3IW4

PRKCA (Protein kinase C alpha type)
Group: AGC
Uniprot: KPCA_HUMAN
Organism: Homo sapiens
Domain boundary: 339 - 597
Resolu: 2.8

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in LW4 Type1 331 - 669 0
B Active DFGin BLAminus in-in in-in LW4 Type1 332 - 666 1
C Active DFGin BLAminus in-in in-in LW4 Type1 330 - 670 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain C
       328        338        348        358 
mpsedrkqps nNLDRVKLTD FNFLMVLGKG SFGKVMLADR 
       368        378        388        398 
KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALLDKPP 
       408        418        428        438 
FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP 
       448        458        468        478 
QAVFYAAEIS IGLFFLHKRG IIYRDLKLDN VMLDSEGHIK 
       488        498        508        518 
IADFGMCKEH MMDGVTTREF CGTPDYIAPE IIAYQPYGKS 
       528        538        548        558 
VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP 
       568        578        588        598 
KSLSKEAVSI CKGLMTKHPA KRLGCGPEGE RDVREHAFFR 
       608        618        628        638 
RIDWEKLENR EIQPPFKPKV cgkgaenFDK FFTRGQPVLT 
       648        658        668          - 
PPDQLVIANI DQSDFEGFSY VNPQFVHPIL QSavhhhhhh


Lower-case residues are disordered in structure.
Mutations: T497E
Phosphorylation: X638,X657