3C4C

BRAF (Serine/threonine-protein kinase B-raf)
Group: TKL
Uniprot: BRAF_HUMAN
Organism: Homo sapiens
Domain boundary: 457 - 716
Resolu: 2.57

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLBplus out-out none-out 324 Type1.5_Back 448 - 721 17
B Inactive DFGout None in-out none-out 324 Type1.5_Back 448 - 721 18
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       453        463        473        483 
rdssDDWEIP DGQITVGQRI GSGSFGTVYK GKWHGDVAVK 
       493        503        513        523 
MLNVTAPTPQ QLQAFKNEVG VLRKTRHVNI LLFMGYSTKP 
       533        543        553        563 
QLAIVTQWCE GSSLYHHLHA SETKFEMKKL IDIARQTARG 
       573        583        593        603 
MDYLHAKSII HRDLKSNNIF LHEDNTVKIG DFglatvksr 
       613        623        633        643 
wsgshqfeql SGSILWMAPE VIRMQDSNPY SFQSDVYAFG 
       653        663        673        683 
IVLYELMTGQ LPYSNINNRD QIIEMVGRGS LSPDLSKVRS 
       693        703        713          - 
NCPKRMKRLM AECLKKKRDE RPSFPRILAE IEELARELSg


Lower-case residues are disordered in structure.
Mutations: I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E
Phosphorylation: None