5JT2

BRAF (Serine/threonine-protein kinase B-raf)
Group: TKL
Uniprot: BRAF_HUMAN
Organism: Homo sapiens
Domain boundary: 457 - 716
Resolu: 2.702

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAplus out-out out-none 6NC Type1.5_Back 448 - 719 11
B Inactive DFGin BLAplus out-out out-none No_ligand No_ligand 448 - 719 16
C Inactive DFGin BLAplus out-out out-none 6NC Type1.5_Back 448 - 719 12
D Inactive DFGin BLAplus out-out out-none No_ligand No_ligand 448 - 718 15
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain D
       453        463        473        483 
gsEFDDWEIP DGQITVGQRI GSGSFGTVYK GKWHGDVAVK 
       493        503        513        523 
MLNVtaPTPQ QLQAFKNEVG VLRKTRHVNI LLFMGYSTKP 
       533        543        553        563 
QLAIVTQWCE GSSLYHHLHA SETKFEMKKL IDIARQTARG 
       573        583        593        603 
MDYLHAKSII HRDLKSNNIF LHEDNTVKIG DFGLATEksr 
       613        623        633        643 
wsgshqfeql sgSILWMAPE VIRmqdsNPY SFQSDVYAFG 
       653        663        673        683 
IVLYELMTGQ LPYSninnrd qiiemvgrgs lSPDLSKVRs 
       693        703        713        723 
NCPKRMKRLM AECLKKKRDE RPSFPRILAE IEELArelsg


Lower-case residues are disordered in structure.
Mutations: I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G
Phosphorylation: None