5HI2

BRAF (Serine/threonine-protein kinase B-raf)
Group: TKL
Uniprot: BRAF_HUMAN
Organism: Homo sapiens
Domain boundary: 457 - 716
Resolu: 2.512

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGout BBAminus in-in none-none BAX Type2 449 - 721 18
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
       445        455        465        475 
mhhhhhgsrd ssdDWEIPDG QITVGQRIGS GSFGTVYKGK 
       485        500        510        520 
WHGDVAVKML TPQQLQAFKN EVGVLRKTRH VNILLFMGYS 
       530        540        550        560 
TKPQLAIVTQ WCEGSSLYHH LHASETKFEM KKLIDIARQT 
       570        580        590        600 
ARGMDYLHAK SIIHRDLKSN NIFLHEDNTV KIGDFGLatv 
       610        620        630        640 
ksrwsgshqf eqlsgSILWM APEVIRMqds NPYSFQSDVY 
       650        660        670        680 
AFGIVLYELM TGQLPYSNIN NRDQIIEMVG RGSLSPDLSK 
       690        700        710        720 
VRSNCPKRMK RLMAECLKKK RDERPSFPRI LAEIEELARE 

Lsg
Lower-case residues are disordered in structure.
Mutations: I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G
Phosphorylation: None