CMGC_CDK16 (Cyclin-dependent kinase 16)

Total number of chains: 5
Active chains: 2
Uniprot: CDK16_HUMAN
Kinase Domain Residues: 165 - 446
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 40.0% AF-Q00536-K1A
DFGout None 2 40.0% 5G6VB
DFGout BBAminus 1 20.0% 5G6VA

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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q00536-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 157 - 454 0 None None Cyclin-dependent kinase 16
AF-Q00536-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 157 - 454 0 None None Cyclin-dependent kinase 16
5G6VA 2.2 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iooo 919 Type2 163 - 474 0 None S319D Cyclin-dependent kinase 16
3MTLA 2.4 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn FEF Type1 163 - 473 0 None S319D Cyclin-dependent kinase 16
5G6VB 2.2 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnno 919 Type2 163 - 475 0 None S319D Cyclin-dependent kinase 16

CMGC_CDK16 (Cyclin-dependent kinase 16)

Total number of chains: 5
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 40.0% AF-Q00536-K1A
DFGout None 2 40.0% 5G6VB
DFGout BBAminus 1 20.0% 5G6VA

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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CDK16_HUMAN AF-Q00536-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 157 - 454 0 None None Cyclin-dependent kinase 16 Homo sapiens
CDK16_HUMAN AF-Q00536-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 157 - 454 0 None None Cyclin-dependent kinase 16 Homo sapiens
CDK16_HUMAN 5G6VA 2.2 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iooo 919 Type2 163 - 474 0 None S319D Cyclin-dependent kinase 16 Homo sapiens
CDK16_HUMAN 3MTLA 2.4 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn FEF Type1 163 - 473 0 None S319D Cyclin-dependent kinase 16 Homo sapiens
CDK16_HUMAN 5G6VB 2.2 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnno 919 Type2 163 - 475 0 None S319D Cyclin-dependent kinase 16 Homo sapiens

CMGC_CDK16 (Cyclin-dependent kinase 16)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism