PRKAA1 (5'-AMP-activated protein kinase catalytic subunit alpha-1)

Group: CAMK
Uniprot: AAPK1_HUMAN
Domain boundary: 27 - 279


Total number of chains: 13
Spatial Dihedral Chains Representative
DFGin BLAminus 4 AF-Q13131-K1A
DFGin ABAminus 2 6C9FA
DFGin None 5 7JHGA
DFGinter None 2 4REDB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
6C9FA 2.924 Inactive DFGin ABAminus out-out in-in R34 STU Allosteric Type1 22 - 558 None X183 0
7JIJA 5.5 Inactive DFGin ABAminus out-in in-in No_ligand No_ligand 22 - 559 None X183 0
6C9GA 2.7 Inactive DFGin BLAminus out-out in-in R93 STU Allosteric Type1 22 - 558 None X183 0
6C9HA 2.65 Inactive DFGin BLAminus out-out in-in R34 STU Allosteric Type1 22 - 558 None None 0
6C9JA 3.05 Active DFGin BLAminus out-in in-in R34 STU Allosteric Type1 22 - 559 None X183 0
AF-Q13131-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 19 - 287 None None 0
7JHHA 3.92 Inactive DFGin None out-out out-out No_ligand No_ligand 22 - 559 None None 0
7JHGA 3.47 Inactive DFGin None out-out out-out TAK Type1 22 - 559 None None 0
7M74A 3.93 Inactive DFGin None out-out out-out TAK Type1 22 - 559 None None 0
4RERA 4.047 Inactive DFGin None in-in in-in STU Type1 20 - 559 E480G,E483A,K485A X183 0
4REWA 4.58 Inactive DFGin None out-out in-out STU Type1 20 - 559 E480G,E483A,K485A None 0
4REDA 2.95 Inactive DFGinter None out-out out-none No_ligand No_ligand 22 - 360 K52A None 9
4REDB 2.95 Inactive DFGinter None out-out out-none No_ligand No_ligand 22 - 360 K52A None 8

PRKAA1 (5'-AMP-activated protein kinase catalytic subunit alpha-1)

Group: CAMK
Total number of chains: 23
Spatial Dihedral Chains Representative
DFGin BLAminus 6 AF-Q13131-K1A
DFGin ABAminus 8 6C9FA
DFGin None 7 4CFHA
DFGinter None 2 4REDB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens AAPK1_HUMAN 6C9FA 2.924 Inactive DFGin ABAminus out-out in-in R34 STU Allosteric Type1 22 - 558 None X183 0
Homo sapiens AAPK1_HUMAN 7JIJA 5.5 Inactive DFGin ABAminus out-in in-in No_ligand No_ligand 22 - 559 None X183 0
Homo sapiens AAPK1_HUMAN 6C9GA 2.7 Inactive DFGin BLAminus out-out in-in R93 STU Allosteric Type1 22 - 558 None X183 0
Homo sapiens AAPK1_HUMAN 6C9HA 2.65 Inactive DFGin BLAminus out-out in-in R34 STU Allosteric Type1 22 - 558 None None 0
Homo sapiens AAPK1_HUMAN 6C9JA 3.05 Active DFGin BLAminus out-in in-in R34 STU Allosteric Type1 22 - 559 None X183 0
Homo sapiens AAPK1_HUMAN AF-Q13131-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 19 - 287 None None 0
Homo sapiens AAPK1_HUMAN 7JHHA 3.92 Inactive DFGin None out-out out-out No_ligand No_ligand 22 - 559 None None 0
Homo sapiens AAPK1_HUMAN 7JHGA 3.47 Inactive DFGin None out-out out-out TAK Type1 22 - 559 None None 0
Homo sapiens AAPK1_HUMAN 7M74A 3.93 Inactive DFGin None out-out out-out TAK Type1 22 - 559 None None 0
Homo sapiens AAPK1_HUMAN 4RERA 4.047 Inactive DFGin None in-in in-in STU Type1 20 - 559 E480G,E483A,K485A X183 0
Homo sapiens AAPK1_HUMAN 4REWA 4.58 Inactive DFGin None out-out in-out STU Type1 20 - 559 E480G,E483A,K485A None 0
Homo sapiens AAPK1_HUMAN 4REDA 2.95 Inactive DFGinter None out-out out-none No_ligand No_ligand 22 - 360 K52A None 9
Homo sapiens AAPK1_HUMAN 4REDB 2.95 Inactive DFGinter None out-out out-none No_ligand No_ligand 22 - 360 K52A None 8
Rattus norvegicus AAPK1_RAT 6E4TA 3.4 Inactive DFGin ABAminus out-in in-out HTV STU Allosteric Type1 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 4QFGA 3.46 Inactive DFGin ABAminus in-in in-in STU Type1 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 4QFRA 3.34 Inactive DFGin ABAminus in-in in-out STU 32J Type1 Allosteric 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 4QFSA 3.55 Inactive DFGin ABAminus in-in in-out STU 32H Type1 Allosteric 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 6E4UA 3.27 Inactive DFGin ABAminus in-in in-out STU HU7 Type1 Allosteric 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 6E4WA 3.35 Inactive DFGin ABAminus out-in in-out STU HUG Type1 Allosteric 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 5T5TA 3.46 Inactive DFGin BLAminus in-in in-out STU Type1 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 5UFUA 3.45 Inactive DFGin BLAminus in-in in-out STU 85V Type1 Allosteric 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 4CFHA 3.24 Inactive DFGin None in-in in-out STU Type1 21 - 481 None X183,X388 0
Rattus norvegicus AAPK1_RAT 5KQ5A 3.41 Inactive DFGin None in-in in-out STU 6VT Type1 Allosteric 21 - 559 None X183 0

PRKAA1 (5'-AMP-activated protein kinase catalytic subunit alpha-1)

Group: CAMK
Total number of chains: 10
Spatial Dihedral Chains Representative
DFGin BLAminus 2 5UFUA
DFGin ABAminus 6 6E4UA
DFGin None 2 4CFHA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Rattus norvegicus AAPK1_RAT 6E4TA 3.4 Inactive DFGin ABAminus out-in in-out HTV STU Allosteric Type1 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 4QFGA 3.46 Inactive DFGin ABAminus in-in in-in STU Type1 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 4QFRA 3.34 Inactive DFGin ABAminus in-in in-out STU 32J Type1 Allosteric 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 4QFSA 3.55 Inactive DFGin ABAminus in-in in-out STU 32H Type1 Allosteric 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 6E4UA 3.27 Inactive DFGin ABAminus in-in in-out STU HU7 Type1 Allosteric 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 6E4WA 3.35 Inactive DFGin ABAminus out-in in-out STU HUG Type1 Allosteric 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 5T5TA 3.46 Inactive DFGin BLAminus in-in in-out STU Type1 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 5UFUA 3.45 Inactive DFGin BLAminus in-in in-out STU 85V Type1 Allosteric 20 - 559 None X183 0
Rattus norvegicus AAPK1_RAT 4CFHA 3.24 Inactive DFGin None in-in in-out STU Type1 21 - 481 None X183,X388 0
Rattus norvegicus AAPK1_RAT 5KQ5A 3.41 Inactive DFGin None in-in in-out STU 6VT Type1 Allosteric 21 - 559 None X183 0