CMGC_CDK16 (Cyclin-dependent kinase 16)

Total number of chains: 5
Active chains: 2
Uniprot: CDK16_HUMAN
Kinase Domain Residues: 165 - 446
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 40.0% AF-Q00536-K1A
DFGout None 2 40.0% 5G6VB
DFGout BBAminus 1 20.0% 5G6VA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK16 AF-Q00536-K1A Q00536 157 454 496.0 No_ligand No_ligand Active DFGin 6.8349 15.0294 BLAminus -128.37, 176.41 51.32, 72.63 -83.71, 18.31 282.47, 71.86 -59.49, -33.67 in-in in 8.8435 Saltbr-in 2.7814 HRD-in -76.26, -46.25 61.0, 15.71 in-in-in SNCiii in-in ActLoopNT-in 2.8361 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.74, 161.73 APE9-dihe-na 62.56, 129.84 APE8-dihe-in -55.49, 135.9 APE8-rot-in 301.33 APE67-dihe-in -64.27, -22.91 -45.28, -46.25 APE12-dist-in 13.102 APE11-dist-in 10.4273 APE10-dist-in 6.7861 APE9-dist-in 3.3016 None None None AF2 -1.0 1.0 1.0 A 298.0 298.0 0 28 28 0 [[165, 446]] 1.0 AF-Q00536-K1 CMGC_CDK16_HUMAN CMGC 7e-84 287.6 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CDK16 AF-Q00536-K3A Q00536 157 454 496.0 No_ligand No_ligand Active DFGin 6.9164 14.7904 BLAminus -137.5, 175.89 54.62, 70.11 -82.26, 16.44 282.92, 75.63 -58.54, -34.14 in-in in 8.8664 Saltbr-in 2.7958 HRD-in -76.75, -47.47 62.81, 12.41 in-in-in SNCiii in-in ActLoopNT-in 2.8956 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.86, 166.74 APE9-dihe-na 61.9, 134.32 APE8-dihe-in -59.11, 136.04 APE8-rot-in 300.14 APE67-dihe-in -62.84, -24.89 -44.4, -48.5 APE12-dist-in 13.0058 APE11-dist-in 10.4407 APE10-dist-in 6.4603 APE9-dist-in 3.428 None None None AF2 -1.0 1.0 1.0 A 298.0 298.0 0 28 28 0 [[165, 446]] 1.0 AF-Q00536-K3 CMGC_CDK16_HUMAN CMGC 7e-84 287.6 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CDK16 5G6VA Q00536 163 474 496.0 919:61475 Type2 Inactive DFGout 14.197 9.592 BBAminus -121.31, 168.89 -135.99, 99.11 -71.7, -18.89 281.11, 104.22 81.3, -120.31 in-in in 8.6104 Saltbr-in 2.6336 HRD-in -70.2, -56.21 78.25, -5.64 in-out-out SNCioo out-out ActLoopNT-out 18.4004 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -97.04, 112.11 APE9-dihe-na -121.65, 12.66 APE8-dihe-out -41.77, -45.44 APE8-rot-in 308.9 APE67-dihe-in -49.91, -30.99 -101.95, -17.17 APE12-dist-in 12.5547 APE11-dist-out 14.3176 APE10-dist-out 12.8314 APE9-dist-out 11.3069 S319D None None XRAY 2.2 0.211 0.271 A 324.0 307.0 5 28 23 5 [[165, 446]] 1.0 5g6v CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CDK16 3MTLA Q00536 163 473 496.0 FEF:60668 Type1 Inactive DFGout 17.3993 7.4716 None -75.13, 154.32 -88.9, 77.74 -154.62, 116.54 227.56, 88.74 78.03, 21.89 in-in in 8.3848 Saltbr-in 2.6411 HRD-out -101.69, 108.56 -74.19, -25.04 in-out-out SNCioo out-out ActLoopNT-out 5.1638 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 102.89 APE8-rot-out 156.53 APE67-dihe-in -61.54, -35.29 -78.56, -14.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S319D None None XRAY 2.4 0.198 0.263 A 324.0 293.0 18 28 16 12 [[165, 446]] 1.0 3mtl CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CDK16 5G6VB Q00536 163 475 496.0 919:61475 Type2 Inactive DFGout 14.7022 10.3484 None -133.8, 175.0 -147.55, 99.49 -161.85, 159.42 69.16, 120.87 -118.14, 117.72 in-in in 8.8188 Saltbr-in 2.7269 HRD-in -62.7, -57.87 75.37, 3.15 in-out-out SNCioo out-out ActLoopNT-out 23.3281 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -26.32 APE8-dihe-out -33.08, -72.64 APE8-rot-in 304.04 APE67-dihe-in -60.88, -29.71 -104.87, 15.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.511 S319D None None XRAY 2.2 0.211 0.271 B 324.0 301.0 12 28 16 12 [[165, 446]] 1.0 5g6v CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16

CMGC_CDK16 (Cyclin-dependent kinase 16)

Total number of chains: 5
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 40.0% AF-Q00536-K1A
DFGout None 2 40.0% 5G6VB
DFGout BBAminus 1 20.0% 5G6VA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK16 CDK16_HUMAN AF-Q00536-K1A Q00536 157 454 496.0 No_ligand No_ligand Active DFGin 6.8349 15.0294 BLAminus -128.37, 176.41 51.32, 72.63 -83.71, 18.31 282.47, 71.86 -59.49, -33.67 in-in in 8.8435 Saltbr-in 2.7814 HRD-in -76.26, -46.25 61.0, 15.71 in-in-in SNCiii in-in ActLoopNT-in 2.8361 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.74, 161.73 APE9-dihe-na 62.56, 129.84 APE8-dihe-in -55.49, 135.9 APE8-rot-in 301.33 APE67-dihe-in -64.27, -22.91 -45.28, -46.25 APE12-dist-in 13.102 APE11-dist-in 10.4273 APE10-dist-in 6.7861 APE9-dist-in 3.3016 None None None AF2 -1.0 1.0 1.0 A 298.0 298.0 0 28 28 0 [[165, 446]] 1.0 AF-Q00536-K1 Homo sapiens CMGC_CDK16_HUMAN CMGC 7e-84 287.6 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CDK16 CDK16_HUMAN AF-Q00536-K3A Q00536 157 454 496.0 No_ligand No_ligand Active DFGin 6.9164 14.7904 BLAminus -137.5, 175.89 54.62, 70.11 -82.26, 16.44 282.92, 75.63 -58.54, -34.14 in-in in 8.8664 Saltbr-in 2.7958 HRD-in -76.75, -47.47 62.81, 12.41 in-in-in SNCiii in-in ActLoopNT-in 2.8956 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.86, 166.74 APE9-dihe-na 61.9, 134.32 APE8-dihe-in -59.11, 136.04 APE8-rot-in 300.14 APE67-dihe-in -62.84, -24.89 -44.4, -48.5 APE12-dist-in 13.0058 APE11-dist-in 10.4407 APE10-dist-in 6.4603 APE9-dist-in 3.428 None None None AF2 -1.0 1.0 1.0 A 298.0 298.0 0 28 28 0 [[165, 446]] 1.0 AF-Q00536-K3 Homo sapiens CMGC_CDK16_HUMAN CMGC 7e-84 287.6 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CDK16 CDK16_HUMAN 5G6VA Q00536 163 474 496.0 919:61475 Type2 Inactive DFGout 14.197 9.592 BBAminus -121.31, 168.89 -135.99, 99.11 -71.7, -18.89 281.11, 104.22 81.3, -120.31 in-in in 8.6104 Saltbr-in 2.6336 HRD-in -70.2, -56.21 78.25, -5.64 in-out-out SNCioo out-out ActLoopNT-out 18.4004 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -97.04, 112.11 APE9-dihe-na -121.65, 12.66 APE8-dihe-out -41.77, -45.44 APE8-rot-in 308.9 APE67-dihe-in -49.91, -30.99 -101.95, -17.17 APE12-dist-in 12.5547 APE11-dist-out 14.3176 APE10-dist-out 12.8314 APE9-dist-out 11.3069 S319D None None XRAY 2.2 0.211 0.271 A 324.0 307.0 5 28 23 5 [[165, 446]] 1.0 5g6v Homo sapiens CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CDK16 CDK16_HUMAN 3MTLA Q00536 163 473 496.0 FEF:60668 Type1 Inactive DFGout 17.3993 7.4716 None -75.13, 154.32 -88.9, 77.74 -154.62, 116.54 227.56, 88.74 78.03, 21.89 in-in in 8.3848 Saltbr-in 2.6411 HRD-out -101.69, 108.56 -74.19, -25.04 in-out-out SNCioo out-out ActLoopNT-out 5.1638 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 102.89 APE8-rot-out 156.53 APE67-dihe-in -61.54, -35.29 -78.56, -14.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S319D None None XRAY 2.4 0.198 0.263 A 324.0 293.0 18 28 16 12 [[165, 446]] 1.0 3mtl Homo sapiens CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CDK16 CDK16_HUMAN 5G6VB Q00536 163 475 496.0 919:61475 Type2 Inactive DFGout 14.7022 10.3484 None -133.8, 175.0 -147.55, 99.49 -161.85, 159.42 69.16, 120.87 -118.14, 117.72 in-in in 8.8188 Saltbr-in 2.7269 HRD-in -62.7, -57.87 75.37, 3.15 in-out-out SNCioo out-out ActLoopNT-out 23.3281 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -26.32 APE8-dihe-out -33.08, -72.64 APE8-rot-in 304.04 APE67-dihe-in -60.88, -29.71 -104.87, 15.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.511 S319D None None XRAY 2.2 0.211 0.271 B 324.0 301.0 12 28 16 12 [[165, 446]] 1.0 5g6v Homo sapiens CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16

CMGC_CDK16 (Cyclin-dependent kinase 16)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name