MAP3K14 (Mitogen-activated protein kinase kinase kinase 14)

Group: STE
Uniprot: M3K14_HUMAN
Domain boundary: 399 - 653


Total number of chains: 23
Spatial Dihedral Chains Representative
DFGin BLAminus 22 AF-Q99558-K1A
DFGin ABAminus 1 4IDTA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
4IDTA 2.4 Inactive DFGin ABAminus in-in in-in T28 Type1 333 - 675 None None 9
AF-Q99558-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 391 - 661 None None 0
4G3DA 2.9 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 332 - 672 None None 0
4G3DB 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 332 - 666 None None 0
4G3DD 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 338 - 657 None None 13
4G3DE 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 332 - 663 None None 15
6WPPA 2.55 Active DFGin BLAminus in-in in-in PZ4 Type1 344 - 674 None None 7
6WPPB 2.55 Active DFGin BLAminus in-in in-in PZ4 Type1 343 - 674 None None 5
6Z1QAAA 2.42 Active DFGin BLAminus in-in in-in Q58 Type1 332 - 676 None None 9
6Z1QBBB 2.42 Active DFGin BLAminus in-in in-in Q58 Type1 332 - 677 None None 9
6Z1TAAA 2.31 Active DFGin BLAminus in-in in-in Q55 Type1 334 - 676 None None 12
6Z1TBBB 2.31 Active DFGin BLAminus in-in in-in Q55 Type1 332 - 677 None None 12
4DN5A 2.5 Active DFGin BLAminus in-in in-in AGS Type1 332 - 675 S549D None 13
4DN5B 2.5 Active DFGin BLAminus in-in in-in AGS Type1 333 - 675 S549D None 13
4IDTB 2.4 Active DFGin BLAminus in-in in-in T28 Type1 334 - 677 None None 9
8YHWA 2.9 Active DFGin BLAminus in-in in-in AGS Type1 334 - 675 None None 6
8YHWB 2.9 Active DFGin BLAminus in-in in-in AGS Type1 334 - 675 None None 7
8YHWC 2.9 Active DFGin BLAminus in-in in-in AGS Type1 334 - 675 None None 7
8YHWD 2.9 Active DFGin BLAminus in-in in-in AGS PE8 Type1 Allosteric 334 - 675 None None 13
4IDVA 2.9 Active DFGin BLAminus in-in in-in 13V Type1.5_Back 331 - 675 None None 0
4IDVB 2.9 Active DFGin BLAminus in-in in-in 13V Type1.5_Back 331 - 675 None None 0
4IDVC 2.9 Active DFGin BLAminus in-in in-in 13V Type1.5_Back 331 - 675 None None 0
4IDVD 2.9 Active DFGin BLAminus in-in in-in 13V Type1.5_Back 331 - 675 None None 0

MAP3K14 (Mitogen-activated protein kinase kinase kinase 14)

Group: STE
Total number of chains: 43
Spatial Dihedral Chains Representative
DFGin BLAminus 42 AF-Q99558-K1A
DFGin ABAminus 1 4IDTA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens M3K14_HUMAN 4IDTA 2.4 Inactive DFGin ABAminus in-in in-in T28 Type1 333 - 675 None None 9
Homo sapiens M3K14_HUMAN AF-Q99558-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 391 - 661 None None 0
Homo sapiens M3K14_HUMAN 4G3DA 2.9 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 332 - 672 None None 0
Homo sapiens M3K14_HUMAN 4G3DB 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 332 - 666 None None 0
Homo sapiens M3K14_HUMAN 4G3DD 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 338 - 657 None None 13
Homo sapiens M3K14_HUMAN 4G3DE 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 332 - 663 None None 15
Homo sapiens M3K14_HUMAN 6WPPA 2.55 Active DFGin BLAminus in-in in-in PZ4 Type1 344 - 674 None None 7
Homo sapiens M3K14_HUMAN 6WPPB 2.55 Active DFGin BLAminus in-in in-in PZ4 Type1 343 - 674 None None 5
Homo sapiens M3K14_HUMAN 6Z1QAAA 2.42 Active DFGin BLAminus in-in in-in Q58 Type1 332 - 676 None None 9
Homo sapiens M3K14_HUMAN 6Z1QBBB 2.42 Active DFGin BLAminus in-in in-in Q58 Type1 332 - 677 None None 9
Homo sapiens M3K14_HUMAN 6Z1TAAA 2.31 Active DFGin BLAminus in-in in-in Q55 Type1 334 - 676 None None 12
Homo sapiens M3K14_HUMAN 6Z1TBBB 2.31 Active DFGin BLAminus in-in in-in Q55 Type1 332 - 677 None None 12
Homo sapiens M3K14_HUMAN 4DN5A 2.5 Active DFGin BLAminus in-in in-in AGS Type1 332 - 675 S549D None 13
Homo sapiens M3K14_HUMAN 4DN5B 2.5 Active DFGin BLAminus in-in in-in AGS Type1 333 - 675 S549D None 13
Homo sapiens M3K14_HUMAN 4IDTB 2.4 Active DFGin BLAminus in-in in-in T28 Type1 334 - 677 None None 9
Homo sapiens M3K14_HUMAN 8YHWA 2.9 Active DFGin BLAminus in-in in-in AGS Type1 334 - 675 None None 6
Homo sapiens M3K14_HUMAN 8YHWB 2.9 Active DFGin BLAminus in-in in-in AGS Type1 334 - 675 None None 7
Homo sapiens M3K14_HUMAN 8YHWC 2.9 Active DFGin BLAminus in-in in-in AGS Type1 334 - 675 None None 7
Homo sapiens M3K14_HUMAN 8YHWD 2.9 Active DFGin BLAminus in-in in-in AGS PE8 Type1 Allosteric 334 - 675 None None 13
Homo sapiens M3K14_HUMAN 4IDVA 2.9 Active DFGin BLAminus in-in in-in 13V Type1.5_Back 331 - 675 None None 0
Homo sapiens M3K14_HUMAN 4IDVB 2.9 Active DFGin BLAminus in-in in-in 13V Type1.5_Back 331 - 675 None None 0
Homo sapiens M3K14_HUMAN 4IDVC 2.9 Active DFGin BLAminus in-in in-in 13V Type1.5_Back 331 - 675 None None 0
Homo sapiens M3K14_HUMAN 4IDVD 2.9 Active DFGin BLAminus in-in in-in 13V Type1.5_Back 331 - 675 None None 0
Mus musculus M3K14_MOUSE 4G3CA 2.15 Active DFGin BLAminus in-in in-in No_ligand No_ligand 334 - 675 None None 13
Mus musculus M3K14_MOUSE 4G3CB 2.15 Active DFGin BLAminus in-in in-in No_ligand No_ligand 334 - 674 None None 0
Mus musculus M3K14_MOUSE 4G3GA 2.5 Active DFGin BLAminus in-in in-in 0WA Type1 345 - 675 V408L None 12
Mus musculus M3K14_MOUSE 4G3FA 1.642 Active DFGin BLAminus in-in in-in 0WB Type1 345 - 675 None None 12
Mus musculus M3K14_MOUSE 5T8PA 2.32 Active DFGin BLAminus in-in in-in 774 Type1 333 - 675 None None 2
Mus musculus M3K14_MOUSE 5T8PB 2.32 Active DFGin BLAminus in-in in-in 774 Type1 334 - 675 None None 0
Mus musculus M3K14_MOUSE 5T8QA 2.63 Active DFGin BLAminus in-in in-in 76Y Type1 334 - 675 None None 5
Mus musculus M3K14_MOUSE 5T8QB 2.63 Active DFGin BLAminus in-in in-in 76Y Type1 334 - 675 None None 0
Mus musculus M3K14_MOUSE 6MYNA 2.744 Active DFGin BLAminus in-in in-in K6Y Type1.5_Back 334 - 675 None None 6
Mus musculus M3K14_MOUSE 6MYNB 2.744 Active DFGin BLAminus in-in in-in K6Y Type1.5_Back 334 - 675 None None 0
Mus musculus M3K14_MOUSE 5T8OA 2.41 Active DFGin BLAminus in-in in-in 76Z Type1.5_Back 334 - 675 None None 4
Mus musculus M3K14_MOUSE 5T8OB 2.41 Active DFGin BLAminus in-in in-in 76Z Type1.5_Back 334 - 675 None None 0
Mus musculus M3K14_MOUSE 6G4YA 2.65 Active DFGin BLAminus in-in in-in ELZ Type1.5_Back 334 - 675 None None 6
Mus musculus M3K14_MOUSE 6G4YB 2.65 Active DFGin BLAminus in-in in-in ELZ Type1.5_Back 334 - 675 None None 0
Mus musculus M3K14_MOUSE 6G4ZA 2.84 Active DFGin BLAminus in-in in-in ELW Type1.5_Back 334 - 675 None None 6
Mus musculus M3K14_MOUSE 6G4ZB 2.84 Active DFGin BLAminus in-in in-in ELW Type1.5_Back 334 - 675 None None 0
Mus musculus M3K14_MOUSE 4G3EA 2.5 Active DFGin BLAminus in-in in-in 0WC Type1.5_Back 334 - 675 None None 13
Mus musculus M3K14_MOUSE 4G3EB 2.5 Active DFGin BLAminus in-in in-in 0WC Type1.5_Back 334 - 675 None None 0
Mus musculus M3K14_MOUSE 7SZRA 2.8 Active DFGin BLAminus in-in in-in DYQ Type1.5_Back 334 - 675 None None 5
Mus musculus M3K14_MOUSE 7SZRB 2.8 Active DFGin BLAminus in-in in-in DYQ Type1.5_Back 334 - 675 None None 0

MAP3K14 (Mitogen-activated protein kinase kinase kinase 14)

Group: STE
Total number of chains: 20
Spatial Dihedral Chains Representative
DFGin BLAminus 20 4G3CB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Mus musculus M3K14_MOUSE 4G3CA 2.15 Active DFGin BLAminus in-in in-in No_ligand No_ligand 334 - 675 None None 13
Mus musculus M3K14_MOUSE 4G3CB 2.15 Active DFGin BLAminus in-in in-in No_ligand No_ligand 334 - 674 None None 0
Mus musculus M3K14_MOUSE 4G3GA 2.5 Active DFGin BLAminus in-in in-in 0WA Type1 345 - 675 V408L None 12
Mus musculus M3K14_MOUSE 4G3FA 1.642 Active DFGin BLAminus in-in in-in 0WB Type1 345 - 675 None None 12
Mus musculus M3K14_MOUSE 5T8PA 2.32 Active DFGin BLAminus in-in in-in 774 Type1 333 - 675 None None 2
Mus musculus M3K14_MOUSE 5T8PB 2.32 Active DFGin BLAminus in-in in-in 774 Type1 334 - 675 None None 0
Mus musculus M3K14_MOUSE 5T8QA 2.63 Active DFGin BLAminus in-in in-in 76Y Type1 334 - 675 None None 5
Mus musculus M3K14_MOUSE 5T8QB 2.63 Active DFGin BLAminus in-in in-in 76Y Type1 334 - 675 None None 0
Mus musculus M3K14_MOUSE 6MYNA 2.744 Active DFGin BLAminus in-in in-in K6Y Type1.5_Back 334 - 675 None None 6
Mus musculus M3K14_MOUSE 6MYNB 2.744 Active DFGin BLAminus in-in in-in K6Y Type1.5_Back 334 - 675 None None 0
Mus musculus M3K14_MOUSE 5T8OA 2.41 Active DFGin BLAminus in-in in-in 76Z Type1.5_Back 334 - 675 None None 4
Mus musculus M3K14_MOUSE 5T8OB 2.41 Active DFGin BLAminus in-in in-in 76Z Type1.5_Back 334 - 675 None None 0
Mus musculus M3K14_MOUSE 6G4YA 2.65 Active DFGin BLAminus in-in in-in ELZ Type1.5_Back 334 - 675 None None 6
Mus musculus M3K14_MOUSE 6G4YB 2.65 Active DFGin BLAminus in-in in-in ELZ Type1.5_Back 334 - 675 None None 0
Mus musculus M3K14_MOUSE 6G4ZA 2.84 Active DFGin BLAminus in-in in-in ELW Type1.5_Back 334 - 675 None None 6
Mus musculus M3K14_MOUSE 6G4ZB 2.84 Active DFGin BLAminus in-in in-in ELW Type1.5_Back 334 - 675 None None 0
Mus musculus M3K14_MOUSE 4G3EA 2.5 Active DFGin BLAminus in-in in-in 0WC Type1.5_Back 334 - 675 None None 13
Mus musculus M3K14_MOUSE 4G3EB 2.5 Active DFGin BLAminus in-in in-in 0WC Type1.5_Back 334 - 675 None None 0
Mus musculus M3K14_MOUSE 7SZRA 2.8 Active DFGin BLAminus in-in in-in DYQ Type1.5_Back 334 - 675 None None 5
Mus musculus M3K14_MOUSE 7SZRB 2.8 Active DFGin BLAminus in-in in-in DYQ Type1.5_Back 334 - 675 None None 0