PDB: 8CHF — 2 kinases

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 2 50.0% 8CHFE
DFGin None 2 50.0% 8CHFA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
STE MAP2K1 MP2K1_HUMAN 8CHFE 4.25 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 62 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8CHFF 4.25 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 62 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
TKL RAF1 RAF1_HUMAN 8CHFA 4.25 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiio 29L Type1 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 8CHFB 4.25 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiio 29L Type1 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase

PDB: 8CHF — 2 kinases

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 2 50.0% 8CHFE
DFGin None 2 50.0% 8CHFA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
STE MAP2K1 MP2K1_HUMAN 8CHFE 4.25 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 62 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 8CHFF 4.25 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 62 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
TKL RAF1 RAF1_HUMAN 8CHFA 4.25 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiio 29L Type1 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
TKL RAF1 RAF1_HUMAN 8CHFB 4.25 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiio 29L Type1 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens

PDB: 8CHF — 2 kinases

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism