CMGC_CDK4 (Cyclin-dependent kinase 4)

Total number of chains: 19
Active chains: 2
Uniprot: CDK4_HUMAN
Kinase Domain Residues: 6 - 295
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 7 36.8% 2W99B
None None 4 21.1% 5FWMK
DFGin BLAminus 3 15.8% AF-P11802-K1A
DFGin None 3 15.8% 2W9FB
DFGin BLAplus 2 10.5% 3G33A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P11802-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 303 0 None None Cyclin-dependent kinase 4
AF-P11802-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 303 0 None None Cyclin-dependent kinase 4
7SJ3A 2.51 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 6ZV Type1 2 - 295 0 TPO172 None Cyclin-dependent kinase 4
3G33A 3.0 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 5 - 295 0 None None Cyclin-dependent kinase 4
3G33C 3.0 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaiii APEdist_oioo No_ligand No_ligand 5 - 295 0 None None Cyclin-dependent kinase 4
6P8GB 2.8 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaiii APEdist_nnno No_ligand No_ligand 18 - 299 0 None G43E,G47E Cyclin-dependent kinase 4
6P8HB 3.19 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 18 - 298 0 None None Cyclin-dependent kinase 4
2W99B 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 2 - 295 0 None G43E,G47E,T172A Cyclin-dependent kinase 4
2W9ZB 2.45 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_oooo No_ligand No_ligand 2 - 295 0 None G43E,G47E,T172A Cyclin-dependent kinase 4
2W96B 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 4 - 295 0 None G43E,G47E,T172D Cyclin-dependent kinase 4
9CSKB 2.253 Inactive DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaioi APEdist_nnoo A1AZ4 Type1 4 - 295 0 None G43E,G47E Cyclin-dependent kinase 4
9CSKD 2.253 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nooo A1AZ4 Type1 4 - 295 0 None G43E,G47E Cyclin-dependent kinase 4
6P8EB 2.3 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 18 - 299 0 None G43E,G47E Cyclin-dependent kinase 4
6P8FB 2.89 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 18 - 299 0 None G43E,G47E Cyclin-dependent kinase 4
2W9FB 2.85 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aanii APEdist_nnnn No_ligand No_ligand 5 - 295 0 None G43E,G47E,T172F Cyclin-dependent kinase 4
5FWKK 3.9 Inactive None‑None none-none out-out nonTYR APEdihe_aaiio APEdist_iioo No_ligand No_ligand 87 - 296 0 None None Cyclin-dependent kinase 4
5FWLK 9.0 Inactive None‑None in-out out-out nonTYR APEdihe_aaiio APEdist_iioo No_ligand No_ligand 5 - 295 0 None None Cyclin-dependent kinase 4
5FWMK 8.0 Inactive None‑None in-out out-out nonTYR APEdihe_aaiio APEdist_iioo No_ligand No_ligand 5 - 295 0 None None Cyclin-dependent kinase 4
5FWPK 7.2 Inactive None‑None none-none out-out nonTYR APEdihe_aaiio APEdist_iioo No_ligand No_ligand 87 - 295 0 None None Cyclin-dependent kinase 4

CMGC_CDK4 (Cyclin-dependent kinase 4)

Total number of chains: 19
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 7 36.8% 2W99B
None None 4 21.1% 5FWMK
DFGin BLAminus 3 15.8% AF-P11802-K1A
DFGin None 3 15.8% 2W9FB
DFGin BLAplus 2 10.5% 3G33A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CDK4_HUMAN AF-P11802-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 303 0 None None Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN AF-P11802-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 303 0 None None Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 7SJ3A 2.51 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 6ZV Type1 2 - 295 0 TPO172 None Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 3G33A 3.0 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 5 - 295 0 None None Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 3G33C 3.0 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaiii APEdist_oioo No_ligand No_ligand 5 - 295 0 None None Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 6P8GB 2.8 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaiii APEdist_nnno No_ligand No_ligand 18 - 299 0 None G43E,G47E Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 6P8HB 3.19 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 18 - 298 0 None None Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 2W99B 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 2 - 295 0 None G43E,G47E,T172A Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 2W9ZB 2.45 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_oooo No_ligand No_ligand 2 - 295 0 None G43E,G47E,T172A Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 2W96B 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 4 - 295 0 None G43E,G47E,T172D Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 9CSKB 2.253 Inactive DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaioi APEdist_nnoo A1AZ4 Type1 4 - 295 0 None G43E,G47E Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 9CSKD 2.253 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_nooo A1AZ4 Type1 4 - 295 0 None G43E,G47E Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 6P8EB 2.3 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 18 - 299 0 None G43E,G47E Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 6P8FB 2.89 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 18 - 299 0 None G43E,G47E Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 2W9FB 2.85 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aanii APEdist_nnnn No_ligand No_ligand 5 - 295 0 None G43E,G47E,T172F Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 5FWKK 3.9 Inactive None‑None none-none out-out nonTYR APEdihe_aaiio APEdist_iioo No_ligand No_ligand 87 - 296 0 None None Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 5FWLK 9.0 Inactive None‑None in-out out-out nonTYR APEdihe_aaiio APEdist_iioo No_ligand No_ligand 5 - 295 0 None None Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 5FWMK 8.0 Inactive None‑None in-out out-out nonTYR APEdihe_aaiio APEdist_iioo No_ligand No_ligand 5 - 295 0 None None Cyclin-dependent kinase 4 Homo sapiens
CDK4_HUMAN 5FWPK 7.2 Inactive None‑None none-none out-out nonTYR APEdihe_aaiio APEdist_iioo No_ligand No_ligand 87 - 295 0 None None Cyclin-dependent kinase 4 Homo sapiens

CMGC_CDK4 (Cyclin-dependent kinase 4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism