CMGC_DYRK2 (Dual specificity tyrosine-phosphorylation-regulated kinase 2)

Total number of chains: 33
Active chains: 5
Uniprot: DYRK2_HUMAN
Kinase Domain Residues: 222 - 535
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 30 90.9% AF-Q92630-K1A
DFGin None 3 9.1% 8HLTB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q92630-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 214 - 543 0 None None Dual specificity tyrosine-phosphorylation-regulated kinase 2
AF-Q92630-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 214 - 543 0 None None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7EJVA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YK2 Type1 151 - 537 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
8HLTA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XSE Type1 151 - 535 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7AKHA 2.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RK8 Type1 146 - 535 0 SEP232,PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
3K2LA 2.36 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 146 - 543 0 SEP232,TPO381,PTR382,SEP442,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DG4A 2.58 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H5R Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DH9A 2.194 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7F Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DHCA 2.592 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H99 Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DHHA 2.486 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7L Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DHKA 2.341 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7O Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DHNA 2.38 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii H7R Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DHOA 3.29 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7U Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DJOA 2.499 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H80 Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DL6A 2.648 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H96 Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DH3A 2.33 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7C Type1 213 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DHVA 2.679 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7X Type1 212 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
4AZFA 2.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 3RA Type1 146 - 536 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7EJVB 2.5 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YK2 Type1 153 - 543 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
3KVWA 2.28 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii IRB Type1 146 - 536 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
5ZTNA 2.496 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii CUR Type1 146 - 536 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
5ZTNB 2.496 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii CUR Type1 146 - 536 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
6HDPA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii FZ5 Type1 146 - 542 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
6HDRA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii CC9 Type1 146 - 536 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
7AKFA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RK5 Type1 146 - 535 0 SEP232,PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
5LXCA 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 7AA Type1 153 - 536 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
5LXCB 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 7AA Type1 153 - 538 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
5LXDA 2.58 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 7A7 Type1 153 - 538 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
5LXDB 2.58 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 7A7 Type1 153 - 538 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
6K0JA 2.352 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii CQO Type1 212 - 536 0 PTR382,SEP458 E256N,L349A Dual specificity tyrosine-phosphorylation-regulated kinase 2
9KQYA 3.2 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 151 - 537 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
8HLTB 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XSE Type1 151 - 537 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
9KQYB 3.2 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1L6I Type1 151 - 537 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2

CMGC_DYRK2 (Dual specificity tyrosine-phosphorylation-regulated kinase 2)

Total number of chains: 33
Active chains: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 30 90.9% AF-Q92630-K1A
DFGin None 3 9.1% 8HLTB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
DYRK2_HUMAN AF-Q92630-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 214 - 543 0 None None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN AF-Q92630-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 214 - 543 0 None None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7EJVA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YK2 Type1 151 - 537 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 8HLTA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XSE Type1 151 - 535 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7AKHA 2.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RK8 Type1 146 - 535 0 SEP232,PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 3K2LA 2.36 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 146 - 543 0 SEP232,TPO381,PTR382,SEP442,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7DG4A 2.58 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H5R Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7DH9A 2.194 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7F Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7DHCA 2.592 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H99 Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7DHHA 2.486 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7L Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7DHKA 2.341 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7O Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7DHNA 2.38 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii H7R Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7DHOA 3.29 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7U Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7DJOA 2.499 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H80 Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7DL6A 2.648 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H96 Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7DH3A 2.33 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7C Type1 213 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7DHVA 2.679 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7X Type1 212 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 4AZFA 2.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 3RA Type1 146 - 536 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7EJVB 2.5 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii YK2 Type1 153 - 543 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 3KVWA 2.28 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii IRB Type1 146 - 536 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 5ZTNA 2.496 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii CUR Type1 146 - 536 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 5ZTNB 2.496 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii CUR Type1 146 - 536 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 6HDPA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii FZ5 Type1 146 - 542 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 6HDRA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii CC9 Type1 146 - 536 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 7AKFA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RK5 Type1 146 - 535 0 SEP232,PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 5LXCA 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 7AA Type1 153 - 536 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 5LXCB 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 7AA Type1 153 - 538 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 5LXDA 2.58 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 7A7 Type1 153 - 538 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 5LXDB 2.58 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 7A7 Type1 153 - 538 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 6K0JA 2.352 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii CQO Type1 212 - 536 0 PTR382,SEP458 E256N,L349A Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 9KQYA 3.2 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 151 - 537 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 8HLTB 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XSE Type1 151 - 537 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
DYRK2_HUMAN 9KQYB 3.2 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1L6I Type1 151 - 537 0 PTR382 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens

CMGC_DYRK2 (Dual specificity tyrosine-phosphorylation-regulated kinase 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism