4WO5

BRAF (Serine/threonine-protein kinase B-raf)
Group: TKL
Uniprot: BRAF_HUMAN
Organism: Homo sapiens
Domain boundary: 457 - 716
Resolu: 2.83

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAplus out-out out-out 324 Type1.5_Back 448 - 721 4
B Inactive DFGin BLAplus out-none out-out 324 Type1.5_Back 450 - 721 15
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
         -          -        453        463 
mgsshhhhhh ssgetvrfqg rdssddWEIP DGQITVGQRI 
       473        483        493        503 
GSGSFGTVYK GKWHGDVAVK MLNVTAPTPQ QLQAFKNEVG 
       513        523        533        543 
VLRKTRHVNI LLFMGYSTKP QLAIVTQWCE GSSLYHHLHA 
       553        563        573        583 
SETKFEMKKL IDIARQTARG MDYLHAKSII HRDLKSNNIF 
       593        603        613        623 
LHEDNTVKIG DFGLATvksr wsgshqfeql sGSILWMAPE 
       633        643        653        663 
VIRMQDSNPY SFQSDVYAFG IVLYELMTGQ LPYSNINNRD 
       673        683        693        703 
QIIEMVGRGS LSPDLSKVRS NCPKRMKRLM AECLKKKRDE 
       713        723 
RPSFPRILAE IEELARELsg
Lower-case residues are disordered in structure.
Mutations: I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G
Phosphorylation: None