Ligand: LW4 (Sotrastaurin)

Total number of chains: 3
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 3IW4A
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC PRKCA KPCA_HUMAN 3IW4A 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LW4 Type1 331 - 669 0 TPO638,SEP657 T497E Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN 3IW4B 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LW4 Type1 332 - 666 0 TPO638,SEP657 T497E Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN 3IW4C 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LW4 Type1 330 - 670 0 TPO638,SEP657 T497E Protein kinase C alpha type

Ligand: LW4 (Sotrastaurin)

Total number of chains: 3
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 3IW4A
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC PRKCA KPCA_HUMAN 3IW4A 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LW4 Type1 331 - 669 0 TPO638,SEP657 T497E Protein kinase C alpha type Homo sapiens
AGC PRKCA KPCA_HUMAN 3IW4B 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LW4 Type1 332 - 666 0 TPO638,SEP657 T497E Protein kinase C alpha type Homo sapiens
AGC PRKCA KPCA_HUMAN 3IW4C 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LW4 Type1 330 - 670 0 TPO638,SEP657 T497E Protein kinase C alpha type Homo sapiens

Ligand: LW4 (Sotrastaurin)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
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Hover over column headers for tooltip help

Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism