4XV1

BRAF (Serine/threonine-protein kinase B-raf)
Group: TKL
Uniprot: BRAF_HUMAN
Organism: Homo sapiens
Domain boundary: 457 - 716
Resolu: 2.47

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAplus out-out none-out 904 Type1.5_Back 449 - 705 17
B None DFGin BLAminus in-out in-none No_ligand No_ligand 449 - 705 15
Representative sequence - Chain B
- 451 461 471
mkkghhhhhh gsrdaadDWE IPDGQITVGQ RIGsgsfgTV
481 491 501 511
YKGKWHGDVA VKMLNVTAPT PQQLQAFKNE VGVLRKTRHV
521 531 541 551
NILLFMGYST KPQLAIVTQW CEGSSLYHHL HASETKFEMK
561 571 581 591
KLIDIARQTA RGMDYLHAKS IIHRDLKSNN IFLHEDNTVK
601 611 621 631
IGDFGLATEk srwsgshqfe qlsgSILWMA PEVIRmqdsN
641 651 661 671
PYSFQSDVYA FGIVLYELMT GQLPYSNINN RDQIIEMVGR
681 691 701 -
GSLSPDLSKV RSNCPKRMKR LMAECLKKKR DERPSFPRIL
-
AEIEELAREL sg
Lower-case residues are disordered in structure.
Mutations: S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R
Phosphorylation: None