3P23

ERN1 (Serine/threonine-protein kinase/endoribonuclease IRE1)
Group: OTHER
Uniprot: ERN1_HUMAN
Organism: Homo sapiens
Domain boundary: 569 - 832
Resolu: 2.7

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLBplus out-out out-in ADP Type1 563 - 963 12
B Inactive DFGin BLBplus out-out out-in ADP Type1 564 - 964 12
C Inactive DFGin BLBplus out-out out-in ADP Type1 561 - 964 11
D Inactive DFGin BLBplus out-out out-in ADP Type1 561 - 963 14
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain D
       555        565        575        585 
mgsspsleqd dgdeeTSVVI VGKISFCPKD VLGHGAEGTI 
       595        605        615        625 
VYRGMFDNRD VAVKRILPEC FSFADREVQL LRESDEHPNV 
       635        645        655        665 
IRYFCTEKDR QFQYIAIELC AATLQEYVEQ KDFAHLGLEP 
       675        685        695        705 
ITLLQQTTSG LAHLHSLNIV HRDLKPHNIL ISMPNAHGKI 
       715        725        735        745 
KAMISDFGLC KKlavgrhsf srrsgvPGTE GWIAPEMLSE 
       755        765        775        785 
DCkeNPTYTV DIFSAGCVFY YVISEGSHPF GKSLQRQANI 
       795        805        815        825 
LLGACSLDCL HPEKHEDVIA RELIEKMIAM DPQKRPSAKH 
       835        845        855        865 
VLKHPFFWSL EKQLQFFQDV SDRIEKESLD GPIVKQLERG 
       875        885        895        905 
GRAVVKMDWR ENITVPLQTD LRKFRTYKGG SVRDLLRAMR 
       915        925        935        945 
NKKHHYRELP AEVRETLGTL PDDFVCYFTS RFPHLLAHTY 
       955        965        975 
RAMELCSHER LFQPYYFHep pepqppvtpd al
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None