4R5Y

BRAF (Serine/threonine-protein kinase B-raf)
Group: TKL
Uniprot: BRAF_HUMAN
Organism: Homo sapiens
Domain boundary: 457 - 716
Resolu: 3.5

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGout BBAminus in-out none-none 3K3 Type2 449 - 720 19
B Inactive DFGout BBAminus in-out out-out 3K3 Type2 449 - 720 14
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
         -        451        461        471 
mkkghhhhhh gsrdssdDWE IPDGQITVGQ RIGSGSFGTV 
       481        491        501        511 
YKGKWHGDVA VKMLNVTAPT PQQLQAFKNE VGVLRKTRHV 
       521        531        541        551 
NILLFMGYST KPQLAIVTQW CEGSSLYHHL HASETKFEMK 
       561        571        581        591 
KLIDIARQTA RGMDYLHAKS IIHRDLKSNN IFLHEDNTVK 
       601        611        621        631 
IGDFGLATek srwsgshqfe qlSGSILWMA PEVIRMqdsn 
       641        651        661        671 
PYSFQSDVYA FGIVLYELMT GQLPYSNINN RDQIIEMVGR 
       681        691        701        711 
GSLSPDLSKV RSNCPKRMKR LMAECLKKKR DERPSFPRIL 
       721 
AEIEELAREl sg
Lower-case residues are disordered in structure.
Mutations: I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G
Phosphorylation: None