMAN TYR 3.8e-108 366.6 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 4TRLA P29317 599 875 976.0 No_ligand No_ligand Inactive DFGin 5.578 14.734 ABAminus -135.74, -21.41 -117.74, 96.0 -97.73, 10.57 299.45, 103.05 -52.99, -46.17 in-in in 8.531 Saltbr-in 3.569 HRD-in -85.62, -43.31 69.59, 2.8 in-in-in SNCiii in-in ActLoopNT-in 3.017 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.67, 134.65 APE9-dihe-in -136.44, 149.6 APE8-dihe-in -75.27, 91.15 APE8-rot-na 24.33 APE67-dihe-in -65.44, -16.63 -52.52, -46.9 APE12-dist-na 11.134 APE11-dist-na 9.323 APE10-dist-na 9.342 APE9-dist-in 5.871 None PTR772 PTR772 XRAY 2.452 0.202 0.25 A 299 269 8 0 0 1 [[613, 873]] 1.0 4trl Homo sapiens TYR_EPHA2_HUMAN TYR 5.1e-108 366.2 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 7KJBA P29317 591 965 976.0 No_ligand No_ligand Inactive DFGin 5.637 14.959 ABAminus -132.91, -22.75 -108.93, 112.29 -125.99, 49.73 298.64, 106.94 -77.0, 170.81 in-in in 8.125 Saltbr-in 2.615 HRD-in -72.92, -40.78 73.25, -13.62 in-out-in SNCioi out-in ActLoopNT-out 9.463 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.09, 163.14 APE9-dihe-in -84.17, 117.21 APE8-dihe-in -72.3, 146.33 APE8-rot-na 29.14 APE67-dihe-in -70.22, -15.1 -63.86, -33.58 APE12-dist-na 13.61 APE11-dist-na 10.299 APE10-dist-na 11.883 APE9-dist-in 5.516 S897E,S901E None None XRAY 2.8 0.2 0.246 A 390 361 5 0 0 0 [[613, 873]] 1.0 7kjb Homo sapiens TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NK0A P29317 602 894 976.0 91E:1001 Type1 Inactive DFGin 5.783 15.305 ABAminus -130.11, -35.9 -103.1, 114.86 -114.18, 27.44 295.79, 97.0 -63.76, -27.15 in-in in 8.887 Saltbr-in 3.583 HRD-in -79.65, -46.58 73.85, -13.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 97.07 APE8-rot-na 324.81 APE67-dihe-in -78.99, -2.17 -57.91, -45.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.597 0.165 0.194 A 306 273 19 0 0 19 [[613, 873]] 1.0 5nk0 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NK8A P29317 605 894 976.0 90Z:1001 Type1 Inactive DFGin 5.897 15.505 ABAminus -130.54, -47.65 -90.06, 119.53 -121.49, 17.1 287.64, 97.95 -115.78, 999.0 in-in in 8.887 Saltbr-in 3.328 HRD-in -77.39, -49.79 77.73, -13.27 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 131.74 APE8-rot-na 323.5 APE67-dihe-in -75.77, -1.63 -58.13, -47.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.761 0.168 0.206 A 306 266 24 0 0 20 [[613, 873]] 1.0 5nk8 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6FNHA P29317 602 889 976.0 DXK:1001 Type1 Inactive DFGin 6.029 15.287 ABAminus -132.89, -13.6 -114.29, 112.91 -120.16, 34.85 297.73, 92.28 -68.77, 147.18 in-in in 8.571 Saltbr-in 2.524 HRD-in -71.64, -49.56 77.94, -13.05 in-out-in SNCioi out-in ActLoopNT-out 10.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.64, 136.2 APE9-dihe-in -91.95, 112.57 APE8-dihe-in -77.45, 142.7 APE8-rot-na 28.74 APE67-dihe-in -60.57, -18.72 -57.08, -38.55 APE12-dist-na 999.0 APE11-dist-na 8.383 APE10-dist-na 12.377 APE9-dist-in 5.447 None None None XRAY 1.379 0.206 0.221 A 306 277 11 0 0 10 [[613, 873]] 1.0 6fnh Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6FNHB P29317 602 882 976.0 DXK:1001 Type1 Inactive DFGin 5.348 15.068 ABAminus -133.93, -15.74 -121.25, 119.84 -118.06, 28.52 301.16, 87.41 -78.43, -76.5 in-in in 8.252 Saltbr-in 2.341 HRD-in -74.5, -47.84 76.45, -12.42 in-out-out SNCioo out-out ActLoopNT-out 6.812 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 153.72 APE9-dihe-in -66.55, 140.49 APE8-dihe-in -67.49, 153.9 APE8-rot-na 28.58 APE67-dihe-in -75.86, -2.19 -123.09, -16.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.248 APE9-dist-out 8.953 None None None XRAY 1.379 0.206 0.221 B 306 271 10 0 0 7 [[613, 873]] 1.0 6fnh Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NK3A P29317 601 888 976.0 92Q:1001 Type1.5_Back Inactive DFGin 5.888 14.932 ABAminus -127.77, -30.16 -98.66, 126.21 -132.36, 33.74 299.85, 97.19 -64.67, 145.97 in-in in 8.62 Saltbr-in 2.695 HRD-in -75.58, -45.96 75.19, -12.86 in-out-in SNCioi out-in ActLoopNT-out 10.261 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.51, 134.59 APE9-dihe-in -90.19, 122.73 APE8-dihe-in -78.28, 138.13 APE8-rot-na 5.98 APE67-dihe-in -79.02, -0.01 -52.35, -44.52 APE12-dist-na 999.0 APE11-dist-na 8.895 APE10-dist-na 12.725 APE9-dist-in 5.457 None None None XRAY 1.586 0.195 0.228 A 306 281 7 0 0 3 [[613, 873]] 1.0 5nk3 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 8QQYA P29317 605 896 976.0 WT3:1001 Type1.5_Back Inactive DFGin 6.022 15.079 ABAminus -143.91, 11.32 -136.78, 112.13 -116.84, 31.35 294.32, 97.84 -60.55, 136.19 in-in in 8.788 Saltbr-in 2.491 HRD-in -70.11, -50.87 79.72, -17.4 in-out-none SNCion out-none ActLoopNT-out 10.219 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -77.4 APE9-dihe-in -90.42, 120.43 APE8-dihe-in -75.55, 139.11 APE8-rot-na 24.19 APE67-dihe-in -77.39, -3.79 -51.26, -47.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.291 APE9-dist-in 5.494 None None None XRAY 1.8 0.191 0.223 A 306 272 20 0 0 10 [[613, 873]] 1.0 8qqy Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 1MQBA P29317 605 887 976.0 ANP:1000 ATPlike Inactive DFGin 5.712 14.924 BLAminus -127.53, -172.03 57.53, 74.63 -109.94, 122.74 306.64, 100.38 176.53, 104.78 in-out in 8.465 Saltbr-out 5.675 HRD-in -62.1, -45.48 77.42, -17.66 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -37.06 APE9-dihe-in -88.14, 119.95 APE8-dihe-in -73.81, 144.85 APE8-rot-na 33.04 APE67-dihe-in -82.72, 0.0 -54.3, -43.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.553 APE9-dist-in 5.598 None None None XRAY 2.3 0.237 0.288 A 333 263 20 0 0 17 [[613, 873]] 1.0 1mqb Homo sapiens TYR_EPHA2_HUMAN TYR 7.4e-108 365.7 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 4P2KA P29317 600 876 976.0 No_ligand No_ligand Inactive DFGin 5.081 15.914 BLAminus -128.03, -172.79 59.15, 70.41 -91.85, 18.3 285.75, 82.84 -52.48, -41.13 in-out in 9.616 Saltbr-out 3.937 HRD-in -82.58, -47.9 75.24, -8.53 out-in-in SNCoii in-in ActLoopNT-in 2.926 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.82, 138.44 APE9-dihe-in -127.64, 156.99 APE8-dihe-in -81.39, 86.24 APE8-rot-na 29.13 APE67-dihe-in -65.57, -17.39 -54.1, -43.92 APE12-dist-na 999.0 APE11-dist-na 9.807 APE10-dist-na 10.152 APE9-dist-in 6.06 None None None XRAY 1.499 0.174 0.19 A 299 259 18 0 0 12 [[613, 873]] 1.0 4p2k Homo sapiens TYR_EPHA2_HUMAN TYR 5.1e-108 366.2 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5EK7A P29317 586 875 976.0 No_ligand No_ligand Inactive DFGin 5.857 15.407 BLAminus -130.66, -168.3 62.02, 69.56 -99.82, 88.13 290.82, 97.38 -94.6, 141.73 in-in in 7.755 Saltbr-in 2.757 HRD-in -76.18, -45.92 76.67, -15.63 in-out-in SNCioi out-in ActLoopNT-out 8.587 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.13, 163.41 APE9-dihe-in -81.65, 120.12 APE8-dihe-in -73.73, 138.8 APE8-rot-na 25.17 APE67-dihe-in -54.48, -26.63 -56.76, -41.48 APE12-dist-na 14.613 APE11-dist-na 10.971 APE10-dist-na 12.398 APE9-dist-in 5.197 None None None XRAY 1.901 0.172 0.205 A 308 286 4 0 0 0 [[613, 873]] 1.0 5ek7 Homo sapiens TYR_EPHA2_HUMAN TYR 5.7e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5EK7B P29317 586 875 976.0 No_ligand No_ligand Inactive DFGin 5.745 15.21 BLAminus -126.54, -164.94 55.71, 72.14 -96.75, 90.29 295.56, 92.81 -90.82, 136.53 in-in in 7.701 Saltbr-in 2.668 HRD-in -71.96, -46.69 77.79, -18.08 in-out-in SNCioi out-in ActLoopNT-out 9.182 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.45, 153.41 APE9-dihe-in -80.92, 121.99 APE8-dihe-in -74.2, 138.52 APE8-rot-na 26.08 APE67-dihe-in -58.89, -22.57 -58.03, -38.86 APE12-dist-na 14.279 APE11-dist-na 10.507 APE10-dist-na 12.63 APE9-dist-in 5.186 None None None XRAY 1.901 0.172 0.205 B 308 286 4 0 0 0 [[613, 873]] 1.0 5ek7 Homo sapiens TYR_EPHA2_HUMAN TYR 5.7e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 8BINA P29317 605 887 976.0 QRR:1005 Type1 Inactive DFGin 6.096 14.933 BLAminus -129.12, -169.3 64.88, 80.64 -107.59, 25.53 298.43, 100.36 -53.06, 139.56 in-in in 8.256 Saltbr-in 2.838 HRD-in -74.83, -46.22 76.7, -15.63 in-out-in SNCioi out-in ActLoopNT-out 9.968 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.47, 132.16 APE9-dihe-in -87.88, 121.44 APE8-dihe-in -71.63, 137.09 APE8-rot-na 27.71 APE67-dihe-in -78.72, -2.32 -51.32, -46.75 APE12-dist-na 999.0 APE11-dist-na 9.181 APE10-dist-na 13.089 APE9-dist-in 5.405 None None None XRAY 1.5 0.134 0.171 A 306 264 19 0 0 9 [[613, 873]] 1.0 8bin Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 8BIOA P29317 605 894 976.0 QRD:1012 Type1.5_Back Inactive DFGin 6.107 14.819 BLAminus -133.27, 178.5 74.5, 81.24 -109.91, 27.01 298.28, 105.83 -55.05, 138.71 in-in in 8.257 Saltbr-in 2.837 HRD-in -75.31, -47.53 77.61, -13.45 in-out-in SNCioi out-in ActLoopNT-out 9.765 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.13, 128.48 APE9-dihe-in -84.61, 123.83 APE8-dihe-in -73.7, 136.2 APE8-rot-na 29.88 APE67-dihe-in -81.02, -0.73 -50.92, -45.76 APE12-dist-na 999.0 APE11-dist-na 9.296 APE10-dist-na 13.21 APE9-dist-in 5.425 None None None XRAY 1.6 0.165 0.199 A 306 273 17 0 0 7 [[613, 873]] 1.0 8bio Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5I9WA P29317 605 895 976.0 ANP:1001 ATPlike Inactive DFGin 6.244 15.281 BLBminus -125.95, -162.36 67.3, 57.63 -98.89, 156.85 294.37, 103.89 164.47, 175.48 in-in in 8.347 Saltbr-in 2.764 HRD-in -75.49, -48.49 78.15, -15.84 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.31 APE8-dihe-in -84.75, 145.17 APE8-rot-na 35.12 APE67-dihe-in -78.8, -3.01 -55.81, -43.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.342 None None None XRAY 1.359 0.17 0.18 A 306 267 24 0 0 18 [[613, 873]] 1.0 5i9w Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 7KJCA P29317 590 976 976.0 ACP:61001 ATPlike Inactive DFGin 5.878 14.93 BLBminus -137.77, -170.41 70.81, 83.37 -119.58, 163.56 301.23, 100.14 146.26, -161.86 in-in in 8.355 Saltbr-in 3.032 HRD-in -75.87, -47.34 76.1, -11.46 in-out-none SNCion out-none ActLoopNT-out 9.669 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 107.51 APE9-dihe-in -145.96, 148.03 APE8-dihe-in -73.29, 89.61 APE8-rot-na 29.38 APE67-dihe-in -67.75, -13.33 -62.67, -32.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.547 APE9-dist-in 6.64 S901E None None XRAY 2.3 0.19 0.226 A 390 373 8 0 0 5 [[613, 873]] 1.0 7kjc Homo sapiens TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 7KJCB P29317 590 965 976.0 ACP:61002 ATPlike Inactive DFGin 5.963 15.204 BLBminus -132.91, -166.6 60.51, 83.21 -117.48, 163.92 299.39, 100.57 145.47, 999.0 in-in in 8.467 Saltbr-in 3.13 HRD-in -75.7, -46.49 74.32, -9.38 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 86.32 APE8-rot-na 29.03 APE67-dihe-in -66.96, -12.86 -66.13, -32.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 S901E None None XRAY 2.3 0.19 0.226 B 390 347 23 0 0 20 [[613, 873]] 1.0 7kjc Homo sapiens TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 7KJAA P29317 590 976 976.0 ACP:61002 ATPlike Inactive DFGin 5.763 14.769 BLBminus -129.59, -174.19 75.99, 88.0 -122.87, 170.51 304.47, 101.43 99.06, 999.0 in-in in 8.424 Saltbr-in 3.055 HRD-in -76.77, -48.29 79.69, -17.22 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.1 APE8-rot-na 32.23 APE67-dihe-in -70.25, -11.59 -65.39, -29.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.19 0.217 A 390 361 20 0 0 20 [[613, 873]] 1.0 7kja Homo sapiens TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5I9XA P29317 604 896 976.0 DB8:1001 Type1 Inactive DFGin 6.007 14.831 BLBminus -129.07, 177.72 76.64, 79.94 -112.75, 156.99 297.29, 98.79 146.97, -174.61 in-in in 8.09 Saltbr-in 3.299 HRD-in -74.57, -46.21 76.15, -16.23 in-out-in SNCioi out-in ActLoopNT-out 10.42 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.78, 113.1 APE9-dihe-in -147.01, 138.26 APE8-dihe-in -78.55, 92.56 APE8-rot-na 31.7 APE67-dihe-in -77.79, -2.98 -59.26, -48.48 APE12-dist-na 999.0 APE11-dist-na 14.091 APE10-dist-na 12.379 APE9-dist-in 6.799 None None None XRAY 1.427 0.166 0.182 A 306 284 9 0 0 4 [[613, 873]] 1.0 5i9x Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5I9YA P29317 600 896 976.0 1N1:1001 Type1 Inactive DFGin 6.222 14.973 BLBminus -129.12, 177.86 73.14, 77.74 -114.09, 153.37 295.9, 102.04 147.64, -171.81 in-in in 8.257 Saltbr-in 2.774 HRD-in -75.07, -47.16 76.83, -16.24 in-out-none SNCion out-none ActLoopNT-out 10.459 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 139.34 APE8-rot-na 36.16 APE67-dihe-in -79.28, -3.2 -53.92, -45.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.228 0.164 0.179 A 306 287 10 0 0 7 [[613, 873]] 1.0 5i9y Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5I9ZA P29317 604 896 976.0 627:1001 Type1 Inactive DFGin 6.395 15.025 BLBminus -135.15, -162.14 63.34, 62.38 -99.38, 153.95 296.28, 106.39 156.26, -159.7 in-in in 8.181 Saltbr-in 3.003 HRD-in -78.26, -45.75 77.15, -16.58 in-out-none SNCion out-none ActLoopNT-out 10.334 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.03 APE8-dihe-in -78.75, 94.25 APE8-rot-na 31.08 APE67-dihe-in -77.33, -1.49 -57.35, -48.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.695 None None None XRAY 1.698 0.162 0.2 A 306 273 20 0 0 14 [[613, 873]] 1.0 5i9z Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5IA0B P29317 600 882 976.0 A5B:1001 Type1 Inactive DFGin 5.553 15.384 BLBminus -126.96, -156.55 64.03, 67.0 -103.77, 142.3 299.95, 99.48 123.44, 148.27 in-in in 8.085 Saltbr-in 3.23 HRD-in -74.38, -46.39 76.24, -14.79 in-out-none SNCion out-none ActLoopNT-out 10.837 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 107.19 APE8-dihe-in -66.68, 140.21 APE8-rot-na 27.23 APE67-dihe-in -76.07, -2.43 -63.36, -38.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.332 None None None XRAY 1.948 0.194 0.225 B 306 266 17 0 0 14 [[613, 873]] 1.0 5ia0 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5IA0C P29317 600 890 976.0 A5B:1001 Type1 Inactive DFGin 6.339 15.027 BLBminus -132.95, -162.71 63.9, 70.2 -105.45, 159.62 303.48, 101.06 149.65, -160.59 in-in in 8.356 Saltbr-in 2.642 HRD-in -77.84, -43.14 69.2, -7.06 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 48.26 APE8-rot-na 27.02 APE67-dihe-in -80.71, 0.8 -57.19, -48.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.948 0.194 0.225 C 306 269 22 0 0 18 [[613, 873]] 1.0 5ia0 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5IA3A P29317 602 896 976.0 P17:1001 Type1 Inactive DFGin 6.244 14.848 BLBminus -140.25, -177.97 75.12, 87.33 -118.87, 162.99 296.17, 108.02 122.4, -163.0 in-in in 8.321 Saltbr-in 2.649 HRD-in -77.68, -48.9 76.3, -15.94 in-out-none SNCion out-none ActLoopNT-out 9.267 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 154.55 APE8-dihe-in -79.35, 94.2 APE8-rot-na 29.88 APE67-dihe-in -64.17, -17.19 -57.49, -47.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.641 None None None XRAY 1.788 0.163 0.204 A 306 275 20 0 0 16 [[613, 873]] 1.0 5ia3 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NJZA P29317 604 896 976.0 8ZH:1001 Type1 Inactive DFGin 6.204 14.895 BLBminus -137.86, -175.05 73.68, 71.15 -106.6, 164.44 297.85, 104.9 122.98, -167.74 in-in in 8.335 Saltbr-in 3.007 HRD-in -74.37, -49.77 78.18, -16.27 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.44 APE8-dihe-in -79.72, 92.34 APE8-rot-na 31.41 APE67-dihe-in -77.02, -1.86 -56.16, -49.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.798 None None None XRAY 1.768 0.165 0.199 A 306 273 20 0 0 17 [[613, 873]] 1.0 5njz Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NK1A P29317 604 896 976.0 90N:1001 Type1 Inactive DFGin 6.261 15.096 BLBminus -137.04, -175.86 73.92, 78.56 -114.15, 154.72 297.57, 106.7 143.73, -170.99 in-in in 8.452 Saltbr-in 3.562 HRD-in -77.13, -47.81 78.79, -17.19 in-out-in SNCioi out-in ActLoopNT-out 10.255 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.69, 107.39 APE9-dihe-in -145.05, 145.15 APE8-dihe-in -80.73, 95.07 APE8-rot-na 28.79 APE67-dihe-in -77.06, -2.71 -57.34, -48.02 APE12-dist-na 999.0 APE11-dist-na 13.98 APE10-dist-na 12.27 APE9-dist-in 6.611 None None None XRAY 1.548 0.168 0.193 A 306 284 9 0 0 4 [[613, 873]] 1.0 5nk1 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NK2A P29317 598 896 976.0 8ZZ:1001 Type1 Inactive DFGin 6.246 14.904 BLBminus -133.56, -173.1 72.69, 80.77 -116.74, 156.82 298.99, 102.92 143.26, -174.99 in-in in 8.21 Saltbr-in 2.846 HRD-in -74.93, -47.15 75.08, -14.22 in-out-in SNCioi out-in ActLoopNT-out 10.494 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.16, 114.72 APE9-dihe-in -143.31, 138.34 APE8-dihe-in -81.16, 89.97 APE8-rot-na 31.9 APE67-dihe-in -81.7, 0.84 -56.09, -45.98 APE12-dist-na 999.0 APE11-dist-na 13.865 APE10-dist-na 12.294 APE9-dist-in 6.761 None None None XRAY 1.649 0.158 0.189 A 306 290 9 0 0 4 [[613, 873]] 1.0 5nk2 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NK4A P29317 601 896 976.0 90E:1001 Type1 Inactive DFGin 6.158 15.103 BLBminus -133.74, -169.69 69.8, 80.22 -113.59, 153.71 298.29, 106.67 147.72, -170.25 in-in in 8.314 Saltbr-in 3.251 HRD-in -74.87, -48.2 78.27, -18.05 in-out-in SNCioi out-in ActLoopNT-out 10.479 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.29, 110.29 APE9-dihe-in -136.95, 141.93 APE8-dihe-in -84.88, 89.59 APE8-rot-na 31.07 APE67-dihe-in -76.16, -4.97 -53.91, -49.3 APE12-dist-na 16.882 APE11-dist-na 13.682 APE10-dist-na 12.249 APE9-dist-in 6.763 None None None XRAY 1.45 0.17 0.197 A 306 290 6 0 0 0 [[613, 873]] 1.0 5nk4 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NK5A P29317 605 896 976.0 90K:1001 Type1 Inactive DFGin 6.073 15.346 BLBminus -137.11, -168.25 74.71, 82.66 -124.01, 156.72 306.75, 105.61 -166.49, 154.07 in-in in 8.84 Saltbr-in 3.409 HRD-in -76.81, -44.59 72.07, -9.98 in-out-in SNCioi out-in ActLoopNT-out 5.007 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.29, 132.5 APE9-dihe-in -59.48, 116.97 APE8-dihe-in -52.03, 120.26 APE8-rot-na 332.57 APE67-dihe-in -73.79, -6.01 -69.09, -20.53 APE12-dist-na 11.958 APE11-dist-na 14.944 APE10-dist-na 17.706 APE9-dist-in 5.639 None None None XRAY 1.329 0.181 0.202 A 306 287 4 0 0 1 [[613, 873]] 1.0 5nk5 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NK6A P29317 605 896 976.0 90W:1001 Type1 Inactive DFGin 6.158 15.114 BLBminus -127.42, -172.48 68.71, 79.04 -114.0, 154.12 297.13, 104.22 145.91, -174.06 in-out in 8.338 Saltbr-out 3.685 HRD-in -77.16, -48.59 77.69, -11.86 out-out-in SNCooi out-in ActLoopNT-out 10.439 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.47, 110.03 APE9-dihe-in -142.84, 150.69 APE8-dihe-in -85.6, 93.63 APE8-rot-na 31.14 APE67-dihe-in -66.03, -18.5 -55.72, -46.87 APE12-dist-na 16.087 APE11-dist-na 13.852 APE10-dist-na 12.323 APE9-dist-in 6.594 None None None XRAY 1.267 0.172 0.186 A 306 284 8 0 0 3 [[613, 873]] 1.0 5nk6 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NK7A P29317 604 896 976.0 8ZZ:1001 Type1 Inactive DFGin 6.311 15.067 BLBminus -131.93, -179.62 72.17, 67.66 -104.91, 158.6 298.18, 102.85 143.87, -168.6 in-in in 8.255 Saltbr-in 2.855 HRD-in -78.48, -45.08 78.22, -20.49 in-out-in SNCioi out-in ActLoopNT-out 10.227 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.4, 104.21 APE9-dihe-in -139.82, 156.78 APE8-dihe-in -85.7, 99.4 APE8-rot-na 30.28 APE67-dihe-in -63.84, -18.12 -58.56, -47.79 APE12-dist-na 999.0 APE11-dist-na 13.79 APE10-dist-na 12.454 APE9-dist-in 6.508 None None None XRAY 1.889 0.171 0.2 A 306 284 9 0 0 4 [[613, 873]] 1.0 5nk7 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NK9A P29317 605 896 976.0 912:1001 Type1 Inactive DFGin 6.242 15.128 BLBminus -137.77, -174.06 71.41, 79.64 -113.27, 155.81 297.43, 105.37 145.29, -173.1 in-out in 8.378 Saltbr-out 5.809 HRD-in -76.8, -48.27 77.51, -16.42 out-out-in SNCooi out-in ActLoopNT-out 10.401 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.34, 98.9 APE9-dihe-in -132.66, 143.35 APE8-dihe-in -81.24, 93.22 APE8-rot-na 31.4 APE67-dihe-in -65.79, -17.82 -56.45, -46.3 APE12-dist-na 999.0 APE11-dist-na 14.026 APE10-dist-na 12.389 APE9-dist-in 6.706 None None None XRAY 1.588 0.164 0.195 A 306 285 7 0 0 2 [[613, 873]] 1.0 5nk9 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NKBA P29317 605 896 976.0 8ZT:1001 Type1 Inactive DFGin 6.287 14.993 BLBminus -131.88, -179.08 75.71, 70.28 -109.86, 150.89 296.07, 101.49 157.0, -166.21 in-in in 8.29 Saltbr-in 2.819 HRD-in -75.0, -44.6 73.88, -12.43 in-out-in SNCioi out-in ActLoopNT-out 10.373 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.59, 110.72 APE9-dihe-in -147.23, 154.27 APE8-dihe-in -91.23, 94.45 APE8-rot-na 33.34 APE67-dihe-in -69.82, -14.68 -57.35, -42.58 APE12-dist-na 999.0 APE11-dist-na 14.1 APE10-dist-na 12.336 APE9-dist-in 6.586 None None None XRAY 1.5 0.161 0.191 A 306 285 7 0 0 2 [[613, 873]] 1.0 5nkb Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NKCA P29317 601 896 976.0 90T:1001 Type1 Inactive DFGin 6.093 14.967 BLBminus -135.22, -175.36 73.65, 77.68 -110.73, 155.72 298.14, 102.52 146.31, -171.29 in-in in 8.289 Saltbr-in 2.822 HRD-in -74.69, -46.81 76.81, -16.71 in-out-none SNCion out-none ActLoopNT-out 10.507 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 105.91 APE9-dihe-in -149.82, 161.92 APE8-dihe-in -87.79, 89.86 APE8-rot-na 31.31 APE67-dihe-in -77.76, -3.77 -54.19, -47.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.424 APE9-dist-in 6.627 None None None XRAY 1.448 0.162 0.191 A 306 286 10 0 0 5 [[613, 873]] 1.0 5nkc Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NKDA P29317 600 896 976.0 91K:1001 Type1 Inactive DFGin 6.132 14.964 BLBminus -134.78, -176.82 73.76, 78.86 -113.54, 153.56 296.08, 104.15 146.36, -174.67 in-in in 8.26 Saltbr-in 2.732 HRD-in -77.14, -45.48 77.12, -16.83 in-out-in SNCioi out-in ActLoopNT-out 10.467 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.01, 117.41 APE9-dihe-in -145.83, 137.51 APE8-dihe-in -78.06, 86.38 APE8-rot-na 30.76 APE67-dihe-in -79.78, -1.96 -53.99, -48.84 APE12-dist-na 999.0 APE11-dist-na 14.179 APE10-dist-na 12.468 APE9-dist-in 6.855 None None None XRAY 1.408 0.186 0.224 A 306 287 10 0 0 4 [[613, 873]] 1.0 5nkd Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NKEA P29317 605 896 976.0 90B:1001 Type1 Inactive DFGin 6.012 15.477 BLBminus -135.64, -171.02 68.87, 95.15 -133.04, 152.12 306.86, 107.41 -169.26, 153.03 in-in in 8.882 Saltbr-in 3.311 HRD-in -76.93, -45.55 75.92, -17.2 in-out-in SNCioi out-in ActLoopNT-out 5.045 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.7, 128.87 APE9-dihe-in -59.73, 120.77 APE8-dihe-in -54.03, 120.5 APE8-rot-na 332.36 APE67-dihe-in -73.93, -4.86 -69.21, -21.3 APE12-dist-na 11.897 APE11-dist-na 14.842 APE10-dist-na 17.564 APE9-dist-in 5.758 None None None XRAY 1.39 0.174 0.204 A 306 292 0 0 0 0 [[613, 873]] 1.0 5nke Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NKFA P29317 605 896 976.0 8ZN:1001 Type1 Inactive DFGin 6.183 15.179 BLBminus -122.27, 177.83 72.21, 78.1 -114.07, 153.93 296.07, 102.17 145.36, -178.0 in-out in 8.364 Saltbr-out 3.743 HRD-in -74.66, -48.65 78.25, -15.54 out-out-in SNCooi out-in ActLoopNT-out 10.321 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.3, 108.22 APE9-dihe-in -143.18, 153.17 APE8-dihe-in -86.73, 90.35 APE8-rot-na 29.73 APE67-dihe-in -65.53, -16.38 -49.82, -51.37 APE12-dist-na 17.118 APE11-dist-na 13.933 APE10-dist-na 12.306 APE9-dist-in 6.58 None None None XRAY 1.099 0.171 0.187 A 306 291 1 0 0 0 [[613, 873]] 1.0 5nkf Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NKGA P29317 605 896 976.0 8ZK:1001 Type1 Inactive DFGin 6.191 15.067 BLBminus -139.5, 179.31 75.9, 82.87 -116.7, 155.72 295.67, 109.55 146.37, 168.26 in-out in 8.42 Saltbr-out 3.808 HRD-in -76.37, -48.88 77.43, -18.77 out-out-in SNCooi out-in ActLoopNT-out 10.076 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.66, 108.62 APE9-dihe-in -143.07, 153.94 APE8-dihe-in -87.68, 91.58 APE8-rot-na 31.26 APE67-dihe-in -64.1, -16.04 -53.74, -48.31 APE12-dist-na 17.441 APE11-dist-na 14.179 APE10-dist-na 12.775 APE9-dist-in 6.551 None None None XRAY 1.1 0.172 0.19 A 306 292 0 0 0 0 [[613, 873]] 1.0 5nkg Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NKHA P29317 601 895 976.0 8ZQ:1001 Type1 Inactive DFGin 5.923 15.358 BLBminus -132.2, -178.54 78.51, 82.02 -119.56, 155.37 305.48, 103.78 -164.13, 152.2 in-in in 8.906 Saltbr-in 3.322 HRD-in -76.4, -43.57 74.34, -17.58 in-out-in SNCioi out-in ActLoopNT-out 4.925 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.22, 130.18 APE9-dihe-in -62.58, 124.79 APE8-dihe-in -55.59, 120.89 APE8-rot-na 328.8 APE67-dihe-in -74.96, -2.98 -49.76, -43.38 APE12-dist-na 11.936 APE11-dist-na 14.877 APE10-dist-na 17.718 APE9-dist-in 5.752 None None None XRAY 1.29 0.171 0.196 A 306 295 0 0 0 0 [[613, 873]] 1.0 5nkh Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NKIA P29317 604 896 976.0 8ZW:1001 Type1 Inactive DFGin 6.234 15.195 BLBminus -131.56, -168.05 65.37, 72.57 -104.34, 158.3 297.86, 102.98 178.28, 999.0 in-in in 8.441 Saltbr-in 3.243 HRD-in -76.06, -48.41 76.01, -12.4 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 71.21 APE8-rot-na 27.11 APE67-dihe-in -79.27, -3.33 -55.7, -45.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.675 0.162 0.189 A 306 268 25 0 0 20 [[613, 873]] 1.0 5nki Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 8BK0A P29317 605 887 976.0 QJI:1007 Type1 Inactive DFGin 6.049 14.931 BLBminus -127.21, -168.15 68.67, 77.36 -114.53, 162.62 293.54, 106.47 142.52, -154.64 in-in in 8.193 Saltbr-in 2.968 HRD-in -70.96, -48.84 78.9, -18.22 in-out-none SNCion out-none ActLoopNT-out 9.874 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.88 APE8-dihe-in -76.9, 140.27 APE8-rot-na 31.9 APE67-dihe-in -78.19, -3.6 -52.58, -46.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.411 None None None XRAY 1.7 0.168 0.195 A 306 266 17 0 0 11 [[613, 873]] 1.0 8bk0 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5IA2A P29317 598 888 976.0 L66:1001 Type1.5_Back Inactive DFGin 6.033 14.258 BLBminus -134.41, -178.14 76.73, 84.08 -119.06, 159.2 303.5, 118.54 144.3, -174.17 in-out in 8.4 Saltbr-out 3.691 HRD-in -77.24, -46.91 75.8, -16.93 out-out-in SNCooi out-in ActLoopNT-out 10.463 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.98, 106.86 APE9-dihe-in -142.72, 149.22 APE8-dihe-in -83.94, 92.51 APE8-rot-na 31.71 APE67-dihe-in -79.44, -1.75 -55.95, -46.88 APE12-dist-na 17.051 APE11-dist-na 14.007 APE10-dist-na 12.274 APE9-dist-in 6.581 None None None XRAY 1.619 0.164 0.199 A 306 287 4 0 0 0 [[613, 873]] 1.0 5ia2 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 4PDOA P29317 590 875 976.0 No_ligand No_ligand Inactive DFGin 5.317 14.854 None -130.75, -10.88 -121.71, 138.39 -133.1, 999.0 295.74, 93.17 999.0, 999.0 in-out in 7.968 Saltbr-out 6.262 HRD-in -77.55, -48.01 73.27, -11.62 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.79, 137.86 APE9-dihe-in -135.53, 157.5 APE8-dihe-in -79.41, 83.0 APE8-rot-na 28.9 APE67-dihe-in -59.48, -20.71 -53.52, -46.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.493 None None None XRAY 2.104 0.162 0.184 A 299 261 25 0 0 18 [[613, 873]] 1.0 4pdo Homo sapiens TYR_EPHA2_HUMAN TYR 5.1e-108 366.2 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 4PDOB P29317 590 875 976.0 No_ligand No_ligand Inactive DFGin 5.288 14.897 None -129.53, -11.31 -121.1, 139.25 -134.72, 999.0 294.46, 94.17 999.0, 999.0 in-out in 7.965 Saltbr-out 6.373 HRD-in -76.29, -48.44 73.45, -12.19 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.42, 139.51 APE9-dihe-in -133.49, 157.9 APE8-dihe-in -78.68, 83.43 APE8-rot-na 28.65 APE67-dihe-in -60.39, -20.86 -55.6, -45.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.495 None None None XRAY 2.104 0.162 0.184 B 299 261 25 0 0 18 [[613, 873]] 1.0 4pdo Homo sapiens TYR_EPHA2_HUMAN TYR 5.1e-108 366.2 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5IA1A P29317 605 888 976.0 ZZL:1001 Type1 Inactive DFGin 5.104 13.44 None -130.45, -159.4 76.21, -65.85 93.22, -3.68 287.63, 98.57 73.71, -159.39 in-in in 8.825 Saltbr-in 3.231 HRD-in -77.12, -51.78 78.89, -19.53 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.06 APE8-dihe-in -70.6, 101.8 APE8-rot-na 29.53 APE67-dihe-in -68.76, -14.33 -55.26, -45.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.783 None None None XRAY 2.036 0.183 0.223 A 306 261 23 0 0 17 [[613, 873]] 1.0 5ia1 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 8XPVA P29317 604 895 976.0 4Z5:1001 Type2 Inactive DFGout 13.269 10.955 BBAminus -137.16, -164.34 -163.18, 122.32 -110.97, 8.06 311.52, 123.3 90.13, 999.0 in-in in 8.833 Saltbr-in 2.927 HRD-in -72.87, -53.95 83.53, -16.47 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.99 APE8-dihe-in -73.48, 86.08 APE8-rot-na 30.77 APE67-dihe-in -77.0, -6.4 -53.93, -46.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.92 None None None XRAY 1.55 0.165 0.19 A 305 267 25 0 0 19 [[613, 873]] 1.0 8xpv Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6FNFA P29317 606 894 976.0 DXH:1001 Type2 Inactive DFGout 12.992 10.763 BBAminus -140.4, -179.53 -150.33, 114.47 -94.22, -1.16 310.54, 140.88 68.04, 21.72 in-in in 8.425 Saltbr-in 3.357 HRD-in -74.62, -50.37 78.48, -11.76 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -19.2 APE8-rot-na 31.74 APE67-dihe-in -65.5, -24.37 -53.32, -41.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.556 0.234 0.273 A 306 267 22 0 0 18 [[613, 873]] 1.0 6fnf Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6FNGA P29317 599 897 976.0 DWT:1001 Type2 Inactive DFGout 13.003 11.523 BBAminus -139.19, -178.13 -146.25, 108.94 -93.08, 5.13 304.04, 131.15 80.25, -172.1 in-in in 8.409 Saltbr-in 2.85 HRD-in -73.52, -50.78 77.08, -12.87 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -61.22 APE9-dihe-in -99.96, 115.38 APE8-dihe-in -66.87, 88.76 APE8-rot-na 27.3 APE67-dihe-in -78.4, -4.06 -49.48, -51.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.12 APE9-dist-in 6.332 None None None XRAY 1.038 0.173 0.187 A 306 277 22 0 0 17 [[613, 873]] 1.0 6fng Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6HESA P29317 599 896 976.0 G0H:1000 Type2 Inactive DFGout 13.0 11.456 BBAminus -140.84, -179.28 -148.61, 107.36 -93.63, 13.04 308.75, 129.86 76.56, 172.95 in-in in 8.276 Saltbr-in 2.835 HRD-in -72.23, -50.85 77.43, -11.81 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 64.34 APE8-rot-na 34.36 APE67-dihe-in -76.07, -4.24 -50.4, -47.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.128 0.181 0.205 A 306 275 23 0 0 18 [[613, 873]] 1.0 6hes Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6HETA P29317 605 896 976.0 G0Q:1000 Type2 Inactive DFGout 13.23 11.152 BBAminus -138.72, -176.67 -152.42, 107.94 -90.19, 0.51 304.31, 145.49 88.53, 172.85 in-in in 8.555 Saltbr-in 2.75 HRD-in -74.56, -51.23 78.24, -13.2 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.74 APE8-rot-na 27.35 APE67-dihe-in -63.24, -19.2 -50.37, -47.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.208 0.192 0.21 A 306 268 24 0 0 19 [[613, 873]] 1.0 6het Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6HEUA P29317 600 896 976.0 G0N:1000 Type2 Inactive DFGout 13.428 11.471 BBAminus -135.37, -173.13 -154.17, 104.42 -83.48, -1.5 307.89, 130.83 75.25, 15.45 in-in in 8.38 Saltbr-in 2.617 HRD-in -73.51, -52.25 80.82, -12.69 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 56.49 APE8-rot-na 34.57 APE67-dihe-in -63.22, -18.27 -50.54, -48.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.719 0.187 0.225 A 306 275 22 0 0 18 [[613, 873]] 1.0 6heu Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6HEVA P29317 600 896 976.0 G0K:1000 Type2 Inactive DFGout 13.304 11.423 BBAminus -139.38, 178.5 -146.09, 105.14 -84.2, -0.45 302.02, 143.7 68.6, 14.09 in-in in 8.373 Saltbr-in 2.733 HRD-in -75.0, -49.44 76.64, -12.46 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.11 APE8-dihe-in -74.12, 88.51 APE8-rot-na 28.82 APE67-dihe-in -64.32, -18.03 -52.58, -48.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.697 None None None XRAY 1.28 0.187 0.197 A 306 275 22 0 0 17 [[613, 873]] 1.0 6hev Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6HEWA P29317 605 896 976.0 G0E:1000 Type2 Inactive DFGout 13.181 11.166 BBAminus -143.0, 179.38 -150.3, 109.84 -93.36, 9.05 309.09, 140.2 80.47, 175.4 in-in in 8.5 Saltbr-in 2.8 HRD-in -75.05, -52.39 79.11, -13.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -72.95, 126.24 APE9-dihe-in -78.88, 131.03 APE8-dihe-in -89.92, 64.71 APE8-rot-na 35.37 APE67-dihe-in -76.18, -3.26 -46.41, -49.44 APE12-dist-na 999.0 APE11-dist-na 5.025 APE10-dist-na 6.292 APE9-dist-out 8.409 None None None XRAY 1.268 0.198 0.221 A 306 272 20 0 0 15 [[613, 873]] 1.0 6hew Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6HEXA P29317 605 896 976.0 G02:1000 Type2 Inactive DFGout 13.19 11.107 BBAminus -140.12, -179.23 -150.38, 108.51 -91.23, 6.14 306.43, 142.83 82.26, 175.38 in-in in 8.434 Saltbr-in 2.729 HRD-in -73.28, -51.82 76.62, -12.43 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.4 APE8-rot-na 27.11 APE67-dihe-in -75.77, -5.12 -48.76, -46.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.413 0.16 0.178 A 306 268 24 0 0 19 [[613, 873]] 1.0 6hex Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6HEYA P29317 600 896 976.0 FZW:1000 Type2 Inactive DFGout 13.026 11.247 BBAminus -140.98, -179.53 -146.83, 106.44 -91.72, 6.73 307.31, 132.08 84.32, 173.9 in-in in 8.425 Saltbr-in 2.662 HRD-in -74.52, -50.25 76.22, -12.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 124.54 APE9-dihe-in -82.41, 126.93 APE8-dihe-in -86.56, 66.8 APE8-rot-na 34.65 APE67-dihe-in -78.59, -4.71 -51.51, -45.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.062 APE9-dist-out 8.408 None None None XRAY 1.367 0.181 0.2 A 306 277 20 0 0 16 [[613, 873]] 1.0 6hey Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6Q7BA P29317 599 896 976.0 HO5:1001 Type2 Inactive DFGout 12.911 11.371 BBAminus -138.71, 179.79 -146.84, 106.31 -90.41, 8.47 305.19, 134.6 81.41, 173.29 in-in in 8.316 Saltbr-in 2.742 HRD-in -74.68, -51.31 81.87, -20.54 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -77.7, 125.36 APE9-dihe-in -78.21, 121.81 APE8-dihe-in -84.83, 65.52 APE8-rot-na 33.52 APE67-dihe-in -76.37, -3.64 -49.88, -47.8 APE12-dist-na 999.0 APE11-dist-na 4.932 APE10-dist-na 6.195 APE9-dist-out 8.418 None None None XRAY 1.009 0.187 0.203 A 306 279 19 0 0 15 [[613, 873]] 1.0 6q7b Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6Q7CA P29317 599 896 976.0 HOK:1001 Type2 Inactive DFGout 12.917 11.472 BBAminus -137.38, 179.65 -145.57, 106.32 -90.51, 8.07 303.39, 136.77 80.89, 177.1 in-in in 8.294 Saltbr-in 2.781 HRD-in -74.02, -50.95 80.0, -17.56 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -79.99, 121.72 APE9-dihe-in -77.16, 123.54 APE8-dihe-in -85.16, 67.12 APE8-rot-na 34.38 APE67-dihe-in -74.23, -4.06 -53.67, -47.44 APE12-dist-na 999.0 APE11-dist-na 5.03 APE10-dist-na 5.916 APE9-dist-out 8.35 None None None XRAY 1.049 0.193 0.212 A 306 277 21 0 0 15 [[613, 873]] 1.0 6q7c Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6Q7DA P29317 600 896 976.0 HOT:1001 Type2 Inactive DFGout 12.832 11.406 BBAminus -137.78, -179.53 -146.23, 105.84 -90.01, 2.59 301.41, 135.77 84.53, 167.57 in-in in 8.335 Saltbr-in 2.787 HRD-in -72.57, -51.45 80.18, -11.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.64 APE8-dihe-in -76.33, 60.43 APE8-rot-na 29.94 APE67-dihe-in -66.35, -17.6 -46.26, -47.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.508 None None None XRAY 0.978 0.186 0.207 A 306 275 22 0 0 18 [[613, 873]] 1.0 6q7d Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6Q7EA P29317 601 896 976.0 HMW:1001 Type2 Inactive DFGout 13.062 11.271 BBAminus -140.13, 179.65 -147.61, 107.28 -87.46, 0.03 301.89, 137.22 84.61, 152.96 in-in in 8.443 Saltbr-in 2.906 HRD-in -73.62, -52.51 81.64, -19.01 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.8 APE8-rot-na 26.99 APE67-dihe-in -64.95, -18.36 -51.27, -48.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.059 0.193 0.211 A 306 272 24 0 0 19 [[613, 873]] 1.0 6q7e Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6Q7GA P29317 601 896 976.0 HO8:1001 Type2 Inactive DFGout 12.842 11.429 BBAminus -139.0, -179.32 -148.27, 106.76 -89.38, 3.41 302.66, 137.0 79.39, 167.4 in-in in 8.405 Saltbr-in 2.922 HRD-in -75.44, -50.26 80.93, -17.54 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 63.75 APE8-rot-na 25.43 APE67-dihe-in -66.95, -18.43 -49.42, -45.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.047 0.187 0.201 A 306 273 23 0 0 19 [[613, 873]] 1.0 6q7g Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 8BM8A P29317 605 895 976.0 QT1:1001 Type2 Inactive DFGout 13.299 11.216 BBAminus -138.05, -176.91 -152.31, 112.71 -97.62, -4.12 309.42, 141.33 100.15, -175.59 in-in in 8.546 Saltbr-in 2.901 HRD-in -70.96, -54.99 79.39, -13.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.88 APE8-dihe-in -86.8, 66.48 APE8-rot-na 40.84 APE67-dihe-in -67.76, -19.03 -49.33, -44.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.122 None None None XRAY 1.68 0.192 0.225 A 306 268 23 0 0 18 [[613, 873]] 1.0 8bm8 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 8BOCA P29317 605 888 976.0 QUF:1001 Type2 Inactive DFGout 13.583 10.813 BBAminus -139.62, -179.28 -151.24, 106.28 -78.98, -6.2 302.64, 171.21 84.05, 5.79 in-in in 8.869 Saltbr-in 3.501 HRD-in -70.68, -54.7 83.35, -19.69 in-out-in SNCioi out-in ActLoopNT-out 12.248 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.53, 160.37 APE9-dihe-in -116.01, 148.45 APE8-dihe-in -79.02, 97.78 APE8-rot-na 34.23 APE67-dihe-in -77.84, -8.8 -56.96, -40.4 APE12-dist-na 12.844 APE11-dist-na 9.325 APE10-dist-na 7.892 APE9-dist-in 5.837 None None None XRAY 1.9 0.248 0.286 A 306 271 13 0 0 0 [[613, 873]] 1.0 8boc Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 8BODA P29317 605 896 976.0 QTX:1001 Type2 Inactive DFGout 13.28 11.166 BBAminus -138.75, 179.02 -151.09, 111.94 -95.2, 7.92 310.36, 138.91 79.28, 170.08 in-in in 8.489 Saltbr-in 2.572 HRD-in -76.72, -52.83 81.46, -18.64 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.32 APE8-rot-na 30.12 APE67-dihe-in -67.2, -16.48 -51.99, -47.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.5 0.162 0.185 A 306 268 24 0 0 19 [[613, 873]] 1.0 8bod Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 8BOGA P29317 600 895 976.0 QUU:1001 Type2 Inactive DFGout 13.093 11.42 BBAminus -138.29, -175.41 -154.02, 110.76 -96.23, 4.72 309.55, 133.75 85.69, 178.97 in-in in 8.614 Saltbr-in 2.847 HRD-in -73.76, -52.45 82.86, -19.49 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.24 APE8-rot-na 33.92 APE67-dihe-in -64.56, -20.52 -51.05, -44.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.47 0.167 0.18 A 306 272 24 0 0 19 [[613, 873]] 1.0 8bog Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 8BOHA P29317 604 896 976.0 R0T:1001 Type2 Inactive DFGout 13.138 10.911 BBAminus -143.82, -179.68 -152.45, 109.89 -96.02, 6.95 308.25, 139.26 81.21, 175.48 in-in in 8.546 Saltbr-in 2.992 HRD-in -74.91, -51.04 79.04, -16.8 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.21 APE8-dihe-in -92.63, 66.3 APE8-rot-na 36.09 APE67-dihe-in -67.47, -18.74 -50.08, -43.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.392 None None None XRAY 1.42 0.159 0.174 A 306 269 24 0 0 18 [[613, 873]] 1.0 8boh Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 8BOIA P29317 604 896 976.0 R0O:1001 Type2 Inactive DFGout 13.283 11.03 BBAminus -141.08, 178.02 -149.45, 111.25 -98.53, 10.32 311.85, 140.9 77.27, 174.45 in-in in 8.259 Saltbr-in 2.911 HRD-in -73.1, -59.86 86.83, -16.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.13 APE8-dihe-in -88.03, 63.64 APE8-rot-na 36.17 APE67-dihe-in -62.77, -20.16 -55.53, -44.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.527 None None None XRAY 1.63 0.181 0.211 A 306 269 24 0 0 18 [[613, 873]] 1.0 8boi Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 8BOKA P29317 605 890 976.0 R0X:1001 Type2 Inactive DFGout 13.153 10.636 BBAminus -138.77, 176.95 -145.73, 113.78 -87.01, -5.08 300.46, 157.21 78.94, 15.26 in-in in 8.101 Saltbr-in 3.246 HRD-in -82.54, -50.07 77.02, -16.97 in-out-in SNCioi out-in ActLoopNT-out 12.259 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.81, 160.7 APE9-dihe-in -116.2, 148.85 APE8-dihe-in -81.74, 100.11 APE8-rot-na 33.49 APE67-dihe-in -73.77, -10.77 -53.43, -43.88 APE12-dist-na 12.757 APE11-dist-na 9.227 APE10-dist-na 7.959 APE9-dist-in 5.767 None None None XRAY 2.02 0.218 0.261 A 306 280 6 0 0 0 [[613, 873]] 1.0 8bok Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 8BOMA P29317 605 896 976.0 QU6:1001 Type2 Inactive DFGout 13.014 11.156 BBAminus -139.26, -174.46 -155.4, 107.51 -92.71, 6.11 307.16, 139.18 85.39, 173.92 in-in in 8.461 Saltbr-in 2.829 HRD-in -74.01, -53.36 79.97, -17.68 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.93 APE8-rot-na 32.87 APE67-dihe-in -77.73, -3.9 -47.13, -48.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.12 0.164 0.177 A 306 267 25 0 0 19 [[613, 873]] 1.0 8bom Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5IA4A P29317 605 877 976.0 88Z:1001 Type2 Inactive DFGout 13.811 6.305 None -141.42, 176.32 -148.43, 94.59 -58.84, -30.4 187.59, 75.41 105.04, 22.91 in-out in 9.571 Saltbr-out 4.687 HRD-in -75.95, -50.56 75.81, -10.01 out-out-in SNCooi out-in ActLoopNT-out 12.322 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.68, 164.18 APE9-dihe-in -115.64, 144.62 APE8-dihe-in -83.58, 93.81 APE8-rot-na 29.41 APE67-dihe-in -65.12, -16.72 -54.94, -46.13 APE12-dist-na 12.548 APE11-dist-na 8.981 APE10-dist-na 8.282 APE9-dist-in 5.911 None None None XRAY 1.797 0.19 0.226 A 306 269 4 0 0 0 [[613, 873]] 1.0 5ia4 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5IA5A P29317 605 880 976.0 GV0:1001 Type2 Inactive DFGout 13.874 6.594 None -143.37, 173.19 -151.4, 82.68 -56.42, -33.09 175.63, 84.97 110.28, 32.23 in-out in 9.576 Saltbr-out 4.012 HRD-in -76.98, -49.24 77.2, -12.17 out-out-in SNCooi out-in ActLoopNT-out 12.64 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.87, 166.66 APE9-dihe-in -109.64, 133.43 APE8-dihe-in -81.98, 92.61 APE8-rot-na 30.46 APE67-dihe-in -66.59, -17.41 -56.37, -44.02 APE12-dist-na 12.683 APE11-dist-na 9.326 APE10-dist-na 8.565 APE9-dist-in 6.138 None None None XRAY 1.776 0.2 0.244 A 306 273 3 0 0 0 [[613, 873]] 1.0 5ia5 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6Q7FA P29317 605 896 976.0 HNZ:1001 Type2 Inactive DFGout 15.869 13.943 None -134.18, 174.7 -157.39, 165.69 -81.97, -172.5 323.46, 97.9 -68.25, 999.0 in-in in 8.496 Saltbr-in 2.797 HRD-in -75.6, -51.64 79.09, -19.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 68.54 APE8-rot-na 24.65 APE67-dihe-in -62.45, -19.38 -49.67, -47.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.204 0.187 0.21 A 306 267 25 0 0 20 [[613, 873]] 1.0 6q7f Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 8BOFA P29317 605 896 976.0 R3L:1001 Type2 Inactive DFGout 13.475 11.246 None -130.77, 177.3 -148.61, 101.8 -81.23, 999.0 310.93, 149.4 999.0, 999.0 in-in in 8.374 Saltbr-in 2.925 HRD-in -72.28, -52.52 79.68, -16.43 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 57.23 APE8-rot-na 32.04 APE67-dihe-in -64.32, -20.17 -51.23, -47.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.82 0.187 0.216 A 306 266 26 0 0 21 [[613, 873]] 1.0 8bof Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5I9VA P29317 605 896 976.0 AGS:1001 ATPlike None DFGin 5.797 14.921 BLAminus -141.81, -171.65 57.06, 75.11 -93.17, 20.3 299.55, 97.8 -61.14, -30.9 in-in in 8.619 Saltbr-in 2.822 HRD-in -77.85, -47.75 76.63, -12.15 in-in-none SNCiin in-none ActLoopNT-in 2.918 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 136.3 APE9-dihe-in -111.36, 131.85 APE8-dihe-in -64.26, 123.12 APE8-rot-na 332.19 APE67-dihe-in -77.38, -2.66 -54.41, -44.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.712 APE9-dist-in 5.342 None None None XRAY 1.458 0.164 0.191 A 306 279 13 0 0 13 [[613, 873]] 1.0 5i9v Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 1MQBB P29317 602 883 976.0 ANP:1001 ATPlike None DFGin 5.691 14.889 BLAminus -139.65, -173.77 51.28, 81.33 -92.67, 10.65 292.99, 95.58 -41.77, -44.65 in-in in 8.273 Saltbr-in 2.64 HRD-in -72.65, -50.06 79.19, -16.04 in-in-none SNCiin in-none ActLoopNT-in 2.992 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -50.3 APE9-dihe-in -134.32, 148.66 APE8-dihe-in -83.15, 83.63 APE8-rot-na 31.61 APE67-dihe-in -80.07, -2.61 -53.54, -47.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.328 APE9-dist-in 6.633 None None None XRAY 2.3 0.237 0.288 B 333 265 17 0 0 13 [[613, 873]] 1.0 1mqb Homo sapiens TYR_EPHA2_HUMAN TYR 7.4e-108 365.7 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 7KJAB P29317 590 965 976.0 ACP:61003 ATPlike None DFGin 5.95 15.319 BLAminus -132.83, -173.32 70.39, 83.56 -118.78, 24.56 302.85, 98.09 -89.22, 999.0 in-in in 8.607 Saltbr-in 3.165 HRD-in -76.56, -48.38 78.92, -16.95 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.75 APE8-rot-na 32.08 APE67-dihe-in -69.28, -11.58 -65.6, -29.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.19 0.217 B 390 349 22 0 0 20 [[613, 873]] 1.0 7kja Homo sapiens TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5I9UA P29317 601 894 976.0 No_ligand No_ligand None DFGin 6.103 15.089 BLAminus -130.24, -168.91 54.89, 69.82 -93.83, 19.72 297.56, 96.24 -63.4, -27.55 in-in in 9.022 Saltbr-in 3.201 HRD-in -78.67, -48.85 76.31, -6.88 in-in-none SNCiin in-none ActLoopNT-in 2.999 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.04 APE8-dihe-in -54.79, 128.06 APE8-rot-na 14.0 APE67-dihe-in -78.34, -2.47 -55.89, -42.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.492 None None None XRAY 1.889 0.166 0.224 A 306 281 13 0 0 13 [[613, 873]] 1.0 5i9u Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5IA0A P29317 604 889 976.0 A5B:1001 Type1 None DFGin 5.75 15.225 BLAminus -131.01, -155.76 61.65, 69.41 -104.69, 91.97 299.22, 100.6 -172.83, 999.0 in-in in 7.988 Saltbr-in 3.057 HRD-in -80.45, -46.02 73.5, -13.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 103.13 APE8-dihe-in -95.39, 103.1 APE8-rot-na 22.72 APE67-dihe-in -72.64, -3.49 -61.44, -50.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.638 None None None XRAY 1.948 0.194 0.225 A 306 263 23 0 0 19 [[613, 873]] 1.0 5ia0 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 5NKAA P29317 605 895 976.0 91H:1001 Type1 None DFGin 5.817 15.43 BLAminus -138.05, -167.81 59.6, 76.5 -90.38, 23.3 298.3, 92.95 -114.03, 999.0 in-in in 8.742 Saltbr-in 3.565 HRD-in -74.33, -47.29 74.19, -12.19 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -56.83 APE9-dihe-in -63.62, 121.18 APE8-dihe-in -54.7, 111.87 APE8-rot-na 330.09 APE67-dihe-in -75.86, -5.14 -47.88, -45.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.701 None None None XRAY 1.377 0.161 0.182 A 306 271 18 0 0 18 [[613, 873]] 1.0 5nka Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
EPHA2_HUMAN 6FNHC P29317 600 890 976.0 DXK:1001 Type1 None DFGin 6.1 15.078 BLAminus -136.98, -166.98 54.47, 77.28 -106.75, 37.52 303.15, 87.48 -109.85, 171.74 in-in in 8.523 Saltbr-in 2.973 HRD-in -71.56, -48.37 75.35, -10.7 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.12 APE8-rot-na 34.55 APE67-dihe-in -53.44, -22.38 -49.0, -43.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.379 0.206 0.221 C 306 270 21 0 0 19 [[613, 873]] 1.0 6fnh Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2

TYR_EPHA2 (Ephrin type-A receptor 2)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name