AKT1 (RAC-alpha serine/threonine-protein kinase)

Group: AGC
Uniprot: AKT1_HUMAN
Domain boundary: 150 - 408


Total number of chains: 34
Spatial Dihedral Chains Representative
DFGin BLAminus 21 AF-P31749-K1A
DFGout BBAminus 5 6HHJA
DFGout None 2 5KCVA
None None 6 6HHIA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P31749-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 142 - 416 None None 0
6BUUA 2.4 Active DFGin BLAminus in-in in-in No_ligand No_ligand 144 - 478 None X308,X473,X477 0
6BUUB 2.4 Active DFGin BLAminus in-in in-in No_ligand No_ligand 144 - 477 None X308,X473,X477 0
6NPZA 2.12 Active DFGin BLAminus in-in in-in No_ligand No_ligand 142 - 478 None X308,X473,X477 0
6NPZB 2.12 Active DFGin BLAminus in-in in-in No_ligand No_ligand 141 - 477 None X308,X473,X477 0
4GV1A 1.49 Active DFGin BLAminus in-in in-in 0XZ Type1 144 - 477 None X308 0
3OCBA 2.7 Active DFGin BLAminus in-in in-in XM1 Type1 144 - 478 S473D X308 0
3OCBB 2.7 Active DFGin BLAminus in-in in-in XM1 Type1 144 - 478 S473D X308 0
3OW4A 2.6 Active DFGin BLAminus in-in in-in SMY Type1 144 - 478 S473D X308 0
3OW4B 2.6 Active DFGin BLAminus in-in in-in SMY Type1 144 - 478 S473D X308 0
3QKLA 1.9 Active DFGin BLAminus in-in in-in SMR Type1 144 - 478 S473D X308 0
3QKMA 2.2 Active DFGin BLAminus in-in in-in SM9 Type1 144 - 478 S473D X308 0
4EKKA 2.8 Active DFGin BLAminus in-in in-in ANP Type1 144 - 477 S473D X308 0
4EKKB 2.8 Active DFGin BLAminus in-in in-in ANP Type1 144 - 477 S473D X308 0
4EKLA 2.0 Active DFGin BLAminus in-in in-in 0RF Type1 144 - 478 S473D X308 0
3CQUA 2.2 Inactive DFGin BLAminus in-out in-in CQU Type1 144 - 478 S473D X308 0
3CQWA 2.0 Active DFGin BLAminus in-in in-in CQW Type1 144 - 478 S473D X308 0
3MV5A 2.47 Active DFGin BLAminus in-in in-in XFE Type1 144 - 477 S473D X308 0
3MVHA 2.01 Active DFGin BLAminus in-in in-in WFE Type1 145 - 476 S473D X308 0
6CCYA 2.18 Active DFGin BLAminus in-in in-in EX4 Type1 144 - 983 N199S,S396P,E397S,T433V X308 0
3QKKA 2.3 Active DFGin BLAminus in-in in-in SMH Type1.5_Front 144 - 478 S473D X308 0
3O96A 2.7 Inactive DFGout BBAminus none-none out-none IQO Allosteric 2 - 429 None None 14
6HHHA 2.7 Inactive DFGout BBAminus none-none out-out G4Q Allosteric 2 - 439 E114A,E115A,E116A None 11
6HHJA 2.3 Inactive DFGout BBAminus out-out out-out G4H Allosteric 3 - 444 E114A,E115A,E116A None 0
6S9WA 2.3 Inactive DFGout BBAminus out-out out-out L1Z Allosteric 3 - 444 E114A,E115A,E116A None 2
4EJNA 2.19 Inactive DFGout BBAminus none-none out-out 0R4 Type1 4 - 438 E114A,E115A,E116A None 5
5KCVA 2.7 Inactive DFGout None none-none none-none 6S1 Allosteric 6 - 438 E114A,E115A,E116A None 16
7APJA 2.05 Inactive DFGout None none-none none-none No_ligand No_ligand 3 - 439 S2N None 18
6HHFA 2.9 Inactive None None none-none out-none G4K Allosteric 3 - 439 E114A,E115A,E116A None 14
6HHGA 2.3 Inactive None None none-none out-out G4T Allosteric 3 - 444 E114A,E115A,E116A None 3
6HHIA 2.7 Inactive None None none-none out-out G4N Allosteric 3 - 444 E114A,E115A,E116A None 3
6S9XA 2.6 Inactive None None none-none out-out L1W Allosteric 3 - 443 E114A,E115A,E116A None 7
7NH4A 2.3 Inactive None None none-none out-out UCE Allosteric 4 - 444 E114A,E115A,E116A None 6
7NH5A 1.9 Inactive None None none-none out-out UC8 Allosteric 3 - 444 E114A,E115A,E116A None 7

AKT1 (RAC-alpha serine/threonine-protein kinase)

Group: AGC
Total number of chains: 34
Spatial Dihedral Chains Representative
DFGin BLAminus 21 AF-P31749-K1A
DFGout BBAminus 5 6HHJA
DFGout None 2 5KCVA
None None 6 6HHIA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens AKT1_HUMAN AF-P31749-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 142 - 416 None None 0
Homo sapiens AKT1_HUMAN 6BUUA 2.4 Active DFGin BLAminus in-in in-in No_ligand No_ligand 144 - 478 None X308,X473,X477 0
Homo sapiens AKT1_HUMAN 6BUUB 2.4 Active DFGin BLAminus in-in in-in No_ligand No_ligand 144 - 477 None X308,X473,X477 0
Homo sapiens AKT1_HUMAN 6NPZA 2.12 Active DFGin BLAminus in-in in-in No_ligand No_ligand 142 - 478 None X308,X473,X477 0
Homo sapiens AKT1_HUMAN 6NPZB 2.12 Active DFGin BLAminus in-in in-in No_ligand No_ligand 141 - 477 None X308,X473,X477 0
Homo sapiens AKT1_HUMAN 4GV1A 1.49 Active DFGin BLAminus in-in in-in 0XZ Type1 144 - 477 None X308 0
Homo sapiens AKT1_HUMAN 3OCBA 2.7 Active DFGin BLAminus in-in in-in XM1 Type1 144 - 478 S473D X308 0
Homo sapiens AKT1_HUMAN 3OCBB 2.7 Active DFGin BLAminus in-in in-in XM1 Type1 144 - 478 S473D X308 0
Homo sapiens AKT1_HUMAN 3OW4A 2.6 Active DFGin BLAminus in-in in-in SMY Type1 144 - 478 S473D X308 0
Homo sapiens AKT1_HUMAN 3OW4B 2.6 Active DFGin BLAminus in-in in-in SMY Type1 144 - 478 S473D X308 0
Homo sapiens AKT1_HUMAN 3QKLA 1.9 Active DFGin BLAminus in-in in-in SMR Type1 144 - 478 S473D X308 0
Homo sapiens AKT1_HUMAN 3QKMA 2.2 Active DFGin BLAminus in-in in-in SM9 Type1 144 - 478 S473D X308 0
Homo sapiens AKT1_HUMAN 4EKKA 2.8 Active DFGin BLAminus in-in in-in ANP Type1 144 - 477 S473D X308 0
Homo sapiens AKT1_HUMAN 4EKKB 2.8 Active DFGin BLAminus in-in in-in ANP Type1 144 - 477 S473D X308 0
Homo sapiens AKT1_HUMAN 4EKLA 2.0 Active DFGin BLAminus in-in in-in 0RF Type1 144 - 478 S473D X308 0
Homo sapiens AKT1_HUMAN 3CQUA 2.2 Inactive DFGin BLAminus in-out in-in CQU Type1 144 - 478 S473D X308 0
Homo sapiens AKT1_HUMAN 3CQWA 2.0 Active DFGin BLAminus in-in in-in CQW Type1 144 - 478 S473D X308 0
Homo sapiens AKT1_HUMAN 3MV5A 2.47 Active DFGin BLAminus in-in in-in XFE Type1 144 - 477 S473D X308 0
Homo sapiens AKT1_HUMAN 3MVHA 2.01 Active DFGin BLAminus in-in in-in WFE Type1 145 - 476 S473D X308 0
Homo sapiens AKT1_HUMAN 6CCYA 2.18 Active DFGin BLAminus in-in in-in EX4 Type1 144 - 983 N199S,S396P,E397S,T433V X308 0
Homo sapiens AKT1_HUMAN 3QKKA 2.3 Active DFGin BLAminus in-in in-in SMH Type1.5_Front 144 - 478 S473D X308 0
Homo sapiens AKT1_HUMAN 3O96A 2.7 Inactive DFGout BBAminus none-none out-none IQO Allosteric 2 - 429 None None 14
Homo sapiens AKT1_HUMAN 6HHHA 2.7 Inactive DFGout BBAminus none-none out-out G4Q Allosteric 2 - 439 E114A,E115A,E116A None 11
Homo sapiens AKT1_HUMAN 6HHJA 2.3 Inactive DFGout BBAminus out-out out-out G4H Allosteric 3 - 444 E114A,E115A,E116A None 0
Homo sapiens AKT1_HUMAN 6S9WA 2.3 Inactive DFGout BBAminus out-out out-out L1Z Allosteric 3 - 444 E114A,E115A,E116A None 2
Homo sapiens AKT1_HUMAN 4EJNA 2.19 Inactive DFGout BBAminus none-none out-out 0R4 Type1 4 - 438 E114A,E115A,E116A None 5
Homo sapiens AKT1_HUMAN 5KCVA 2.7 Inactive DFGout None none-none none-none 6S1 Allosteric 6 - 438 E114A,E115A,E116A None 16
Homo sapiens AKT1_HUMAN 7APJA 2.05 Inactive DFGout None none-none none-none No_ligand No_ligand 3 - 439 S2N None 18
Homo sapiens AKT1_HUMAN 6HHFA 2.9 Inactive None None none-none out-none G4K Allosteric 3 - 439 E114A,E115A,E116A None 14
Homo sapiens AKT1_HUMAN 6HHGA 2.3 Inactive None None none-none out-out G4T Allosteric 3 - 444 E114A,E115A,E116A None 3
Homo sapiens AKT1_HUMAN 6HHIA 2.7 Inactive None None none-none out-out G4N Allosteric 3 - 444 E114A,E115A,E116A None 3
Homo sapiens AKT1_HUMAN 6S9XA 2.6 Inactive None None none-none out-out L1W Allosteric 3 - 443 E114A,E115A,E116A None 7
Homo sapiens AKT1_HUMAN 7NH4A 2.3 Inactive None None none-none out-out UCE Allosteric 4 - 444 E114A,E115A,E116A None 6
Homo sapiens AKT1_HUMAN 7NH5A 1.9 Inactive None None none-none out-out UC8 Allosteric 3 - 444 E114A,E115A,E116A None 7

AKT1 (RAC-alpha serine/threonine-protein kinase)

No non-human structures known.