CMGC_DYRK2 (Dual specificity tyrosine-phosphorylation-regulated kinase 2)

Total number of chains: 33
Active chains: 5
Family: CMGC
Uniprot: DYRK2_HUMAN
Kinase Domain Residues: 222 - 535
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 30 90.9% AF-Q92630-K1A
DFGin None 3 9.1% 8HLTB

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q92630-K1A 214 543 601.0 No_ligand No_ligand Active DFGin 6.939 14.864 BLAminus -126.07, 177.15 62.42, 65.44 -81.73, 10.25 284.63, 80.53 -64.64, -17.85 in-in in 8.728 Saltbr-in 2.723 HRD-in -66.96, -37.74 67.08, -16.77 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 175.12 APE9-dihe-na 60.6, 144.79 APE8-dihe-in -65.13, 137.41 APE8-rot-in 294.19 APE67-dihe-in -65.52, -19.21 -50.69, -46.33 APE12-dist-in 12.882 APE11-dist-in 11.334 APE10-dist-in 7.287 APE9-dist-in 3.021 None None None AF2 -1.0 1.0 1.0 A 330 330 0 0 0 0 [[222, 535]] 1.0 AF-Q92630-K1 CMGC_DYRK2_HUMAN CMGC 5.8e-99 337.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
AF-Q92630-K3A 214 543 601.0 No_ligand No_ligand Active DFGin 6.623 14.471 BLAminus -128.09, 177.13 63.4, 64.99 -80.7, 10.08 289.17, 77.94 -66.05, -16.49 in-in in 8.839 Saltbr-in 2.734 HRD-in -72.99, -34.76 62.62, -5.57 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.48, 175.5 APE9-dihe-na 61.64, 142.59 APE8-dihe-in -63.51, 134.37 APE8-rot-in 293.35 APE67-dihe-in -63.69, -20.47 -54.61, -45.06 APE12-dist-in 12.796 APE11-dist-in 11.341 APE10-dist-in 7.03 APE9-dist-in 3.09 None None None AF2 -1.0 1.0 1.0 A 330 330 0 0 0 0 [[222, 535]] 1.0 AF-Q92630-K3 CMGC_DYRK2_HUMAN CMGC 5.8e-99 337.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7EJVA 151 537 601.0 YK2:60501 Type1 Active DFGin 6.9 15.424 BLAminus -121.6, -175.71 52.95, 74.47 -89.12, 21.12 283.92, 70.74 -60.92, -24.61 in-in in 8.982 Saltbr-in 3.13 HRD-in -72.41, -42.76 75.36, 0.64 in-in-in SNCiii in-in ActLoopNT-in 2.755 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.92, 162.27 APE9-dihe-na 76.47, 145.84 APE8-dihe-in -66.78, 142.47 APE8-rot-in 275.38 APE67-dihe-in -56.79, -30.59 -58.46, -46.41 APE12-dist-in 12.918 APE11-dist-in 11.297 APE10-dist-in 6.969 APE9-dist-in 3.304 None PTR382 PTR382 XRAY 2.5 0.202 0.246 A 387 385 2 0 0 0 [[222, 535]] 1.0 7ejv CMGC_DYRK2_HUMAN CMGC 1e-98 336.2 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
8HLTA 151 535 601.0 XSE:60501 Type1 Active DFGin 7.153 15.661 BLAminus -128.03, -174.41 42.45, 74.99 -83.08, 17.4 279.93, 74.95 -62.5, -19.89 in-in in 9.177 Saltbr-in 2.717 HRD-in -71.74, -44.48 73.83, 0.55 in-in-in SNCiii in-in ActLoopNT-in 2.747 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.16, 170.0 APE9-dihe-na 71.16, 164.17 APE8-dihe-in -84.62, 135.53 APE8-rot-in 250.25 APE67-dihe-in -56.1, -31.76 -49.25, -50.28 APE12-dist-in 13.315 APE11-dist-in 11.966 APE10-dist-in 7.57 APE9-dist-in 3.21 None PTR382 PTR382 XRAY 2.8 0.213 0.267 A 393 385 0 0 0 0 [[222, 535]] 1.0 8hlt CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7AKHA 146 535 601.0 RK8:60601 Type1 Active DFGin 6.926 15.074 BLAminus -121.6, -171.14 52.21, 81.66 -96.01, 25.36 287.39, 72.64 -67.66, -23.05 in-in in 9.121 Saltbr-in 2.705 HRD-in -56.66, -58.54 81.07, -0.93 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.43, 168.94 APE9-dihe-na 72.6, 150.47 APE8-dihe-in -61.43, 140.56 APE8-rot-in 278.26 APE67-dihe-in -62.31, -24.44 -52.56, -49.45 APE12-dist-in 12.815 APE11-dist-in 11.442 APE10-dist-in 6.914 APE9-dist-in 3.229 None SEP232,PTR382,SEP458 SEP232,PTR382,SEP458 XRAY 2.85 0.188 0.245 A 429 390 0 0 0 0 [[222, 535]] 1.0 7akh CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
3K2LA 146 543 601.0 No_ligand No_ligand Inactive DFGin 7.095 15.241 BLAminus -127.38, 178.65 61.29, 89.71 -107.22, 23.8 277.85, 81.5 -75.9, -16.57 in-in in 8.858 Saltbr-in 2.965 HRD-in -80.34, -48.51 75.91, -1.73 in-in-out SNCiio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.89, 168.99 APE9-dihe-na 66.37, 164.94 APE8-dihe-in -92.92, 137.86 APE8-rot-out 183.76 APE67-dihe-in -63.43, -18.18 -49.75, -48.38 APE12-dist-in 12.59 APE11-dist-in 11.884 APE10-dist-in 7.261 APE9-dist-in 3.098 None SEP232,TPO381,PTR382,SEP442,SEP458 SEP232,TPO381,PTR382,SEP442,SEP458 XRAY 2.36 0.228 0.288 A 429 397 0 0 0 0 [[222, 535]] 1.0 3k2l CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DG4A 215 538 601.0 H5R:601 Type1 Inactive DFGin 7.076 15.315 BLAminus -112.18, -176.63 54.26, 82.32 -95.55, 24.49 281.35, 68.71 -70.68, -16.69 in-in in 9.062 Saltbr-in 2.632 HRD-in -72.69, -45.13 72.43, 4.61 in-in-out SNCiio in-out ActLoopNT-in 2.829 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.35, 168.65 APE9-dihe-na 72.59, 152.62 APE8-dihe-in -75.5, 133.34 APE8-rot-out 190.89 APE67-dihe-in -53.88, -27.24 -50.74, -49.3 APE12-dist-in 13.02 APE11-dist-in 11.794 APE10-dist-in 7.365 APE9-dist-in 3.357 None PTR382,SEP458 PTR382,SEP458 XRAY 2.58 0.206 0.249 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dg4 CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DH9A 215 538 601.0 H7F:601 Type1 Inactive DFGin 6.955 15.393 BLAminus -118.25, -176.44 52.33, 72.66 -86.4, 22.32 285.5, 71.17 -68.46, -16.6 in-in in 9.091 Saltbr-in 2.818 HRD-in -67.52, -48.86 77.78, -1.22 in-in-out SNCiio in-out ActLoopNT-in 2.826 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.21, 165.64 APE9-dihe-na 77.26, 152.01 APE8-dihe-in -71.35, 136.19 APE8-rot-out 186.16 APE67-dihe-in -56.24, -27.47 -53.15, -48.91 APE12-dist-in 13.085 APE11-dist-in 11.935 APE10-dist-in 7.588 APE9-dist-in 3.308 None PTR382,SEP458 PTR382,SEP458 XRAY 2.194 0.19 0.218 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dh9 CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DHCA 215 538 601.0 H99:601 Type1 Inactive DFGin 6.897 15.183 BLAminus -120.85, -173.65 54.47, 76.85 -89.75, 13.16 285.05, 71.42 -59.73, -14.3 in-in in 9.165 Saltbr-in 2.836 HRD-in -67.26, -47.7 73.48, 5.77 in-in-out SNCiio in-out ActLoopNT-in 2.79 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.28, 171.52 APE9-dihe-na 72.07, 147.78 APE8-dihe-in -70.3, 140.28 APE8-rot-out 189.19 APE67-dihe-in -57.12, -25.22 -59.04, -44.86 APE12-dist-in 13.016 APE11-dist-in 11.9 APE10-dist-in 7.482 APE9-dist-in 3.275 None PTR382,SEP458 PTR382,SEP458 XRAY 2.592 0.17 0.217 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dhc CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DHHA 215 538 601.0 H7L:601 Type1 Inactive DFGin 7.002 15.315 BLAminus -121.49, -175.98 53.38, 75.83 -90.0, 17.27 285.73, 67.63 -60.12, -17.2 in-in in 9.069 Saltbr-in 2.831 HRD-in -72.48, -43.45 72.8, 3.03 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.98, 162.3 APE9-dihe-na 71.38, 148.19 APE8-dihe-in -71.4, 141.57 APE8-rot-out 161.34 APE67-dihe-in -65.17, -19.89 -55.14, -43.22 APE12-dist-in 12.9 APE11-dist-in 11.849 APE10-dist-in 7.619 APE9-dist-in 3.387 None PTR382,SEP458 PTR382,SEP458 XRAY 2.486 0.195 0.245 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dhh CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DHKA 215 538 601.0 H7O:601 Type1 Inactive DFGin 7.052 15.35 BLAminus -117.35, 177.72 56.81, 75.07 -85.18, 19.92 283.41, 63.05 -63.85, -33.36 in-in in 9.196 Saltbr-in 2.644 HRD-in -71.37, -46.63 75.15, -1.94 in-in-out SNCiio in-out ActLoopNT-in 2.906 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -118.3, 166.48 APE9-dihe-na 68.65, 147.66 APE8-dihe-in -62.61, 137.42 APE8-rot-out 200.1 APE67-dihe-in -57.5, -27.74 -53.83, -48.57 APE12-dist-in 12.955 APE11-dist-in 11.738 APE10-dist-in 7.593 APE9-dist-in 3.202 None PTR382,SEP458 PTR382,SEP458 XRAY 2.341 0.199 0.257 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dhk CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DHNA 215 538 601.0 H7R:601 Type1 Inactive DFGin 6.943 15.204 BLAminus -121.26, -177.62 55.21, 78.31 -90.06, 20.47 287.34, 73.71 -59.07, -25.63 in-out in 9.064 Saltbr-out 3.683 HRD-in -71.04, -47.07 70.57, 6.17 out-in-out SNCoio in-out ActLoopNT-in 2.681 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.33, 167.28 APE9-dihe-na 70.26, 153.99 APE8-dihe-in -74.79, 138.71 APE8-rot-out 162.7 APE67-dihe-in -57.15, -24.62 -55.14, -47.5 APE12-dist-in 13.035 APE11-dist-in 11.859 APE10-dist-in 7.473 APE9-dist-in 3.339 None PTR382,SEP458 PTR382,SEP458 XRAY 2.38 0.187 0.223 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dhn CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DHOA 215 538 601.0 H7U:601 Type1 Inactive DFGin 7.024 15.384 BLAminus -119.43, -172.42 42.56, 78.27 -84.62, 15.62 281.95, 67.94 -55.62, -33.56 in-in in 9.274 Saltbr-in 2.624 HRD-in -82.16, -38.69 68.11, 7.67 in-in-out SNCiio in-out ActLoopNT-in 2.83 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.77, 178.86 APE9-dihe-na 69.78, 147.69 APE8-dihe-in -69.75, 134.88 APE8-rot-out 211.6 APE67-dihe-in -60.55, -23.47 -49.02, -52.25 APE12-dist-in 12.813 APE11-dist-in 11.959 APE10-dist-in 7.417 APE9-dist-in 3.473 None PTR382,SEP458 PTR382,SEP458 XRAY 3.29 0.188 0.259 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dho CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DJOA 215 538 601.0 H80:601 Type1 Inactive DFGin 6.825 15.46 BLAminus -127.28, -171.08 53.55, 75.01 -93.19, 14.88 276.88, 71.94 -62.8, -14.89 in-in in 9.123 Saltbr-in 2.61 HRD-in -68.11, -47.05 70.53, 3.02 in-in-out SNCiio in-out ActLoopNT-in 2.794 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.85, 165.38 APE9-dihe-na 72.88, 157.2 APE8-dihe-in -82.18, 142.51 APE8-rot-out 184.87 APE67-dihe-in -72.03, -23.08 -61.29, -39.89 APE12-dist-in 12.99 APE11-dist-in 11.881 APE10-dist-in 7.591 APE9-dist-in 3.376 None PTR382,SEP458 PTR382,SEP458 XRAY 2.499 0.184 0.234 A 324 324 0 0 0 0 [[222, 535]] 1.0 7djo CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DL6A 215 538 601.0 H96:601 Type1 Inactive DFGin 7.152 15.218 BLAminus -117.62, -177.39 53.85, 78.98 -93.5, 18.12 285.84, 68.07 -63.99, -13.06 in-in in 9.043 Saltbr-in 2.543 HRD-in -67.53, -45.24 75.47, 0.91 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.16, 165.64 APE9-dihe-na 68.7, 158.66 APE8-dihe-in -84.48, 139.38 APE8-rot-out 172.15 APE67-dihe-in -59.22, -22.44 -52.23, -48.32 APE12-dist-in 13.001 APE11-dist-in 11.777 APE10-dist-in 7.505 APE9-dist-in 3.173 None PTR382,SEP458 PTR382,SEP458 XRAY 2.648 0.177 0.232 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dl6 CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DH3A 213 538 601.0 H7C:601 Type1 Inactive DFGin 7.045 15.26 BLAminus -119.08, -179.53 58.29, 74.58 -88.67, 21.96 286.19, 71.25 -64.16, -21.81 in-in in 8.924 Saltbr-in 3.399 HRD-in -71.55, -47.36 71.56, 3.54 in-in-out SNCiio in-out ActLoopNT-in 2.739 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.02, 171.08 APE9-dihe-na 72.29, 151.84 APE8-dihe-in -71.94, 135.94 APE8-rot-out 194.0 APE67-dihe-in -56.42, -28.28 -53.31, -46.8 APE12-dist-in 13.015 APE11-dist-in 11.909 APE10-dist-in 7.475 APE9-dist-in 3.347 None PTR382,SEP458 PTR382,SEP458 XRAY 2.33 0.195 0.217 A 326 326 0 0 0 0 [[222, 535]] 1.0 7dh3 CMGC_DYRK2_HUMAN CMGC 5.5e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7DHVA 212 538 601.0 H7X:601 Type1 Inactive DFGin 7.004 15.218 BLAminus -128.46, -170.28 43.26, 83.31 -95.73, 25.21 286.23, 69.56 -68.03, -32.6 in-in in 8.932 Saltbr-in 2.635 HRD-in -77.4, -41.95 73.79, 2.43 in-in-out SNCiio in-out ActLoopNT-in 2.712 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.51, 169.17 APE9-dihe-na 70.62, 163.65 APE8-dihe-in -91.1, 137.8 APE8-rot-out 165.09 APE67-dihe-in -63.71, -20.64 -53.82, -42.56 APE12-dist-in 12.705 APE11-dist-in 11.639 APE10-dist-in 7.382 APE9-dist-in 3.329 None PTR382,SEP458 PTR382,SEP458 XRAY 2.679 0.193 0.249 A 327 327 0 0 0 0 [[222, 535]] 1.0 7dhv CMGC_DYRK2_HUMAN CMGC 5.6e-99 337.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
4AZFA 146 536 601.0 3RA:60600 Type1 Inactive DFGin 6.995 15.39 BLAminus -118.77, 179.61 61.33, 77.52 -93.54, 30.44 283.47, 77.53 -76.64, -12.42 in-in in 9.082 Saltbr-in 2.733 HRD-in -73.11, -47.79 80.4, -7.32 in-in-out SNCiio in-out ActLoopNT-in 2.921 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -141.82, 174.61 APE9-dihe-na 70.03, 158.03 APE8-dihe-in -81.89, 134.84 APE8-rot-out 174.41 APE67-dihe-in -64.03, -20.73 -38.64, -55.03 APE12-dist-in 10.247 APE11-dist-in 11.617 APE10-dist-in 7.116 APE9-dist-in 3.212 None PTR382,SEP458 PTR382,SEP458 XRAY 2.55 0.2 0.255 A 417 389 2 0 0 0 [[222, 535]] 1.0 4azf CMGC_DYRK2_HUMAN CMGC 1.3e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7EJVB 153 543 601.0 YK2:60501 Type1 Inactive DFGin 7.155 15.775 BLAminus -119.43, -178.81 52.81, 76.66 -89.1, 19.14 283.4, 73.64 -64.56, -23.63 in-out in 8.918 Saltbr-out 3.623 HRD-in -70.75, -42.53 75.19, 1.74 out-in-in SNCoii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.05, 163.39 APE9-dihe-na 74.33, 145.19 APE8-dihe-in -65.87, 144.25 APE8-rot-in 282.1 APE67-dihe-in -56.42, -28.58 -55.11, -50.7 APE12-dist-in 13.028 APE11-dist-in 11.768 APE10-dist-in 7.569 APE9-dist-in 3.367 None PTR382 PTR382 XRAY 2.5 0.202 0.246 B 391 391 0 0 0 0 [[222, 535]] 1.0 7ejv CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
3KVWA 146 536 601.0 IRB:60001 Type1 Inactive DFGin 6.948 15.117 BLAminus -111.07, -179.04 64.3, 75.68 -93.62, 22.45 282.14, 79.62 -72.21, -11.84 in-in in 9.088 Saltbr-in 2.684 HRD-in -73.11, -47.89 78.54, -3.21 in-in-out SNCiio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.44, 168.47 APE9-dihe-na 69.36, 159.88 APE8-dihe-in -78.87, 139.14 APE8-rot-out 177.13 APE67-dihe-in -55.72, -26.97 -53.0, -51.24 APE12-dist-in 13.447 APE11-dist-in 11.708 APE10-dist-in 7.236 APE9-dist-in 3.158 None PTR382,SEP458 PTR382,SEP458 XRAY 2.28 0.211 0.26 A 429 389 2 0 0 0 [[222, 535]] 1.0 3kvw CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
5ZTNA 146 536 601.0 CUR:60501 Type1 Inactive DFGin 7.044 14.917 BLAminus -121.02, -170.84 55.37, 74.14 -90.27, 24.89 284.91, 71.59 -68.02, -21.72 in-in in 9.038 Saltbr-in 3.201 HRD-in -75.34, -43.05 70.76, 4.4 in-in-out SNCiio in-out ActLoopNT-in 2.991 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.75, -1.92 APE9-dihe-na -118.6, 178.64 APE8-dihe-in -75.97, 135.26 APE8-rot-out 181.93 APE67-dihe-in -60.16, -23.88 -54.39, -47.99 APE12-dist-in 13.019 APE11-dist-in 11.6 APE10-dist-in 7.156 APE9-dist-in 3.639 None PTR382,SEP458 PTR382,SEP458 XRAY 2.496 0.2 0.244 A 429 384 7 0 0 0 [[222, 535]] 1.0 5ztn CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
5ZTNB 146 536 601.0 CUR:60501 Type1 Inactive DFGin 6.985 14.938 BLAminus -121.23, -170.26 54.62, 73.44 -89.58, 24.17 284.13, 70.16 -67.88, -20.27 in-in in 9.125 Saltbr-in 3.318 HRD-in -75.96, -42.97 70.51, 4.22 in-in-out SNCiio in-out ActLoopNT-in 2.915 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.98, -2.03 APE9-dihe-na -118.4, 178.1 APE8-dihe-in -73.54, 134.92 APE8-rot-out 181.22 APE67-dihe-in -60.19, -23.13 -53.91, -47.68 APE12-dist-in 13.056 APE11-dist-in 11.551 APE10-dist-in 7.147 APE9-dist-in 3.663 None PTR382,SEP458 PTR382,SEP458 XRAY 2.496 0.2 0.244 B 429 384 7 0 0 0 [[222, 535]] 1.0 5ztn CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
6HDPA 146 542 601.0 FZ5:60501 Type1 Inactive DFGin 6.931 15.235 BLAminus -114.28, 179.49 62.03, 77.41 -96.04, 25.56 278.7, 72.31 -76.29, -11.59 in-in in 9.224 Saltbr-in 3.383 HRD-in -70.91, -50.83 77.22, 0.35 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -141.94, 167.37 APE9-dihe-na 71.47, 153.79 APE8-dihe-in -72.94, 137.06 APE8-rot-out 179.54 APE67-dihe-in -60.52, -24.48 -51.62, -50.78 APE12-dist-in 13.278 APE11-dist-in 11.659 APE10-dist-in 7.064 APE9-dist-in 3.22 None PTR382,SEP458 PTR382,SEP458 XRAY 2.3 0.186 0.238 A 429 397 0 0 0 0 [[222, 535]] 1.0 6hdp CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
6HDRA 146 536 601.0 CC9:60501 Type1 Inactive DFGin 6.939 14.832 BLAminus -116.98, -175.8 60.97, 77.21 -96.77, 23.88 280.67, 81.52 -78.88, -6.9 in-in in 9.328 Saltbr-in 3.505 HRD-in -71.46, -52.99 79.25, 3.29 in-in-out SNCiio in-out ActLoopNT-in 2.804 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.88, 167.44 APE9-dihe-na 70.73, 153.88 APE8-dihe-in -70.98, 134.66 APE8-rot-out 177.54 APE67-dihe-in -61.24, -20.91 -50.8, -48.3 APE12-dist-in 12.885 APE11-dist-in 11.357 APE10-dist-in 6.899 APE9-dist-in 3.222 None PTR382,SEP458 PTR382,SEP458 XRAY 2.2 0.192 0.243 A 429 389 2 0 0 0 [[222, 535]] 1.0 6hdr CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
7AKFA 146 535 601.0 RK5:60601 Type1 Inactive DFGin 6.785 14.751 BLAminus -116.54, -178.37 61.83, 93.06 -112.09, 28.57 283.6, 77.78 -86.48, 0.57 in-in in 8.763 Saltbr-in 2.658 HRD-in -67.66, -54.85 75.7, 9.17 in-in-out SNCiio in-out ActLoopNT-in 2.989 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.94, 166.25 APE9-dihe-na 63.8, 156.1 APE8-dihe-in -67.55, 128.45 APE8-rot-out 225.46 APE67-dihe-in -65.91, -25.18 -38.34, -48.5 APE12-dist-in 12.873 APE11-dist-in 11.166 APE10-dist-in 6.714 APE9-dist-in 3.342 None SEP232,PTR382,SEP458 SEP232,PTR382,SEP458 XRAY 2.6 0.192 0.259 A 429 390 0 0 0 0 [[222, 535]] 1.0 7akf CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
5LXCA 153 536 601.0 7AA:60501 Type1 Inactive DFGin 7.077 15.396 BLAminus -127.7, 168.29 65.71, 89.28 -103.99, 15.3 281.54, 81.72 -66.81, -20.15 in-in in 8.692 Saltbr-in 2.893 HRD-in -69.9, -43.78 75.48, 2.4 in-in-out SNCiio in-out ActLoopNT-in 2.899 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.55, 166.23 APE9-dihe-na 72.78, 145.6 APE8-dihe-in -76.68, 135.17 APE8-rot-out 177.09 APE67-dihe-in -59.77, -30.24 -44.95, -46.79 APE12-dist-in 13.342 APE11-dist-in 11.748 APE10-dist-in 7.517 APE9-dist-in 3.286 None PTR382 PTR382 XRAY 2.15 0.208 0.254 A 408 384 0 0 0 0 [[222, 535]] 1.0 5lxc CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
5LXCB 153 538 601.0 7AA:60501 Type1 Inactive DFGin 7.058 15.351 BLAminus -125.13, 171.0 62.64, 89.27 -105.23, 19.5 281.52, 82.75 -66.91, -27.57 in-in in 8.807 Saltbr-in 2.978 HRD-in -70.76, -50.91 83.26, -7.25 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.21, 164.87 APE9-dihe-na 72.46, 149.37 APE8-dihe-in -74.96, 138.82 APE8-rot-out 175.15 APE67-dihe-in -59.45, -29.64 -49.5, -49.1 APE12-dist-in 13.348 APE11-dist-in 11.697 APE10-dist-in 7.461 APE9-dist-in 3.137 None PTR382 PTR382 XRAY 2.15 0.208 0.254 B 408 386 0 0 0 0 [[222, 535]] 1.0 5lxc CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
5LXDA 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.044 15.038 BLAminus -123.98, 173.69 67.75, 85.87 -103.32, 20.02 290.69, 80.27 -60.79, -26.58 in-in in 8.985 Saltbr-in 2.718 HRD-in -78.02, -45.82 73.2, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.87, 166.87 APE9-dihe-na 75.57, 144.69 APE8-dihe-in -63.57, 135.03 APE8-rot-out 186.77 APE67-dihe-in -56.98, -18.46 -55.94, -51.68 APE12-dist-in 13.257 APE11-dist-in 12.121 APE10-dist-in 7.648 APE9-dist-in 3.33 None PTR382 PTR382 XRAY 2.58 0.2 0.253 A 408 386 0 0 0 0 [[222, 535]] 1.0 5lxd CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
5LXDB 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.017 15.002 BLAminus -125.15, 174.13 66.86, 85.87 -102.41, 18.55 290.97, 80.01 -60.53, -24.71 in-in in 8.991 Saltbr-in 2.786 HRD-in -79.02, -46.62 74.88, 2.37 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.84, 168.16 APE9-dihe-na 73.17, 145.14 APE8-dihe-in -63.72, 133.94 APE8-rot-out 182.75 APE67-dihe-in -55.28, -20.15 -52.56, -53.24 APE12-dist-in 13.282 APE11-dist-in 12.127 APE10-dist-in 7.665 APE9-dist-in 3.299 None PTR382 PTR382 XRAY 2.58 0.2 0.253 B 408 386 0 0 0 0 [[222, 535]] 1.0 5lxd CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
6K0JA 212 536 601.0 CQO:60601 Type1 Inactive DFGin 7.065 15.359 BLAminus -116.77, 179.78 59.52, 75.88 -89.73, 24.44 286.49, 66.6 -65.24, -18.56 in-in in 9.258 Saltbr-in 2.849 HRD-in -66.29, -47.14 70.83, 1.21 in-in-out SNCiio in-out ActLoopNT-in 2.859 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.01, 167.62 APE9-dihe-na 74.56, 150.55 APE8-dihe-in -69.83, 137.05 APE8-rot-out 181.49 APE67-dihe-in -55.27, -26.64 -53.33, -50.0 APE12-dist-in 13.006 APE11-dist-in 11.846 APE10-dist-in 7.514 APE9-dist-in 3.362 E256N,L349A PTR382,SEP458 PTR382,SEP458 XRAY 2.352 0.175 0.209 A 327 325 0 0 0 0 [[222, 535]] 1.0 6k0j CMGC_DYRK2_HUMAN CMGC 5.6e-98 333.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
9KQYA 151 537 601.0 No_ligand No_ligand Inactive DFGin 6.559 15.306 None -118.46, -58.2 -76.39, 93.69 -100.84, 14.42 280.8, 85.79 -66.94, -30.92 in-in in 8.842 Saltbr-in 2.954 HRD-in -69.15, -42.93 69.8, -4.72 in-in-in SNCiii in-in ActLoopNT-in 2.747 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.16, 173.73 APE9-dihe-na 69.18, 145.61 APE8-dihe-in -65.57, 148.39 APE8-rot-in 308.71 APE67-dihe-in -62.63, -39.04 -60.44, -42.14 APE12-dist-in 13.024 APE11-dist-in 11.654 APE10-dist-in 7.133 APE9-dist-in 3.15 None PTR382 PTR382 XRAY 3.2 0.233 0.276 A 407 387 0 0 0 0 [[222, 535]] 1.0 9kqy CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
8HLTB 151 537 601.0 XSE:60501 Type1 Inactive DFGin 6.677 15.172 None -123.1, -45.42 -92.76, 76.97 -82.13, 19.07 287.19, 77.16 -64.05, -27.16 in-in in 8.966 Saltbr-in 2.975 HRD-in -75.54, -44.65 72.51, -4.12 in-in-in SNCiii in-in ActLoopNT-in 2.784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.69, 168.46 APE9-dihe-na 73.66, 156.43 APE8-dihe-in -77.8, 146.18 APE8-rot-in 309.51 APE67-dihe-in -59.07, -35.58 -50.16, -47.35 APE12-dist-in 12.987 APE11-dist-in 11.623 APE10-dist-in 7.106 APE9-dist-in 3.124 None PTR382 PTR382 XRAY 2.8 0.213 0.267 B 393 387 0 0 0 0 [[222, 535]] 1.0 8hlt CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
9KQYB 151 537 601.0 A1L6I:60501 Type1 Inactive DFGin 6.842 15.41 None -119.38, -59.48 -76.49, 94.24 -100.04, 16.54 278.63, 76.93 -66.67, -33.1 in-in in 8.734 Saltbr-in 2.848 HRD-in -67.3, -42.38 69.63, -4.95 in-in-in SNCiii in-in ActLoopNT-in 2.752 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.07, 173.43 APE9-dihe-na 69.88, 144.62 APE8-dihe-in -65.72, 149.7 APE8-rot-in 302.89 APE67-dihe-in -61.87, -38.72 -60.58, -43.15 APE12-dist-in 12.537 APE11-dist-in 11.054 APE10-dist-in 6.618 APE9-dist-in 3.234 None PTR382 PTR382 XRAY 3.2 0.233 0.276 B 407 387 0 0 0 0 [[222, 535]] 1.0 9kqy CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

CMGC_DYRK2 (Dual specificity tyrosine-phosphorylation-regulated kinase 2)

Total number of chains: 33
Active chains: 5
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 30 90.9% AF-Q92630-K1A
DFGin None 3 9.1% 8HLTB

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
DYRK2_HUMAN AF-Q92630-K1A Q92630 214 543 601.0 No_ligand No_ligand Active DFGin 6.939 14.864 BLAminus -126.07, 177.15 62.42, 65.44 -81.73, 10.25 284.63, 80.53 -64.64, -17.85 in-in in 8.728 Saltbr-in 2.723 HRD-in -66.96, -37.74 67.08, -16.77 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 175.12 APE9-dihe-na 60.6, 144.79 APE8-dihe-in -65.13, 137.41 APE8-rot-in 294.19 APE67-dihe-in -65.52, -19.21 -50.69, -46.33 APE12-dist-in 12.882 APE11-dist-in 11.334 APE10-dist-in 7.287 APE9-dist-in 3.021 None None None AF2 -1.0 1.0 1.0 A 330 330 0 0 0 0 [[222, 535]] 1.0 AF-Q92630-K1 Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.8e-99 337.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN AF-Q92630-K3A Q92630 214 543 601.0 No_ligand No_ligand Active DFGin 6.623 14.471 BLAminus -128.09, 177.13 63.4, 64.99 -80.7, 10.08 289.17, 77.94 -66.05, -16.49 in-in in 8.839 Saltbr-in 2.734 HRD-in -72.99, -34.76 62.62, -5.57 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.48, 175.5 APE9-dihe-na 61.64, 142.59 APE8-dihe-in -63.51, 134.37 APE8-rot-in 293.35 APE67-dihe-in -63.69, -20.47 -54.61, -45.06 APE12-dist-in 12.796 APE11-dist-in 11.341 APE10-dist-in 7.03 APE9-dist-in 3.09 None None None AF2 -1.0 1.0 1.0 A 330 330 0 0 0 0 [[222, 535]] 1.0 AF-Q92630-K3 Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.8e-99 337.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7EJVA Q92630 151 537 601.0 YK2:60501 Type1 Active DFGin 6.9 15.424 BLAminus -121.6, -175.71 52.95, 74.47 -89.12, 21.12 283.92, 70.74 -60.92, -24.61 in-in in 8.982 Saltbr-in 3.13 HRD-in -72.41, -42.76 75.36, 0.64 in-in-in SNCiii in-in ActLoopNT-in 2.755 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.92, 162.27 APE9-dihe-na 76.47, 145.84 APE8-dihe-in -66.78, 142.47 APE8-rot-in 275.38 APE67-dihe-in -56.79, -30.59 -58.46, -46.41 APE12-dist-in 12.918 APE11-dist-in 11.297 APE10-dist-in 6.969 APE9-dist-in 3.304 None PTR382 PTR382 XRAY 2.5 0.202 0.246 A 387 385 2 0 0 0 [[222, 535]] 1.0 7ejv Homo sapiens CMGC_DYRK2_HUMAN CMGC 1e-98 336.2 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 8HLTA Q92630 151 535 601.0 XSE:60501 Type1 Active DFGin 7.153 15.661 BLAminus -128.03, -174.41 42.45, 74.99 -83.08, 17.4 279.93, 74.95 -62.5, -19.89 in-in in 9.177 Saltbr-in 2.717 HRD-in -71.74, -44.48 73.83, 0.55 in-in-in SNCiii in-in ActLoopNT-in 2.747 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.16, 170.0 APE9-dihe-na 71.16, 164.17 APE8-dihe-in -84.62, 135.53 APE8-rot-in 250.25 APE67-dihe-in -56.1, -31.76 -49.25, -50.28 APE12-dist-in 13.315 APE11-dist-in 11.966 APE10-dist-in 7.57 APE9-dist-in 3.21 None PTR382 PTR382 XRAY 2.8 0.213 0.267 A 393 385 0 0 0 0 [[222, 535]] 1.0 8hlt Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7AKHA Q92630 146 535 601.0 RK8:60601 Type1 Active DFGin 6.926 15.074 BLAminus -121.6, -171.14 52.21, 81.66 -96.01, 25.36 287.39, 72.64 -67.66, -23.05 in-in in 9.121 Saltbr-in 2.705 HRD-in -56.66, -58.54 81.07, -0.93 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.43, 168.94 APE9-dihe-na 72.6, 150.47 APE8-dihe-in -61.43, 140.56 APE8-rot-in 278.26 APE67-dihe-in -62.31, -24.44 -52.56, -49.45 APE12-dist-in 12.815 APE11-dist-in 11.442 APE10-dist-in 6.914 APE9-dist-in 3.229 None SEP232,PTR382,SEP458 SEP232,PTR382,SEP458 XRAY 2.85 0.188 0.245 A 429 390 0 0 0 0 [[222, 535]] 1.0 7akh Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 3K2LA Q92630 146 543 601.0 No_ligand No_ligand Inactive DFGin 7.095 15.241 BLAminus -127.38, 178.65 61.29, 89.71 -107.22, 23.8 277.85, 81.5 -75.9, -16.57 in-in in 8.858 Saltbr-in 2.965 HRD-in -80.34, -48.51 75.91, -1.73 in-in-out SNCiio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.89, 168.99 APE9-dihe-na 66.37, 164.94 APE8-dihe-in -92.92, 137.86 APE8-rot-out 183.76 APE67-dihe-in -63.43, -18.18 -49.75, -48.38 APE12-dist-in 12.59 APE11-dist-in 11.884 APE10-dist-in 7.261 APE9-dist-in 3.098 None SEP232,TPO381,PTR382,SEP442,SEP458 SEP232,TPO381,PTR382,SEP442,SEP458 XRAY 2.36 0.228 0.288 A 429 397 0 0 0 0 [[222, 535]] 1.0 3k2l Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7DG4A Q92630 215 538 601.0 H5R:601 Type1 Inactive DFGin 7.076 15.315 BLAminus -112.18, -176.63 54.26, 82.32 -95.55, 24.49 281.35, 68.71 -70.68, -16.69 in-in in 9.062 Saltbr-in 2.632 HRD-in -72.69, -45.13 72.43, 4.61 in-in-out SNCiio in-out ActLoopNT-in 2.829 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.35, 168.65 APE9-dihe-na 72.59, 152.62 APE8-dihe-in -75.5, 133.34 APE8-rot-out 190.89 APE67-dihe-in -53.88, -27.24 -50.74, -49.3 APE12-dist-in 13.02 APE11-dist-in 11.794 APE10-dist-in 7.365 APE9-dist-in 3.357 None PTR382,SEP458 PTR382,SEP458 XRAY 2.58 0.206 0.249 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dg4 Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7DH9A Q92630 215 538 601.0 H7F:601 Type1 Inactive DFGin 6.955 15.393 BLAminus -118.25, -176.44 52.33, 72.66 -86.4, 22.32 285.5, 71.17 -68.46, -16.6 in-in in 9.091 Saltbr-in 2.818 HRD-in -67.52, -48.86 77.78, -1.22 in-in-out SNCiio in-out ActLoopNT-in 2.826 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.21, 165.64 APE9-dihe-na 77.26, 152.01 APE8-dihe-in -71.35, 136.19 APE8-rot-out 186.16 APE67-dihe-in -56.24, -27.47 -53.15, -48.91 APE12-dist-in 13.085 APE11-dist-in 11.935 APE10-dist-in 7.588 APE9-dist-in 3.308 None PTR382,SEP458 PTR382,SEP458 XRAY 2.194 0.19 0.218 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dh9 Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7DHCA Q92630 215 538 601.0 H99:601 Type1 Inactive DFGin 6.897 15.183 BLAminus -120.85, -173.65 54.47, 76.85 -89.75, 13.16 285.05, 71.42 -59.73, -14.3 in-in in 9.165 Saltbr-in 2.836 HRD-in -67.26, -47.7 73.48, 5.77 in-in-out SNCiio in-out ActLoopNT-in 2.79 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.28, 171.52 APE9-dihe-na 72.07, 147.78 APE8-dihe-in -70.3, 140.28 APE8-rot-out 189.19 APE67-dihe-in -57.12, -25.22 -59.04, -44.86 APE12-dist-in 13.016 APE11-dist-in 11.9 APE10-dist-in 7.482 APE9-dist-in 3.275 None PTR382,SEP458 PTR382,SEP458 XRAY 2.592 0.17 0.217 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dhc Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7DHHA Q92630 215 538 601.0 H7L:601 Type1 Inactive DFGin 7.002 15.315 BLAminus -121.49, -175.98 53.38, 75.83 -90.0, 17.27 285.73, 67.63 -60.12, -17.2 in-in in 9.069 Saltbr-in 2.831 HRD-in -72.48, -43.45 72.8, 3.03 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.98, 162.3 APE9-dihe-na 71.38, 148.19 APE8-dihe-in -71.4, 141.57 APE8-rot-out 161.34 APE67-dihe-in -65.17, -19.89 -55.14, -43.22 APE12-dist-in 12.9 APE11-dist-in 11.849 APE10-dist-in 7.619 APE9-dist-in 3.387 None PTR382,SEP458 PTR382,SEP458 XRAY 2.486 0.195 0.245 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dhh Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7DHKA Q92630 215 538 601.0 H7O:601 Type1 Inactive DFGin 7.052 15.35 BLAminus -117.35, 177.72 56.81, 75.07 -85.18, 19.92 283.41, 63.05 -63.85, -33.36 in-in in 9.196 Saltbr-in 2.644 HRD-in -71.37, -46.63 75.15, -1.94 in-in-out SNCiio in-out ActLoopNT-in 2.906 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -118.3, 166.48 APE9-dihe-na 68.65, 147.66 APE8-dihe-in -62.61, 137.42 APE8-rot-out 200.1 APE67-dihe-in -57.5, -27.74 -53.83, -48.57 APE12-dist-in 12.955 APE11-dist-in 11.738 APE10-dist-in 7.593 APE9-dist-in 3.202 None PTR382,SEP458 PTR382,SEP458 XRAY 2.341 0.199 0.257 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dhk Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7DHNA Q92630 215 538 601.0 H7R:601 Type1 Inactive DFGin 6.943 15.204 BLAminus -121.26, -177.62 55.21, 78.31 -90.06, 20.47 287.34, 73.71 -59.07, -25.63 in-out in 9.064 Saltbr-out 3.683 HRD-in -71.04, -47.07 70.57, 6.17 out-in-out SNCoio in-out ActLoopNT-in 2.681 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.33, 167.28 APE9-dihe-na 70.26, 153.99 APE8-dihe-in -74.79, 138.71 APE8-rot-out 162.7 APE67-dihe-in -57.15, -24.62 -55.14, -47.5 APE12-dist-in 13.035 APE11-dist-in 11.859 APE10-dist-in 7.473 APE9-dist-in 3.339 None PTR382,SEP458 PTR382,SEP458 XRAY 2.38 0.187 0.223 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dhn Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7DHOA Q92630 215 538 601.0 H7U:601 Type1 Inactive DFGin 7.024 15.384 BLAminus -119.43, -172.42 42.56, 78.27 -84.62, 15.62 281.95, 67.94 -55.62, -33.56 in-in in 9.274 Saltbr-in 2.624 HRD-in -82.16, -38.69 68.11, 7.67 in-in-out SNCiio in-out ActLoopNT-in 2.83 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.77, 178.86 APE9-dihe-na 69.78, 147.69 APE8-dihe-in -69.75, 134.88 APE8-rot-out 211.6 APE67-dihe-in -60.55, -23.47 -49.02, -52.25 APE12-dist-in 12.813 APE11-dist-in 11.959 APE10-dist-in 7.417 APE9-dist-in 3.473 None PTR382,SEP458 PTR382,SEP458 XRAY 3.29 0.188 0.259 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dho Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7DJOA Q92630 215 538 601.0 H80:601 Type1 Inactive DFGin 6.825 15.46 BLAminus -127.28, -171.08 53.55, 75.01 -93.19, 14.88 276.88, 71.94 -62.8, -14.89 in-in in 9.123 Saltbr-in 2.61 HRD-in -68.11, -47.05 70.53, 3.02 in-in-out SNCiio in-out ActLoopNT-in 2.794 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.85, 165.38 APE9-dihe-na 72.88, 157.2 APE8-dihe-in -82.18, 142.51 APE8-rot-out 184.87 APE67-dihe-in -72.03, -23.08 -61.29, -39.89 APE12-dist-in 12.99 APE11-dist-in 11.881 APE10-dist-in 7.591 APE9-dist-in 3.376 None PTR382,SEP458 PTR382,SEP458 XRAY 2.499 0.184 0.234 A 324 324 0 0 0 0 [[222, 535]] 1.0 7djo Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7DL6A Q92630 215 538 601.0 H96:601 Type1 Inactive DFGin 7.152 15.218 BLAminus -117.62, -177.39 53.85, 78.98 -93.5, 18.12 285.84, 68.07 -63.99, -13.06 in-in in 9.043 Saltbr-in 2.543 HRD-in -67.53, -45.24 75.47, 0.91 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.16, 165.64 APE9-dihe-na 68.7, 158.66 APE8-dihe-in -84.48, 139.38 APE8-rot-out 172.15 APE67-dihe-in -59.22, -22.44 -52.23, -48.32 APE12-dist-in 13.001 APE11-dist-in 11.777 APE10-dist-in 7.505 APE9-dist-in 3.173 None PTR382,SEP458 PTR382,SEP458 XRAY 2.648 0.177 0.232 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dl6 Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7DH3A Q92630 213 538 601.0 H7C:601 Type1 Inactive DFGin 7.045 15.26 BLAminus -119.08, -179.53 58.29, 74.58 -88.67, 21.96 286.19, 71.25 -64.16, -21.81 in-in in 8.924 Saltbr-in 3.399 HRD-in -71.55, -47.36 71.56, 3.54 in-in-out SNCiio in-out ActLoopNT-in 2.739 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.02, 171.08 APE9-dihe-na 72.29, 151.84 APE8-dihe-in -71.94, 135.94 APE8-rot-out 194.0 APE67-dihe-in -56.42, -28.28 -53.31, -46.8 APE12-dist-in 13.015 APE11-dist-in 11.909 APE10-dist-in 7.475 APE9-dist-in 3.347 None PTR382,SEP458 PTR382,SEP458 XRAY 2.33 0.195 0.217 A 326 326 0 0 0 0 [[222, 535]] 1.0 7dh3 Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.5e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7DHVA Q92630 212 538 601.0 H7X:601 Type1 Inactive DFGin 7.004 15.218 BLAminus -128.46, -170.28 43.26, 83.31 -95.73, 25.21 286.23, 69.56 -68.03, -32.6 in-in in 8.932 Saltbr-in 2.635 HRD-in -77.4, -41.95 73.79, 2.43 in-in-out SNCiio in-out ActLoopNT-in 2.712 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.51, 169.17 APE9-dihe-na 70.62, 163.65 APE8-dihe-in -91.1, 137.8 APE8-rot-out 165.09 APE67-dihe-in -63.71, -20.64 -53.82, -42.56 APE12-dist-in 12.705 APE11-dist-in 11.639 APE10-dist-in 7.382 APE9-dist-in 3.329 None PTR382,SEP458 PTR382,SEP458 XRAY 2.679 0.193 0.249 A 327 327 0 0 0 0 [[222, 535]] 1.0 7dhv Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.6e-99 337.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 4AZFA Q92630 146 536 601.0 3RA:60600 Type1 Inactive DFGin 6.995 15.39 BLAminus -118.77, 179.61 61.33, 77.52 -93.54, 30.44 283.47, 77.53 -76.64, -12.42 in-in in 9.082 Saltbr-in 2.733 HRD-in -73.11, -47.79 80.4, -7.32 in-in-out SNCiio in-out ActLoopNT-in 2.921 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -141.82, 174.61 APE9-dihe-na 70.03, 158.03 APE8-dihe-in -81.89, 134.84 APE8-rot-out 174.41 APE67-dihe-in -64.03, -20.73 -38.64, -55.03 APE12-dist-in 10.247 APE11-dist-in 11.617 APE10-dist-in 7.116 APE9-dist-in 3.212 None PTR382,SEP458 PTR382,SEP458 XRAY 2.55 0.2 0.255 A 417 389 2 0 0 0 [[222, 535]] 1.0 4azf Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.3e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7EJVB Q92630 153 543 601.0 YK2:60501 Type1 Inactive DFGin 7.155 15.775 BLAminus -119.43, -178.81 52.81, 76.66 -89.1, 19.14 283.4, 73.64 -64.56, -23.63 in-out in 8.918 Saltbr-out 3.623 HRD-in -70.75, -42.53 75.19, 1.74 out-in-in SNCoii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.05, 163.39 APE9-dihe-na 74.33, 145.19 APE8-dihe-in -65.87, 144.25 APE8-rot-in 282.1 APE67-dihe-in -56.42, -28.58 -55.11, -50.7 APE12-dist-in 13.028 APE11-dist-in 11.768 APE10-dist-in 7.569 APE9-dist-in 3.367 None PTR382 PTR382 XRAY 2.5 0.202 0.246 B 391 391 0 0 0 0 [[222, 535]] 1.0 7ejv Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 3KVWA Q92630 146 536 601.0 IRB:60001 Type1 Inactive DFGin 6.948 15.117 BLAminus -111.07, -179.04 64.3, 75.68 -93.62, 22.45 282.14, 79.62 -72.21, -11.84 in-in in 9.088 Saltbr-in 2.684 HRD-in -73.11, -47.89 78.54, -3.21 in-in-out SNCiio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.44, 168.47 APE9-dihe-na 69.36, 159.88 APE8-dihe-in -78.87, 139.14 APE8-rot-out 177.13 APE67-dihe-in -55.72, -26.97 -53.0, -51.24 APE12-dist-in 13.447 APE11-dist-in 11.708 APE10-dist-in 7.236 APE9-dist-in 3.158 None PTR382,SEP458 PTR382,SEP458 XRAY 2.28 0.211 0.26 A 429 389 2 0 0 0 [[222, 535]] 1.0 3kvw Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 5ZTNA Q92630 146 536 601.0 CUR:60501 Type1 Inactive DFGin 7.044 14.917 BLAminus -121.02, -170.84 55.37, 74.14 -90.27, 24.89 284.91, 71.59 -68.02, -21.72 in-in in 9.038 Saltbr-in 3.201 HRD-in -75.34, -43.05 70.76, 4.4 in-in-out SNCiio in-out ActLoopNT-in 2.991 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.75, -1.92 APE9-dihe-na -118.6, 178.64 APE8-dihe-in -75.97, 135.26 APE8-rot-out 181.93 APE67-dihe-in -60.16, -23.88 -54.39, -47.99 APE12-dist-in 13.019 APE11-dist-in 11.6 APE10-dist-in 7.156 APE9-dist-in 3.639 None PTR382,SEP458 PTR382,SEP458 XRAY 2.496 0.2 0.244 A 429 384 7 0 0 0 [[222, 535]] 1.0 5ztn Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 5ZTNB Q92630 146 536 601.0 CUR:60501 Type1 Inactive DFGin 6.985 14.938 BLAminus -121.23, -170.26 54.62, 73.44 -89.58, 24.17 284.13, 70.16 -67.88, -20.27 in-in in 9.125 Saltbr-in 3.318 HRD-in -75.96, -42.97 70.51, 4.22 in-in-out SNCiio in-out ActLoopNT-in 2.915 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.98, -2.03 APE9-dihe-na -118.4, 178.1 APE8-dihe-in -73.54, 134.92 APE8-rot-out 181.22 APE67-dihe-in -60.19, -23.13 -53.91, -47.68 APE12-dist-in 13.056 APE11-dist-in 11.551 APE10-dist-in 7.147 APE9-dist-in 3.663 None PTR382,SEP458 PTR382,SEP458 XRAY 2.496 0.2 0.244 B 429 384 7 0 0 0 [[222, 535]] 1.0 5ztn Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 6HDPA Q92630 146 542 601.0 FZ5:60501 Type1 Inactive DFGin 6.931 15.235 BLAminus -114.28, 179.49 62.03, 77.41 -96.04, 25.56 278.7, 72.31 -76.29, -11.59 in-in in 9.224 Saltbr-in 3.383 HRD-in -70.91, -50.83 77.22, 0.35 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -141.94, 167.37 APE9-dihe-na 71.47, 153.79 APE8-dihe-in -72.94, 137.06 APE8-rot-out 179.54 APE67-dihe-in -60.52, -24.48 -51.62, -50.78 APE12-dist-in 13.278 APE11-dist-in 11.659 APE10-dist-in 7.064 APE9-dist-in 3.22 None PTR382,SEP458 PTR382,SEP458 XRAY 2.3 0.186 0.238 A 429 397 0 0 0 0 [[222, 535]] 1.0 6hdp Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 6HDRA Q92630 146 536 601.0 CC9:60501 Type1 Inactive DFGin 6.939 14.832 BLAminus -116.98, -175.8 60.97, 77.21 -96.77, 23.88 280.67, 81.52 -78.88, -6.9 in-in in 9.328 Saltbr-in 3.505 HRD-in -71.46, -52.99 79.25, 3.29 in-in-out SNCiio in-out ActLoopNT-in 2.804 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.88, 167.44 APE9-dihe-na 70.73, 153.88 APE8-dihe-in -70.98, 134.66 APE8-rot-out 177.54 APE67-dihe-in -61.24, -20.91 -50.8, -48.3 APE12-dist-in 12.885 APE11-dist-in 11.357 APE10-dist-in 6.899 APE9-dist-in 3.222 None PTR382,SEP458 PTR382,SEP458 XRAY 2.2 0.192 0.243 A 429 389 2 0 0 0 [[222, 535]] 1.0 6hdr Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 7AKFA Q92630 146 535 601.0 RK5:60601 Type1 Inactive DFGin 6.785 14.751 BLAminus -116.54, -178.37 61.83, 93.06 -112.09, 28.57 283.6, 77.78 -86.48, 0.57 in-in in 8.763 Saltbr-in 2.658 HRD-in -67.66, -54.85 75.7, 9.17 in-in-out SNCiio in-out ActLoopNT-in 2.989 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.94, 166.25 APE9-dihe-na 63.8, 156.1 APE8-dihe-in -67.55, 128.45 APE8-rot-out 225.46 APE67-dihe-in -65.91, -25.18 -38.34, -48.5 APE12-dist-in 12.873 APE11-dist-in 11.166 APE10-dist-in 6.714 APE9-dist-in 3.342 None SEP232,PTR382,SEP458 SEP232,PTR382,SEP458 XRAY 2.6 0.192 0.259 A 429 390 0 0 0 0 [[222, 535]] 1.0 7akf Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 5LXCA Q92630 153 536 601.0 7AA:60501 Type1 Inactive DFGin 7.077 15.396 BLAminus -127.7, 168.29 65.71, 89.28 -103.99, 15.3 281.54, 81.72 -66.81, -20.15 in-in in 8.692 Saltbr-in 2.893 HRD-in -69.9, -43.78 75.48, 2.4 in-in-out SNCiio in-out ActLoopNT-in 2.899 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.55, 166.23 APE9-dihe-na 72.78, 145.6 APE8-dihe-in -76.68, 135.17 APE8-rot-out 177.09 APE67-dihe-in -59.77, -30.24 -44.95, -46.79 APE12-dist-in 13.342 APE11-dist-in 11.748 APE10-dist-in 7.517 APE9-dist-in 3.286 None PTR382 PTR382 XRAY 2.15 0.208 0.254 A 408 384 0 0 0 0 [[222, 535]] 1.0 5lxc Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 5LXCB Q92630 153 538 601.0 7AA:60501 Type1 Inactive DFGin 7.058 15.351 BLAminus -125.13, 171.0 62.64, 89.27 -105.23, 19.5 281.52, 82.75 -66.91, -27.57 in-in in 8.807 Saltbr-in 2.978 HRD-in -70.76, -50.91 83.26, -7.25 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.21, 164.87 APE9-dihe-na 72.46, 149.37 APE8-dihe-in -74.96, 138.82 APE8-rot-out 175.15 APE67-dihe-in -59.45, -29.64 -49.5, -49.1 APE12-dist-in 13.348 APE11-dist-in 11.697 APE10-dist-in 7.461 APE9-dist-in 3.137 None PTR382 PTR382 XRAY 2.15 0.208 0.254 B 408 386 0 0 0 0 [[222, 535]] 1.0 5lxc Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 5LXDA Q92630 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.044 15.038 BLAminus -123.98, 173.69 67.75, 85.87 -103.32, 20.02 290.69, 80.27 -60.79, -26.58 in-in in 8.985 Saltbr-in 2.718 HRD-in -78.02, -45.82 73.2, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.87, 166.87 APE9-dihe-na 75.57, 144.69 APE8-dihe-in -63.57, 135.03 APE8-rot-out 186.77 APE67-dihe-in -56.98, -18.46 -55.94, -51.68 APE12-dist-in 13.257 APE11-dist-in 12.121 APE10-dist-in 7.648 APE9-dist-in 3.33 None PTR382 PTR382 XRAY 2.58 0.2 0.253 A 408 386 0 0 0 0 [[222, 535]] 1.0 5lxd Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 5LXDB Q92630 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.017 15.002 BLAminus -125.15, 174.13 66.86, 85.87 -102.41, 18.55 290.97, 80.01 -60.53, -24.71 in-in in 8.991 Saltbr-in 2.786 HRD-in -79.02, -46.62 74.88, 2.37 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.84, 168.16 APE9-dihe-na 73.17, 145.14 APE8-dihe-in -63.72, 133.94 APE8-rot-out 182.75 APE67-dihe-in -55.28, -20.15 -52.56, -53.24 APE12-dist-in 13.282 APE11-dist-in 12.127 APE10-dist-in 7.665 APE9-dist-in 3.299 None PTR382 PTR382 XRAY 2.58 0.2 0.253 B 408 386 0 0 0 0 [[222, 535]] 1.0 5lxd Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 6K0JA Q92630 212 536 601.0 CQO:60601 Type1 Inactive DFGin 7.065 15.359 BLAminus -116.77, 179.78 59.52, 75.88 -89.73, 24.44 286.49, 66.6 -65.24, -18.56 in-in in 9.258 Saltbr-in 2.849 HRD-in -66.29, -47.14 70.83, 1.21 in-in-out SNCiio in-out ActLoopNT-in 2.859 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.01, 167.62 APE9-dihe-na 74.56, 150.55 APE8-dihe-in -69.83, 137.05 APE8-rot-out 181.49 APE67-dihe-in -55.27, -26.64 -53.33, -50.0 APE12-dist-in 13.006 APE11-dist-in 11.846 APE10-dist-in 7.514 APE9-dist-in 3.362 E256N,L349A PTR382,SEP458 PTR382,SEP458 XRAY 2.352 0.175 0.209 A 327 325 0 0 0 0 [[222, 535]] 1.0 6k0j Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.6e-98 333.8 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 9KQYA Q92630 151 537 601.0 No_ligand No_ligand Inactive DFGin 6.559 15.306 None -118.46, -58.2 -76.39, 93.69 -100.84, 14.42 280.8, 85.79 -66.94, -30.92 in-in in 8.842 Saltbr-in 2.954 HRD-in -69.15, -42.93 69.8, -4.72 in-in-in SNCiii in-in ActLoopNT-in 2.747 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.16, 173.73 APE9-dihe-na 69.18, 145.61 APE8-dihe-in -65.57, 148.39 APE8-rot-in 308.71 APE67-dihe-in -62.63, -39.04 -60.44, -42.14 APE12-dist-in 13.024 APE11-dist-in 11.654 APE10-dist-in 7.133 APE9-dist-in 3.15 None PTR382 PTR382 XRAY 3.2 0.233 0.276 A 407 387 0 0 0 0 [[222, 535]] 1.0 9kqy Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 8HLTB Q92630 151 537 601.0 XSE:60501 Type1 Inactive DFGin 6.677 15.172 None -123.1, -45.42 -92.76, 76.97 -82.13, 19.07 287.19, 77.16 -64.05, -27.16 in-in in 8.966 Saltbr-in 2.975 HRD-in -75.54, -44.65 72.51, -4.12 in-in-in SNCiii in-in ActLoopNT-in 2.784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.69, 168.46 APE9-dihe-na 73.66, 156.43 APE8-dihe-in -77.8, 146.18 APE8-rot-in 309.51 APE67-dihe-in -59.07, -35.58 -50.16, -47.35 APE12-dist-in 12.987 APE11-dist-in 11.623 APE10-dist-in 7.106 APE9-dist-in 3.124 None PTR382 PTR382 XRAY 2.8 0.213 0.267 B 393 387 0 0 0 0 [[222, 535]] 1.0 8hlt Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2_HUMAN 9KQYB Q92630 151 537 601.0 A1L6I:60501 Type1 Inactive DFGin 6.842 15.41 None -119.38, -59.48 -76.49, 94.24 -100.04, 16.54 278.63, 76.93 -66.67, -33.1 in-in in 8.734 Saltbr-in 2.848 HRD-in -67.3, -42.38 69.63, -4.95 in-in-in SNCiii in-in ActLoopNT-in 2.752 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.07, 173.43 APE9-dihe-na 69.88, 144.62 APE8-dihe-in -65.72, 149.7 APE8-rot-in 302.89 APE67-dihe-in -61.87, -38.72 -60.58, -43.15 APE12-dist-in 12.537 APE11-dist-in 11.054 APE10-dist-in 6.618 APE9-dist-in 3.234 None PTR382 PTR382 XRAY 3.2 0.233 0.276 B 407 387 0 0 0 0 [[222, 535]] 1.0 9kqy Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

CMGC_DYRK2 (Dual specificity tyrosine-phosphorylation-regulated kinase 2)

Total number of chains: 0
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name