LCK (Tyrosine-protein kinase Lck)

Group: TYR
Uniprot: LCK_HUMAN
Domain boundary: 245 - 496


Total number of chains: 38
Spatial Dihedral Chains Representative
DFGin BLAminus 27 AF-P06239-K1A
DFGin BLBminus 1 3B2WA
DFGin BLBplus 2 4C3FA
DFGout BBAminus 6 6PDJA
DFGout None 2 2OFVA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P06239-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 237 - 504 None None 0
3LCKA 1.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 231 - 501 None X394 0
2OF2A 2.0 Active DFGin BLAminus in-in in-in 547 Type1 231 - 501 None None 0
2OF4A 2.7 Active DFGin BLAminus in-in in-in 979 Type1 231 - 501 None None 0
3BYOA 2.0 Active DFGin BLAminus in-in in-in AM9 Type1 231 - 501 None X394 0
2OFUA 2.0 Active DFGin BLAminus in-in in-in 1N9 Type1 229 - 501 None X394 0
1QPCA 1.6 Active DFGin BLAminus in-in in-in ANP Type1 231 - 502 None X394 0
1QPEA 2.0 Active DFGin BLAminus in-in in-in PP2 Type1 231 - 501 None X394 0
1QPJA 2.2 Active DFGin BLAminus in-in in-in STU Type1 236 - 501 None X394 0
2ZM1A 2.1 Active DFGin BLAminus in-in in-in KSF Type1 231 - 501 None X394 0
2ZM4A 2.7 Active DFGin BLAminus in-in in-in KSM Type1 231 - 501 None X394 0
2ZYBA 2.55 Active DFGin BLAminus in-in in-in KSL Type1 231 - 501 None X394 0
3AC1A 1.99 Active DFGin BLAminus in-in in-in KZI Type1 231 - 502 None X394 0
3AC2A 2.1 Active DFGin BLAminus in-in in-in KSE Type1 231 - 502 None X394 0
3AC3A 2.55 Active DFGin BLAminus in-in in-in KSH Type1 231 - 502 None X394 0
3AC4A 2.7 Active DFGin BLAminus in-in in-in KZL Type1 231 - 502 None X394 0
3AC5A 2.5 Active DFGin BLAminus in-in in-in KZM Type1 231 - 502 None X394 0
3AC8A 2.3 Inactive DFGin BLAminus in-out in-in KSK Type1 231 - 501 None X394 0
3ACJA 2.2 Active DFGin BLAminus in-in in-in KSS Type1 231 - 502 None X394 0
3ACKA 2.6 Active DFGin BLAminus in-in in-in KSR Type1 231 - 502 None X394 0
3AD4A 2.2 Active DFGin BLAminus in-in in-in KBM Type1 231 - 502 None X394 0
3AD5A 2.0 Active DFGin BLAminus in-in in-in 5PB Type1 230 - 502 None X394 0
3AD6A 2.15 Active DFGin BLAminus in-in in-in KSC Type1 230 - 502 None X394 0
3KXZA 2.37 Active DFGin BLAminus in-in in-in 925 Type1 238 - 501 None X394 0
1QPDA 2.0 Active DFGin BLAminus in-in in-in STU Type1 231 - 502 None X394 0
3BYMA 2.0 Active DFGin BLAminus in-in in-in AM0 Type1.5_Back 230 - 501 None X394 0
3KMMA 2.8 Active DFGin BLAminus in-in in-in LHL Type1.5_Back 231 - 501 Y505F X394 0
3B2WA 2.3 Inactive DFGin BLBminus in-in out-in 9NH Type1 238 - 500 None None 2
3MPMA 1.95 Inactive DFGin BLBplus in-in out-out 5LK Type1 238 - 498 D364N None 4
4C3FA 1.72 Inactive DFGin BLBplus in-in out-out 7KW Type1 238 - 498 D364N None 4
6PDJA 1.81 Inactive DFGout BBAminus out-none in-in ODJ Type1.5_Front 225 - 500 None X394 0
2OG8A 2.3 Inactive DFGout BBAminus in-in none-none 1N8 Type2 237 - 499 None None 17
2OG8B 2.3 Inactive DFGout BBAminus in-in none-none 1N8 Type2 237 - 499 None None 16
3BYSA 2.2 Inactive DFGout BBAminus in-in none-none AM5 Type2 230 - 501 None None 17
3BYUA 2.3 Inactive DFGout BBAminus in-in none-in AM6 Type2 231 - 501 None None 15
2PL0A 2.8 Inactive DFGout BBAminus in-in out-in STI Type2 231 - 498 None None 0
2OFVA 2.0 Inactive DFGout None in-in none-none 242 Type2 232 - 498 None None 17
2OFVB 2.0 Inactive DFGout None in-in out-none 242 Type2 232 - 498 None None 11

LCK (Tyrosine-protein kinase Lck)

Group: TYR
Total number of chains: 38
Spatial Dihedral Chains Representative
DFGin BLAminus 27 AF-P06239-K1A
DFGin BLBminus 1 3B2WA
DFGin BLBplus 2 4C3FA
DFGout BBAminus 6 6PDJA
DFGout None 2 2OFVA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens LCK_HUMAN AF-P06239-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 237 - 504 None None 0
Homo sapiens LCK_HUMAN 3LCKA 1.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 231 - 501 None X394 0
Homo sapiens LCK_HUMAN 2OF2A 2.0 Active DFGin BLAminus in-in in-in 547 Type1 231 - 501 None None 0
Homo sapiens LCK_HUMAN 2OF4A 2.7 Active DFGin BLAminus in-in in-in 979 Type1 231 - 501 None None 0
Homo sapiens LCK_HUMAN 3BYOA 2.0 Active DFGin BLAminus in-in in-in AM9 Type1 231 - 501 None X394 0
Homo sapiens LCK_HUMAN 2OFUA 2.0 Active DFGin BLAminus in-in in-in 1N9 Type1 229 - 501 None X394 0
Homo sapiens LCK_HUMAN 1QPCA 1.6 Active DFGin BLAminus in-in in-in ANP Type1 231 - 502 None X394 0
Homo sapiens LCK_HUMAN 1QPEA 2.0 Active DFGin BLAminus in-in in-in PP2 Type1 231 - 501 None X394 0
Homo sapiens LCK_HUMAN 1QPJA 2.2 Active DFGin BLAminus in-in in-in STU Type1 236 - 501 None X394 0
Homo sapiens LCK_HUMAN 2ZM1A 2.1 Active DFGin BLAminus in-in in-in KSF Type1 231 - 501 None X394 0
Homo sapiens LCK_HUMAN 2ZM4A 2.7 Active DFGin BLAminus in-in in-in KSM Type1 231 - 501 None X394 0
Homo sapiens LCK_HUMAN 2ZYBA 2.55 Active DFGin BLAminus in-in in-in KSL Type1 231 - 501 None X394 0
Homo sapiens LCK_HUMAN 3AC1A 1.99 Active DFGin BLAminus in-in in-in KZI Type1 231 - 502 None X394 0
Homo sapiens LCK_HUMAN 3AC2A 2.1 Active DFGin BLAminus in-in in-in KSE Type1 231 - 502 None X394 0
Homo sapiens LCK_HUMAN 3AC3A 2.55 Active DFGin BLAminus in-in in-in KSH Type1 231 - 502 None X394 0
Homo sapiens LCK_HUMAN 3AC4A 2.7 Active DFGin BLAminus in-in in-in KZL Type1 231 - 502 None X394 0
Homo sapiens LCK_HUMAN 3AC5A 2.5 Active DFGin BLAminus in-in in-in KZM Type1 231 - 502 None X394 0
Homo sapiens LCK_HUMAN 3AC8A 2.3 Inactive DFGin BLAminus in-out in-in KSK Type1 231 - 501 None X394 0
Homo sapiens LCK_HUMAN 3ACJA 2.2 Active DFGin BLAminus in-in in-in KSS Type1 231 - 502 None X394 0
Homo sapiens LCK_HUMAN 3ACKA 2.6 Active DFGin BLAminus in-in in-in KSR Type1 231 - 502 None X394 0
Homo sapiens LCK_HUMAN 3AD4A 2.2 Active DFGin BLAminus in-in in-in KBM Type1 231 - 502 None X394 0
Homo sapiens LCK_HUMAN 3AD5A 2.0 Active DFGin BLAminus in-in in-in 5PB Type1 230 - 502 None X394 0
Homo sapiens LCK_HUMAN 3AD6A 2.15 Active DFGin BLAminus in-in in-in KSC Type1 230 - 502 None X394 0
Homo sapiens LCK_HUMAN 3KXZA 2.37 Active DFGin BLAminus in-in in-in 925 Type1 238 - 501 None X394 0
Homo sapiens LCK_HUMAN 1QPDA 2.0 Active DFGin BLAminus in-in in-in STU Type1 231 - 502 None X394 0
Homo sapiens LCK_HUMAN 3BYMA 2.0 Active DFGin BLAminus in-in in-in AM0 Type1.5_Back 230 - 501 None X394 0
Homo sapiens LCK_HUMAN 3KMMA 2.8 Active DFGin BLAminus in-in in-in LHL Type1.5_Back 231 - 501 Y505F X394 0
Homo sapiens LCK_HUMAN 3B2WA 2.3 Inactive DFGin BLBminus in-in out-in 9NH Type1 238 - 500 None None 2
Homo sapiens LCK_HUMAN 3MPMA 1.95 Inactive DFGin BLBplus in-in out-out 5LK Type1 238 - 498 D364N None 4
Homo sapiens LCK_HUMAN 4C3FA 1.72 Inactive DFGin BLBplus in-in out-out 7KW Type1 238 - 498 D364N None 4
Homo sapiens LCK_HUMAN 6PDJA 1.81 Inactive DFGout BBAminus out-none in-in ODJ Type1.5_Front 225 - 500 None X394 0
Homo sapiens LCK_HUMAN 2OG8A 2.3 Inactive DFGout BBAminus in-in none-none 1N8 Type2 237 - 499 None None 17
Homo sapiens LCK_HUMAN 2OG8B 2.3 Inactive DFGout BBAminus in-in none-none 1N8 Type2 237 - 499 None None 16
Homo sapiens LCK_HUMAN 3BYSA 2.2 Inactive DFGout BBAminus in-in none-none AM5 Type2 230 - 501 None None 17
Homo sapiens LCK_HUMAN 3BYUA 2.3 Inactive DFGout BBAminus in-in none-in AM6 Type2 231 - 501 None None 15
Homo sapiens LCK_HUMAN 2PL0A 2.8 Inactive DFGout BBAminus in-in out-in STI Type2 231 - 498 None None 0
Homo sapiens LCK_HUMAN 2OFVA 2.0 Inactive DFGout None in-in none-none 242 Type2 232 - 498 None None 17
Homo sapiens LCK_HUMAN 2OFVB 2.0 Inactive DFGout None in-in out-none 242 Type2 232 - 498 None None 11

LCK (Tyrosine-protein kinase Lck)

No non-human structures known.