MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4)

Group: STE
Uniprot: M4K4_HUMAN
Domain boundary: 25 - 289


Total number of chains: 35
Spatial Dihedral Chains Representative
DFGin BLAminus 5 AF-O95819-K1A
DFGin BLBplus 11 4U40A
DFGinter None 2 4U3YA
DFGout BBAminus 1 4U3YB
DFGout None 15 4U43B
None None 1 4U42B
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-O95819-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 17 - 297 None None 0
4OBPA 2.27 Inactive DFGin BLAminus in-in in-out 2QU Type1 13 - 310 None None 9
4U44A 2.43 Inactive DFGin BLAminus in-in out-out 3D9 Type1 12 - 310 None None 10
4U45A 2.58 Inactive DFGin BLAminus in-in in-out 3DC Type1 12 - 311 None None 9
4ZK5A 2.89 Inactive DFGin BLAminus in-in in-out 4P4 Type1 17 - 311 None None 9
4U42A 2.504 Inactive DFGin BLBplus in-in none-out 3C8 Type1 16 - 310 T181E None 13
4ZP5A 2.29 Inactive DFGin BLBplus in-out none-out 4QG Type1 14 - 309 None None 12
5DI1A 2.9 Inactive DFGin BLBplus in-out none-out 5DF Type1 13 - 309 None None 12
5J95A 2.5 Inactive DFGin BLBplus in-in none-out 6HH Type1 14 - 309 None None 12
4RVTA 2.4 Inactive DFGin BLBplus in-in none-out 3XM Type1 14 - 309 None None 11
4OBOA 2.1 Inactive DFGin BLBplus out-out none-out 2QV Type1 16 - 310 None None 11
4OBQA 2.19 Inactive DFGin BLBplus out-out none-out 2QT Type1 16 - 311 None None 11
4U40A 2.3 Inactive DFGin BLBplus out-out out-out ANP Type1 17 - 311 None None 0
4U41A 2.2 Inactive DFGin BLBplus out-out none-out 3C8 Type1 16 - 310 None None 11
4U43A 2.18 Inactive DFGin BLBplus in-in none-out 3D8 Type1 14 - 311 None None 11
5W5QA 2.33 Inactive DFGin BLBplus out-out out-out 9X4 Type1.5_Back 17 - 311 None None 0
4U3ZA 2.09 Inactive DFGinter None out-out out-out No_ligand No_ligand 17 - 311 T181E None 0
4U3YA 1.45 Inactive DFGinter None out-out out-out No_ligand No_ligand 17 - 311 None None 0
4U3YB 1.45 Inactive DFGout BBAminus out-out out-out No_ligand No_ligand 8 - 311 None None 0
4U3ZB 2.09 Inactive DFGout None out-out out-out No_ligand No_ligand 14 - 311 T181E None 0
4ZP5B 2.29 Inactive DFGout None out-out out-out No_ligand No_ligand 10 - 309 None None 0
5DI1B 2.9 Inactive DFGout None out-out out-out No_ligand No_ligand 10 - 309 None None 0
5J95B 2.5 Inactive DFGout None out-out out-out No_ligand No_ligand 10 - 309 None None 0
4RVTB 2.4 Inactive DFGout None out-out out-out No_ligand No_ligand 13 - 311 None None 0
4OBOB 2.1 Inactive DFGout None out-out out-out No_ligand No_ligand 12 - 311 None None 0
4OBPB 2.27 Inactive DFGout None out-out out-out No_ligand No_ligand 14 - 311 None None 0
4OBQB 2.19 Inactive DFGout None out-out out-out No_ligand No_ligand 13 - 311 None None 0
4U40B 2.3 Inactive DFGout None out-out out-out No_ligand No_ligand 13 - 311 None None 0
4U41B 2.2 Inactive DFGout None out-out out-out No_ligand No_ligand 12 - 311 None None 0
4U43B 2.18 Inactive DFGout None out-out out-out No_ligand No_ligand 10 - 311 None None 0
4U44B 2.43 Inactive DFGout None out-out out-out No_ligand No_ligand 14 - 311 None None 0
4U45B 2.58 Inactive DFGout None out-out out-out No_ligand No_ligand 13 - 311 None None 0
4ZK5B 2.89 Inactive DFGout None out-out out-out No_ligand No_ligand 13 - 311 None None 0
5W5QB 2.33 Inactive DFGout None out-out out-out No_ligand No_ligand 13 - 311 None None 0
4U42B 2.504 Inactive None None none-none none-out 3C8 Type1 17 - 310 T181E None 11

MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4)

Group: STE
Total number of chains: 35
Spatial Dihedral Chains Representative
DFGin BLAminus 5 AF-O95819-K1A
DFGin BLBplus 11 4U40A
DFGinter None 2 4U3YA
DFGout BBAminus 1 4U3YB
DFGout None 15 4U43B
None None 1 4U42B
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens M4K4_HUMAN AF-O95819-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 17 - 297 None None 0
Homo sapiens M4K4_HUMAN 4OBPA 2.27 Inactive DFGin BLAminus in-in in-out 2QU Type1 13 - 310 None None 9
Homo sapiens M4K4_HUMAN 4U44A 2.43 Inactive DFGin BLAminus in-in out-out 3D9 Type1 12 - 310 None None 10
Homo sapiens M4K4_HUMAN 4U45A 2.58 Inactive DFGin BLAminus in-in in-out 3DC Type1 12 - 311 None None 9
Homo sapiens M4K4_HUMAN 4ZK5A 2.89 Inactive DFGin BLAminus in-in in-out 4P4 Type1 17 - 311 None None 9
Homo sapiens M4K4_HUMAN 4U42A 2.504 Inactive DFGin BLBplus in-in none-out 3C8 Type1 16 - 310 T181E None 13
Homo sapiens M4K4_HUMAN 4ZP5A 2.29 Inactive DFGin BLBplus in-out none-out 4QG Type1 14 - 309 None None 12
Homo sapiens M4K4_HUMAN 5DI1A 2.9 Inactive DFGin BLBplus in-out none-out 5DF Type1 13 - 309 None None 12
Homo sapiens M4K4_HUMAN 5J95A 2.5 Inactive DFGin BLBplus in-in none-out 6HH Type1 14 - 309 None None 12
Homo sapiens M4K4_HUMAN 4RVTA 2.4 Inactive DFGin BLBplus in-in none-out 3XM Type1 14 - 309 None None 11
Homo sapiens M4K4_HUMAN 4OBOA 2.1 Inactive DFGin BLBplus out-out none-out 2QV Type1 16 - 310 None None 11
Homo sapiens M4K4_HUMAN 4OBQA 2.19 Inactive DFGin BLBplus out-out none-out 2QT Type1 16 - 311 None None 11
Homo sapiens M4K4_HUMAN 4U40A 2.3 Inactive DFGin BLBplus out-out out-out ANP Type1 17 - 311 None None 0
Homo sapiens M4K4_HUMAN 4U41A 2.2 Inactive DFGin BLBplus out-out none-out 3C8 Type1 16 - 310 None None 11
Homo sapiens M4K4_HUMAN 4U43A 2.18 Inactive DFGin BLBplus in-in none-out 3D8 Type1 14 - 311 None None 11
Homo sapiens M4K4_HUMAN 5W5QA 2.33 Inactive DFGin BLBplus out-out out-out 9X4 Type1.5_Back 17 - 311 None None 0
Homo sapiens M4K4_HUMAN 4U3ZA 2.09 Inactive DFGinter None out-out out-out No_ligand No_ligand 17 - 311 T181E None 0
Homo sapiens M4K4_HUMAN 4U3YA 1.45 Inactive DFGinter None out-out out-out No_ligand No_ligand 17 - 311 None None 0
Homo sapiens M4K4_HUMAN 4U3YB 1.45 Inactive DFGout BBAminus out-out out-out No_ligand No_ligand 8 - 311 None None 0
Homo sapiens M4K4_HUMAN 4U3ZB 2.09 Inactive DFGout None out-out out-out No_ligand No_ligand 14 - 311 T181E None 0
Homo sapiens M4K4_HUMAN 4ZP5B 2.29 Inactive DFGout None out-out out-out No_ligand No_ligand 10 - 309 None None 0
Homo sapiens M4K4_HUMAN 5DI1B 2.9 Inactive DFGout None out-out out-out No_ligand No_ligand 10 - 309 None None 0
Homo sapiens M4K4_HUMAN 5J95B 2.5 Inactive DFGout None out-out out-out No_ligand No_ligand 10 - 309 None None 0
Homo sapiens M4K4_HUMAN 4RVTB 2.4 Inactive DFGout None out-out out-out No_ligand No_ligand 13 - 311 None None 0
Homo sapiens M4K4_HUMAN 4OBOB 2.1 Inactive DFGout None out-out out-out No_ligand No_ligand 12 - 311 None None 0
Homo sapiens M4K4_HUMAN 4OBPB 2.27 Inactive DFGout None out-out out-out No_ligand No_ligand 14 - 311 None None 0
Homo sapiens M4K4_HUMAN 4OBQB 2.19 Inactive DFGout None out-out out-out No_ligand No_ligand 13 - 311 None None 0
Homo sapiens M4K4_HUMAN 4U40B 2.3 Inactive DFGout None out-out out-out No_ligand No_ligand 13 - 311 None None 0
Homo sapiens M4K4_HUMAN 4U41B 2.2 Inactive DFGout None out-out out-out No_ligand No_ligand 12 - 311 None None 0
Homo sapiens M4K4_HUMAN 4U43B 2.18 Inactive DFGout None out-out out-out No_ligand No_ligand 10 - 311 None None 0
Homo sapiens M4K4_HUMAN 4U44B 2.43 Inactive DFGout None out-out out-out No_ligand No_ligand 14 - 311 None None 0
Homo sapiens M4K4_HUMAN 4U45B 2.58 Inactive DFGout None out-out out-out No_ligand No_ligand 13 - 311 None None 0
Homo sapiens M4K4_HUMAN 4ZK5B 2.89 Inactive DFGout None out-out out-out No_ligand No_ligand 13 - 311 None None 0
Homo sapiens M4K4_HUMAN 5W5QB 2.33 Inactive DFGout None out-out out-out No_ligand No_ligand 13 - 311 None None 0
Homo sapiens M4K4_HUMAN 4U42B 2.504 Inactive None None none-none none-out 3C8 Type1 17 - 310 T181E None 11

MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4)

No non-human structures known.