4FK3

BRAF (Serine/threonine-protein kinase B-raf)
Group: TKL
Uniprot: BRAF_HUMAN
Organism: Homo sapiens
Domain boundary: 457 - 716
Resolu: 2.65

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAplus out-out none-out 325 Type1.5_Back 448 - 718 17
B Inactive DFGin None in-out in-out No_ligand No_ligand 448 - 721 13
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
         -        451        461        471 
mkkghhhhhh gsrdssDDWE IPDGQITVGQ RIGSGSFGTV 
       481        491        501        511 
YKGKWHGDVA VKMLNVTAPT PQQLQAFKNE VGVLRKTRHV 
       521        531        541        551 
NILLFMGYST KPQLAIVTQW CEGSSLYHHL HASETKFEMK 
       561        571        581        591 
KLIDIARQTA RGMDYLHAKS IIHRDLKSNN IFLHEDNTVK 
       601        611        621        631 
IGDFGLATEk srwsgshqfe qlSGSILWMA PEVIRmqdsN 
       641        651        661        671 
PYSFQSDVYA FGIVLYELMT GQLPYSNINN RDQIIEMVGR 
       681        691        701        711 
GSLSPDLSKV RSNCPKRMKR LMAECLKKKR DERPSFPRIL 
       721 
AEIEELAREL sg
Lower-case residues are disordered in structure.
Mutations: I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G
Phosphorylation: None