4H58

BRAF (Serine/threonine-protein kinase B-raf)
Group: TKL
Uniprot: BRAF_HUMAN
Organism: Homo sapiens
Domain boundary: 457 - 716
Resolu: 3.1

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None in-in in-out 10Z Type1 448 - 722 12
B Inactive DFGin ABAminus in-in in-out No_ligand No_ligand 448 - 722 13
C Inactive DFGout BBAminus in-in out-out No_ligand No_ligand 449 - 722 0
Representative sequence - Chain C
457 467 477 487
dDWEIPDGQI TVGQRIGSGS FGTVYKGKWH GDVAVKMLNV
497 507 517 527
TAPTPQQLQA FKNEVGVLRK TRHVNILLFM GYSTKPQLAI
537 547 557 567
VTQWCEGSSL YHHLHIIETK FEMIKLIDIA RQTAQGMDYL
577 587 597 607
HAKSIIHRDL KSNNIFLHED LTVKIGDFGL ATVKSRWSGS
617 627 637 647
HQFEQLSGSI LWMAPEVIRM QdkNPYSFQS DVYAFGIVLY
657 667 677 687
ELMTGQLPYS NINNRDQIIF MVGRGYLSPD LSKVRSNCPK
697 707 717
AMKRLMAECL KKKRDERPLF PQILASIELL ARSLP
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None