GSK3B (Glycogen synthase kinase-3 beta)

Group: CMGC
Uniprot: GSK3B_HUMAN
Domain boundary: 56 - 340


Total number of chains: 155
Spatial Dihedral Chains Representative
DFGin BLAminus 153 AF-P49841-K1A
DFGin ABAminus 2 6Y9SA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
6Y9SA 2.03 Inactive DFGin ABAminus in-in in-in OHK Type1 35 - 383 None X216 0
6Y9SB 2.03 Inactive DFGin ABAminus in-in in-in OHK Type1 35 - 383 None X216 0
AF-P49841-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 48 - 348 None None 0
1GNGA 2.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 36 - 385 None X216 0
1GNGB 2.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 28 - 384 None X216 0
1H8FA 2.8 Active DFGin BLAminus in-in in-in No_ligand No_ligand 35 - 386 None None 0
1H8FB 2.8 Active DFGin BLAminus in-in in-in No_ligand No_ligand 35 - 384 None None 0
1I09A 2.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 25 - 384 None None 0
1I09B 2.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 37 - 382 None None 0
6HK7A 3.2 Active DFGin BLAminus in-in in-in G8N Type1 36 - 382 None X216 0
7SXHA 2.09 Active DFGin BLAminus in-in in-in D1E Type1 37 - 383 None X216 0
7U2ZA 2.21 Active DFGin BLAminus in-in in-in L7C Type1 35 - 382 None None 0
7U2ZB 2.21 Active DFGin BLAminus in-in in-in L7C Type1 35 - 382 None None 0
3F7ZA 2.4 Active DFGin BLAminus in-in in-in 34O Type1 35 - 383 None X216 0
3F7ZB 2.4 Active DFGin BLAminus in-in in-in 34O Type1 35 - 383 None X216 0
3SD0A 2.7 Active DFGin BLAminus in-in in-in TSK Type1 35 - 384 None None 0
3SD0B 2.7 Active DFGin BLAminus in-in in-in TSK Type1 35 - 383 None None 0
3ZDIA 2.645 Active DFGin BLAminus in-in in-in UGJ Type1 36 - 384 None X216 0
4B7TA 2.772 Active DFGin BLAminus in-in in-in CWT Type1 35 - 384 None None 0
6HK3A 2.35 Active DFGin BLAminus in-in in-in G8B Type1 35 - 384 None X216 0
6HK3B 2.35 Active DFGin BLAminus in-in in-in G8B Type1 35 - 384 None X216 0
6HK4A 2.5 Active DFGin BLAminus in-in in-in G8E Type1 35 - 384 None X216 0
6HK4B 2.5 Active DFGin BLAminus in-in in-in G8E Type1 35 - 384 None X216 0
6Y9RA 2.08 Active DFGin BLAminus in-in in-in OH8 Type1 35 - 384 None X216 0
5F94A 2.51 Active DFGin BLAminus in-in in-in 3UO Type1 36 - 381 None None 0
5F94B 2.51 Active DFGin BLAminus in-in in-in 3UO Type1 37 - 385 None None 0
5F95A 2.525 Active DFGin BLAminus in-in in-in 3UP Type1 36 - 383 None None 0
5F95B 2.525 Active DFGin BLAminus in-in in-in 3UP Type1 36 - 385 None None 0
7U31A 2.38 Active DFGin BLAminus in-in in-in L7I Type1 36 - 385 None None 0
7U31B 2.38 Active DFGin BLAminus in-in in-in L7I Type1 37 - 382 None None 0
7SXJA 1.85 Active DFGin BLAminus in-in in-in 6VL Type1 34 - 383 None X216 0
7OY5A 2.57 Active DFGin BLAminus in-in in-in 39I Type1 35 - 385 None None 0
7OY5B 2.57 Active DFGin BLAminus in-in in-in 39I Type1 35 - 383 None None 0
7U33A 2.6 Active DFGin BLAminus in-in in-in L7R Type1 36 - 385 None None 0
7U33B 2.6 Active DFGin BLAminus in-in in-in L7R Type1 37 - 382 None None 0
7U36A 2.75 Active DFGin BLAminus in-in in-in L7W Type1 36 - 385 None None 0
7U36B 2.75 Active DFGin BLAminus in-in in-in L7W Type1 37 - 382 None None 0
2OW3A 2.8 Active DFGin BLAminus in-in in-in BIM Type1 35 - 385 None X216 0
2OW3B 2.8 Active DFGin BLAminus in-in in-in BIM Type1 35 - 386 None X216 0
1O9UA 2.4 Active DFGin BLAminus in-in in-in ADZ Type1 35 - 384 None X216 0
3GB2A 2.4 Active DFGin BLAminus in-in in-in G3B Type1 35 - 383 None X216 0
6TCUA 2.14 Active DFGin BLAminus in-in in-in N1Q Type1 35 - 384 None X216 0
5T31A 2.85 Active DFGin BLAminus in-in in-in 6VL Type1 35 - 381 D133E X216 0
5T31B 2.85 Active DFGin BLAminus in-in in-in 6VL Type1 36 - 382 D133E X216 0
7Z1FA 3.0 Active DFGin BLAminus in-in in-in 3NG Type1 28 - 383 None X216 0
7Z1FB 3.0 Active DFGin BLAminus in-in in-in 3NG Type1 38 - 382 None X216 0
7Z1GA 2.85 Active DFGin BLAminus in-in in-in 3NG Type1 27 - 383 None None 0
7B6FA 2.05 Active DFGin BLAminus in-in in-in SZW Type1 36 - 382 None X216 0
8AUZA 2.66 Active DFGin BLAminus in-in in-in O9C Type1 27 - 381 None X216 0
8AUZB 2.66 Active DFGin BLAminus in-in in-in O9C Type1 27 - 381 None X216 0
8AV1A 2.15 Active DFGin BLAminus in-in in-in O9L Type1 27 - 381 None X216 0
8AV1B 2.15 Active DFGin BLAminus in-in in-in O9L Type1 27 - 381 None X216 0
4AFJA 1.98 Active DFGin BLAminus in-in in-in SJJ Type1 36 - 384 None X216 0
4AFJB 1.98 Active DFGin BLAminus in-in in-in SJJ Type1 34 - 384 None X216 0
6GN1A 2.6 Active DFGin BLAminus in-in in-in F4N Type1 36 - 383 None X216 0
6GN1B 2.6 Active DFGin BLAminus in-in in-in F4N Type1 36 - 383 None X216 0
3ZRKA 2.37 Active DFGin BLAminus in-in in-in ZRK Type1 36 - 384 None X216 0
3ZRKB 2.37 Active DFGin BLAminus in-in in-in ZRK Type1 36 - 384 None X216 0
3ZRLA 2.48 Active DFGin BLAminus in-in in-in ZRL Type1 36 - 385 None X216 0
3ZRLB 2.48 Active DFGin BLAminus in-in in-in ZRL Type1 36 - 384 None X216 0
3ZRMA 2.49 Active DFGin BLAminus in-in in-in ZRM Type1 36 - 383 None X216 0
3ZRMB 2.49 Active DFGin BLAminus in-in in-in ZRM Type1 36 - 384 None X216 0
4NM5A 2.3 Active DFGin BLAminus in-in in-in ADP Type1 24 - 383 None None 0
4NM7A 2.3 Active DFGin BLAminus in-in in-in ADP Type1 25 - 383 None None 0
5K5NA 2.2 Active DFGin BLAminus in-in in-in 6QH Type1 36 - 382 V28G X216 0
5K5NB 2.2 Active DFGin BLAminus in-in in-in 6QH Type1 36 - 384 V28G X216 0
2O5KA 3.2 Active DFGin BLAminus in-in in-in HBM Type1 35 - 384 None None 0
4DITA 2.6 None DFGin BLAminus in-in in-none 0KD Type1 35 - 387 None X216 4
4NM0A 2.5 Active DFGin BLAminus in-in in-in ADP Type1 26 - 383 None None 0
4NM3A 2.1 Active DFGin BLAminus in-in in-in ADP Type1 6 - 383 None X9 0
1R0EA 2.25 Active DFGin BLAminus in-in in-in DFN Type1 35 - 383 None None 0
1R0EB 2.25 Active DFGin BLAminus in-in in-in DFN Type1 35 - 383 None None 0
1UV5A 2.8 Active DFGin BLAminus in-in in-in BRW Type1 35 - 383 None None 0
1Q5KA 1.94 Active DFGin BLAminus in-in in-in TMU Type1 35 - 384 None None 0
1Q5KB 1.94 Active DFGin BLAminus in-in in-in TMU Type1 35 - 384 None None 0
3I4BA 2.3 Active DFGin BLAminus in-in in-in Z48 Type1 25 - 385 None None 0
3I4BB 2.3 Active DFGin BLAminus in-in in-in Z48 Type1 36 - 382 None None 0
3L1SA 2.9 Active DFGin BLAminus in-in in-in Z92 Type1 25 - 384 None None 0
3L1SB 2.9 Active DFGin BLAminus in-in in-in Z92 Type1 36 - 382 None None 0
6GJOA 2.91 Active DFGin BLAminus in-in in-in F1B Type1 35 - 383 None None 0
6GJOB 2.91 Active DFGin BLAminus in-in in-in F1B Type1 35 - 383 None None 0
1J1BA 1.8 Active DFGin BLAminus in-in in-in ANP Type1 35 - 388 None None 0
1J1BB 1.8 Active DFGin BLAminus in-in in-in ANP Type1 23 - 386 None None 0
1J1CA 2.1 Active DFGin BLAminus in-in in-in ADP Type1 35 - 388 None None 0
1J1CB 2.1 Active DFGin BLAminus in-in in-in ADP Type1 23 - 386 None None 0
2JLDA 2.35 Active DFGin BLAminus in-in in-in AG1 Type1 35 - 385 None None 0
2JLDB 2.35 Active DFGin BLAminus in-in in-in AG1 Type1 35 - 384 None None 0
3M1SA 3.134 Active DFGin BLAminus in-in in-in DW1 Type1 35 - 385 None None 0
3M1SB 3.134 Active DFGin BLAminus in-in in-in DW1 Type1 35 - 384 None None 0
3PUPA 2.99 Active DFGin BLAminus in-in in-in OS1 Type1 35 - 382 None None 0
3PUPB 2.99 Active DFGin BLAminus in-in in-in OS1 Type1 35 - 383 None None 0
6B8JA 2.595 Active DFGin BLAminus in-in in-in 65C Type1 37 - 384 None X216 0
6H0UA 2.3 Active DFGin BLAminus in-in in-in FKB Type1 36 - 383 None None 0
6H0UB 2.3 Active DFGin BLAminus in-in in-in FKB Type1 36 - 383 None None 0
6V6LA 2.19 Active DFGin BLAminus in-in in-in QQA Type1 37 - 384 None X216 0
1PYXA 2.4 Active DFGin BLAminus in-in in-in ANP Type1 35 - 386 None None 0
1PYXB 2.4 Active DFGin BLAminus in-in in-in ANP Type1 35 - 383 None None 0
3DU8A 2.2 Active DFGin BLAminus in-in in-in 553 Type1 35 - 382 None None 0
3DU8B 2.2 Active DFGin BLAminus in-in in-in 553 Type1 35 - 385 None None 0
1Q3DA 2.2 Active DFGin BLAminus in-in in-in STU Type1 35 - 385 None None 0
1Q3DB 2.2 Active DFGin BLAminus in-in in-in STU Type1 35 - 383 None None 0
1Q3WA 2.3 Active DFGin BLAminus in-in in-in ATU Type1 35 - 386 None None 0
1Q3WB 2.3 Active DFGin BLAminus in-in in-in ATU Type1 35 - 383 None None 0
1Q41A 2.1 Active DFGin BLAminus in-in in-in IXM Type1 35 - 386 None None 0
1Q41B 2.1 Active DFGin BLAminus in-in in-in IXM Type1 35 - 383 None None 0
1Q4LA 2.77 Active DFGin BLAminus in-in in-in 679 Type1 35 - 386 None None 0
1Q4LB 2.77 Active DFGin BLAminus in-in in-in 679 Type1 35 - 383 None None 0
3Q3BA 2.7 Active DFGin BLAminus in-in in-in 55E Type1 35 - 386 None None 0
3Q3BB 2.7 Active DFGin BLAminus in-in in-in 55E Type1 35 - 383 None None 0
4J1RA 2.702 Active DFGin BLAminus in-in in-in I5R Type1 36 - 383 None X216 0
4J1RB 2.702 Active DFGin BLAminus in-in in-in I5R Type1 36 - 384 None X216 0
4J1RC 2.702 Active DFGin BLAminus in-in in-in I5R Type1 36 - 384 None X216 0
4J1RD 2.702 Active DFGin BLAminus in-in in-in I5R Type1 36 - 384 None X216 0
4J71A 2.31 Active DFGin BLAminus in-in in-in 1JX Type1 36 - 383 None X216 0
4J71B 2.31 Active DFGin BLAminus in-in in-in 1JX Type1 36 - 383 None X216 0
5HLNA 3.1 Active DFGin BLAminus in-in in-in 65C Type1 34 - 384 None X216 0
5HLNB 3.1 Active DFGin BLAminus in-in in-in 65C Type1 37 - 383 None X216 0
5HLPA 2.45 Active DFGin BLAminus in-in in-in 65A Type1 36 - 382 None X216,X277 0
5HLPB 2.45 Active DFGin BLAminus in-in in-in 65A Type1 36 - 383 None X216,X277 0
5KPKA 2.4 Active DFGin BLAminus in-in in-in 6VK Type1 35 - 384 None X216 0
5KPKB 2.4 Active DFGin BLAminus in-in in-in 6VK Type1 35 - 383 None X216 0
5KPLA 2.6 Active DFGin BLAminus in-in in-in 6VL Type1 36 - 384 None X216 0
5KPLB 2.6 Active DFGin BLAminus in-in in-in 6VL Type1 36 - 383 None X216 0
5KPMA 2.69 Active DFGin BLAminus in-in in-in 6VM Type1 36 - 383 None X216 0
5KPMB 2.69 Active DFGin BLAminus in-in in-in 6VM Type1 36 - 384 None X216 0
4IQ6A 3.12 Active DFGin BLAminus in-in in-in IQ6 Type1 37 - 382 None None 0
3SAYA 2.231 Active DFGin BLAminus in-in in-in OFT Type1 35 - 384 None X216 0
3SAYB 2.231 Active DFGin BLAminus in-in in-in OFT Type1 35 - 382 None X216 0
4PTCA 2.711 Active DFGin BLAminus in-in in-in 2WE Type1 36 - 381 None None 0
4PTCB 2.711 Active DFGin BLAminus in-in in-in 2WE Type1 35 - 385 None None 0
4PTEA 2.033 Active DFGin BLAminus in-in in-in 2WF Type1 36 - 382 None None 0
4PTEB 2.033 Active DFGin BLAminus in-in in-in 2WF Type1 36 - 385 None None 0
4PTGA 2.361 Active DFGin BLAminus in-in in-in 2WG Type1 36 - 382 None None 0
4PTGB 2.361 Active DFGin BLAminus in-in in-in 2WG Type1 37 - 385 None None 0
8DJCA 2.463 Active DFGin BLAminus in-in in-in UAU Type1 35 - 382 None None 0
8DJCB 2.463 Active DFGin BLAminus in-in in-in UAU Type1 35 - 385 None None 0
8DJDA 2.205 Active DFGin BLAminus in-in in-in U3E Type1 36 - 383 None None 0
8DJDB 2.205 Active DFGin BLAminus in-in in-in U3E Type1 36 - 384 None None 0
8DJEA 2.374 Active DFGin BLAminus in-in in-in U6S Type1 36 - 384 None None 0
8DJEB 2.374 Active DFGin BLAminus in-in in-in U6S Type1 36 - 385 None None 0
8FF8A 2.33 Active DFGin BLAminus in-in in-in XV0 Type1 36 - 382 None None 0
8FF8B 2.33 Active DFGin BLAminus in-in in-in XV0 Type1 36 - 385 None None 0
3F88A 2.6 Active DFGin BLAminus in-in in-in 3HT Type1 35 - 383 None X216 0
3F88B 2.6 Active DFGin BLAminus in-in in-in 3HT Type1 35 - 383 None X216 0
4ACCA 2.21 Active DFGin BLAminus in-in in-in 7YG Type1 35 - 385 None None 0
4ACCB 2.21 Active DFGin BLAminus in-in in-in 7YG Type1 35 - 385 None None 0
4ACDA 2.6 Active DFGin BLAminus in-in in-in GR9 Type1 35 - 385 None None 0
4ACDB 2.6 Active DFGin BLAminus in-in in-in GR9 Type1 35 - 385 None None 0
4ACGA 2.6 Active DFGin BLAminus in-in in-in 6LQ Type1 35 - 385 None None 0
4ACGB 2.6 Active DFGin BLAminus in-in in-in 6LQ Type1 35 - 385 None None 0
4ACHA 2.6 Active DFGin BLAminus in-in in-in KDI Type1 35 - 385 None None 0
4ACHB 2.6 Active DFGin BLAminus in-in in-in KDI Type1 35 - 385 None None 0
5OY4A 3.2 Active DFGin BLAminus in-in in-in B4K Type1.5_Back 36 - 385 None X216 0
5OY4B 3.2 Active DFGin BLAminus in-in in-in B4K Type1.5_Back 30 - 384 None X216 0
4IQ6B 3.12 Active DFGin BLAminus in-in in-in IQ6 Type1.5_Back 37 - 382 None None 0

GSK3B (Glycogen synthase kinase-3 beta)

Group: CMGC
Total number of chains: 162
Spatial Dihedral Chains Representative
DFGin BLAminus 159 AF-P49841-K1A
DFGin ABAminus 3 5AIRA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens GSK3B_HUMAN 6Y9SA 2.03 Inactive DFGin ABAminus in-in in-in OHK Type1 35 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 6Y9SB 2.03 Inactive DFGin ABAminus in-in in-in OHK Type1 35 - 383 None X216 0
Homo sapiens GSK3B_HUMAN AF-P49841-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 48 - 348 None None 0
Homo sapiens GSK3B_HUMAN 1GNGA 2.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 36 - 385 None X216 0
Homo sapiens GSK3B_HUMAN 1GNGB 2.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 28 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 1H8FA 2.8 Active DFGin BLAminus in-in in-in No_ligand No_ligand 35 - 386 None None 0
Homo sapiens GSK3B_HUMAN 1H8FB 2.8 Active DFGin BLAminus in-in in-in No_ligand No_ligand 35 - 384 None None 0
Homo sapiens GSK3B_HUMAN 1I09A 2.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 25 - 384 None None 0
Homo sapiens GSK3B_HUMAN 1I09B 2.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 37 - 382 None None 0
Homo sapiens GSK3B_HUMAN 6HK7A 3.2 Active DFGin BLAminus in-in in-in G8N Type1 36 - 382 None X216 0
Homo sapiens GSK3B_HUMAN 7SXHA 2.09 Active DFGin BLAminus in-in in-in D1E Type1 37 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 7U2ZA 2.21 Active DFGin BLAminus in-in in-in L7C Type1 35 - 382 None None 0
Homo sapiens GSK3B_HUMAN 7U2ZB 2.21 Active DFGin BLAminus in-in in-in L7C Type1 35 - 382 None None 0
Homo sapiens GSK3B_HUMAN 3F7ZA 2.4 Active DFGin BLAminus in-in in-in 34O Type1 35 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 3F7ZB 2.4 Active DFGin BLAminus in-in in-in 34O Type1 35 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 3SD0A 2.7 Active DFGin BLAminus in-in in-in TSK Type1 35 - 384 None None 0
Homo sapiens GSK3B_HUMAN 3SD0B 2.7 Active DFGin BLAminus in-in in-in TSK Type1 35 - 383 None None 0
Homo sapiens GSK3B_HUMAN 3ZDIA 2.645 Active DFGin BLAminus in-in in-in UGJ Type1 36 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 4B7TA 2.772 Active DFGin BLAminus in-in in-in CWT Type1 35 - 384 None None 0
Homo sapiens GSK3B_HUMAN 6HK3A 2.35 Active DFGin BLAminus in-in in-in G8B Type1 35 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 6HK3B 2.35 Active DFGin BLAminus in-in in-in G8B Type1 35 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 6HK4A 2.5 Active DFGin BLAminus in-in in-in G8E Type1 35 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 6HK4B 2.5 Active DFGin BLAminus in-in in-in G8E Type1 35 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 6Y9RA 2.08 Active DFGin BLAminus in-in in-in OH8 Type1 35 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 5F94A 2.51 Active DFGin BLAminus in-in in-in 3UO Type1 36 - 381 None None 0
Homo sapiens GSK3B_HUMAN 5F94B 2.51 Active DFGin BLAminus in-in in-in 3UO Type1 37 - 385 None None 0
Homo sapiens GSK3B_HUMAN 5F95A 2.525 Active DFGin BLAminus in-in in-in 3UP Type1 36 - 383 None None 0
Homo sapiens GSK3B_HUMAN 5F95B 2.525 Active DFGin BLAminus in-in in-in 3UP Type1 36 - 385 None None 0
Homo sapiens GSK3B_HUMAN 7U31A 2.38 Active DFGin BLAminus in-in in-in L7I Type1 36 - 385 None None 0
Homo sapiens GSK3B_HUMAN 7U31B 2.38 Active DFGin BLAminus in-in in-in L7I Type1 37 - 382 None None 0
Homo sapiens GSK3B_HUMAN 7SXJA 1.85 Active DFGin BLAminus in-in in-in 6VL Type1 34 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 7OY5A 2.57 Active DFGin BLAminus in-in in-in 39I Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 7OY5B 2.57 Active DFGin BLAminus in-in in-in 39I Type1 35 - 383 None None 0
Homo sapiens GSK3B_HUMAN 7U33A 2.6 Active DFGin BLAminus in-in in-in L7R Type1 36 - 385 None None 0
Homo sapiens GSK3B_HUMAN 7U33B 2.6 Active DFGin BLAminus in-in in-in L7R Type1 37 - 382 None None 0
Homo sapiens GSK3B_HUMAN 7U36A 2.75 Active DFGin BLAminus in-in in-in L7W Type1 36 - 385 None None 0
Homo sapiens GSK3B_HUMAN 7U36B 2.75 Active DFGin BLAminus in-in in-in L7W Type1 37 - 382 None None 0
Homo sapiens GSK3B_HUMAN 2OW3A 2.8 Active DFGin BLAminus in-in in-in BIM Type1 35 - 385 None X216 0
Homo sapiens GSK3B_HUMAN 2OW3B 2.8 Active DFGin BLAminus in-in in-in BIM Type1 35 - 386 None X216 0
Homo sapiens GSK3B_HUMAN 1O9UA 2.4 Active DFGin BLAminus in-in in-in ADZ Type1 35 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 3GB2A 2.4 Active DFGin BLAminus in-in in-in G3B Type1 35 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 6TCUA 2.14 Active DFGin BLAminus in-in in-in N1Q Type1 35 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 5T31A 2.85 Active DFGin BLAminus in-in in-in 6VL Type1 35 - 381 D133E X216 0
Homo sapiens GSK3B_HUMAN 5T31B 2.85 Active DFGin BLAminus in-in in-in 6VL Type1 36 - 382 D133E X216 0
Homo sapiens GSK3B_HUMAN 7Z1FA 3.0 Active DFGin BLAminus in-in in-in 3NG Type1 28 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 7Z1FB 3.0 Active DFGin BLAminus in-in in-in 3NG Type1 38 - 382 None X216 0
Homo sapiens GSK3B_HUMAN 7Z1GA 2.85 Active DFGin BLAminus in-in in-in 3NG Type1 27 - 383 None None 0
Homo sapiens GSK3B_HUMAN 7B6FA 2.05 Active DFGin BLAminus in-in in-in SZW Type1 36 - 382 None X216 0
Homo sapiens GSK3B_HUMAN 8AUZA 2.66 Active DFGin BLAminus in-in in-in O9C Type1 27 - 381 None X216 0
Homo sapiens GSK3B_HUMAN 8AUZB 2.66 Active DFGin BLAminus in-in in-in O9C Type1 27 - 381 None X216 0
Homo sapiens GSK3B_HUMAN 8AV1A 2.15 Active DFGin BLAminus in-in in-in O9L Type1 27 - 381 None X216 0
Homo sapiens GSK3B_HUMAN 8AV1B 2.15 Active DFGin BLAminus in-in in-in O9L Type1 27 - 381 None X216 0
Homo sapiens GSK3B_HUMAN 4AFJA 1.98 Active DFGin BLAminus in-in in-in SJJ Type1 36 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 4AFJB 1.98 Active DFGin BLAminus in-in in-in SJJ Type1 34 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 6GN1A 2.6 Active DFGin BLAminus in-in in-in F4N Type1 36 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 6GN1B 2.6 Active DFGin BLAminus in-in in-in F4N Type1 36 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 3ZRKA 2.37 Active DFGin BLAminus in-in in-in ZRK Type1 36 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 3ZRKB 2.37 Active DFGin BLAminus in-in in-in ZRK Type1 36 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 3ZRLA 2.48 Active DFGin BLAminus in-in in-in ZRL Type1 36 - 385 None X216 0
Homo sapiens GSK3B_HUMAN 3ZRLB 2.48 Active DFGin BLAminus in-in in-in ZRL Type1 36 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 3ZRMA 2.49 Active DFGin BLAminus in-in in-in ZRM Type1 36 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 3ZRMB 2.49 Active DFGin BLAminus in-in in-in ZRM Type1 36 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 4NM5A 2.3 Active DFGin BLAminus in-in in-in ADP Type1 24 - 383 None None 0
Homo sapiens GSK3B_HUMAN 4NM7A 2.3 Active DFGin BLAminus in-in in-in ADP Type1 25 - 383 None None 0
Homo sapiens GSK3B_HUMAN 5K5NA 2.2 Active DFGin BLAminus in-in in-in 6QH Type1 36 - 382 V28G X216 0
Homo sapiens GSK3B_HUMAN 5K5NB 2.2 Active DFGin BLAminus in-in in-in 6QH Type1 36 - 384 V28G X216 0
Homo sapiens GSK3B_HUMAN 2O5KA 3.2 Active DFGin BLAminus in-in in-in HBM Type1 35 - 384 None None 0
Homo sapiens GSK3B_HUMAN 4DITA 2.6 None DFGin BLAminus in-in in-none 0KD Type1 35 - 387 None X216 4
Homo sapiens GSK3B_HUMAN 4NM0A 2.5 Active DFGin BLAminus in-in in-in ADP Type1 26 - 383 None None 0
Homo sapiens GSK3B_HUMAN 4NM3A 2.1 Active DFGin BLAminus in-in in-in ADP Type1 6 - 383 None X9 0
Homo sapiens GSK3B_HUMAN 1R0EA 2.25 Active DFGin BLAminus in-in in-in DFN Type1 35 - 383 None None 0
Homo sapiens GSK3B_HUMAN 1R0EB 2.25 Active DFGin BLAminus in-in in-in DFN Type1 35 - 383 None None 0
Homo sapiens GSK3B_HUMAN 1UV5A 2.8 Active DFGin BLAminus in-in in-in BRW Type1 35 - 383 None None 0
Homo sapiens GSK3B_HUMAN 1Q5KA 1.94 Active DFGin BLAminus in-in in-in TMU Type1 35 - 384 None None 0
Homo sapiens GSK3B_HUMAN 1Q5KB 1.94 Active DFGin BLAminus in-in in-in TMU Type1 35 - 384 None None 0
Homo sapiens GSK3B_HUMAN 3I4BA 2.3 Active DFGin BLAminus in-in in-in Z48 Type1 25 - 385 None None 0
Homo sapiens GSK3B_HUMAN 3I4BB 2.3 Active DFGin BLAminus in-in in-in Z48 Type1 36 - 382 None None 0
Homo sapiens GSK3B_HUMAN 3L1SA 2.9 Active DFGin BLAminus in-in in-in Z92 Type1 25 - 384 None None 0
Homo sapiens GSK3B_HUMAN 3L1SB 2.9 Active DFGin BLAminus in-in in-in Z92 Type1 36 - 382 None None 0
Homo sapiens GSK3B_HUMAN 6GJOA 2.91 Active DFGin BLAminus in-in in-in F1B Type1 35 - 383 None None 0
Homo sapiens GSK3B_HUMAN 6GJOB 2.91 Active DFGin BLAminus in-in in-in F1B Type1 35 - 383 None None 0
Homo sapiens GSK3B_HUMAN 1J1BA 1.8 Active DFGin BLAminus in-in in-in ANP Type1 35 - 388 None None 0
Homo sapiens GSK3B_HUMAN 1J1BB 1.8 Active DFGin BLAminus in-in in-in ANP Type1 23 - 386 None None 0
Homo sapiens GSK3B_HUMAN 1J1CA 2.1 Active DFGin BLAminus in-in in-in ADP Type1 35 - 388 None None 0
Homo sapiens GSK3B_HUMAN 1J1CB 2.1 Active DFGin BLAminus in-in in-in ADP Type1 23 - 386 None None 0
Homo sapiens GSK3B_HUMAN 2JLDA 2.35 Active DFGin BLAminus in-in in-in AG1 Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 2JLDB 2.35 Active DFGin BLAminus in-in in-in AG1 Type1 35 - 384 None None 0
Homo sapiens GSK3B_HUMAN 3M1SA 3.134 Active DFGin BLAminus in-in in-in DW1 Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 3M1SB 3.134 Active DFGin BLAminus in-in in-in DW1 Type1 35 - 384 None None 0
Homo sapiens GSK3B_HUMAN 3PUPA 2.99 Active DFGin BLAminus in-in in-in OS1 Type1 35 - 382 None None 0
Homo sapiens GSK3B_HUMAN 3PUPB 2.99 Active DFGin BLAminus in-in in-in OS1 Type1 35 - 383 None None 0
Homo sapiens GSK3B_HUMAN 6B8JA 2.595 Active DFGin BLAminus in-in in-in 65C Type1 37 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 6H0UA 2.3 Active DFGin BLAminus in-in in-in FKB Type1 36 - 383 None None 0
Homo sapiens GSK3B_HUMAN 6H0UB 2.3 Active DFGin BLAminus in-in in-in FKB Type1 36 - 383 None None 0
Homo sapiens GSK3B_HUMAN 6V6LA 2.19 Active DFGin BLAminus in-in in-in QQA Type1 37 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 1PYXA 2.4 Active DFGin BLAminus in-in in-in ANP Type1 35 - 386 None None 0
Homo sapiens GSK3B_HUMAN 1PYXB 2.4 Active DFGin BLAminus in-in in-in ANP Type1 35 - 383 None None 0
Homo sapiens GSK3B_HUMAN 3DU8A 2.2 Active DFGin BLAminus in-in in-in 553 Type1 35 - 382 None None 0
Homo sapiens GSK3B_HUMAN 3DU8B 2.2 Active DFGin BLAminus in-in in-in 553 Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 1Q3DA 2.2 Active DFGin BLAminus in-in in-in STU Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 1Q3DB 2.2 Active DFGin BLAminus in-in in-in STU Type1 35 - 383 None None 0
Homo sapiens GSK3B_HUMAN 1Q3WA 2.3 Active DFGin BLAminus in-in in-in ATU Type1 35 - 386 None None 0
Homo sapiens GSK3B_HUMAN 1Q3WB 2.3 Active DFGin BLAminus in-in in-in ATU Type1 35 - 383 None None 0
Homo sapiens GSK3B_HUMAN 1Q41A 2.1 Active DFGin BLAminus in-in in-in IXM Type1 35 - 386 None None 0
Homo sapiens GSK3B_HUMAN 1Q41B 2.1 Active DFGin BLAminus in-in in-in IXM Type1 35 - 383 None None 0
Homo sapiens GSK3B_HUMAN 1Q4LA 2.77 Active DFGin BLAminus in-in in-in 679 Type1 35 - 386 None None 0
Homo sapiens GSK3B_HUMAN 1Q4LB 2.77 Active DFGin BLAminus in-in in-in 679 Type1 35 - 383 None None 0
Homo sapiens GSK3B_HUMAN 3Q3BA 2.7 Active DFGin BLAminus in-in in-in 55E Type1 35 - 386 None None 0
Homo sapiens GSK3B_HUMAN 3Q3BB 2.7 Active DFGin BLAminus in-in in-in 55E Type1 35 - 383 None None 0
Homo sapiens GSK3B_HUMAN 4J1RA 2.702 Active DFGin BLAminus in-in in-in I5R Type1 36 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 4J1RB 2.702 Active DFGin BLAminus in-in in-in I5R Type1 36 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 4J1RC 2.702 Active DFGin BLAminus in-in in-in I5R Type1 36 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 4J1RD 2.702 Active DFGin BLAminus in-in in-in I5R Type1 36 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 4J71A 2.31 Active DFGin BLAminus in-in in-in 1JX Type1 36 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 4J71B 2.31 Active DFGin BLAminus in-in in-in 1JX Type1 36 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 5HLNA 3.1 Active DFGin BLAminus in-in in-in 65C Type1 34 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 5HLNB 3.1 Active DFGin BLAminus in-in in-in 65C Type1 37 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 5HLPA 2.45 Active DFGin BLAminus in-in in-in 65A Type1 36 - 382 None X216,X277 0
Homo sapiens GSK3B_HUMAN 5HLPB 2.45 Active DFGin BLAminus in-in in-in 65A Type1 36 - 383 None X216,X277 0
Homo sapiens GSK3B_HUMAN 5KPKA 2.4 Active DFGin BLAminus in-in in-in 6VK Type1 35 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 5KPKB 2.4 Active DFGin BLAminus in-in in-in 6VK Type1 35 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 5KPLA 2.6 Active DFGin BLAminus in-in in-in 6VL Type1 36 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 5KPLB 2.6 Active DFGin BLAminus in-in in-in 6VL Type1 36 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 5KPMA 2.69 Active DFGin BLAminus in-in in-in 6VM Type1 36 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 5KPMB 2.69 Active DFGin BLAminus in-in in-in 6VM Type1 36 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 4IQ6A 3.12 Active DFGin BLAminus in-in in-in IQ6 Type1 37 - 382 None None 0
Homo sapiens GSK3B_HUMAN 3SAYA 2.231 Active DFGin BLAminus in-in in-in OFT Type1 35 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 3SAYB 2.231 Active DFGin BLAminus in-in in-in OFT Type1 35 - 382 None X216 0
Homo sapiens GSK3B_HUMAN 4PTCA 2.711 Active DFGin BLAminus in-in in-in 2WE Type1 36 - 381 None None 0
Homo sapiens GSK3B_HUMAN 4PTCB 2.711 Active DFGin BLAminus in-in in-in 2WE Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 4PTEA 2.033 Active DFGin BLAminus in-in in-in 2WF Type1 36 - 382 None None 0
Homo sapiens GSK3B_HUMAN 4PTEB 2.033 Active DFGin BLAminus in-in in-in 2WF Type1 36 - 385 None None 0
Homo sapiens GSK3B_HUMAN 4PTGA 2.361 Active DFGin BLAminus in-in in-in 2WG Type1 36 - 382 None None 0
Homo sapiens GSK3B_HUMAN 4PTGB 2.361 Active DFGin BLAminus in-in in-in 2WG Type1 37 - 385 None None 0
Homo sapiens GSK3B_HUMAN 8DJCA 2.463 Active DFGin BLAminus in-in in-in UAU Type1 35 - 382 None None 0
Homo sapiens GSK3B_HUMAN 8DJCB 2.463 Active DFGin BLAminus in-in in-in UAU Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 8DJDA 2.205 Active DFGin BLAminus in-in in-in U3E Type1 36 - 383 None None 0
Homo sapiens GSK3B_HUMAN 8DJDB 2.205 Active DFGin BLAminus in-in in-in U3E Type1 36 - 384 None None 0
Homo sapiens GSK3B_HUMAN 8DJEA 2.374 Active DFGin BLAminus in-in in-in U6S Type1 36 - 384 None None 0
Homo sapiens GSK3B_HUMAN 8DJEB 2.374 Active DFGin BLAminus in-in in-in U6S Type1 36 - 385 None None 0
Homo sapiens GSK3B_HUMAN 8FF8A 2.33 Active DFGin BLAminus in-in in-in XV0 Type1 36 - 382 None None 0
Homo sapiens GSK3B_HUMAN 8FF8B 2.33 Active DFGin BLAminus in-in in-in XV0 Type1 36 - 385 None None 0
Homo sapiens GSK3B_HUMAN 3F88A 2.6 Active DFGin BLAminus in-in in-in 3HT Type1 35 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 3F88B 2.6 Active DFGin BLAminus in-in in-in 3HT Type1 35 - 383 None X216 0
Homo sapiens GSK3B_HUMAN 4ACCA 2.21 Active DFGin BLAminus in-in in-in 7YG Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 4ACCB 2.21 Active DFGin BLAminus in-in in-in 7YG Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 4ACDA 2.6 Active DFGin BLAminus in-in in-in GR9 Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 4ACDB 2.6 Active DFGin BLAminus in-in in-in GR9 Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 4ACGA 2.6 Active DFGin BLAminus in-in in-in 6LQ Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 4ACGB 2.6 Active DFGin BLAminus in-in in-in 6LQ Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 4ACHA 2.6 Active DFGin BLAminus in-in in-in KDI Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 4ACHB 2.6 Active DFGin BLAminus in-in in-in KDI Type1 35 - 385 None None 0
Homo sapiens GSK3B_HUMAN 5OY4A 3.2 Active DFGin BLAminus in-in in-in B4K Type1.5_Back 36 - 385 None X216 0
Homo sapiens GSK3B_HUMAN 5OY4B 3.2 Active DFGin BLAminus in-in in-in B4K Type1.5_Back 30 - 384 None X216 0
Homo sapiens GSK3B_HUMAN 4IQ6B 3.12 Active DFGin BLAminus in-in in-in IQ6 Type1.5_Back 37 - 382 None None 0
Mus musculus GSK3B_MOUSE 5AIRA 2.53 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 26 - 383 None None 0
Mus musculus GSK3B_MOUSE 6AE3C 2.14 Active DFGin BLAminus in-in in-in No_ligand No_ligand 37 - 383 None X216 0
Mus musculus GSK3B_MOUSE 6AE3D 2.14 Active DFGin BLAminus in-in in-in No_ligand No_ligand 36 - 382 None X216 0
Mus musculus GSK3B_MOUSE 5AIRB 2.53 Active DFGin BLAminus in-in in-in No_ligand No_ligand 22 - 384 None None 0
Mus musculus GSK3B_MOUSE 4NU1A 2.5 Active DFGin BLAminus in-in in-in ADP Type1 6 - 383 None X9 0
Mus musculus GSK3B_MOUSE 6AE3A 2.14 Active DFGin BLAminus in-in in-in MRI Type1 36 - 387 None X216 0
Mus musculus GSK3B_MOUSE 6AE3B 2.14 Active DFGin BLAminus in-in in-in MRI Type1 36 - 384 None X216 0

GSK3B (Glycogen synthase kinase-3 beta)

Group: CMGC
Total number of chains: 7
Spatial Dihedral Chains Representative
DFGin BLAminus 6 4NU1A
DFGin ABAminus 1 5AIRA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Mus musculus GSK3B_MOUSE 5AIRA 2.53 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 26 - 383 None None 0
Mus musculus GSK3B_MOUSE 6AE3C 2.14 Active DFGin BLAminus in-in in-in No_ligand No_ligand 37 - 383 None X216 0
Mus musculus GSK3B_MOUSE 6AE3D 2.14 Active DFGin BLAminus in-in in-in No_ligand No_ligand 36 - 382 None X216 0
Mus musculus GSK3B_MOUSE 5AIRB 2.53 Active DFGin BLAminus in-in in-in No_ligand No_ligand 22 - 384 None None 0
Mus musculus GSK3B_MOUSE 4NU1A 2.5 Active DFGin BLAminus in-in in-in ADP Type1 6 - 383 None X9 0
Mus musculus GSK3B_MOUSE 6AE3A 2.14 Active DFGin BLAminus in-in in-in MRI Type1 36 - 387 None X216 0
Mus musculus GSK3B_MOUSE 6AE3B 2.14 Active DFGin BLAminus in-in in-in MRI Type1 36 - 384 None X216 0