8C1I

AURKA (Aurora kinase A)
Group: CAMK
Uniprot: AURKA_HUMAN
Organism: Homo sapiens
Domain boundary: 133 - 383
Resolu: 2.81

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus in-in in-out ADP T1L T5L Type1 Allosteric Allosteric 126 - 388 3
Representative sequence - Chain A
133 143 153 163
mgRQWALEDF EIGRPLGKGK FGNVYLAREK QSKFILALKV
173 183 193 203
LFKAQLEKAG VEHQLRREVE IQSHLRHPNI LRLYGYFHDA
213 223 233 243
TRVYLILEYA PLGTVYRELQ KLSKFDEQRT ATYITELANA
253 263 273 283
LSYCHSKRVI HRDIKPENLL LGSAGELKIA DFGWSVHAPS
293 303 313 323
SRRTtlaGTL DYLPPEMIEG RMHDEKVDLW SLGVLCYEFL
333 343 353 363
VGKPPFEANT YQETYKRISR VEFTFPDFVT EGARDLISRL
373 383
LKHNPSQRPM LREVLEHPWI TANSS
Lower-case residues are disordered in structure.
Mutations: C290A
Phosphorylation: None