4RZV

BRAF (Serine/threonine-protein kinase B-raf)
Group: TKL
Uniprot: BRAF_HUMAN
Organism: Homo sapiens
Domain boundary: 457 - 716
Resolu: 2.994

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAplus out-out out-out 032 Type1.5_Back 449 - 721 12
B Inactive DFGin BLAplus out-out out-out 032 Type1.5_Back 449 - 722 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       452        462        472        482 
rrdssdDWEI PDGQITVGQR IGSGSFGTVY KGKWHGDVAV 
       492        502        512        522 
KMLNVTAPTP QQLQAFKNEV GVLRKTHHVN ILLFMGYSTK 
       532        542        552        562 
PQLAIVTQWC EGSSLYHHLH ASETKFEMKK LIDIARQTAR 
       572        582        592        602 
GMDYLHAKSI IHRDLKSNNI FLHEDNTVKI GDFGLATVKS 
       612        622        632        642 
RWSGSHQFEQ LSGSILWMAP EVIRMQdsnP YSFQSDVYAF 
       652        662        672        682 
GIVLYELMTG QLPYSNINNR DQIIEMVGRG SLSPDLSKVR 
       692        702        712        722 
SNCPKRMKRL MAECLKKKRD ERPSFPRILA EIEELARELS 

g
Lower-case residues are disordered in structure.
Mutations: R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G
Phosphorylation: None