Ligand: RK8

Total number of chains: 3
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 3 7AKHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC DYRK1A DYR1A_HUMAN 7AKE 2.3 Inactive DFGin‑BLAminus in-in in-out RK8 Type1 148 - 481 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7AKE 2.3 Inactive DFGin‑BLAminus in-in in-out RK8 Type1 148 - 481 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK2 DYRK2_HUMAN 7AKH 2.85 Active DFGin‑BLAminus in-in in-in RK8 Type1 146 - 535 0 X232,X382,X458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2

Ligand: RK8

Total number of chains: 3
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 3 7AKHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC DYRK1A DYR1A_HUMAN 7AKE 2.3 Inactive DFGin‑BLAminus in-in in-out RK8 Type1 148 - 481 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 7AKE 2.3 Inactive DFGin‑BLAminus in-in in-out RK8 Type1 148 - 481 0 X321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK2 DYRK2_HUMAN 7AKH 2.85 Active DFGin‑BLAminus in-in in-in RK8 Type1 146 - 535 0 X232,X382,X458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens

Ligand: RK8

Total number of chains: 0
Spatial label Dihedral label Number of Chains Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism