6R49

AURKA (Aurora kinase A)
Group: CAMK
Uniprot: AURKA_HUMAN
Organism: Homo sapiens
Domain boundary: 133 - 383
Resolu: 2.209

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus in-in in-out ADP JSB Type1 Allosteric 127 - 391 5
Representative sequence - Chain A
128 138 148 158
gameskkrQW ALEDFEIGRP LGKGKFGNVY LAREKQSKFI
168 178 188 198
LALKVLFKAQ LEKAGVEHQL RREVEIQSHL RHPNILRLYG
208 218 228 238
YFHDATRVYL ILEYAPLGTV YRELQKLSKF DEQRTATYIT
248 258 268 278
ELANALSYCH SKRVIHRDIK PENLLLGSAG ELKIADFGWS
288 298 308 318
VHAPSSRrtt laGTLDYLPP EMIEGRMHDE KVDLWSLGVL
328 338 348 358
CYEFLVGKPP FEANTYQETY KRISRVEFTF PDFVTEGARD
368 378 388 398
LISRLLKHNP SQRPMLREVL EHPWITANSS KPSnaqnkes

askqs
Lower-case residues are disordered in structure.
Mutations: C290A,C393A
Phosphorylation: X288