EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3)

Group: OTHER
Uniprot: E2AK3_HUMAN
Domain boundary: 593 - 1077


Total number of chains: 14
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q9NZJ5-K1A
DFGin None 8 7MF0AAA
DFGout BBAminus 4 4X7KA
DFGout None 1 4X7HA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q9NZJ5-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 585 - 1085 None None 0
4X7OA 2.65 Inactive DFGin None out-out none-none 3Z6 Type1 585 - 1081 D937N None 29
7MF0AAA 2.809 Inactive DFGin None out-out none-none Z6P Type1 586 - 1080 D937N None 27
8EQ9AAA 2.86 Inactive DFGin None out-out none-none WPB Type1 585 - 1080 D937N None 27
8EQDAAA 2.92 Inactive DFGin None out-out out-none WPX Type1 585 - 1080 D937N None 25
4G31A 2.28 Inactive DFGin None out-out none-out 0WH Type1.5_Back 588 - 1080 None None 26
4G34A 2.7 Inactive DFGin None out-out none-out 924 Type1.5_Back 588 - 1079 None None 27
4M7IA 2.34 Inactive DFGin None out-out none-out 27D Type1.5_Back 588 - 1080 None None 26
8EQEAAA 2.559 Inactive DFGin None out-out out-none WQ2 Type1.5_Back 585 - 1080 D937N None 26
4X7JA 2.3 Inactive DFGout BBAminus out-out none-none 3Z1 Type1 585 - 1086 D937N None 28
4X7KA 1.8 Inactive DFGout BBAminus out-out out-none 3Z3 Type2 585 - 1087 D937N None 26
4X7LA 1.9 Inactive DFGout BBAminus out-out out-none 3Z4 Type2 585 - 1087 D937N None 26
4X7NA 2.35 Inactive DFGout BBAminus out-out out-none 3Z5 Type2 585 - 1087 D937N None 26
4X7HA 2.0 Inactive DFGout None out-out none-none 3Z2 Type2 585 - 1086 D937N None 29

EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3)

Group: OTHER
Total number of chains: 15
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q9NZJ5-K1A
DFGin None 9 7MF0AAA
DFGout BBAminus 4 4X7KA
DFGout None 1 4X7HA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens E2AK3_HUMAN AF-Q9NZJ5-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 585 - 1085 None None 0
Homo sapiens E2AK3_HUMAN 4X7OA 2.65 Inactive DFGin None out-out none-none 3Z6 Type1 585 - 1081 D937N None 29
Homo sapiens E2AK3_HUMAN 7MF0AAA 2.809 Inactive DFGin None out-out none-none Z6P Type1 586 - 1080 D937N None 27
Homo sapiens E2AK3_HUMAN 8EQ9AAA 2.86 Inactive DFGin None out-out none-none WPB Type1 585 - 1080 D937N None 27
Homo sapiens E2AK3_HUMAN 8EQDAAA 2.92 Inactive DFGin None out-out out-none WPX Type1 585 - 1080 D937N None 25
Homo sapiens E2AK3_HUMAN 4G31A 2.28 Inactive DFGin None out-out none-out 0WH Type1.5_Back 588 - 1080 None None 26
Homo sapiens E2AK3_HUMAN 4G34A 2.7 Inactive DFGin None out-out none-out 924 Type1.5_Back 588 - 1079 None None 27
Homo sapiens E2AK3_HUMAN 4M7IA 2.34 Inactive DFGin None out-out none-out 27D Type1.5_Back 588 - 1080 None None 26
Homo sapiens E2AK3_HUMAN 8EQEAAA 2.559 Inactive DFGin None out-out out-none WQ2 Type1.5_Back 585 - 1080 D937N None 26
Homo sapiens E2AK3_HUMAN 4X7JA 2.3 Inactive DFGout BBAminus out-out none-none 3Z1 Type1 585 - 1086 D937N None 28
Homo sapiens E2AK3_HUMAN 4X7KA 1.8 Inactive DFGout BBAminus out-out out-none 3Z3 Type2 585 - 1087 D937N None 26
Homo sapiens E2AK3_HUMAN 4X7LA 1.9 Inactive DFGout BBAminus out-out out-none 3Z4 Type2 585 - 1087 D937N None 26
Homo sapiens E2AK3_HUMAN 4X7NA 2.35 Inactive DFGout BBAminus out-out out-none 3Z5 Type2 585 - 1087 D937N None 26
Homo sapiens E2AK3_HUMAN 4X7HA 2.0 Inactive DFGout None out-out none-none 3Z2 Type2 585 - 1086 D937N None 29
Mus musculus E2AK3_MOUSE 3QD2B 2.81 Inactive DFGin None in-in in-none No_ligand No_ligand 582 - 1078 None X980 15

EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3)

Group: OTHER
Total number of chains: 1
Spatial Dihedral Chains Representative
DFGin None 1 3QD2B
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Mus musculus E2AK3_MOUSE 3QD2B 2.81 Inactive DFGin None in-in in-none No_ligand No_ligand 582 - 1078 None X980 15