5AAA

IRAK4 (Interleukin-1 receptor-associated kinase 4)
ALK (ALK tyrosine kinase receptor)
Group: TKL TYR
Uniprot: IRAK4_HUMAN ALK_HUMAN
Organism: Homo sapiens
Domain boundary: 175 - 456 1116 - 1385
Resolution: 1.73

Chain id Group Gene UniprotID Protein Organism Activity Spatial Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
AAA TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 Homo sapiens Inactive DFGin BLAminus in-out in-in R73 Type1 163 - 459 4
A TYR ALK ALK_HUMAN ALK tyrosine kinase receptor Homo sapiens Inactive DFGin ABAminus in-out out-out VGH Type1 1093 - 1401 6
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
      1094       1104       1114       1124 
mahhhhhhNP NYCFAGKTSS ISDLKEVPRK NITLIRGLGH 
      1134       1144       1154       1164 
GAFGEVYEGQ VsgmpndpsP LQVAVKTLPE VCSEQDELDF 
      1174       1184       1194       1204 
LMEALIISKF NHQNIVRCIG VSLQSLPRFI LLEFMAGGDL 
      1214       1224       1234       1244 
KSFLRETRPR PSQPSSLAML DLLHVARDIA CGCQYLEENH 
      1254       1264       1274       1284 
FIHRDIAARN CLLTCPGPGR VAKIGDFGMA RDIYRasyyr 
      1294       1304       1314       1324 
kGGCAMLPVK WMPPEAFMEG IFTSKTDTWS FGVLLWEIFS 
      1334       1344       1354       1364 
LGYMPYPSKS NQEVLEFVTS GGRMDPPKNC PGPVYRIMTQ 
      1374       1384       1394       1404 
CWQHQPEDRP NFAIILERIE YCTQDPDVIN TALPIEYgpl 

veeeekv
Lower-case residues are disordered in structure.
Mutations: L1198F
Phosphorylation: None