RIPK1 (Receptor-interacting serine/threonine-protein kinase 1)

Group: TKL
Uniprot: RIPK1_HUMAN
Domain boundary: 17 - 287


Total number of chains: 43
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q13546-K1A
DFGout BBAminus 42 4ITJB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q13546-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 9 - 295 None None 0
6C3EB 2.6 Inactive DFGout BBAminus out-out out-out EJY Type1 10 - 294 None None 19
7XMKA 2.376 Inactive DFGout BBAminus out-out out-out GO4 Type1 10 - 294 C34A,C127A,C233A,C240A None 15
7XMKB 2.376 Inactive DFGout BBAminus out-out out-none GO4 Type1 9 - 294 C34A,C127A,C233A,C240A None 20
7YDXB 2.642 Inactive DFGout BBAminus out-out out-out 3CI Type1 9 - 294 C34A,C127A,C233A,C240A None 16
8I2NA 2.29 Inactive DFGout BBAminus out-out out-out O4U Type1 7 - 294 C34A,C127A,C233A,C240A None 10
5HX6B 2.23 Inactive DFGout BBAminus out-out out-none 65U Type1 9 - 294 C34A,C127A,C233A,C240A None 12
5TX5B 2.56 Inactive DFGout BBAminus out-out out-none 7MJ Type1 9 - 294 C34A,C127A,C233A,C240A None 12
6OCQA 2.793 Inactive DFGout BBAminus out-out out-none M5J Type1 8 - 294 C34A,C127A,C233A,C240A None 19
6RLNB 2.87 Inactive DFGout BBAminus out-out out-none K8K Type1 7 - 294 C34A,C127A,C233A,C240A None 12
4ITJA 1.8 Inactive DFGout BBAminus out-out out-out 1HX Type2 8 - 294 C34A,C127A,C233A,C240A None 18
4ITJB 1.8 Inactive DFGout BBAminus out-out out-none 1HX Type2 7 - 294 C34A,C127A,C233A,C240A None 12
7YDXA 2.642 Inactive DFGout BBAminus out-out out-out 3CI Type2 8 - 294 C34A,C127A,C233A,C240A None 11
8I2NB 2.29 Inactive DFGout BBAminus out-out out-out O4U Type2 7 - 294 C34A,C127A,C233A,C240A None 16
7FD0A 2.0 Inactive DFGout BBAminus out-out out-none 3IU Type2 9 - 294 C34A,C127A,C233A,C240A None 20
7FD0B 2.0 Inactive DFGout BBAminus out-out out-out 3IU Type2 10 - 294 C34A,C127A,C233A,C240A None 19
4NEUA 2.57 Inactive DFGout BBAminus in-in out-in Q1A Type2 6 - 313 None None 22
4NEUB 2.57 Inactive DFGout BBAminus in-in none-none Q1A Type2 7 - 310 None None 29
6C3EA 2.6 Inactive DFGout BBAminus out-out out-out EJY Type3 9 - 293 None None 17
4ITHA 2.25 Inactive DFGout BBAminus out-out out-out RCM Type3 8 - 294 C34A,C127A,C233A,C240A None 19
4ITHB 2.25 Inactive DFGout BBAminus out-out out-out RCM Type3 7 - 294 C34A,C127A,C233A,C240A None 12
4ITIA 2.86 Inactive DFGout BBAminus out-out out-out 1HW Type3 8 - 294 C34A,C127A,C233A,C240A None 10
4ITIB 2.86 Inactive DFGout BBAminus out-out out-out 1HW Type3 7 - 294 C34A,C127A,C233A,C240A None 11
6NYHA 2.1 Inactive DFGout BBAminus out-out out-out L8D Type3 8 - 294 C34A,C127A,C233A,C240A None 12
6NYHB 2.1 Inactive DFGout BBAminus out-out out-out L8D Type3 11 - 294 C34A,C127A,C233A,C240A None 18
7FCZA 2.21 Inactive DFGout BBAminus out-out out-out 3IF Type3 10 - 294 C34A,C127A,C233A,C240A None 18
7FCZB 2.21 Inactive DFGout BBAminus out-out out-out 3IF Type3 7 - 294 C34A,C127A,C233A,C240A None 17
6C4DA 2.52 Inactive DFGout BBAminus out-out out-out EJP Type3 8 - 294 None None 13
6C4DB 2.52 Inactive DFGout BBAminus out-out out-out EJP Type3 7 - 294 None None 16
6C4DC 2.52 Inactive DFGout BBAminus out-out out-out EJP Type3 10 - 294 None None 18
6C4DD 2.52 Inactive DFGout BBAminus out-out out-out EJP Type3 5 - 293 None None 16
5HX6A 2.23 Inactive DFGout BBAminus out-out out-out 65U Type3 10 - 294 C34A,C127A,C233A,C240A None 18
5TX5A 2.56 Inactive DFGout BBAminus out-out out-out 7MJ Type3 10 - 294 C34A,C127A,C233A,C240A None 18
6HHOA 3.49 Inactive DFGout BBAminus out-out out-out G4W Type3 8 - 294 C34A,C127A,C233A,C240A None 11
6HHOB 3.49 Inactive DFGout BBAminus out-out out-none G4W Type3 7 - 294 C34A,C127A,C233A,C240A None 12
6OCQB 2.793 Inactive DFGout BBAminus out-out out-none M5J Type3 7 - 294 C34A,C127A,C233A,C240A None 12
6R5FA 3.25 Inactive DFGout BBAminus out-out out-none JSW Type3 9 - 294 C34A,C127A,C233A,C240A None 16
6R5FB 3.25 Inactive DFGout BBAminus out-out out-out JSW Type3 10 - 294 C34A,C127A,C233A,C240A None 17
6R5FC 3.25 Inactive DFGout BBAminus out-out out-out JSW Type3 9 - 294 C34A,C127A,C233A,C240A None 16
6R5FD 3.25 Inactive DFGout BBAminus out-out out-out JSW Type3 11 - 294 C34A,C127A,C233A,C240A None 17
6RLNA 2.87 Inactive DFGout BBAminus out-out out-out K8K Type3 8 - 294 C34A,C127A,C233A,C240A None 11
6NW2A 2.0 Inactive DFGout BBAminus out-out out-none L4Y Type3 8 - 294 None None 12
6NW2B 2.0 Inactive DFGout BBAminus out-out out-out L4Y Type3 11 - 294 None None 18

RIPK1 (Receptor-interacting serine/threonine-protein kinase 1)

Group: TKL
Total number of chains: 43
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q13546-K1A
DFGout BBAminus 42 4ITJB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens RIPK1_HUMAN AF-Q13546-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 9 - 295 None None 0
Homo sapiens RIPK1_HUMAN 6C3EB 2.6 Inactive DFGout BBAminus out-out out-out EJY Type1 10 - 294 None None 19
Homo sapiens RIPK1_HUMAN 7XMKA 2.376 Inactive DFGout BBAminus out-out out-out GO4 Type1 10 - 294 C34A,C127A,C233A,C240A None 15
Homo sapiens RIPK1_HUMAN 7XMKB 2.376 Inactive DFGout BBAminus out-out out-none GO4 Type1 9 - 294 C34A,C127A,C233A,C240A None 20
Homo sapiens RIPK1_HUMAN 7YDXB 2.642 Inactive DFGout BBAminus out-out out-out 3CI Type1 9 - 294 C34A,C127A,C233A,C240A None 16
Homo sapiens RIPK1_HUMAN 8I2NA 2.29 Inactive DFGout BBAminus out-out out-out O4U Type1 7 - 294 C34A,C127A,C233A,C240A None 10
Homo sapiens RIPK1_HUMAN 5HX6B 2.23 Inactive DFGout BBAminus out-out out-none 65U Type1 9 - 294 C34A,C127A,C233A,C240A None 12
Homo sapiens RIPK1_HUMAN 5TX5B 2.56 Inactive DFGout BBAminus out-out out-none 7MJ Type1 9 - 294 C34A,C127A,C233A,C240A None 12
Homo sapiens RIPK1_HUMAN 6OCQA 2.793 Inactive DFGout BBAminus out-out out-none M5J Type1 8 - 294 C34A,C127A,C233A,C240A None 19
Homo sapiens RIPK1_HUMAN 6RLNB 2.87 Inactive DFGout BBAminus out-out out-none K8K Type1 7 - 294 C34A,C127A,C233A,C240A None 12
Homo sapiens RIPK1_HUMAN 4ITJA 1.8 Inactive DFGout BBAminus out-out out-out 1HX Type2 8 - 294 C34A,C127A,C233A,C240A None 18
Homo sapiens RIPK1_HUMAN 4ITJB 1.8 Inactive DFGout BBAminus out-out out-none 1HX Type2 7 - 294 C34A,C127A,C233A,C240A None 12
Homo sapiens RIPK1_HUMAN 7YDXA 2.642 Inactive DFGout BBAminus out-out out-out 3CI Type2 8 - 294 C34A,C127A,C233A,C240A None 11
Homo sapiens RIPK1_HUMAN 8I2NB 2.29 Inactive DFGout BBAminus out-out out-out O4U Type2 7 - 294 C34A,C127A,C233A,C240A None 16
Homo sapiens RIPK1_HUMAN 7FD0A 2.0 Inactive DFGout BBAminus out-out out-none 3IU Type2 9 - 294 C34A,C127A,C233A,C240A None 20
Homo sapiens RIPK1_HUMAN 7FD0B 2.0 Inactive DFGout BBAminus out-out out-out 3IU Type2 10 - 294 C34A,C127A,C233A,C240A None 19
Homo sapiens RIPK1_HUMAN 4NEUA 2.57 Inactive DFGout BBAminus in-in out-in Q1A Type2 6 - 313 None None 22
Homo sapiens RIPK1_HUMAN 4NEUB 2.57 Inactive DFGout BBAminus in-in none-none Q1A Type2 7 - 310 None None 29
Homo sapiens RIPK1_HUMAN 6C3EA 2.6 Inactive DFGout BBAminus out-out out-out EJY Type3 9 - 293 None None 17
Homo sapiens RIPK1_HUMAN 4ITHA 2.25 Inactive DFGout BBAminus out-out out-out RCM Type3 8 - 294 C34A,C127A,C233A,C240A None 19
Homo sapiens RIPK1_HUMAN 4ITHB 2.25 Inactive DFGout BBAminus out-out out-out RCM Type3 7 - 294 C34A,C127A,C233A,C240A None 12
Homo sapiens RIPK1_HUMAN 4ITIA 2.86 Inactive DFGout BBAminus out-out out-out 1HW Type3 8 - 294 C34A,C127A,C233A,C240A None 10
Homo sapiens RIPK1_HUMAN 4ITIB 2.86 Inactive DFGout BBAminus out-out out-out 1HW Type3 7 - 294 C34A,C127A,C233A,C240A None 11
Homo sapiens RIPK1_HUMAN 6NYHA 2.1 Inactive DFGout BBAminus out-out out-out L8D Type3 8 - 294 C34A,C127A,C233A,C240A None 12
Homo sapiens RIPK1_HUMAN 6NYHB 2.1 Inactive DFGout BBAminus out-out out-out L8D Type3 11 - 294 C34A,C127A,C233A,C240A None 18
Homo sapiens RIPK1_HUMAN 7FCZA 2.21 Inactive DFGout BBAminus out-out out-out 3IF Type3 10 - 294 C34A,C127A,C233A,C240A None 18
Homo sapiens RIPK1_HUMAN 7FCZB 2.21 Inactive DFGout BBAminus out-out out-out 3IF Type3 7 - 294 C34A,C127A,C233A,C240A None 17
Homo sapiens RIPK1_HUMAN 6C4DA 2.52 Inactive DFGout BBAminus out-out out-out EJP Type3 8 - 294 None None 13
Homo sapiens RIPK1_HUMAN 6C4DB 2.52 Inactive DFGout BBAminus out-out out-out EJP Type3 7 - 294 None None 16
Homo sapiens RIPK1_HUMAN 6C4DC 2.52 Inactive DFGout BBAminus out-out out-out EJP Type3 10 - 294 None None 18
Homo sapiens RIPK1_HUMAN 6C4DD 2.52 Inactive DFGout BBAminus out-out out-out EJP Type3 5 - 293 None None 16
Homo sapiens RIPK1_HUMAN 5HX6A 2.23 Inactive DFGout BBAminus out-out out-out 65U Type3 10 - 294 C34A,C127A,C233A,C240A None 18
Homo sapiens RIPK1_HUMAN 5TX5A 2.56 Inactive DFGout BBAminus out-out out-out 7MJ Type3 10 - 294 C34A,C127A,C233A,C240A None 18
Homo sapiens RIPK1_HUMAN 6HHOA 3.49 Inactive DFGout BBAminus out-out out-out G4W Type3 8 - 294 C34A,C127A,C233A,C240A None 11
Homo sapiens RIPK1_HUMAN 6HHOB 3.49 Inactive DFGout BBAminus out-out out-none G4W Type3 7 - 294 C34A,C127A,C233A,C240A None 12
Homo sapiens RIPK1_HUMAN 6OCQB 2.793 Inactive DFGout BBAminus out-out out-none M5J Type3 7 - 294 C34A,C127A,C233A,C240A None 12
Homo sapiens RIPK1_HUMAN 6R5FA 3.25 Inactive DFGout BBAminus out-out out-none JSW Type3 9 - 294 C34A,C127A,C233A,C240A None 16
Homo sapiens RIPK1_HUMAN 6R5FB 3.25 Inactive DFGout BBAminus out-out out-out JSW Type3 10 - 294 C34A,C127A,C233A,C240A None 17
Homo sapiens RIPK1_HUMAN 6R5FC 3.25 Inactive DFGout BBAminus out-out out-out JSW Type3 9 - 294 C34A,C127A,C233A,C240A None 16
Homo sapiens RIPK1_HUMAN 6R5FD 3.25 Inactive DFGout BBAminus out-out out-out JSW Type3 11 - 294 C34A,C127A,C233A,C240A None 17
Homo sapiens RIPK1_HUMAN 6RLNA 2.87 Inactive DFGout BBAminus out-out out-out K8K Type3 8 - 294 C34A,C127A,C233A,C240A None 11
Homo sapiens RIPK1_HUMAN 6NW2A 2.0 Inactive DFGout BBAminus out-out out-none L4Y Type3 8 - 294 None None 12
Homo sapiens RIPK1_HUMAN 6NW2B 2.0 Inactive DFGout BBAminus out-out out-out L4Y Type3 11 - 294 None None 18

RIPK1 (Receptor-interacting serine/threonine-protein kinase 1)

No non-human structures known.