CMGC_DYRK2 (Dual specificity tyrosine-phosphorylation-regulated kinase 2)

Total number of chains: 33
Active chains: 5
Uniprot: DYRK2_HUMAN
Kinase Domain Residues: 222 - 535
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 30 90.9% AF-Q92630-K1A
DFGin None 3 9.1% 8HLTB

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
DYRK2 AF-Q92630-K1A Q92630 214 543 601.0 No_ligand No_ligand Active DFGin 6.9387 14.8642 BLAminus -126.07, 177.15 62.42, 65.44 -81.73, 10.25 284.63, 80.53 -64.64, -17.85 in-in in 8.7276 Saltbr-in 2.7234 HRD-in -66.96, -37.74 67.08, -16.77 in-in-in SNCiii in-in ActLoopNT-in 2.8481 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 175.12 APE9-dihe-na 60.6, 144.79 APE8-dihe-in -65.13, 137.41 APE8-rot-in 294.19 APE67-dihe-in -65.52, -19.21 -50.69, -46.33 APE12-dist-in 12.8823 APE11-dist-in 11.3343 APE10-dist-in 7.2875 APE9-dist-in 3.0213 None None None AF2 -1.0 1.0 1.0 A 330.0 330.0 0 25 25 0 [[222, 535]] 1.0 AF-Q92630-K1 CMGC_DYRK2_HUMAN CMGC 5.8e-99 337.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 AF-Q92630-K3A Q92630 214 543 601.0 No_ligand No_ligand Active DFGin 6.6226 14.4713 BLAminus -128.09, 177.13 63.4, 64.99 -80.7, 10.08 289.17, 77.94 -66.05, -16.49 in-in in 8.8393 Saltbr-in 2.7344 HRD-in -72.99, -34.76 62.62, -5.57 in-in-in SNCiii in-in ActLoopNT-in 2.8816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.48, 175.5 APE9-dihe-na 61.64, 142.59 APE8-dihe-in -63.51, 134.37 APE8-rot-in 293.35 APE67-dihe-in -63.69, -20.47 -54.61, -45.06 APE12-dist-in 12.7962 APE11-dist-in 11.3413 APE10-dist-in 7.0304 APE9-dist-in 3.0904 None None None AF2 -1.0 1.0 1.0 A 330.0 330.0 0 25 25 0 [[222, 535]] 1.0 AF-Q92630-K3 CMGC_DYRK2_HUMAN CMGC 5.8e-99 337.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7EJVA Q92630 151 537 601.0 YK2:60501 Type1 Active DFGin 6.9004 15.4242 BLAminus -121.6, -175.71 52.95, 74.47 -89.12, 21.12 283.92, 70.74 -60.92, -24.61 in-in in 8.9819 Saltbr-in 3.1299 HRD-in -72.41, -42.76 75.36, 0.64 in-in-in SNCiii in-in ActLoopNT-in 2.7545 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.92, 162.27 APE9-dihe-na 76.47, 145.84 APE8-dihe-in -66.78, 142.47 APE8-rot-in 275.38 APE67-dihe-in -56.79, -30.59 -58.46, -46.41 APE12-dist-in 12.9176 APE11-dist-in 11.2975 APE10-dist-in 6.969 APE9-dist-in 3.3038 None PTR382 PTR382 XRAY 2.5 0.202 0.246 A 387.0 385.0 2 25 25 0 [[222, 535]] 1.0 7ejv CMGC_DYRK2_HUMAN CMGC 1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 8HLTA Q92630 151 535 601.0 XSE:60501 Type1 Active DFGin 7.1534 15.6614 BLAminus -128.03, -174.41 42.45, 74.99 -83.08, 17.4 279.93, 74.95 -62.5, -19.89 in-in in 9.1767 Saltbr-in 2.717 HRD-in -71.74, -44.48 73.83, 0.55 in-in-in SNCiii in-in ActLoopNT-in 2.7466 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.16, 170.0 APE9-dihe-na 71.16, 164.17 APE8-dihe-in -84.62, 135.53 APE8-rot-in 250.25 APE67-dihe-in -56.1, -31.76 -49.25, -50.28 APE12-dist-in 13.3151 APE11-dist-in 11.9661 APE10-dist-in 7.5704 APE9-dist-in 3.2103 None PTR382 PTR382 XRAY 2.8 0.213 0.267 A 393.0 385.0 0 25 25 0 [[222, 535]] 1.0 8hlt CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7AKHA Q92630 146 535 601.0 RK8:60601 Type1 Active DFGin 6.9258 15.0741 BLAminus -121.6, -171.14 52.21, 81.66 -96.01, 25.36 287.39, 72.64 -67.66, -23.05 in-in in 9.1211 Saltbr-in 2.7055 HRD-in -56.66, -58.54 81.07, -0.93 in-in-in SNCiii in-in ActLoopNT-in 2.8215 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.43, 168.94 APE9-dihe-na 72.6, 150.47 APE8-dihe-in -61.43, 140.56 APE8-rot-in 278.26 APE67-dihe-in -62.31, -24.44 -52.56, -49.45 APE12-dist-in 12.8152 APE11-dist-in 11.4419 APE10-dist-in 6.9138 APE9-dist-in 3.2295 None SEP232,PTR382,SEP458 SEP232,PTR382,SEP458 XRAY 2.85 0.188 0.245 A 429.0 390.0 0 25 25 0 [[222, 535]] 1.0 7akh CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 3K2LA Q92630 146 543 601.0 No_ligand No_ligand Inactive DFGin 7.0945 15.2406 BLAminus -127.38, 178.65 61.29, 89.71 -107.22, 23.8 277.85, 81.5 -75.9, -16.57 in-in in 8.8579 Saltbr-in 2.9651 HRD-in -80.34, -48.51 75.91, -1.73 in-in-out SNCiio in-out ActLoopNT-in 2.9735 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.89, 168.99 APE9-dihe-na 66.37, 164.94 APE8-dihe-in -92.92, 137.86 APE8-rot-out 183.76 APE67-dihe-in -63.43, -18.18 -49.75, -48.38 APE12-dist-in 12.5898 APE11-dist-in 11.8845 APE10-dist-in 7.261 APE9-dist-in 3.098 None SEP232,TPO381,PTR382,SEP442,SEP458 SEP232,TPO381,PTR382,SEP442,SEP458 XRAY 2.36 0.228 0.288 A 429.0 397.0 0 25 25 0 [[222, 535]] 1.0 3k2l CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7DG4A Q92630 215 538 601.0 H5R:601 Type1 Inactive DFGin 7.0763 15.315 BLAminus -112.18, -176.63 54.26, 82.32 -95.55, 24.49 281.35, 68.71 -70.68, -16.69 in-in in 9.062 Saltbr-in 2.6319 HRD-in -72.69, -45.13 72.43, 4.61 in-in-out SNCiio in-out ActLoopNT-in 2.8293 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.35, 168.65 APE9-dihe-na 72.59, 152.62 APE8-dihe-in -75.5, 133.34 APE8-rot-out 190.89 APE67-dihe-in -53.88, -27.24 -50.74, -49.3 APE12-dist-in 13.02 APE11-dist-in 11.7939 APE10-dist-in 7.3648 APE9-dist-in 3.357 None PTR382,SEP458 PTR382,SEP458 XRAY 2.58 0.206 0.249 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dg4 CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7DH9A Q92630 215 538 601.0 H7F:601 Type1 Inactive DFGin 6.9547 15.3926 BLAminus -118.25, -176.44 52.33, 72.66 -86.4, 22.32 285.5, 71.17 -68.46, -16.6 in-in in 9.0913 Saltbr-in 2.8181 HRD-in -67.52, -48.86 77.78, -1.22 in-in-out SNCiio in-out ActLoopNT-in 2.8265 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.21, 165.64 APE9-dihe-na 77.26, 152.01 APE8-dihe-in -71.35, 136.19 APE8-rot-out 186.16 APE67-dihe-in -56.24, -27.47 -53.15, -48.91 APE12-dist-in 13.0845 APE11-dist-in 11.9349 APE10-dist-in 7.5884 APE9-dist-in 3.3083 None PTR382,SEP458 PTR382,SEP458 XRAY 2.194 0.19 0.218 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dh9 CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7DHCA Q92630 215 538 601.0 H99:601 Type1 Inactive DFGin 6.8966 15.1826 BLAminus -120.85, -173.65 54.47, 76.85 -89.75, 13.16 285.05, 71.42 -59.73, -14.3 in-in in 9.1652 Saltbr-in 2.8364 HRD-in -67.26, -47.7 73.48, 5.77 in-in-out SNCiio in-out ActLoopNT-in 2.7902 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.28, 171.52 APE9-dihe-na 72.07, 147.78 APE8-dihe-in -70.3, 140.28 APE8-rot-out 189.19 APE67-dihe-in -57.12, -25.22 -59.04, -44.86 APE12-dist-in 13.0161 APE11-dist-in 11.9001 APE10-dist-in 7.4823 APE9-dist-in 3.2753 None PTR382,SEP458 PTR382,SEP458 XRAY 2.592 0.17 0.217 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dhc CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7DHHA Q92630 215 538 601.0 H7L:601 Type1 Inactive DFGin 7.002 15.3152 BLAminus -121.49, -175.98 53.38, 75.83 -90.0, 17.27 285.73, 67.63 -60.12, -17.2 in-in in 9.0689 Saltbr-in 2.8308 HRD-in -72.48, -43.45 72.8, 3.03 in-in-out SNCiio in-out ActLoopNT-in 2.9337 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.98, 162.3 APE9-dihe-na 71.38, 148.19 APE8-dihe-in -71.4, 141.57 APE8-rot-out 161.34 APE67-dihe-in -65.17, -19.89 -55.14, -43.22 APE12-dist-in 12.9003 APE11-dist-in 11.8493 APE10-dist-in 7.6186 APE9-dist-in 3.387 None PTR382,SEP458 PTR382,SEP458 XRAY 2.486 0.195 0.245 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dhh CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7DHKA Q92630 215 538 601.0 H7O:601 Type1 Inactive DFGin 7.0516 15.3496 BLAminus -117.35, 177.72 56.81, 75.07 -85.18, 19.92 283.41, 63.05 -63.85, -33.36 in-in in 9.1962 Saltbr-in 2.644 HRD-in -71.37, -46.63 75.15, -1.94 in-in-out SNCiio in-out ActLoopNT-in 2.9058 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -118.3, 166.48 APE9-dihe-na 68.65, 147.66 APE8-dihe-in -62.61, 137.42 APE8-rot-out 200.1 APE67-dihe-in -57.5, -27.74 -53.83, -48.57 APE12-dist-in 12.9551 APE11-dist-in 11.7375 APE10-dist-in 7.5928 APE9-dist-in 3.202 None PTR382,SEP458 PTR382,SEP458 XRAY 2.341 0.199 0.257 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dhk CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7DHNA Q92630 215 538 601.0 H7R:601 Type1 Inactive DFGin 6.9431 15.2041 BLAminus -121.26, -177.62 55.21, 78.31 -90.06, 20.47 287.34, 73.71 -59.07, -25.63 in-out in 9.0642 Saltbr-out 3.6827 HRD-in -71.04, -47.07 70.57, 6.17 out-in-out SNCoio in-out ActLoopNT-in 2.6809 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.33, 167.28 APE9-dihe-na 70.26, 153.99 APE8-dihe-in -74.79, 138.71 APE8-rot-out 162.7 APE67-dihe-in -57.15, -24.62 -55.14, -47.5 APE12-dist-in 13.035 APE11-dist-in 11.8593 APE10-dist-in 7.4728 APE9-dist-in 3.3391 None PTR382,SEP458 PTR382,SEP458 XRAY 2.38 0.187 0.223 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dhn CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7DHOA Q92630 215 538 601.0 H7U:601 Type1 Inactive DFGin 7.024 15.3843 BLAminus -119.43, -172.42 42.56, 78.27 -84.62, 15.62 281.95, 67.94 -55.62, -33.56 in-in in 9.2745 Saltbr-in 2.6242 HRD-in -82.16, -38.69 68.11, 7.67 in-in-out SNCiio in-out ActLoopNT-in 2.8305 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.77, 178.86 APE9-dihe-na 69.78, 147.69 APE8-dihe-in -69.75, 134.88 APE8-rot-out 211.6 APE67-dihe-in -60.55, -23.47 -49.02, -52.25 APE12-dist-in 12.8134 APE11-dist-in 11.9594 APE10-dist-in 7.4166 APE9-dist-in 3.4727 None PTR382,SEP458 PTR382,SEP458 XRAY 3.29 0.188 0.259 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dho CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7DJOA Q92630 215 538 601.0 H80:601 Type1 Inactive DFGin 6.8253 15.4595 BLAminus -127.28, -171.08 53.55, 75.01 -93.19, 14.88 276.88, 71.94 -62.8, -14.89 in-in in 9.1229 Saltbr-in 2.6104 HRD-in -68.11, -47.05 70.53, 3.02 in-in-out SNCiio in-out ActLoopNT-in 2.7942 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.85, 165.38 APE9-dihe-na 72.88, 157.2 APE8-dihe-in -82.18, 142.51 APE8-rot-out 184.87 APE67-dihe-in -72.03, -23.08 -61.29, -39.89 APE12-dist-in 12.9903 APE11-dist-in 11.8814 APE10-dist-in 7.5908 APE9-dist-in 3.3761 None PTR382,SEP458 PTR382,SEP458 XRAY 2.499 0.184 0.234 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7djo CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7DL6A Q92630 215 538 601.0 H96:601 Type1 Inactive DFGin 7.152 15.2183 BLAminus -117.62, -177.39 53.85, 78.98 -93.5, 18.12 285.84, 68.07 -63.99, -13.06 in-in in 9.0435 Saltbr-in 2.5426 HRD-in -67.53, -45.24 75.47, 0.91 in-in-out SNCiio in-out ActLoopNT-in 2.9201 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.16, 165.64 APE9-dihe-na 68.7, 158.66 APE8-dihe-in -84.48, 139.38 APE8-rot-out 172.15 APE67-dihe-in -59.22, -22.44 -52.23, -48.32 APE12-dist-in 13.0011 APE11-dist-in 11.7774 APE10-dist-in 7.5046 APE9-dist-in 3.1728 None PTR382,SEP458 PTR382,SEP458 XRAY 2.648 0.177 0.232 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dl6 CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7DH3A Q92630 213 538 601.0 H7C:601 Type1 Inactive DFGin 7.0449 15.2604 BLAminus -119.08, -179.53 58.29, 74.58 -88.67, 21.96 286.19, 71.25 -64.16, -21.81 in-in in 8.9242 Saltbr-in 3.3992 HRD-in -71.55, -47.36 71.56, 3.54 in-in-out SNCiio in-out ActLoopNT-in 2.7391 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.02, 171.08 APE9-dihe-na 72.29, 151.84 APE8-dihe-in -71.94, 135.94 APE8-rot-out 194.0 APE67-dihe-in -56.42, -28.28 -53.31, -46.8 APE12-dist-in 13.0151 APE11-dist-in 11.909 APE10-dist-in 7.475 APE9-dist-in 3.3468 None PTR382,SEP458 PTR382,SEP458 XRAY 2.33 0.195 0.217 A 326.0 326.0 0 25 25 0 [[222, 535]] 1.0 7dh3 CMGC_DYRK2_HUMAN CMGC 5.5e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7DHVA Q92630 212 538 601.0 H7X:601 Type1 Inactive DFGin 7.0038 15.2179 BLAminus -128.46, -170.28 43.26, 83.31 -95.73, 25.21 286.23, 69.56 -68.03, -32.6 in-in in 8.9319 Saltbr-in 2.6354 HRD-in -77.4, -41.95 73.79, 2.43 in-in-out SNCiio in-out ActLoopNT-in 2.7123 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.51, 169.17 APE9-dihe-na 70.62, 163.65 APE8-dihe-in -91.1, 137.8 APE8-rot-out 165.09 APE67-dihe-in -63.71, -20.64 -53.82, -42.56 APE12-dist-in 12.7046 APE11-dist-in 11.6386 APE10-dist-in 7.382 APE9-dist-in 3.3289 None PTR382,SEP458 PTR382,SEP458 XRAY 2.679 0.193 0.249 A 327.0 327.0 0 25 25 0 [[222, 535]] 1.0 7dhv CMGC_DYRK2_HUMAN CMGC 5.6e-99 337.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 4AZFA Q92630 146 536 601.0 3RA:60600 Type1 Inactive DFGin 6.9946 15.3904 BLAminus -118.77, 179.61 61.33, 77.52 -93.54, 30.44 283.47, 77.53 -76.64, -12.42 in-in in 9.0817 Saltbr-in 2.7335 HRD-in -73.11, -47.79 80.4, -7.32 in-in-out SNCiio in-out ActLoopNT-in 2.9212 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -141.82, 174.61 APE9-dihe-na 70.03, 158.03 APE8-dihe-in -81.89, 134.84 APE8-rot-out 174.41 APE67-dihe-in -64.03, -20.73 -38.64, -55.03 APE12-dist-in 10.2473 APE11-dist-in 11.6168 APE10-dist-in 7.1161 APE9-dist-in 3.2122 None PTR382,SEP458 PTR382,SEP458 XRAY 2.55 0.2 0.255 A 417.0 389.0 2 25 25 0 [[222, 535]] 1.0 4azf CMGC_DYRK2_HUMAN CMGC 1.3e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7EJVB Q92630 153 543 601.0 YK2:60501 Type1 Inactive DFGin 7.1548 15.7755 BLAminus -119.43, -178.81 52.81, 76.66 -89.1, 19.14 283.4, 73.64 -64.56, -23.63 in-out in 8.918 Saltbr-out 3.6232 HRD-in -70.75, -42.53 75.19, 1.74 out-in-in SNCoii in-in ActLoopNT-in 2.8738 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.05, 163.39 APE9-dihe-na 74.33, 145.19 APE8-dihe-in -65.87, 144.25 APE8-rot-in 282.1 APE67-dihe-in -56.42, -28.58 -55.11, -50.7 APE12-dist-in 13.0281 APE11-dist-in 11.7681 APE10-dist-in 7.5692 APE9-dist-in 3.367 None PTR382 PTR382 XRAY 2.5 0.202 0.246 B 391.0 391.0 0 25 25 0 [[222, 535]] 1.0 7ejv CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 3KVWA Q92630 146 536 601.0 IRB:60001 Type1 Inactive DFGin 6.9484 15.1169 BLAminus -111.07, -179.04 64.3, 75.68 -93.62, 22.45 282.14, 79.62 -72.21, -11.84 in-in in 9.0883 Saltbr-in 2.684 HRD-in -73.11, -47.89 78.54, -3.21 in-in-out SNCiio in-out ActLoopNT-in 2.9013 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.44, 168.47 APE9-dihe-na 69.36, 159.88 APE8-dihe-in -78.87, 139.14 APE8-rot-out 177.13 APE67-dihe-in -55.72, -26.97 -53.0, -51.24 APE12-dist-in 13.4473 APE11-dist-in 11.7082 APE10-dist-in 7.2359 APE9-dist-in 3.1584 None PTR382,SEP458 PTR382,SEP458 XRAY 2.28 0.211 0.26 A 429.0 389.0 2 25 25 0 [[222, 535]] 1.0 3kvw CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 5ZTNA Q92630 146 536 601.0 CUR:60501 Type1 Inactive DFGin 7.0437 14.9172 BLAminus -121.02, -170.84 55.37, 74.14 -90.27, 24.89 284.91, 71.59 -68.02, -21.72 in-in in 9.0378 Saltbr-in 3.2009 HRD-in -75.34, -43.05 70.76, 4.4 in-in-out SNCiio in-out ActLoopNT-in 2.9913 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.75, -1.92 APE9-dihe-na -118.6, 178.64 APE8-dihe-in -75.97, 135.26 APE8-rot-out 181.93 APE67-dihe-in -60.16, -23.88 -54.39, -47.99 APE12-dist-in 13.019 APE11-dist-in 11.6003 APE10-dist-in 7.1559 APE9-dist-in 3.639 None PTR382,SEP458 PTR382,SEP458 XRAY 2.496 0.2 0.244 A 429.0 384.0 7 25 25 0 [[222, 535]] 1.0 5ztn CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 5ZTNB Q92630 146 536 601.0 CUR:60501 Type1 Inactive DFGin 6.9849 14.9376 BLAminus -121.23, -170.26 54.62, 73.44 -89.58, 24.17 284.13, 70.16 -67.88, -20.27 in-in in 9.1252 Saltbr-in 3.3183 HRD-in -75.96, -42.97 70.51, 4.22 in-in-out SNCiio in-out ActLoopNT-in 2.9154 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.98, -2.03 APE9-dihe-na -118.4, 178.1 APE8-dihe-in -73.54, 134.92 APE8-rot-out 181.22 APE67-dihe-in -60.19, -23.13 -53.91, -47.68 APE12-dist-in 13.0555 APE11-dist-in 11.5514 APE10-dist-in 7.147 APE9-dist-in 3.6627 None PTR382,SEP458 PTR382,SEP458 XRAY 2.496 0.2 0.244 B 429.0 384.0 7 25 25 0 [[222, 535]] 1.0 5ztn CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 6HDPA Q92630 146 542 601.0 FZ5:60501 Type1 Inactive DFGin 6.9313 15.2349 BLAminus -114.28, 179.49 62.03, 77.41 -96.04, 25.56 278.7, 72.31 -76.29, -11.59 in-in in 9.2241 Saltbr-in 3.383 HRD-in -70.91, -50.83 77.22, 0.35 in-in-out SNCiio in-out ActLoopNT-in 2.7631 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -141.94, 167.37 APE9-dihe-na 71.47, 153.79 APE8-dihe-in -72.94, 137.06 APE8-rot-out 179.54 APE67-dihe-in -60.52, -24.48 -51.62, -50.78 APE12-dist-in 13.2778 APE11-dist-in 11.6594 APE10-dist-in 7.0638 APE9-dist-in 3.2198 None PTR382,SEP458 PTR382,SEP458 XRAY 2.3 0.186 0.238 A 429.0 397.0 0 25 25 0 [[222, 535]] 1.0 6hdp CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 6HDRA Q92630 146 536 601.0 CC9:60501 Type1 Inactive DFGin 6.9387 14.8325 BLAminus -116.98, -175.8 60.97, 77.21 -96.77, 23.88 280.67, 81.52 -78.88, -6.9 in-in in 9.3283 Saltbr-in 3.5045 HRD-in -71.46, -52.99 79.25, 3.29 in-in-out SNCiio in-out ActLoopNT-in 2.8036 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.88, 167.44 APE9-dihe-na 70.73, 153.88 APE8-dihe-in -70.98, 134.66 APE8-rot-out 177.54 APE67-dihe-in -61.24, -20.91 -50.8, -48.3 APE12-dist-in 12.8854 APE11-dist-in 11.3565 APE10-dist-in 6.8992 APE9-dist-in 3.2221 None PTR382,SEP458 PTR382,SEP458 XRAY 2.2 0.192 0.243 A 429.0 389.0 2 25 25 0 [[222, 535]] 1.0 6hdr CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 7AKFA Q92630 146 535 601.0 RK5:60601 Type1 Inactive DFGin 6.7845 14.7511 BLAminus -116.54, -178.37 61.83, 93.06 -112.09, 28.57 283.6, 77.78 -86.48, 0.57 in-in in 8.7634 Saltbr-in 2.6577 HRD-in -67.66, -54.85 75.7, 9.17 in-in-out SNCiio in-out ActLoopNT-in 2.9894 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.94, 166.25 APE9-dihe-na 63.8, 156.1 APE8-dihe-in -67.55, 128.45 APE8-rot-out 225.46 APE67-dihe-in -65.91, -25.18 -38.34, -48.5 APE12-dist-in 12.8731 APE11-dist-in 11.1665 APE10-dist-in 6.7142 APE9-dist-in 3.3418 None SEP232,PTR382,SEP458 SEP232,PTR382,SEP458 XRAY 2.6 0.192 0.259 A 429.0 390.0 0 25 25 0 [[222, 535]] 1.0 7akf CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 5LXCA Q92630 153 536 601.0 7AA:60501 Type1 Inactive DFGin 7.0765 15.3959 BLAminus -127.7, 168.29 65.71, 89.28 -103.99, 15.3 281.54, 81.72 -66.81, -20.15 in-in in 8.6919 Saltbr-in 2.8935 HRD-in -69.9, -43.78 75.48, 2.4 in-in-out SNCiio in-out ActLoopNT-in 2.8987 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.55, 166.23 APE9-dihe-na 72.78, 145.6 APE8-dihe-in -76.68, 135.17 APE8-rot-out 177.09 APE67-dihe-in -59.77, -30.24 -44.95, -46.79 APE12-dist-in 13.3422 APE11-dist-in 11.7482 APE10-dist-in 7.517 APE9-dist-in 3.2859 None PTR382 PTR382 XRAY 2.15 0.208 0.254 A 408.0 384.0 0 25 25 0 [[222, 535]] 1.0 5lxc CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 5LXCB Q92630 153 538 601.0 7AA:60501 Type1 Inactive DFGin 7.0576 15.3507 BLAminus -125.13, 171.0 62.64, 89.27 -105.23, 19.5 281.52, 82.75 -66.91, -27.57 in-in in 8.8073 Saltbr-in 2.9781 HRD-in -70.76, -50.91 83.26, -7.25 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.21, 164.87 APE9-dihe-na 72.46, 149.37 APE8-dihe-in -74.96, 138.82 APE8-rot-out 175.15 APE67-dihe-in -59.45, -29.64 -49.5, -49.1 APE12-dist-in 13.3485 APE11-dist-in 11.6973 APE10-dist-in 7.4606 APE9-dist-in 3.1371 None PTR382 PTR382 XRAY 2.15 0.208 0.254 B 408.0 386.0 0 25 25 0 [[222, 535]] 1.0 5lxc CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 5LXDA Q92630 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.0444 15.0379 BLAminus -123.98, 173.69 67.75, 85.87 -103.32, 20.02 290.69, 80.27 -60.79, -26.58 in-in in 8.9847 Saltbr-in 2.7177 HRD-in -78.02, -45.82 73.2, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.9329 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.87, 166.87 APE9-dihe-na 75.57, 144.69 APE8-dihe-in -63.57, 135.03 APE8-rot-out 186.77 APE67-dihe-in -56.98, -18.46 -55.94, -51.68 APE12-dist-in 13.2571 APE11-dist-in 12.1214 APE10-dist-in 7.6479 APE9-dist-in 3.3298 None PTR382 PTR382 XRAY 2.58 0.2 0.253 A 408.0 386.0 0 25 25 0 [[222, 535]] 1.0 5lxd CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 5LXDB Q92630 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.0169 15.0025 BLAminus -125.15, 174.13 66.86, 85.87 -102.41, 18.55 290.97, 80.01 -60.53, -24.71 in-in in 8.9909 Saltbr-in 2.7861 HRD-in -79.02, -46.62 74.88, 2.37 in-in-out SNCiio in-out ActLoopNT-in 2.8668 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.84, 168.16 APE9-dihe-na 73.17, 145.14 APE8-dihe-in -63.72, 133.94 APE8-rot-out 182.75 APE67-dihe-in -55.28, -20.15 -52.56, -53.24 APE12-dist-in 13.2821 APE11-dist-in 12.1273 APE10-dist-in 7.6646 APE9-dist-in 3.299 None PTR382 PTR382 XRAY 2.58 0.2 0.253 B 408.0 386.0 0 25 25 0 [[222, 535]] 1.0 5lxd CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 6K0JA Q92630 212 536 601.0 CQO:60601 Type1 Inactive DFGin 7.0653 15.3589 BLAminus -116.77, 179.78 59.52, 75.88 -89.73, 24.44 286.49, 66.6 -65.24, -18.56 in-in in 9.2581 Saltbr-in 2.8488 HRD-in -66.29, -47.14 70.83, 1.21 in-in-out SNCiio in-out ActLoopNT-in 2.8592 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.01, 167.62 APE9-dihe-na 74.56, 150.55 APE8-dihe-in -69.83, 137.05 APE8-rot-out 181.49 APE67-dihe-in -55.27, -26.64 -53.33, -50.0 APE12-dist-in 13.0056 APE11-dist-in 11.8461 APE10-dist-in 7.5138 APE9-dist-in 3.3617 E256N,L349A PTR382,SEP458 PTR382,SEP458 XRAY 2.352 0.175 0.209 A 327.0 325.0 0 25 25 0 [[222, 535]] 1.0 6k0j CMGC_DYRK2_HUMAN CMGC 5.6e-98 333.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 9KQYA Q92630 151 537 601.0 No_ligand No_ligand Inactive DFGin 6.5585 15.3057 None -118.46, -58.2 -76.39, 93.69 -100.84, 14.42 280.8, 85.79 -66.94, -30.92 in-in in 8.8424 Saltbr-in 2.9544 HRD-in -69.15, -42.93 69.8, -4.72 in-in-in SNCiii in-in ActLoopNT-in 2.7465 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.16, 173.73 APE9-dihe-na 69.18, 145.61 APE8-dihe-in -65.57, 148.39 APE8-rot-in 308.71 APE67-dihe-in -62.63, -39.04 -60.44, -42.14 APE12-dist-in 13.0235 APE11-dist-in 11.6538 APE10-dist-in 7.1331 APE9-dist-in 3.1497 None PTR382 PTR382 XRAY 3.2 0.233 0.276 A 407.0 387.0 0 25 25 0 [[222, 535]] 1.0 9kqy CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 8HLTB Q92630 151 537 601.0 XSE:60501 Type1 Inactive DFGin 6.6774 15.1725 None -123.1, -45.42 -92.76, 76.97 -82.13, 19.07 287.19, 77.16 -64.05, -27.16 in-in in 8.9659 Saltbr-in 2.9746 HRD-in -75.54, -44.65 72.51, -4.12 in-in-in SNCiii in-in ActLoopNT-in 2.7835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.69, 168.46 APE9-dihe-na 73.66, 156.43 APE8-dihe-in -77.8, 146.18 APE8-rot-in 309.51 APE67-dihe-in -59.07, -35.58 -50.16, -47.35 APE12-dist-in 12.9871 APE11-dist-in 11.6227 APE10-dist-in 7.106 APE9-dist-in 3.1243 None PTR382 PTR382 XRAY 2.8 0.213 0.267 B 393.0 387.0 0 25 25 0 [[222, 535]] 1.0 8hlt CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 9KQYB Q92630 151 537 601.0 A1L6I:60501 Type1 Inactive DFGin 6.8416 15.4099 None -119.38, -59.48 -76.49, 94.24 -100.04, 16.54 278.63, 76.93 -66.67, -33.1 in-in in 8.7342 Saltbr-in 2.8484 HRD-in -67.3, -42.38 69.63, -4.95 in-in-in SNCiii in-in ActLoopNT-in 2.752 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.07, 173.43 APE9-dihe-na 69.88, 144.62 APE8-dihe-in -65.72, 149.7 APE8-rot-in 302.89 APE67-dihe-in -61.87, -38.72 -60.58, -43.15 APE12-dist-in 12.5365 APE11-dist-in 11.0539 APE10-dist-in 6.6176 APE9-dist-in 3.2336 None PTR382 PTR382 XRAY 3.2 0.233 0.276 B 407.0 387.0 0 25 25 0 [[222, 535]] 1.0 9kqy CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

CMGC_DYRK2 (Dual specificity tyrosine-phosphorylation-regulated kinase 2)

Total number of chains: 33
Active chains: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 30 90.9% AF-Q92630-K1A
DFGin None 3 9.1% 8HLTB

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
DYRK2 DYRK2_HUMAN AF-Q92630-K1A Q92630 214 543 601.0 No_ligand No_ligand Active DFGin 6.9387 14.8642 BLAminus -126.07, 177.15 62.42, 65.44 -81.73, 10.25 284.63, 80.53 -64.64, -17.85 in-in in 8.7276 Saltbr-in 2.7234 HRD-in -66.96, -37.74 67.08, -16.77 in-in-in SNCiii in-in ActLoopNT-in 2.8481 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 175.12 APE9-dihe-na 60.6, 144.79 APE8-dihe-in -65.13, 137.41 APE8-rot-in 294.19 APE67-dihe-in -65.52, -19.21 -50.69, -46.33 APE12-dist-in 12.8823 APE11-dist-in 11.3343 APE10-dist-in 7.2875 APE9-dist-in 3.0213 None None None AF2 -1.0 1.0 1.0 A 330.0 330.0 0 25 25 0 [[222, 535]] 1.0 AF-Q92630-K1 Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.8e-99 337.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN AF-Q92630-K3A Q92630 214 543 601.0 No_ligand No_ligand Active DFGin 6.6226 14.4713 BLAminus -128.09, 177.13 63.4, 64.99 -80.7, 10.08 289.17, 77.94 -66.05, -16.49 in-in in 8.8393 Saltbr-in 2.7344 HRD-in -72.99, -34.76 62.62, -5.57 in-in-in SNCiii in-in ActLoopNT-in 2.8816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.48, 175.5 APE9-dihe-na 61.64, 142.59 APE8-dihe-in -63.51, 134.37 APE8-rot-in 293.35 APE67-dihe-in -63.69, -20.47 -54.61, -45.06 APE12-dist-in 12.7962 APE11-dist-in 11.3413 APE10-dist-in 7.0304 APE9-dist-in 3.0904 None None None AF2 -1.0 1.0 1.0 A 330.0 330.0 0 25 25 0 [[222, 535]] 1.0 AF-Q92630-K3 Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.8e-99 337.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7EJVA Q92630 151 537 601.0 YK2:60501 Type1 Active DFGin 6.9004 15.4242 BLAminus -121.6, -175.71 52.95, 74.47 -89.12, 21.12 283.92, 70.74 -60.92, -24.61 in-in in 8.9819 Saltbr-in 3.1299 HRD-in -72.41, -42.76 75.36, 0.64 in-in-in SNCiii in-in ActLoopNT-in 2.7545 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.92, 162.27 APE9-dihe-na 76.47, 145.84 APE8-dihe-in -66.78, 142.47 APE8-rot-in 275.38 APE67-dihe-in -56.79, -30.59 -58.46, -46.41 APE12-dist-in 12.9176 APE11-dist-in 11.2975 APE10-dist-in 6.969 APE9-dist-in 3.3038 None PTR382 PTR382 XRAY 2.5 0.202 0.246 A 387.0 385.0 2 25 25 0 [[222, 535]] 1.0 7ejv Homo sapiens CMGC_DYRK2_HUMAN CMGC 1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 8HLTA Q92630 151 535 601.0 XSE:60501 Type1 Active DFGin 7.1534 15.6614 BLAminus -128.03, -174.41 42.45, 74.99 -83.08, 17.4 279.93, 74.95 -62.5, -19.89 in-in in 9.1767 Saltbr-in 2.717 HRD-in -71.74, -44.48 73.83, 0.55 in-in-in SNCiii in-in ActLoopNT-in 2.7466 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.16, 170.0 APE9-dihe-na 71.16, 164.17 APE8-dihe-in -84.62, 135.53 APE8-rot-in 250.25 APE67-dihe-in -56.1, -31.76 -49.25, -50.28 APE12-dist-in 13.3151 APE11-dist-in 11.9661 APE10-dist-in 7.5704 APE9-dist-in 3.2103 None PTR382 PTR382 XRAY 2.8 0.213 0.267 A 393.0 385.0 0 25 25 0 [[222, 535]] 1.0 8hlt Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7AKHA Q92630 146 535 601.0 RK8:60601 Type1 Active DFGin 6.9258 15.0741 BLAminus -121.6, -171.14 52.21, 81.66 -96.01, 25.36 287.39, 72.64 -67.66, -23.05 in-in in 9.1211 Saltbr-in 2.7055 HRD-in -56.66, -58.54 81.07, -0.93 in-in-in SNCiii in-in ActLoopNT-in 2.8215 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.43, 168.94 APE9-dihe-na 72.6, 150.47 APE8-dihe-in -61.43, 140.56 APE8-rot-in 278.26 APE67-dihe-in -62.31, -24.44 -52.56, -49.45 APE12-dist-in 12.8152 APE11-dist-in 11.4419 APE10-dist-in 6.9138 APE9-dist-in 3.2295 None SEP232,PTR382,SEP458 SEP232,PTR382,SEP458 XRAY 2.85 0.188 0.245 A 429.0 390.0 0 25 25 0 [[222, 535]] 1.0 7akh Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 3K2LA Q92630 146 543 601.0 No_ligand No_ligand Inactive DFGin 7.0945 15.2406 BLAminus -127.38, 178.65 61.29, 89.71 -107.22, 23.8 277.85, 81.5 -75.9, -16.57 in-in in 8.8579 Saltbr-in 2.9651 HRD-in -80.34, -48.51 75.91, -1.73 in-in-out SNCiio in-out ActLoopNT-in 2.9735 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.89, 168.99 APE9-dihe-na 66.37, 164.94 APE8-dihe-in -92.92, 137.86 APE8-rot-out 183.76 APE67-dihe-in -63.43, -18.18 -49.75, -48.38 APE12-dist-in 12.5898 APE11-dist-in 11.8845 APE10-dist-in 7.261 APE9-dist-in 3.098 None SEP232,TPO381,PTR382,SEP442,SEP458 SEP232,TPO381,PTR382,SEP442,SEP458 XRAY 2.36 0.228 0.288 A 429.0 397.0 0 25 25 0 [[222, 535]] 1.0 3k2l Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7DG4A Q92630 215 538 601.0 H5R:601 Type1 Inactive DFGin 7.0763 15.315 BLAminus -112.18, -176.63 54.26, 82.32 -95.55, 24.49 281.35, 68.71 -70.68, -16.69 in-in in 9.062 Saltbr-in 2.6319 HRD-in -72.69, -45.13 72.43, 4.61 in-in-out SNCiio in-out ActLoopNT-in 2.8293 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.35, 168.65 APE9-dihe-na 72.59, 152.62 APE8-dihe-in -75.5, 133.34 APE8-rot-out 190.89 APE67-dihe-in -53.88, -27.24 -50.74, -49.3 APE12-dist-in 13.02 APE11-dist-in 11.7939 APE10-dist-in 7.3648 APE9-dist-in 3.357 None PTR382,SEP458 PTR382,SEP458 XRAY 2.58 0.206 0.249 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dg4 Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7DH9A Q92630 215 538 601.0 H7F:601 Type1 Inactive DFGin 6.9547 15.3926 BLAminus -118.25, -176.44 52.33, 72.66 -86.4, 22.32 285.5, 71.17 -68.46, -16.6 in-in in 9.0913 Saltbr-in 2.8181 HRD-in -67.52, -48.86 77.78, -1.22 in-in-out SNCiio in-out ActLoopNT-in 2.8265 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.21, 165.64 APE9-dihe-na 77.26, 152.01 APE8-dihe-in -71.35, 136.19 APE8-rot-out 186.16 APE67-dihe-in -56.24, -27.47 -53.15, -48.91 APE12-dist-in 13.0845 APE11-dist-in 11.9349 APE10-dist-in 7.5884 APE9-dist-in 3.3083 None PTR382,SEP458 PTR382,SEP458 XRAY 2.194 0.19 0.218 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dh9 Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7DHCA Q92630 215 538 601.0 H99:601 Type1 Inactive DFGin 6.8966 15.1826 BLAminus -120.85, -173.65 54.47, 76.85 -89.75, 13.16 285.05, 71.42 -59.73, -14.3 in-in in 9.1652 Saltbr-in 2.8364 HRD-in -67.26, -47.7 73.48, 5.77 in-in-out SNCiio in-out ActLoopNT-in 2.7902 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.28, 171.52 APE9-dihe-na 72.07, 147.78 APE8-dihe-in -70.3, 140.28 APE8-rot-out 189.19 APE67-dihe-in -57.12, -25.22 -59.04, -44.86 APE12-dist-in 13.0161 APE11-dist-in 11.9001 APE10-dist-in 7.4823 APE9-dist-in 3.2753 None PTR382,SEP458 PTR382,SEP458 XRAY 2.592 0.17 0.217 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dhc Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7DHHA Q92630 215 538 601.0 H7L:601 Type1 Inactive DFGin 7.002 15.3152 BLAminus -121.49, -175.98 53.38, 75.83 -90.0, 17.27 285.73, 67.63 -60.12, -17.2 in-in in 9.0689 Saltbr-in 2.8308 HRD-in -72.48, -43.45 72.8, 3.03 in-in-out SNCiio in-out ActLoopNT-in 2.9337 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.98, 162.3 APE9-dihe-na 71.38, 148.19 APE8-dihe-in -71.4, 141.57 APE8-rot-out 161.34 APE67-dihe-in -65.17, -19.89 -55.14, -43.22 APE12-dist-in 12.9003 APE11-dist-in 11.8493 APE10-dist-in 7.6186 APE9-dist-in 3.387 None PTR382,SEP458 PTR382,SEP458 XRAY 2.486 0.195 0.245 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dhh Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7DHKA Q92630 215 538 601.0 H7O:601 Type1 Inactive DFGin 7.0516 15.3496 BLAminus -117.35, 177.72 56.81, 75.07 -85.18, 19.92 283.41, 63.05 -63.85, -33.36 in-in in 9.1962 Saltbr-in 2.644 HRD-in -71.37, -46.63 75.15, -1.94 in-in-out SNCiio in-out ActLoopNT-in 2.9058 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -118.3, 166.48 APE9-dihe-na 68.65, 147.66 APE8-dihe-in -62.61, 137.42 APE8-rot-out 200.1 APE67-dihe-in -57.5, -27.74 -53.83, -48.57 APE12-dist-in 12.9551 APE11-dist-in 11.7375 APE10-dist-in 7.5928 APE9-dist-in 3.202 None PTR382,SEP458 PTR382,SEP458 XRAY 2.341 0.199 0.257 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dhk Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7DHNA Q92630 215 538 601.0 H7R:601 Type1 Inactive DFGin 6.9431 15.2041 BLAminus -121.26, -177.62 55.21, 78.31 -90.06, 20.47 287.34, 73.71 -59.07, -25.63 in-out in 9.0642 Saltbr-out 3.6827 HRD-in -71.04, -47.07 70.57, 6.17 out-in-out SNCoio in-out ActLoopNT-in 2.6809 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.33, 167.28 APE9-dihe-na 70.26, 153.99 APE8-dihe-in -74.79, 138.71 APE8-rot-out 162.7 APE67-dihe-in -57.15, -24.62 -55.14, -47.5 APE12-dist-in 13.035 APE11-dist-in 11.8593 APE10-dist-in 7.4728 APE9-dist-in 3.3391 None PTR382,SEP458 PTR382,SEP458 XRAY 2.38 0.187 0.223 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dhn Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7DHOA Q92630 215 538 601.0 H7U:601 Type1 Inactive DFGin 7.024 15.3843 BLAminus -119.43, -172.42 42.56, 78.27 -84.62, 15.62 281.95, 67.94 -55.62, -33.56 in-in in 9.2745 Saltbr-in 2.6242 HRD-in -82.16, -38.69 68.11, 7.67 in-in-out SNCiio in-out ActLoopNT-in 2.8305 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.77, 178.86 APE9-dihe-na 69.78, 147.69 APE8-dihe-in -69.75, 134.88 APE8-rot-out 211.6 APE67-dihe-in -60.55, -23.47 -49.02, -52.25 APE12-dist-in 12.8134 APE11-dist-in 11.9594 APE10-dist-in 7.4166 APE9-dist-in 3.4727 None PTR382,SEP458 PTR382,SEP458 XRAY 3.29 0.188 0.259 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dho Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7DJOA Q92630 215 538 601.0 H80:601 Type1 Inactive DFGin 6.8253 15.4595 BLAminus -127.28, -171.08 53.55, 75.01 -93.19, 14.88 276.88, 71.94 -62.8, -14.89 in-in in 9.1229 Saltbr-in 2.6104 HRD-in -68.11, -47.05 70.53, 3.02 in-in-out SNCiio in-out ActLoopNT-in 2.7942 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.85, 165.38 APE9-dihe-na 72.88, 157.2 APE8-dihe-in -82.18, 142.51 APE8-rot-out 184.87 APE67-dihe-in -72.03, -23.08 -61.29, -39.89 APE12-dist-in 12.9903 APE11-dist-in 11.8814 APE10-dist-in 7.5908 APE9-dist-in 3.3761 None PTR382,SEP458 PTR382,SEP458 XRAY 2.499 0.184 0.234 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7djo Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7DL6A Q92630 215 538 601.0 H96:601 Type1 Inactive DFGin 7.152 15.2183 BLAminus -117.62, -177.39 53.85, 78.98 -93.5, 18.12 285.84, 68.07 -63.99, -13.06 in-in in 9.0435 Saltbr-in 2.5426 HRD-in -67.53, -45.24 75.47, 0.91 in-in-out SNCiio in-out ActLoopNT-in 2.9201 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.16, 165.64 APE9-dihe-na 68.7, 158.66 APE8-dihe-in -84.48, 139.38 APE8-rot-out 172.15 APE67-dihe-in -59.22, -22.44 -52.23, -48.32 APE12-dist-in 13.0011 APE11-dist-in 11.7774 APE10-dist-in 7.5046 APE9-dist-in 3.1728 None PTR382,SEP458 PTR382,SEP458 XRAY 2.648 0.177 0.232 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dl6 Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7DH3A Q92630 213 538 601.0 H7C:601 Type1 Inactive DFGin 7.0449 15.2604 BLAminus -119.08, -179.53 58.29, 74.58 -88.67, 21.96 286.19, 71.25 -64.16, -21.81 in-in in 8.9242 Saltbr-in 3.3992 HRD-in -71.55, -47.36 71.56, 3.54 in-in-out SNCiio in-out ActLoopNT-in 2.7391 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.02, 171.08 APE9-dihe-na 72.29, 151.84 APE8-dihe-in -71.94, 135.94 APE8-rot-out 194.0 APE67-dihe-in -56.42, -28.28 -53.31, -46.8 APE12-dist-in 13.0151 APE11-dist-in 11.909 APE10-dist-in 7.475 APE9-dist-in 3.3468 None PTR382,SEP458 PTR382,SEP458 XRAY 2.33 0.195 0.217 A 326.0 326.0 0 25 25 0 [[222, 535]] 1.0 7dh3 Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.5e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7DHVA Q92630 212 538 601.0 H7X:601 Type1 Inactive DFGin 7.0038 15.2179 BLAminus -128.46, -170.28 43.26, 83.31 -95.73, 25.21 286.23, 69.56 -68.03, -32.6 in-in in 8.9319 Saltbr-in 2.6354 HRD-in -77.4, -41.95 73.79, 2.43 in-in-out SNCiio in-out ActLoopNT-in 2.7123 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.51, 169.17 APE9-dihe-na 70.62, 163.65 APE8-dihe-in -91.1, 137.8 APE8-rot-out 165.09 APE67-dihe-in -63.71, -20.64 -53.82, -42.56 APE12-dist-in 12.7046 APE11-dist-in 11.6386 APE10-dist-in 7.382 APE9-dist-in 3.3289 None PTR382,SEP458 PTR382,SEP458 XRAY 2.679 0.193 0.249 A 327.0 327.0 0 25 25 0 [[222, 535]] 1.0 7dhv Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.6e-99 337.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 4AZFA Q92630 146 536 601.0 3RA:60600 Type1 Inactive DFGin 6.9946 15.3904 BLAminus -118.77, 179.61 61.33, 77.52 -93.54, 30.44 283.47, 77.53 -76.64, -12.42 in-in in 9.0817 Saltbr-in 2.7335 HRD-in -73.11, -47.79 80.4, -7.32 in-in-out SNCiio in-out ActLoopNT-in 2.9212 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -141.82, 174.61 APE9-dihe-na 70.03, 158.03 APE8-dihe-in -81.89, 134.84 APE8-rot-out 174.41 APE67-dihe-in -64.03, -20.73 -38.64, -55.03 APE12-dist-in 10.2473 APE11-dist-in 11.6168 APE10-dist-in 7.1161 APE9-dist-in 3.2122 None PTR382,SEP458 PTR382,SEP458 XRAY 2.55 0.2 0.255 A 417.0 389.0 2 25 25 0 [[222, 535]] 1.0 4azf Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.3e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7EJVB Q92630 153 543 601.0 YK2:60501 Type1 Inactive DFGin 7.1548 15.7755 BLAminus -119.43, -178.81 52.81, 76.66 -89.1, 19.14 283.4, 73.64 -64.56, -23.63 in-out in 8.918 Saltbr-out 3.6232 HRD-in -70.75, -42.53 75.19, 1.74 out-in-in SNCoii in-in ActLoopNT-in 2.8738 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.05, 163.39 APE9-dihe-na 74.33, 145.19 APE8-dihe-in -65.87, 144.25 APE8-rot-in 282.1 APE67-dihe-in -56.42, -28.58 -55.11, -50.7 APE12-dist-in 13.0281 APE11-dist-in 11.7681 APE10-dist-in 7.5692 APE9-dist-in 3.367 None PTR382 PTR382 XRAY 2.5 0.202 0.246 B 391.0 391.0 0 25 25 0 [[222, 535]] 1.0 7ejv Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 3KVWA Q92630 146 536 601.0 IRB:60001 Type1 Inactive DFGin 6.9484 15.1169 BLAminus -111.07, -179.04 64.3, 75.68 -93.62, 22.45 282.14, 79.62 -72.21, -11.84 in-in in 9.0883 Saltbr-in 2.684 HRD-in -73.11, -47.89 78.54, -3.21 in-in-out SNCiio in-out ActLoopNT-in 2.9013 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.44, 168.47 APE9-dihe-na 69.36, 159.88 APE8-dihe-in -78.87, 139.14 APE8-rot-out 177.13 APE67-dihe-in -55.72, -26.97 -53.0, -51.24 APE12-dist-in 13.4473 APE11-dist-in 11.7082 APE10-dist-in 7.2359 APE9-dist-in 3.1584 None PTR382,SEP458 PTR382,SEP458 XRAY 2.28 0.211 0.26 A 429.0 389.0 2 25 25 0 [[222, 535]] 1.0 3kvw Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 5ZTNA Q92630 146 536 601.0 CUR:60501 Type1 Inactive DFGin 7.0437 14.9172 BLAminus -121.02, -170.84 55.37, 74.14 -90.27, 24.89 284.91, 71.59 -68.02, -21.72 in-in in 9.0378 Saltbr-in 3.2009 HRD-in -75.34, -43.05 70.76, 4.4 in-in-out SNCiio in-out ActLoopNT-in 2.9913 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.75, -1.92 APE9-dihe-na -118.6, 178.64 APE8-dihe-in -75.97, 135.26 APE8-rot-out 181.93 APE67-dihe-in -60.16, -23.88 -54.39, -47.99 APE12-dist-in 13.019 APE11-dist-in 11.6003 APE10-dist-in 7.1559 APE9-dist-in 3.639 None PTR382,SEP458 PTR382,SEP458 XRAY 2.496 0.2 0.244 A 429.0 384.0 7 25 25 0 [[222, 535]] 1.0 5ztn Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 5ZTNB Q92630 146 536 601.0 CUR:60501 Type1 Inactive DFGin 6.9849 14.9376 BLAminus -121.23, -170.26 54.62, 73.44 -89.58, 24.17 284.13, 70.16 -67.88, -20.27 in-in in 9.1252 Saltbr-in 3.3183 HRD-in -75.96, -42.97 70.51, 4.22 in-in-out SNCiio in-out ActLoopNT-in 2.9154 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.98, -2.03 APE9-dihe-na -118.4, 178.1 APE8-dihe-in -73.54, 134.92 APE8-rot-out 181.22 APE67-dihe-in -60.19, -23.13 -53.91, -47.68 APE12-dist-in 13.0555 APE11-dist-in 11.5514 APE10-dist-in 7.147 APE9-dist-in 3.6627 None PTR382,SEP458 PTR382,SEP458 XRAY 2.496 0.2 0.244 B 429.0 384.0 7 25 25 0 [[222, 535]] 1.0 5ztn Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 6HDPA Q92630 146 542 601.0 FZ5:60501 Type1 Inactive DFGin 6.9313 15.2349 BLAminus -114.28, 179.49 62.03, 77.41 -96.04, 25.56 278.7, 72.31 -76.29, -11.59 in-in in 9.2241 Saltbr-in 3.383 HRD-in -70.91, -50.83 77.22, 0.35 in-in-out SNCiio in-out ActLoopNT-in 2.7631 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -141.94, 167.37 APE9-dihe-na 71.47, 153.79 APE8-dihe-in -72.94, 137.06 APE8-rot-out 179.54 APE67-dihe-in -60.52, -24.48 -51.62, -50.78 APE12-dist-in 13.2778 APE11-dist-in 11.6594 APE10-dist-in 7.0638 APE9-dist-in 3.2198 None PTR382,SEP458 PTR382,SEP458 XRAY 2.3 0.186 0.238 A 429.0 397.0 0 25 25 0 [[222, 535]] 1.0 6hdp Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 6HDRA Q92630 146 536 601.0 CC9:60501 Type1 Inactive DFGin 6.9387 14.8325 BLAminus -116.98, -175.8 60.97, 77.21 -96.77, 23.88 280.67, 81.52 -78.88, -6.9 in-in in 9.3283 Saltbr-in 3.5045 HRD-in -71.46, -52.99 79.25, 3.29 in-in-out SNCiio in-out ActLoopNT-in 2.8036 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.88, 167.44 APE9-dihe-na 70.73, 153.88 APE8-dihe-in -70.98, 134.66 APE8-rot-out 177.54 APE67-dihe-in -61.24, -20.91 -50.8, -48.3 APE12-dist-in 12.8854 APE11-dist-in 11.3565 APE10-dist-in 6.8992 APE9-dist-in 3.2221 None PTR382,SEP458 PTR382,SEP458 XRAY 2.2 0.192 0.243 A 429.0 389.0 2 25 25 0 [[222, 535]] 1.0 6hdr Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 7AKFA Q92630 146 535 601.0 RK5:60601 Type1 Inactive DFGin 6.7845 14.7511 BLAminus -116.54, -178.37 61.83, 93.06 -112.09, 28.57 283.6, 77.78 -86.48, 0.57 in-in in 8.7634 Saltbr-in 2.6577 HRD-in -67.66, -54.85 75.7, 9.17 in-in-out SNCiio in-out ActLoopNT-in 2.9894 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.94, 166.25 APE9-dihe-na 63.8, 156.1 APE8-dihe-in -67.55, 128.45 APE8-rot-out 225.46 APE67-dihe-in -65.91, -25.18 -38.34, -48.5 APE12-dist-in 12.8731 APE11-dist-in 11.1665 APE10-dist-in 6.7142 APE9-dist-in 3.3418 None SEP232,PTR382,SEP458 SEP232,PTR382,SEP458 XRAY 2.6 0.192 0.259 A 429.0 390.0 0 25 25 0 [[222, 535]] 1.0 7akf Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.5e-98 335.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 5LXCA Q92630 153 536 601.0 7AA:60501 Type1 Inactive DFGin 7.0765 15.3959 BLAminus -127.7, 168.29 65.71, 89.28 -103.99, 15.3 281.54, 81.72 -66.81, -20.15 in-in in 8.6919 Saltbr-in 2.8935 HRD-in -69.9, -43.78 75.48, 2.4 in-in-out SNCiio in-out ActLoopNT-in 2.8987 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.55, 166.23 APE9-dihe-na 72.78, 145.6 APE8-dihe-in -76.68, 135.17 APE8-rot-out 177.09 APE67-dihe-in -59.77, -30.24 -44.95, -46.79 APE12-dist-in 13.3422 APE11-dist-in 11.7482 APE10-dist-in 7.517 APE9-dist-in 3.2859 None PTR382 PTR382 XRAY 2.15 0.208 0.254 A 408.0 384.0 0 25 25 0 [[222, 535]] 1.0 5lxc Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 5LXCB Q92630 153 538 601.0 7AA:60501 Type1 Inactive DFGin 7.0576 15.3507 BLAminus -125.13, 171.0 62.64, 89.27 -105.23, 19.5 281.52, 82.75 -66.91, -27.57 in-in in 8.8073 Saltbr-in 2.9781 HRD-in -70.76, -50.91 83.26, -7.25 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.21, 164.87 APE9-dihe-na 72.46, 149.37 APE8-dihe-in -74.96, 138.82 APE8-rot-out 175.15 APE67-dihe-in -59.45, -29.64 -49.5, -49.1 APE12-dist-in 13.3485 APE11-dist-in 11.6973 APE10-dist-in 7.4606 APE9-dist-in 3.1371 None PTR382 PTR382 XRAY 2.15 0.208 0.254 B 408.0 386.0 0 25 25 0 [[222, 535]] 1.0 5lxc Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 5LXDA Q92630 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.0444 15.0379 BLAminus -123.98, 173.69 67.75, 85.87 -103.32, 20.02 290.69, 80.27 -60.79, -26.58 in-in in 8.9847 Saltbr-in 2.7177 HRD-in -78.02, -45.82 73.2, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.9329 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.87, 166.87 APE9-dihe-na 75.57, 144.69 APE8-dihe-in -63.57, 135.03 APE8-rot-out 186.77 APE67-dihe-in -56.98, -18.46 -55.94, -51.68 APE12-dist-in 13.2571 APE11-dist-in 12.1214 APE10-dist-in 7.6479 APE9-dist-in 3.3298 None PTR382 PTR382 XRAY 2.58 0.2 0.253 A 408.0 386.0 0 25 25 0 [[222, 535]] 1.0 5lxd Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 5LXDB Q92630 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.0169 15.0025 BLAminus -125.15, 174.13 66.86, 85.87 -102.41, 18.55 290.97, 80.01 -60.53, -24.71 in-in in 8.9909 Saltbr-in 2.7861 HRD-in -79.02, -46.62 74.88, 2.37 in-in-out SNCiio in-out ActLoopNT-in 2.8668 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.84, 168.16 APE9-dihe-na 73.17, 145.14 APE8-dihe-in -63.72, 133.94 APE8-rot-out 182.75 APE67-dihe-in -55.28, -20.15 -52.56, -53.24 APE12-dist-in 13.2821 APE11-dist-in 12.1273 APE10-dist-in 7.6646 APE9-dist-in 3.299 None PTR382 PTR382 XRAY 2.58 0.2 0.253 B 408.0 386.0 0 25 25 0 [[222, 535]] 1.0 5lxd Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 6K0JA Q92630 212 536 601.0 CQO:60601 Type1 Inactive DFGin 7.0653 15.3589 BLAminus -116.77, 179.78 59.52, 75.88 -89.73, 24.44 286.49, 66.6 -65.24, -18.56 in-in in 9.2581 Saltbr-in 2.8488 HRD-in -66.29, -47.14 70.83, 1.21 in-in-out SNCiio in-out ActLoopNT-in 2.8592 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.01, 167.62 APE9-dihe-na 74.56, 150.55 APE8-dihe-in -69.83, 137.05 APE8-rot-out 181.49 APE67-dihe-in -55.27, -26.64 -53.33, -50.0 APE12-dist-in 13.0056 APE11-dist-in 11.8461 APE10-dist-in 7.5138 APE9-dist-in 3.3617 E256N,L349A PTR382,SEP458 PTR382,SEP458 XRAY 2.352 0.175 0.209 A 327.0 325.0 0 25 25 0 [[222, 535]] 1.0 6k0j Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.6e-98 333.8 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 9KQYA Q92630 151 537 601.0 No_ligand No_ligand Inactive DFGin 6.5585 15.3057 None -118.46, -58.2 -76.39, 93.69 -100.84, 14.42 280.8, 85.79 -66.94, -30.92 in-in in 8.8424 Saltbr-in 2.9544 HRD-in -69.15, -42.93 69.8, -4.72 in-in-in SNCiii in-in ActLoopNT-in 2.7465 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.16, 173.73 APE9-dihe-na 69.18, 145.61 APE8-dihe-in -65.57, 148.39 APE8-rot-in 308.71 APE67-dihe-in -62.63, -39.04 -60.44, -42.14 APE12-dist-in 13.0235 APE11-dist-in 11.6538 APE10-dist-in 7.1331 APE9-dist-in 3.1497 None PTR382 PTR382 XRAY 3.2 0.233 0.276 A 407.0 387.0 0 25 25 0 [[222, 535]] 1.0 9kqy Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 8HLTB Q92630 151 537 601.0 XSE:60501 Type1 Inactive DFGin 6.6774 15.1725 None -123.1, -45.42 -92.76, 76.97 -82.13, 19.07 287.19, 77.16 -64.05, -27.16 in-in in 8.9659 Saltbr-in 2.9746 HRD-in -75.54, -44.65 72.51, -4.12 in-in-in SNCiii in-in ActLoopNT-in 2.7835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.69, 168.46 APE9-dihe-na 73.66, 156.43 APE8-dihe-in -77.8, 146.18 APE8-rot-in 309.51 APE67-dihe-in -59.07, -35.58 -50.16, -47.35 APE12-dist-in 12.9871 APE11-dist-in 11.6227 APE10-dist-in 7.106 APE9-dist-in 3.1243 None PTR382 PTR382 XRAY 2.8 0.213 0.267 B 393.0 387.0 0 25 25 0 [[222, 535]] 1.0 8hlt Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.1e-98 336.2 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
DYRK2 DYRK2_HUMAN 9KQYB Q92630 151 537 601.0 A1L6I:60501 Type1 Inactive DFGin 6.8416 15.4099 None -119.38, -59.48 -76.49, 94.24 -100.04, 16.54 278.63, 76.93 -66.67, -33.1 in-in in 8.7342 Saltbr-in 2.8484 HRD-in -67.3, -42.38 69.63, -4.95 in-in-in SNCiii in-in ActLoopNT-in 2.752 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.07, 173.43 APE9-dihe-na 69.88, 144.62 APE8-dihe-in -65.72, 149.7 APE8-rot-in 302.89 APE67-dihe-in -61.87, -38.72 -60.58, -43.15 APE12-dist-in 12.5365 APE11-dist-in 11.0539 APE10-dist-in 6.6176 APE9-dist-in 3.2336 None PTR382 PTR382 XRAY 3.2 0.233 0.276 B 407.0 387.0 0 25 25 0 [[222, 535]] 1.0 9kqy Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

CMGC_DYRK2 (Dual specificity tyrosine-phosphorylation-regulated kinase 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name