CMGC_CDK4 (Cyclin-dependent kinase 4)

Total number of chains: 19
Active chains: 2
Uniprot: CDK4_HUMAN
Kinase Domain Residues: 6 - 295
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 7 36.8% 2W99B
None None 4 21.1% 5FWMK
DFGin BLAminus 3 15.8% AF-P11802-K1A
DFGin None 3 15.8% 2W9FB
DFGin BLAplus 2 10.5% 3G33A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK4 AF-P11802-K1A P11802 1 303 303.0 No_ligand No_ligand Active DFGin 6.8029 14.995 BLAminus -137.66, 171.64 56.56, 71.26 -80.71, 15.18 285.08, 74.27 -60.34, -28.29 in-in in 8.8995 Saltbr-in 2.7745 HRD-in -77.54, -48.17 63.23, 20.72 in-in-in SNCiii in-in ActLoopNT-in 3.0232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.62, 157.99 APE9-dihe-na 61.06, 139.42 APE8-dihe-in -60.75, 138.1 APE8-rot-in 302.5 APE67-dihe-in -66.16, -25.38 -46.32, -43.78 APE12-dist-in 13.3032 APE11-dist-in 10.416 APE10-dist-in 6.967 APE9-dist-in 3.4354 None None None AF2 -1.0 1.0 1.0 A 303.0 303.0 0 27 27 0 [[6, 295]] 1.0 AF-P11802-K1 CMGC_CDK4_HUMAN CMGC 2.4e-82 284.9 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 AF-P11802-K3A P11802 1 303 303.0 No_ligand No_ligand Active DFGin 6.9722 14.3157 BLAminus -140.64, 174.46 58.54, 61.37 -72.05, 12.34 289.32, 86.11 -59.58, -31.21 in-in in 8.8302 Saltbr-in 2.7457 HRD-in -75.54, -47.18 65.98, 12.71 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.97, 162.78 APE9-dihe-na 63.84, 134.0 APE8-dihe-in -55.38, 131.53 APE8-rot-in 300.45 APE67-dihe-in -65.87, -21.72 -45.36, -43.6 APE12-dist-in 13.0073 APE11-dist-in 10.6559 APE10-dist-in 6.6855 APE9-dist-in 3.4209 None None None AF2 -1.0 1.0 1.0 A 303.0 303.0 0 27 27 0 [[6, 295]] 1.0 AF-P11802-K3 CMGC_CDK4_HUMAN CMGC 2.4e-82 284.9 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 7SJ3A P11802 2 295 303.0 6ZV:60401 Type1 Inactive DFGin 6.9922 14.3054 BLAminus -134.61, 173.86 64.49, 87.43 -108.0, 21.13 290.63, 78.01 -69.87, -19.84 in-in in 8.5505 Saltbr-in 2.9614 HRD-in -78.15, -54.2 69.76, 16.04 in-in-out SNCiio in-out ActLoopNT-in 3.0086 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.11, 167.62 APE9-dihe-na 67.71, 141.27 APE8-dihe-in -65.69, 157.5 APE8-rot-out 56.97 APE67-dihe-in -70.07, -15.52 -57.83, -49.15 APE12-dist-in 13.4012 APE11-dist-in 11.6347 APE10-dist-in 7.2107 APE9-dist-in 3.3524 None TPO172 TPO172 XRAY 2.51 0.201 0.234 A 311.0 274.0 20 27 27 0 [[6, 295]] 1.0 7sj3 CMGC_CDK4_HUMAN CMGC 2.7e-82 284.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 3G33A P11802 5 295 303.0 No_ligand No_ligand Inactive DFGin 6.2285 13.0663 BLAplus -142.88, 171.64 56.0, 47.42 -95.76, -74.88 39.74, 92.76 -89.1, 52.66 out-out out 13.3936 Saltbr-out 12.7365 HRD-out -70.47, 107.14 -77.38, -11.34 out-out-out SNCooo out-out ActLoopNT-out 9.146 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -112.02, 17.47 APE9-dihe-na -57.13, 123.8 APE8-dihe-in -75.56, 115.53 APE8-rot-in 296.37 APE67-dihe-in -75.06, -38.76 -107.48, 26.51 APE12-dist-out 15.1485 APE11-dist-out 19.7087 APE10-dist-out 18.8827 APE9-dist-out 10.6827 None None None XRAY 3.0 0.283 0.314 A 308.0 291.0 0 27 27 0 [[6, 295]] 1.0 3g33 CMGC_CDK4_HUMAN CMGC 2.6e-82 284.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 3G33C P11802 5 295 303.0 No_ligand No_ligand Inactive DFGin 6.2302 13.0724 BLAplus -142.73, 171.58 56.35, 47.2 -95.59, -75.01 39.79, 92.46 -89.05, 52.74 out-out out 13.3987 Saltbr-out 12.7558 HRD-out -70.38, 107.08 -77.21, -11.68 out-out-out SNCooo out-out ActLoopNT-out 9.1443 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -122.56, 127.03 APE9-dihe-na -128.56, 160.4 APE8-dihe-in -71.99, 118.06 APE8-rot-in 294.93 APE67-dihe-in -75.17, -38.51 -107.42, 26.48 APE12-dist-out 18.59 APE11-dist-in 13.776 APE10-dist-out 18.297 APE9-dist-out 10.4233 None None None XRAY 3.0 0.283 0.314 C 308.0 291.0 0 27 27 0 [[6, 295]] 1.0 3g33 CMGC_CDK4_HUMAN CMGC 2.6e-82 284.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 6P8GB P11802 18 299 303.0 No_ligand No_ligand Inactive DFGin 7.1962 13.9996 BLBplus -153.95, 174.6 57.94, 70.96 -149.12, 152.68 49.52, 84.31 64.32, 40.52 out-out out 12.385 Saltbr-out 12.423 HRD-in -69.44, -39.33 67.19, -14.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.23 APE8-dihe-in -106.55, 111.77 APE8-rot-in 291.28 APE67-dihe-in -76.6, -17.58 -96.95, 7.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7466 G43E,G47E None None XRAY 2.8 0.224 0.275 B 302.0 259.0 32 27 13 14 [[6, 295]] 1.0 6p8g CMGC_CDK4_HUMAN CMGC 1.6e-83 288.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 6P8HB P11802 18 298 303.0 No_ligand No_ligand Inactive DFGin 7.0108 15.5918 BLBplus -151.65, 177.24 57.52, 73.66 -156.35, 151.02 52.92, 86.88 58.49, 38.13 out-out out 13.7366 Saltbr-out 10.388 HRD-in -69.37, -37.71 69.34, -28.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.75 APE8-rot-out 182.85 APE67-dihe-in -68.26, -48.6 -91.47, 8.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.19 0.208 0.258 B 302.0 258.0 32 27 12 15 [[6, 295]] 1.0 6p8h CMGC_CDK4_HUMAN CMGC 1.6e-83 288.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 2W99B P11802 2 295 303.0 No_ligand No_ligand Inactive DFGin 6.2845 11.5695 BLBplus -145.47, 169.48 48.57, 20.39 -49.3, 153.47 41.84, 18.47 63.82, -59.07 out-out out 13.6804 Saltbr-out 15.5131 HRD-out -88.75, 141.71 -89.35, -72.61 out-out-out SNCooo out-out ActLoopNT-out 7.0234 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -81.95, -60.57 APE9-dihe-na 70.09, 34.59 APE8-dihe-in -58.25, 59.54 APE8-rot-in 321.92 APE67-dihe-out -80.18, -28.44 -67.38, 50.76 APE12-dist-out 15.2384 APE11-dist-out 14.8692 APE10-dist-out 15.43 APE9-dist-out 10.634 G43E,G47E,T172A None None XRAY 2.8 0.216 0.27 B 306.0 291.0 0 27 27 0 [[6, 295]] 1.0 2w99 CMGC_CDK4_HUMAN CMGC 7.4e-83 286.6 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 2W9ZB P11802 2 295 303.0 No_ligand No_ligand Inactive DFGin 6.8202 13.1654 BLBplus -127.71, 158.61 66.14, 21.58 -72.53, 154.81 42.87, 70.59 55.81, 36.49 out-out out 13.7253 Saltbr-out 14.7818 HRD-in -83.81, -63.81 80.62, -18.22 out-out-out SNCooo out-out ActLoopNT-out 7.3755 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na 45.46, -155.55 APE9-dihe-na 162.76, -163.54 APE8-dihe-out 166.61, 46.87 APE8-rot-out 176.1 APE67-dihe-in -56.1, -15.07 -48.29, 2.32 APE12-dist-out 15.9035 APE11-dist-out 14.9661 APE10-dist-out 15.6944 APE9-dist-out 10.4291 G43E,G47E,T172A None None XRAY 2.45 0.228 0.272 B 306.0 287.0 4 27 27 0 [[6, 295]] 1.0 2w9z CMGC_CDK4_HUMAN CMGC 7.4e-83 286.6 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 2W96B P11802 4 295 303.0 No_ligand No_ligand Inactive DFGin 6.3573 13.1839 BLBplus -130.56, 159.68 70.54, 19.8 -84.14, 138.34 49.7, 90.7 82.01, 16.89 out-out out 14.1405 Saltbr-out 14.8158 HRD-in -73.44, -58.67 84.56, -28.84 out-out-out SNCooo out-out ActLoopNT-out 7.3487 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -141.55, -5.42 APE9-dihe-na 22.28, 70.45 APE8-dihe-in -71.88, 106.42 APE8-rot-in 301.99 APE67-dihe-in -68.93, -11.24 -109.69, 5.09 APE12-dist-out 15.5462 APE11-dist-out 15.9533 APE10-dist-out 15.4616 APE9-dist-out 9.9992 G43E,G47E,T172D None None XRAY 2.3 0.205 0.259 B 306.0 267.0 22 27 27 0 [[6, 295]] 1.0 2w96 CMGC_CDK4_HUMAN CMGC 5.9e-83 286.9 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 9CSKB P11802 4 295 303.0 A1AZ4:69001 Type1 Inactive DFGin 6.9052 13.3928 BLBplus -140.66, 168.34 59.22, 51.64 -130.79, 158.66 53.74, 83.38 77.64, 9.34 out-none out 13.5537 Saltbr-none 999.0 HRD-in -60.89, -53.65 80.76, -9.31 none-out-out SNCnoo out-out ActLoopNT-out 8.7596 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -46.27 APE9-dihe-na -134.2, 153.76 APE8-dihe-in -75.16, 135.6 APE8-rot-out 61.41 APE67-dihe-in -65.27, -24.32 -94.32, 14.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.1832 APE9-dist-out 10.5352 G43E,G47E None None XRAY 2.253 0.226 0.27 B 314.0 279.0 10 27 20 7 [[6, 295]] 1.0 9csk CMGC_CDK4_HUMAN CMGC 1.9e-83 288.5 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 9CSKD P11802 4 295 303.0 A1AZ4:69001 Type1 Inactive DFGin 7.0136 14.0439 BLBplus -138.98, 169.16 59.76, 52.66 -134.78, 161.94 55.22, 78.79 76.68, 11.21 out-out out 13.4275 Saltbr-out 10.2232 HRD-in -62.07, -51.58 81.35, -6.14 out-out-out SNCooo out-out ActLoopNT-out 9.454 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -156.16, 3.85 APE9-dihe-na -56.17, 137.0 APE8-dihe-in -71.98, 128.93 APE8-rot-in 298.58 APE67-dihe-in -69.3, -22.17 -104.55, 15.99 APE12-dist-none 999.0 APE11-dist-out 19.2537 APE10-dist-out 19.0019 APE9-dist-out 9.7368 G43E,G47E None None XRAY 2.253 0.226 0.27 D 314.0 283.0 6 27 21 6 [[6, 295]] 1.0 9csk CMGC_CDK4_HUMAN CMGC 1.9e-83 288.5 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 6P8EB P11802 18 299 303.0 No_ligand No_ligand Inactive DFGin 7.0044 13.6286 None -117.77, -72.88 -107.88, 78.51 -118.9, 163.81 54.02, 80.6 48.95, 65.67 out-out out 12.409 Saltbr-out 13.388 HRD-in -64.13, -55.39 86.4, -18.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.05 APE8-rot-out 188.09 APE67-dihe-in -66.03, -29.27 -109.32, 4.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 G43E,G47E None None XRAY 2.3 0.175 0.222 B 302.0 260.0 31 27 12 15 [[6, 295]] 1.0 6p8e CMGC_CDK4_HUMAN CMGC 1.6e-83 288.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 6P8FB P11802 18 299 303.0 No_ligand No_ligand Inactive DFGin 6.7494 13.7427 None -149.06, 177.93 56.83, 84.9 -168.16, 150.56 57.88, 90.12 60.26, 33.17 out-out out 12.4664 Saltbr-out 11.937 HRD-in -67.53, -46.86 65.41, -6.49 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 167.16 APE8-dihe-in -108.02, 135.84 APE8-rot-out 185.16 APE67-dihe-in -61.26, -17.97 -103.23, 9.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3291 G43E,G47E None None XRAY 2.89 0.189 0.242 B 302.0 262.0 29 27 14 13 [[6, 295]] 1.0 6p8f CMGC_CDK4_HUMAN CMGC 1.6e-83 288.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 2W9FB P11802 5 295 303.0 No_ligand No_ligand Inactive DFGin 7.1342 12.7862 None -118.14, -62.46 -136.13, 77.76 -93.66, 151.53 25.95, 76.09 57.89, -6.88 out-out out 13.7541 Saltbr-out 16.4265 HRD-in -86.38, -51.14 71.27, -31.56 out-out-none SNCoon out-none ActLoopNT-out 7.2591 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 96.26 APE8-rot-in 295.94 APE67-dihe-in -52.44, -36.01 -70.67, 6.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 G43E,G47E,T172F None None XRAY 2.85 0.229 0.3 B 306.0 261.0 27 27 21 6 [[6, 295]] 1.0 2w9f CMGC_CDK4_HUMAN CMGC 1.5e-82 285.6 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 5FWKK P11802 87 296 303.0 No_ligand No_ligand Inactive None 999.0 999.0 None -149.87, 165.29 70.66, 78.41 -92.74, 75.44 300.44, 112.3 89.8, 154.06 none-none none 999.0 Saltbr-none 999.0 HRD-out -162.96, 58.72 -62.47, -12.05 none-out-out SNCnoo out-out ActLoopNT-out 7.6291 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -59.54, -39.45 APE9-dihe-na -48.41, 147.28 APE8-dihe-in -51.05, 115.81 APE8-rot-in 300.88 APE67-dihe-out -70.78, -11.85 -94.22, 53.82 APE12-dist-in 8.3252 APE11-dist-in 10.4532 APE10-dist-out 15.0462 APE9-dist-out 12.8934 None None None EM 3.9 999.0 999.0 K 310.0 210.0 81 27 27 0 [[6, 295]] 1.0 5fwk CMGC_CDK4_HUMAN CMGC 2.7e-82 284.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 5FWLK P11802 5 295 303.0 No_ligand No_ligand Inactive None 48.1987 49.2195 None -149.04, 167.22 70.51, 77.19 -94.69, 75.52 299.88, 116.65 91.08, 152.36 in-out in 9.3607 Saltbr-out 7.7861 HRD-out -162.84, 59.23 -64.44, -13.38 out-out-out SNCooo out-out ActLoopNT-out 7.678 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -55.89, -38.57 APE9-dihe-na -48.82, 148.99 APE8-dihe-in -50.56, 116.76 APE8-rot-in 300.07 APE67-dihe-out -70.78, -12.08 -94.78, 54.09 APE12-dist-in 8.4735 APE11-dist-in 10.5119 APE10-dist-out 15.1148 APE9-dist-out 12.9513 None None None EM 9.0 999.0 999.0 K 310.0 291.0 0 27 27 0 [[6, 295]] 1.0 5fwl CMGC_CDK4_HUMAN CMGC 2.7e-82 284.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 5FWMK P11802 5 295 303.0 No_ligand No_ligand Inactive None 55.9795 47.2536 None -148.61, 165.82 70.36, 77.56 -94.31, 75.71 300.0, 116.31 91.42, 152.54 in-out in 9.991 Saltbr-out 6.8718 HRD-out -162.91, 59.01 -63.71, -13.05 out-out-out SNCooo out-out ActLoopNT-out 7.6742 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -58.09, -39.57 APE9-dihe-na -48.6, 148.94 APE8-dihe-in -50.63, 116.26 APE8-rot-in 299.96 APE67-dihe-out -70.37, -11.94 -94.86, 54.58 APE12-dist-in 8.3719 APE11-dist-in 10.5059 APE10-dist-out 15.0897 APE9-dist-out 13.0112 None None None EM 8.0 999.0 999.0 K 310.0 291.0 0 27 27 0 [[6, 295]] 1.0 5fwm CMGC_CDK4_HUMAN CMGC 2.7e-82 284.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 5FWPK P11802 87 295 303.0 No_ligand No_ligand Inactive None 999.0 999.0 None -148.56, 165.77 70.31, 77.45 -94.72, 75.34 299.55, 116.81 91.01, 152.89 none-none none 999.0 Saltbr-none 999.0 HRD-out -162.95, 59.33 -63.99, -13.24 none-out-out SNCnoo out-out ActLoopNT-out 7.6157 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -52.1, -37.6 APE9-dihe-na -48.76, 149.1 APE8-dihe-in -50.61, 116.92 APE8-rot-in 300.06 APE67-dihe-out -70.39, -11.86 -95.32, 54.3 APE12-dist-in 8.5016 APE11-dist-in 10.4933 APE10-dist-out 15.1178 APE9-dist-out 12.9747 None None None EM 7.2 999.0 999.0 K 310.0 209.0 81 27 27 0 [[6, 295]] 1.0 5fwp CMGC_CDK4_HUMAN CMGC 2.7e-82 284.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4

CMGC_CDK4 (Cyclin-dependent kinase 4)

Total number of chains: 19
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 7 36.8% 2W99B
None None 4 21.1% 5FWMK
DFGin BLAminus 3 15.8% AF-P11802-K1A
DFGin None 3 15.8% 2W9FB
DFGin BLAplus 2 10.5% 3G33A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK4 CDK4_HUMAN AF-P11802-K1A P11802 1 303 303.0 No_ligand No_ligand Active DFGin 6.8029 14.995 BLAminus -137.66, 171.64 56.56, 71.26 -80.71, 15.18 285.08, 74.27 -60.34, -28.29 in-in in 8.8995 Saltbr-in 2.7745 HRD-in -77.54, -48.17 63.23, 20.72 in-in-in SNCiii in-in ActLoopNT-in 3.0232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.62, 157.99 APE9-dihe-na 61.06, 139.42 APE8-dihe-in -60.75, 138.1 APE8-rot-in 302.5 APE67-dihe-in -66.16, -25.38 -46.32, -43.78 APE12-dist-in 13.3032 APE11-dist-in 10.416 APE10-dist-in 6.967 APE9-dist-in 3.4354 None None None AF2 -1.0 1.0 1.0 A 303.0 303.0 0 27 27 0 [[6, 295]] 1.0 AF-P11802-K1 Homo sapiens CMGC_CDK4_HUMAN CMGC 2.4e-82 284.9 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN AF-P11802-K3A P11802 1 303 303.0 No_ligand No_ligand Active DFGin 6.9722 14.3157 BLAminus -140.64, 174.46 58.54, 61.37 -72.05, 12.34 289.32, 86.11 -59.58, -31.21 in-in in 8.8302 Saltbr-in 2.7457 HRD-in -75.54, -47.18 65.98, 12.71 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.97, 162.78 APE9-dihe-na 63.84, 134.0 APE8-dihe-in -55.38, 131.53 APE8-rot-in 300.45 APE67-dihe-in -65.87, -21.72 -45.36, -43.6 APE12-dist-in 13.0073 APE11-dist-in 10.6559 APE10-dist-in 6.6855 APE9-dist-in 3.4209 None None None AF2 -1.0 1.0 1.0 A 303.0 303.0 0 27 27 0 [[6, 295]] 1.0 AF-P11802-K3 Homo sapiens CMGC_CDK4_HUMAN CMGC 2.4e-82 284.9 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 7SJ3A P11802 2 295 303.0 6ZV:60401 Type1 Inactive DFGin 6.9922 14.3054 BLAminus -134.61, 173.86 64.49, 87.43 -108.0, 21.13 290.63, 78.01 -69.87, -19.84 in-in in 8.5505 Saltbr-in 2.9614 HRD-in -78.15, -54.2 69.76, 16.04 in-in-out SNCiio in-out ActLoopNT-in 3.0086 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.11, 167.62 APE9-dihe-na 67.71, 141.27 APE8-dihe-in -65.69, 157.5 APE8-rot-out 56.97 APE67-dihe-in -70.07, -15.52 -57.83, -49.15 APE12-dist-in 13.4012 APE11-dist-in 11.6347 APE10-dist-in 7.2107 APE9-dist-in 3.3524 None TPO172 TPO172 XRAY 2.51 0.201 0.234 A 311.0 274.0 20 27 27 0 [[6, 295]] 1.0 7sj3 Homo sapiens CMGC_CDK4_HUMAN CMGC 2.7e-82 284.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 3G33A P11802 5 295 303.0 No_ligand No_ligand Inactive DFGin 6.2285 13.0663 BLAplus -142.88, 171.64 56.0, 47.42 -95.76, -74.88 39.74, 92.76 -89.1, 52.66 out-out out 13.3936 Saltbr-out 12.7365 HRD-out -70.47, 107.14 -77.38, -11.34 out-out-out SNCooo out-out ActLoopNT-out 9.146 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -112.02, 17.47 APE9-dihe-na -57.13, 123.8 APE8-dihe-in -75.56, 115.53 APE8-rot-in 296.37 APE67-dihe-in -75.06, -38.76 -107.48, 26.51 APE12-dist-out 15.1485 APE11-dist-out 19.7087 APE10-dist-out 18.8827 APE9-dist-out 10.6827 None None None XRAY 3.0 0.283 0.314 A 308.0 291.0 0 27 27 0 [[6, 295]] 1.0 3g33 Homo sapiens CMGC_CDK4_HUMAN CMGC 2.6e-82 284.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 3G33C P11802 5 295 303.0 No_ligand No_ligand Inactive DFGin 6.2302 13.0724 BLAplus -142.73, 171.58 56.35, 47.2 -95.59, -75.01 39.79, 92.46 -89.05, 52.74 out-out out 13.3987 Saltbr-out 12.7558 HRD-out -70.38, 107.08 -77.21, -11.68 out-out-out SNCooo out-out ActLoopNT-out 9.1443 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -122.56, 127.03 APE9-dihe-na -128.56, 160.4 APE8-dihe-in -71.99, 118.06 APE8-rot-in 294.93 APE67-dihe-in -75.17, -38.51 -107.42, 26.48 APE12-dist-out 18.59 APE11-dist-in 13.776 APE10-dist-out 18.297 APE9-dist-out 10.4233 None None None XRAY 3.0 0.283 0.314 C 308.0 291.0 0 27 27 0 [[6, 295]] 1.0 3g33 Homo sapiens CMGC_CDK4_HUMAN CMGC 2.6e-82 284.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 6P8GB P11802 18 299 303.0 No_ligand No_ligand Inactive DFGin 7.1962 13.9996 BLBplus -153.95, 174.6 57.94, 70.96 -149.12, 152.68 49.52, 84.31 64.32, 40.52 out-out out 12.385 Saltbr-out 12.423 HRD-in -69.44, -39.33 67.19, -14.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.23 APE8-dihe-in -106.55, 111.77 APE8-rot-in 291.28 APE67-dihe-in -76.6, -17.58 -96.95, 7.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7466 G43E,G47E None None XRAY 2.8 0.224 0.275 B 302.0 259.0 32 27 13 14 [[6, 295]] 1.0 6p8g Homo sapiens CMGC_CDK4_HUMAN CMGC 1.6e-83 288.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 6P8HB P11802 18 298 303.0 No_ligand No_ligand Inactive DFGin 7.0108 15.5918 BLBplus -151.65, 177.24 57.52, 73.66 -156.35, 151.02 52.92, 86.88 58.49, 38.13 out-out out 13.7366 Saltbr-out 10.388 HRD-in -69.37, -37.71 69.34, -28.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.75 APE8-rot-out 182.85 APE67-dihe-in -68.26, -48.6 -91.47, 8.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.19 0.208 0.258 B 302.0 258.0 32 27 12 15 [[6, 295]] 1.0 6p8h Homo sapiens CMGC_CDK4_HUMAN CMGC 1.6e-83 288.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 2W99B P11802 2 295 303.0 No_ligand No_ligand Inactive DFGin 6.2845 11.5695 BLBplus -145.47, 169.48 48.57, 20.39 -49.3, 153.47 41.84, 18.47 63.82, -59.07 out-out out 13.6804 Saltbr-out 15.5131 HRD-out -88.75, 141.71 -89.35, -72.61 out-out-out SNCooo out-out ActLoopNT-out 7.0234 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -81.95, -60.57 APE9-dihe-na 70.09, 34.59 APE8-dihe-in -58.25, 59.54 APE8-rot-in 321.92 APE67-dihe-out -80.18, -28.44 -67.38, 50.76 APE12-dist-out 15.2384 APE11-dist-out 14.8692 APE10-dist-out 15.43 APE9-dist-out 10.634 G43E,G47E,T172A None None XRAY 2.8 0.216 0.27 B 306.0 291.0 0 27 27 0 [[6, 295]] 1.0 2w99 Homo sapiens CMGC_CDK4_HUMAN CMGC 7.4e-83 286.6 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 2W9ZB P11802 2 295 303.0 No_ligand No_ligand Inactive DFGin 6.8202 13.1654 BLBplus -127.71, 158.61 66.14, 21.58 -72.53, 154.81 42.87, 70.59 55.81, 36.49 out-out out 13.7253 Saltbr-out 14.7818 HRD-in -83.81, -63.81 80.62, -18.22 out-out-out SNCooo out-out ActLoopNT-out 7.3755 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na 45.46, -155.55 APE9-dihe-na 162.76, -163.54 APE8-dihe-out 166.61, 46.87 APE8-rot-out 176.1 APE67-dihe-in -56.1, -15.07 -48.29, 2.32 APE12-dist-out 15.9035 APE11-dist-out 14.9661 APE10-dist-out 15.6944 APE9-dist-out 10.4291 G43E,G47E,T172A None None XRAY 2.45 0.228 0.272 B 306.0 287.0 4 27 27 0 [[6, 295]] 1.0 2w9z Homo sapiens CMGC_CDK4_HUMAN CMGC 7.4e-83 286.6 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 2W96B P11802 4 295 303.0 No_ligand No_ligand Inactive DFGin 6.3573 13.1839 BLBplus -130.56, 159.68 70.54, 19.8 -84.14, 138.34 49.7, 90.7 82.01, 16.89 out-out out 14.1405 Saltbr-out 14.8158 HRD-in -73.44, -58.67 84.56, -28.84 out-out-out SNCooo out-out ActLoopNT-out 7.3487 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -141.55, -5.42 APE9-dihe-na 22.28, 70.45 APE8-dihe-in -71.88, 106.42 APE8-rot-in 301.99 APE67-dihe-in -68.93, -11.24 -109.69, 5.09 APE12-dist-out 15.5462 APE11-dist-out 15.9533 APE10-dist-out 15.4616 APE9-dist-out 9.9992 G43E,G47E,T172D None None XRAY 2.3 0.205 0.259 B 306.0 267.0 22 27 27 0 [[6, 295]] 1.0 2w96 Homo sapiens CMGC_CDK4_HUMAN CMGC 5.9e-83 286.9 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 9CSKB P11802 4 295 303.0 A1AZ4:69001 Type1 Inactive DFGin 6.9052 13.3928 BLBplus -140.66, 168.34 59.22, 51.64 -130.79, 158.66 53.74, 83.38 77.64, 9.34 out-none out 13.5537 Saltbr-none 999.0 HRD-in -60.89, -53.65 80.76, -9.31 none-out-out SNCnoo out-out ActLoopNT-out 8.7596 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -46.27 APE9-dihe-na -134.2, 153.76 APE8-dihe-in -75.16, 135.6 APE8-rot-out 61.41 APE67-dihe-in -65.27, -24.32 -94.32, 14.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.1832 APE9-dist-out 10.5352 G43E,G47E None None XRAY 2.253 0.226 0.27 B 314.0 279.0 10 27 20 7 [[6, 295]] 1.0 9csk Homo sapiens CMGC_CDK4_HUMAN CMGC 1.9e-83 288.5 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 9CSKD P11802 4 295 303.0 A1AZ4:69001 Type1 Inactive DFGin 7.0136 14.0439 BLBplus -138.98, 169.16 59.76, 52.66 -134.78, 161.94 55.22, 78.79 76.68, 11.21 out-out out 13.4275 Saltbr-out 10.2232 HRD-in -62.07, -51.58 81.35, -6.14 out-out-out SNCooo out-out ActLoopNT-out 9.454 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -156.16, 3.85 APE9-dihe-na -56.17, 137.0 APE8-dihe-in -71.98, 128.93 APE8-rot-in 298.58 APE67-dihe-in -69.3, -22.17 -104.55, 15.99 APE12-dist-none 999.0 APE11-dist-out 19.2537 APE10-dist-out 19.0019 APE9-dist-out 9.7368 G43E,G47E None None XRAY 2.253 0.226 0.27 D 314.0 283.0 6 27 21 6 [[6, 295]] 1.0 9csk Homo sapiens CMGC_CDK4_HUMAN CMGC 1.9e-83 288.5 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 6P8EB P11802 18 299 303.0 No_ligand No_ligand Inactive DFGin 7.0044 13.6286 None -117.77, -72.88 -107.88, 78.51 -118.9, 163.81 54.02, 80.6 48.95, 65.67 out-out out 12.409 Saltbr-out 13.388 HRD-in -64.13, -55.39 86.4, -18.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.05 APE8-rot-out 188.09 APE67-dihe-in -66.03, -29.27 -109.32, 4.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 G43E,G47E None None XRAY 2.3 0.175 0.222 B 302.0 260.0 31 27 12 15 [[6, 295]] 1.0 6p8e Homo sapiens CMGC_CDK4_HUMAN CMGC 1.6e-83 288.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 6P8FB P11802 18 299 303.0 No_ligand No_ligand Inactive DFGin 6.7494 13.7427 None -149.06, 177.93 56.83, 84.9 -168.16, 150.56 57.88, 90.12 60.26, 33.17 out-out out 12.4664 Saltbr-out 11.937 HRD-in -67.53, -46.86 65.41, -6.49 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 167.16 APE8-dihe-in -108.02, 135.84 APE8-rot-out 185.16 APE67-dihe-in -61.26, -17.97 -103.23, 9.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3291 G43E,G47E None None XRAY 2.89 0.189 0.242 B 302.0 262.0 29 27 14 13 [[6, 295]] 1.0 6p8f Homo sapiens CMGC_CDK4_HUMAN CMGC 1.6e-83 288.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 2W9FB P11802 5 295 303.0 No_ligand No_ligand Inactive DFGin 7.1342 12.7862 None -118.14, -62.46 -136.13, 77.76 -93.66, 151.53 25.95, 76.09 57.89, -6.88 out-out out 13.7541 Saltbr-out 16.4265 HRD-in -86.38, -51.14 71.27, -31.56 out-out-none SNCoon out-none ActLoopNT-out 7.2591 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 96.26 APE8-rot-in 295.94 APE67-dihe-in -52.44, -36.01 -70.67, 6.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 G43E,G47E,T172F None None XRAY 2.85 0.229 0.3 B 306.0 261.0 27 27 21 6 [[6, 295]] 1.0 2w9f Homo sapiens CMGC_CDK4_HUMAN CMGC 1.5e-82 285.6 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 5FWKK P11802 87 296 303.0 No_ligand No_ligand Inactive None 999.0 999.0 None -149.87, 165.29 70.66, 78.41 -92.74, 75.44 300.44, 112.3 89.8, 154.06 none-none none 999.0 Saltbr-none 999.0 HRD-out -162.96, 58.72 -62.47, -12.05 none-out-out SNCnoo out-out ActLoopNT-out 7.6291 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -59.54, -39.45 APE9-dihe-na -48.41, 147.28 APE8-dihe-in -51.05, 115.81 APE8-rot-in 300.88 APE67-dihe-out -70.78, -11.85 -94.22, 53.82 APE12-dist-in 8.3252 APE11-dist-in 10.4532 APE10-dist-out 15.0462 APE9-dist-out 12.8934 None None None EM 3.9 999.0 999.0 K 310.0 210.0 81 27 27 0 [[6, 295]] 1.0 5fwk Homo sapiens CMGC_CDK4_HUMAN CMGC 2.7e-82 284.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 5FWLK P11802 5 295 303.0 No_ligand No_ligand Inactive None 48.1987 49.2195 None -149.04, 167.22 70.51, 77.19 -94.69, 75.52 299.88, 116.65 91.08, 152.36 in-out in 9.3607 Saltbr-out 7.7861 HRD-out -162.84, 59.23 -64.44, -13.38 out-out-out SNCooo out-out ActLoopNT-out 7.678 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -55.89, -38.57 APE9-dihe-na -48.82, 148.99 APE8-dihe-in -50.56, 116.76 APE8-rot-in 300.07 APE67-dihe-out -70.78, -12.08 -94.78, 54.09 APE12-dist-in 8.4735 APE11-dist-in 10.5119 APE10-dist-out 15.1148 APE9-dist-out 12.9513 None None None EM 9.0 999.0 999.0 K 310.0 291.0 0 27 27 0 [[6, 295]] 1.0 5fwl Homo sapiens CMGC_CDK4_HUMAN CMGC 2.7e-82 284.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 5FWMK P11802 5 295 303.0 No_ligand No_ligand Inactive None 55.9795 47.2536 None -148.61, 165.82 70.36, 77.56 -94.31, 75.71 300.0, 116.31 91.42, 152.54 in-out in 9.991 Saltbr-out 6.8718 HRD-out -162.91, 59.01 -63.71, -13.05 out-out-out SNCooo out-out ActLoopNT-out 7.6742 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -58.09, -39.57 APE9-dihe-na -48.6, 148.94 APE8-dihe-in -50.63, 116.26 APE8-rot-in 299.96 APE67-dihe-out -70.37, -11.94 -94.86, 54.58 APE12-dist-in 8.3719 APE11-dist-in 10.5059 APE10-dist-out 15.0897 APE9-dist-out 13.0112 None None None EM 8.0 999.0 999.0 K 310.0 291.0 0 27 27 0 [[6, 295]] 1.0 5fwm Homo sapiens CMGC_CDK4_HUMAN CMGC 2.7e-82 284.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4
CDK4 CDK4_HUMAN 5FWPK P11802 87 295 303.0 No_ligand No_ligand Inactive None 999.0 999.0 None -148.56, 165.77 70.31, 77.45 -94.72, 75.34 299.55, 116.81 91.01, 152.89 none-none none 999.0 Saltbr-none 999.0 HRD-out -162.95, 59.33 -63.99, -13.24 none-out-out SNCnoo out-out ActLoopNT-out 7.6157 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -52.1, -37.6 APE9-dihe-na -48.76, 149.1 APE8-dihe-in -50.61, 116.92 APE8-rot-in 300.06 APE67-dihe-out -70.39, -11.86 -95.32, 54.3 APE12-dist-in 8.5016 APE11-dist-in 10.4933 APE10-dist-out 15.1178 APE9-dist-out 12.9747 None None None EM 7.2 999.0 999.0 K 310.0 209.0 81 27 27 0 [[6, 295]] 1.0 5fwp Homo sapiens CMGC_CDK4_HUMAN CMGC 2.7e-82 284.8 1.0 301.0 301.0 157 158 159 161 163 35 56 60 137 139 138 140.0 196 184 179 178 177 176 175 174 173 94 Cyclin-dependent kinase 4

CMGC_CDK4 (Cyclin-dependent kinase 4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name