7MFF

BRAF (Serine/threonine-protein kinase B-raf)
Group: TKL
Uniprot: BRAF_HUMAN
Organism: Homo sapiens
Domain boundary: 457 - 716
Resolu: 3.89

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus in-out in-out 215 Type1 449 - 732 13
B Active DFGin BLAminus in-in in-in 215 Type1 449 - 733 13
Representative sequence - Chain B
10 20 30 40
maalsggggg gaepgqalfn gdmepeagag agaaassaad
50 60 70 80
paipeevwni kqmikltqeh iealldkfgg ehnppsiyle
90 100 110 120
ayeeytskld alqqreqqll eslgngtdfs vsssasmdtv
130 140 150 160
tsssssslsv lpsslsvfqn ptdvarsnpk spqkpivrvf
170 180 190 200
lpnkqrtvvp arcgvtvrds lkkalmmrgl ipeccavyri
210 220 230 240
qdgekkpigw dtdiswltge elhvevlenv pltthnfvrk
250 260 270 280
tfftlafcdf crkllfqgfr cqtcgykfhq rcstevplmc
290 300 310 320
vnydqldllf vskffehhpi pqeeaslaet altsgsspsa
330 340 350 360
pasdsigpqi ltspspsksi pipqpfrpad edhrnqfgqr
370 380 390 400
drsssapnvh intiepvnid dlirdqgfrg dggsttglsa
410 420 430 440
tppaslpgsl tnvkalqksp gpqrerksss ssedrnrmkt
450 460 470 480
lgrrdssdDW EIPDGQITVG QRIGSGSFGT VYKGKWHGDV
490 500 510 520
AVKMLNVTAP TPQQLQAFKN EVGVLRKTRH VNILLFMGYS
530 540 550 560
TKPQLAIVTQ WCEGSSLYHH LHIIETKFEM IKLIDIARQT
570 580 590 600
AQGMDYLHAK SIIHRDLKSN NIFLHEDLTV KIGDFGLATV
610 620 630 640
ksrwsgshqf eqlSGSILWM APEVIRMQDK NPYSFQSDVY
650 660 670 680
AFGIVLYELM TGQLPYSNIN NRDQIIFMVG RGYLSPDLSK
690 700 710 720
VRSNCPKAMK RLMAECLKKK RDERPLFPQI LASIELLARS
730 740 750 760
LPKIHRSASE PSLnragfqt edfslyacas pktpiqaggy

gafpvh
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X365,X729